Unraveling the Puzzle: Health Benefits of Probiotics—A Comprehensive Review

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(5), С. 1436 - 1436

Опубликована: Март 1, 2024

A growing number of probiotic-containing products are on the market, and their use is increasing. Probiotics thought to support health gut microbiota, which in turn might prevent or delay onset gastrointestinal tract disorders. Obesity, type 2 diabetes, autism, osteoporosis, some immunological illnesses among conditions that have been shown possibly benefit from probiotics. In addition ability favorably affect diseases, probiotics represent a defense system enhancing intestinal, nutritional, oral health. Depending microbial strain utilized, can variable beneficial properties. Although many species available, most widely employed ones lactic acid bacteria bifidobacteria. The usefulness these dependent both origin capacity promote valuable clinical tool supporting health, immune function, metabolic balance. When used appropriately, may provide benefits such as reduced risk disorders, enhanced immunity, improved Most popular probiotics, advantages, mode action topic this narrative review article, aimed reader with comprehensive reappraisal matter.

Язык: Английский

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Gut-liver axis: Pathophysiological concepts and medical perspective in chronic liver diseases

Seminars in Immunology, Год журнала: 2024, Номер 71, С. 101859 - 101859

Опубликована: Янв. 21, 2024

Язык: Английский

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Probiotics and Food Bioactives: Unraveling Their Impact on Gut Microbiome, Inflammation, and Metabolic Health

Probiotics and Antimicrobial Proteins, Год журнала: 2025, Номер unknown

Опубликована: Янв. 14, 2025

Язык: Английский

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A review on probiotics and dietary bioactives: Insights on metabolic well-being, gut microbiota, and inflammatory responses

Food Chemistry Advances, Год журнала: 2025, Номер 6, С. 100919 - 100919

Опубликована: Фев. 11, 2025

Язык: Английский

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Gut–Brain Axis and Neuroinflammation: The Role of Gut Permeability and the Kynurenine Pathway in Neurological Disorders

Cellular and Molecular Neurobiology, Год журнала: 2024, Номер 44(1)

Опубликована: Окт. 8, 2024

The increasing prevalence of neurological disorders such as Alzheimer's, Parkinson's, and multiple sclerosis presents a significant global health challenge. Despite extensive research, the precise mechanisms underlying these conditions remain elusive, with current treatments primarily addressing symptoms rather than root causes. Emerging evidence suggests that gut permeability kynurenine pathway are involved in pathogenesis conditions, offering promising targets for novel therapeutic preventive strategies. Gut refers to intestinal lining's ability selectively allow essential nutrients into bloodstream while blocking harmful substances. Various factors, including poor diet, stress, infections, genetic predispositions, can compromise integrity, leading increased permeability. This condition facilitates translocation toxins bacteria systemic circulation, triggering widespread inflammation impacts via gut-brain axis. axis (GBA) is complex communication network between central nervous system. Dysbiosis, an imbalance microbiota, increase inflammation, exacerbating neuroinflammation-a key factor disorders. pathway, primary route tryptophan metabolism, significantly implicated this process. Dysregulation context leads production neurotoxic metabolites, quinolinic acid, which contribute neuronal damage progression narrative review highlights potential progress understanding mechanisms. Interventions targeting maintaining balanced microbiota through probiotics, lifestyle modifications show promise reducing neuroinflammation supporting brain health. In addition, pharmacological approaches aimed at modulating directly, inhibitors indoleamine 2,3-dioxygenase, offer avenues new treatments. Understanding interconnected pathways crucial developing effective strategies prevent manage

Язык: Английский

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The use of probiotics and prebiotics in decolonizing pathogenic bacteria from the gut; a systematic review and meta-analysis of clinical outcomes

Gut Microbes, Год журнала: 2024, Номер 16(1)

Опубликована: Май 22, 2024

Repeated exposure to antibiotics and changes in the diet environment shift gut microbial diversity composition, making host susceptible pathogenic infection. The emergence ongoing spread of AMR pathogens is a challenging public health issue. Recent evidence showed that probiotics prebiotics may play role decolonizing drug-resistant by enhancing colonization resistance gut. This review aims analyze available from human-controlled trials determine effect size probiotic interventions bacteria We further studied effects human animal studies. PubMed, Embase, Web Science, Scopus, CINAHL were used collect articles. random-effects model meta-analysis was pool data. GRADE Pro Cochrane collaboration tools assess bias quality evidence. Out 1395 citations, 29 RCTs eligible, involving 2871 subjects who underwent either or placebo treatment decolonize pathogens. persistence after 22%(probiotics) 30.8%(placebo). pooled odds ratio 0.59(95% CI:0.43-0.81), favoring with moderate certainty (

Язык: Английский

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Recent advances in the probiotic application of the Bacillus as a potential candidate in the sustainable development of aquaculture

Aquaculture, Год журнала: 2024, Номер 594, С. 741432 - 741432

Опубликована: Авг. 3, 2024

Язык: Английский

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Human Papillomavirus Infections and the Role Played by Cervical and Cervico-Vaginal Microbiota—Evidence from Next-Generation Sequencing Studies

Cancers, Год журнала: 2024, Номер 16(2), С. 399 - 399

Опубликована: Янв. 17, 2024

This comprehensive review encompasses studies examining changes in the cervical and cervico-vaginal microbiota (CM CVM) relation to human papillomavirus (HPV) using next-generation sequencing (NGS) technology. HPV infection remains a prominent global health concern, with spectrum of manifestations, from benign lesions life-threatening cancers. The CM CVM, unique collection microorganisms inhabiting cervix/vagina, has emerged as critical player health. Recent research indicated that disruptions characterized by decrease Lactobacillus overgrowth other bacteria, might increase risk persistence progression abnormalities. alteration or CVM been linked higher likelihood dysplasia. NGS technology revolutionized study microbiome, providing insights into microbial diversity, dynamics, taxonomic classifications. Bacterial 16S rRNA gene sequencing, proven invaluable characterizing shedding light on its role infections paving way for more tailored strategies combat diseases. NGS-based offer personalized an individual’s microbiome. knowledge holds promise development novel diagnostic tools, targeted therapies, preventive interventions cervix-related conditions, including cancer.

Язык: Английский

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Emerging Approaches for Mitigating Biofilm-Formation-Associated Infections in Farm, Wild, and Companion Animals

Pathogens, Год журнала: 2024, Номер 13(4), С. 320 - 320

Опубликована: Апрель 13, 2024

The importance of addressing the problem biofilms in farm, wild, and companion animals lies their pervasive impact on animal health welfare. Biofilms, as resilient communities microorganisms, pose a persistent challenge causing infections complicating treatment strategies. Recognizing understanding mitigating biofilm formation is critical to ensuring welfare variety settings, from farms wild animals. Effectively this issue not only improves overall individual animals, but also contributes broader goals sustainable agriculture, wildlife conservation, responsible pet ownership. This review examines current diseases elucidates complex processes involved. limitations traditional antibiotic treatments, mechanisms resistance associated with are explored. focus alternative therapeutic strategies control biofilm, illuminating case studies providing valuable context practical insights. In conclusion, highlights exploring emerging approaches mitigate It consolidates existing knowledge, gaps understanding, encourages further research address facet health. comprehensive perspective provided by serves foundation for future investigations interventions improve management biofilm-associated diverse populations.

Язык: Английский

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Interactions between Dietary Antioxidants, Dietary Fiber and the Gut Microbiome: Their Putative Role in Inflammation and Cancer

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(15), С. 8250 - 8250

Опубликована: Июль 28, 2024

The intricate relationship between the gastrointestinal (GI) microbiome and progression of chronic non-communicable diseases underscores significance developing strategies to modulate GI microbiota for promoting human health. administration probiotics prebiotics represents a good strategy that enhances population beneficial bacteria in intestinal lumen post-consumption, which has positive impact on In addition, dietary fibers serve as significant energy source inhabiting cecum colon. Research articles reviews sourced from various global databases were systematically analyzed using specific phrases keywords investigate these relationships. There is clear association fiber intake improved colon function, gut motility, reduced colorectal cancer (CRC) risk. Moreover, state health reflected reciprocal bidirectional relationships among food, antioxidants, inflammation, body composition. They are known their antioxidant properties ability inhibit angiogenesis, metastasis, cell proliferation. Additionally, they promote survival, immune inflammatory responses, inactivate pro-carcinogens. These actions collectively contribute role prevention. different investigations, supplements containing vitamins have been shown lower risk types. contrast, some evidence suggests taking can increase cancer. Ultimately, collaborative efforts immunologists, clinicians, nutritionists, dietitians imperative designing well-structured nutritional trials corroborate clinical efficacy therapy managing inflammation preventing carcinogenesis. This review seeks explore interrelationships fiber, microbiome, with particular focus potential implications

Язык: Английский

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