bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 4, 2025
Abstract
Bacteroidota,
a
diverse
phylum
of
bacteria,
are
increasingly
recognized
for
their
significant
contributions
to
host
health,
particularly
through
antimicrobial
and
probiotic
properties.
This
study
investigates
the
functional
diversity
potential
42
new
Bacteroidota
strains
enriched
identified
from
hosts,
including
mouse
ceca
human
stool
samples.
Using
16S
rRNA
gene
sequencing,
we
phylogenetically
characterized
genera
Bacteroides,
Phocaeicola
Sphingobacterium
assessed
properties
related
potential.
The
were
evaluated
concerning
ability
inhibit
biofilm
formation
WHO
declared
clinically
pathogens,
gram-positive
Staphylococcus
aureus
epidermidis
,
gram-negative
Klebsiella
oxytoca
Pseudomonas
aeruginosa
eukaryotic
fungus
Candida
albicans.
Additionally,
investigated
bile
salt
hydrolase
quorum
quenching
activities
strains,
key
traits
associated
with
efficacy.
Our
findings
demonstrate
that
all
examined
consistently
exhibit
capacity
but
different
extent.
Furthermore,
14
showed
activity,
39
highlighting
High
inhibition
as
well
activity
against
both
autoinducers,
AHL
AI-2,
predominantly
observed
in
Bacteroides
caecimuris
muris
making
them
attractive
candidates
next-generation
probiotics.
Overall,
this
advances
field
probiotics
by
identifying
promising
therapeutic
applications
potentially
revolutionizing
approaches
microbiome-based
interventions
pathogen
control
clinical
settings.
Journal of Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
13(5), P. 1436 - 1436
Published: March 1, 2024
A
growing
number
of
probiotic-containing
products
are
on
the
market,
and
their
use
is
increasing.
Probiotics
thought
to
support
health
gut
microbiota,
which
in
turn
might
prevent
or
delay
onset
gastrointestinal
tract
disorders.
Obesity,
type
2
diabetes,
autism,
osteoporosis,
some
immunological
illnesses
among
conditions
that
have
been
shown
possibly
benefit
from
probiotics.
In
addition
ability
favorably
affect
diseases,
probiotics
represent
a
defense
system
enhancing
intestinal,
nutritional,
oral
health.
Depending
microbial
strain
utilized,
can
variable
beneficial
properties.
Although
many
species
available,
most
widely
employed
ones
lactic
acid
bacteria
bifidobacteria.
The
usefulness
these
dependent
both
origin
capacity
promote
valuable
clinical
tool
supporting
health,
immune
function,
metabolic
balance.
When
used
appropriately,
may
provide
benefits
such
as
reduced
risk
disorders,
enhanced
immunity,
improved
Most
popular
probiotics,
advantages,
mode
action
topic
this
narrative
review
article,
aimed
reader
with
comprehensive
reappraisal
matter.
Cellular and Molecular Neurobiology,
Journal Year:
2024,
Volume and Issue:
44(1)
Published: Oct. 8, 2024
The
increasing
prevalence
of
neurological
disorders
such
as
Alzheimer's,
Parkinson's,
and
multiple
sclerosis
presents
a
significant
global
health
challenge.
Despite
extensive
research,
the
precise
mechanisms
underlying
these
conditions
remain
elusive,
with
current
treatments
primarily
addressing
symptoms
rather
than
root
causes.
Emerging
evidence
suggests
that
gut
permeability
kynurenine
pathway
are
involved
in
pathogenesis
conditions,
offering
promising
targets
for
novel
therapeutic
preventive
strategies.
Gut
refers
to
intestinal
lining's
ability
selectively
allow
essential
nutrients
into
bloodstream
while
blocking
harmful
substances.
Various
factors,
including
poor
diet,
stress,
infections,
genetic
predispositions,
can
compromise
integrity,
leading
increased
permeability.
This
condition
facilitates
translocation
toxins
bacteria
systemic
circulation,
triggering
widespread
inflammation
impacts
via
gut-brain
axis.
axis
(GBA)
is
complex
communication
network
between
central
nervous
system.
Dysbiosis,
an
imbalance
microbiota,
increase
inflammation,
exacerbating
neuroinflammation-a
key
factor
disorders.
pathway,
primary
route
tryptophan
metabolism,
significantly
implicated
this
process.
Dysregulation
context
leads
production
neurotoxic
metabolites,
quinolinic
acid,
which
contribute
neuronal
damage
progression
narrative
review
highlights
potential
progress
understanding
mechanisms.
Interventions
targeting
maintaining
balanced
microbiota
through
probiotics,
lifestyle
modifications
show
promise
reducing
neuroinflammation
supporting
brain
health.
In
addition,
pharmacological
approaches
aimed
at
modulating
directly,
inhibitors
indoleamine
2,3-dioxygenase,
offer
avenues
new
treatments.
Understanding
interconnected
pathways
crucial
developing
effective
strategies
prevent
manage
Gut Microbes,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: May 22, 2024
Repeated
exposure
to
antibiotics
and
changes
in
the
diet
environment
shift
gut
microbial
diversity
composition,
making
host
susceptible
pathogenic
infection.
The
emergence
ongoing
spread
of
AMR
pathogens
is
a
challenging
public
health
issue.
Recent
evidence
showed
that
probiotics
prebiotics
may
play
role
decolonizing
drug-resistant
by
enhancing
colonization
resistance
gut.
This
review
aims
analyze
available
from
human-controlled
trials
determine
effect
size
probiotic
interventions
bacteria
We
further
studied
effects
human
animal
studies.
PubMed,
Embase,
Web
Science,
Scopus,
CINAHL
were
used
collect
articles.
random-effects
model
meta-analysis
was
pool
data.
GRADE
Pro
Cochrane
collaboration
tools
assess
bias
quality
evidence.
Out
1395
citations,
29
RCTs
eligible,
involving
2871
subjects
who
underwent
either
or
placebo
treatment
decolonize
pathogens.
persistence
after
22%(probiotics)
30.8%(placebo).
pooled
odds
ratio
0.59(95%
CI:0.43-0.81),
favoring
with
moderate
certainty
(
