CytoJournal,
Год журнала:
2022,
Номер
19, С. 42 - 42
Опубликована: Июнь 14, 2022
The
cervical
cancer
screening
has
been
based
conventionally
on
cytologic
analysis.
With
advances
in
understanding
the
role
of
human
papillomavirus,
cotesting
applied.
But
most
patients
subjected
to
colposcopy
did
not
benefit,
except
cases
with
HSIL
[high-grade
squamous
intraepithelial
lesion]
cytology.
Because
this,
a
step
increase
sensitivity
detect
cancers
and
pre-cancers
but
higher
specificity
minimal
overdiagnosis
leading
prevention
unindicated
biopsies
is
highly
desired.
Such
triaging
abnormal
results
expected
minimize
invasive
interventions
because
low
false
positivity.
availability
methodologies
quantitatively
qualitatively
enhanced
cell-blocks
from
residual
liquid
cytology
specimens,
immunostaining
can
be
performed
for
multiple
immunomarkers
potential
objectivity
triage
initial
test
results.
This
further
inclusion
AV
marker
application
SCIP
(subtractive
coordinate
immunoreactivity
pattern)
approach.
are
also
resource
performing
other
ancillary
studies
including
molecular
pathology
proteomics/metabolomics
as
tests
future.
review
explores
specimen
cell-blocking
algorithmic
manner
adjunct
ASCCP
management
guidelines
improved
patient
care.
Vaccines,
Год журнала:
2023,
Номер
11(6), С. 1060 - 1060
Опубликована: Июнь 4, 2023
Background
and
aim:
Human
papillomavirus
(HPV)
is
sexually
transmitted,
one
of
the
three
most
common
transmitted
infections
(STIs)
in
both
males
females,
viral
STI.
A
crucial
public
health
strategy
to
protect
people
against
HPV
vaccination,
which
has
shown
its
effectiveness
preventing
HPV-related
diseases.
Presently,
types
vaccines
are
available
(bivalent,
quadrivalent,
nonvalent),
they
all
target
two
oncogenic
virus
genotypes
(HPV
16
18).
In
recent
years,
need
implement
vaccination
programmes
that
include
genders
been
discussed
order
achieve
herd
immunity
HPV.
To
date,
only
a
few
countries
have
included
young
their
programmes.
Thus,
our
objective
with
this
review
provide
an
overview
epidemiology
prevention
strategies
report
latest
findings
from
scientific
literature.
Journal of Medical Virology,
Год журнала:
2022,
Номер
95(1)
Опубликована: Дек. 7, 2022
Merkel
cell
carcinoma
(MCC)
is
an
aggressive
skin
malignancy
with
two
distinct
etiologies.
The
first,
which
accounts
for
the
highest
proportion,
caused
by
polyomavirus
(MCPyV),
a
DNA
tumor
virus.
A
second,
UV-induced,
MCC
form
has
also
been
identified.
Few
diagnostic,
prognostic,
and
therapeutic
options
are
available.
MicroRNAs
(miRNAs)
small
noncoding
RNA
molecules,
play
key
role
in
regulating
various
physiologic
cellular
functions
including
cycling,
proliferation,
differentiation,
apoptosis.
Numerous
miRNAs
dysregulated
cancer,
acting
as
either
suppressors
or
oncomiRs.
aim
of
this
review
to
collect,
summarize,
discuss
recent
findings
on
whose
dysregulation
assumed
MCC.
potential
clinical
application
diagnostic
prognostic
biomarkers
described.
In
future,
will
potentially
gain
significance
improvement
options.
Frontiers in Oncology,
Год журнала:
2022,
Номер
12
Опубликована: Июнь 1, 2022
Numerous
studies
support
that
Human
papillomavirus
(HPV)
can
cause
cervical
cancer.
However,
few
have
surveyed
the
heterogeneity
of
HPV
infected
or
uninfected
(HPV+
and
HPV-)
cancer
(CESC)
patients.
Integration
scRNA-seq
TCGA
data
to
analyze
HPV+
HPV-
patients
on
a
single-cell
level
could
improve
understanding
cellular
mechanisms
during
HPV-induced
cancer.CESC
obtained
from
Gene
Expression
Omnibus
(GEO)
database
Seurat,
Monocle3
package
were
used
for
analysis.
The
ESTIMATE
was
single-sample
gene
immune
score,
CIBERSORT
identify
scores
cells,
"WGCNA"
weighted
correlation
network
Univariate
Cox
LASSO
regression
performed
establish
survival
relapse
signatures.
KEGG
GO
analyses
signature
gene.
Profiling
Interactive
Analysis
Pan-cancer
analysis.In
CESC
group,
CD8+
T
cells
B
down-regulated,
whereas
reg
CD4+
epithelial
up-regulated
according
data.
Survival
analysis
TCGA-CESC
revealed
increased
expression
naive
favors
probability
WGCNA,
univariate
Cox,
established
9-genes
7-gene
model.
identified
IKZF3,
FOXP3,
JAK3
had
similar
distribution
effects
in
HPV-associated
HNSC.Analysis
bulk
RNA-seq
samples
transcriptional
state
infiltration.
models
adjusted
assess
prognostic
risk
accurately.
Hub
genes
represent
protection
associated
HNSC
while
showing
irrelevant
other
potential
HPV-related
cancers.
Background
and
aim:
Human
Papillomavirus
(HPV)
is
sexually
transmitted,
one
of
the
three
most
common
transmitted
infections
(STIs)
in
both
males
females,
viral
STI.
A
crucial
public
health
strategy
to
protect
people
against
HPV
through
vaccination,
which
has
shown
its
effectiveness
preventing
related
diseases.
Presently
types
vaccines
are
available
(bivalent,
quadrivalent,
nonavalent)
they
all
target
at
least
two
oncogenic
virus
genotypes
(HPV
16,
18).
In
past
few
years,
need
implement
vaccination
programmes
that
include
genders
been
discussed
order
achieve
herd
immunity
HPV.
To
date,
only
a
countries
have
included
young
their
programmes,
so
we
aim
this
review
provide
an
overview
epidemiology
prevention
strategies
prevent
it,
reporting
latest
findings
from
scientific
literature.
Experimental Oncology,
Год журнала:
2025,
Номер
46(4), С. 387 - 392
Опубликована: Фев. 20, 2025
Background.
Cervical
cancer
is
a
major
health
concern,
with
human
papillomaviruses
(HPV)
infection
being
key
risk
factor.
However,
not
all
HPV-infected
individuals
develop
cancer,
suggesting
the
additional
factors
may
be
involved.
This
study
aims
to
evaluate
differences
in
miR-155
and
-205
expression
cervical
tissue
dysplasia
depending
on
presence
of
HPV
confirmed
diagnosis.
Materials
Methods.
The
30
formalin-fixed
paraffin-embedded
primary
biopsy
samples
was
evaluated
using
RT-PCR.
Results.
levels
miRNA-155
without
malignant
transformation
lower
than
these
carcinoma
situ
tissues
(0.74
±
0.21
1.65
0.42
vs.
1.37
0.18
2.35
0.32,
respectively).
In
cases,
we
found
higher
(1.6
1.38
times,
respectively)
CIN-3/
HSIL
compared
CIN-2/HSIL
samples.
both
miRNAs
tended
increase
HPV-positive
cases
HPV-negative
signs
transformation,
respectively.
Conclusions.
obtained
data
indicate
potential
relationship
between
profile
-205.
Abstract
Background
and
Purpose
MicroRNAs
(miRNAs)
play
multifaceted
roles
in
cervical
cancer
therapy,
including
regulating
progression,
metastasis,
drug
resistance,
HPV
control,
metabolic
alterations.
This
study
aims
to
provide
a
comprehensive
bibliometric
analysis
of
the
existing
literature
on
miRNAs
cancer,
offering
insights
into
research
trends,
key
contributors,
emerging
themes
guide
future
investigations
enhance
therapeutic
strategies.
Method
We
conducted
systematic
search
Web
Science
PubMed
database
for
published
between
January
2010
December
2024.
A
total
4034
records
were
retrieved
analyzed
using
VOSviewer
CiteSpace
software
visualization
trend
analysis.
Results
Over
past
fifteen
years,
miRNA
showed
significant
upward
before
2020,
then
gradually
declined
starting
from
2021.
The
reveals
that
Tang
Hua
are
most
active
authors,
China
is
influential
country.
"Plos
One"
journal
publishes
articles.
Besides,
Tianjin
Medical
University
productive
institution.
top
three
high-frequency
keywords
"cervical
cancer",
"expression"
"invasion".
Recent
keyword
indicates
notable
feature
current
deep
integration
basic
clinical
application.
Particularly,
cross-integration
non-coding
RNA
network
with
technologies
such
as
nanotechnology
artificial
intelligence
promoting
precise
diagnosis
treatment
system
cancer.
These
findings
highlight
interest
understanding
miRNA-mediated
pathways
their
significance
Conclusion
provides
overview
landscape
identifying
institutions,
trends.
While
does
not
predict
direction
treatment,
it
offers
valuable
state
potential
areas
further
exploration.
underscore
importance
continued
investigation
mechanisms
applications
advance
management.
