Closing the loop between brain and electrical stimulation: towards precision neuromodulation treatments

Translational Psychiatry, Год журнала: 2023, Номер 13(1)

Опубликована: Авг. 14, 2023

Abstract One of the most critical challenges in using noninvasive brain stimulation (NIBS) techniques for treatment psychiatric and neurologic disorders is inter- intra-individual variability response to NIBS. Response variations previous findings suggest that one-size-fits-all approach does not seem appropriate option enhancing outcomes. While there a growing body evidence feasibility effectiveness individualized NIBS approaches, optimal way achieve this yet be determined. Transcranial electrical (tES) one showing promising results modulating outcomes several disorders, but it faces same challenge individual optimization. With new computational methodological advances, tES can integrated with real-time functional magnetic resonance imaging (rtfMRI) establish closed-loop tES-fMRI individually optimized neuromodulation. Closed-loop systems aim optimize parameters based on minimizing differences between model current state desired value maximize expected clinical outcome. The space fMRI applications includes (1) vs. data acquisition timing, (2) context (task-based or resting-state), (3) inherent oscillations, (4) dose-response function, (5) target trait (6) optimization algorithm. technology has advantages over non-individualized open-loop reshape future neuromodulation objective clinically relevant such as drug cue reactivity substance use disorder considering both inter variations. Using multi-level behavior measures input individualize provides framework designing personalized protocols precision psychiatry.

Язык: Английский

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Transcranial Alternating Current Stimulation to Modulate Alpha Activity: A Systematic Review

Neuromodulation Technology at the Neural Interface, Год журнала: 2023, Номер 26(8), С. 1549 - 1584

Опубликована: Янв. 31, 2023

Transcranial alternating current stimulation (tACS) has been one of numerous investigation methods used for their potential to modulate brain oscillations; however, such investigations have given contradictory results and a lack standardization.In this systematic review, we aimed assess the tACS alpha spectral power. The secondary outcome was identification methodologic key parameters, adverse effects, sensations.Studies in healthy adults who were receiving active sham intervention or any differential condition included. main assessed increase/decrease power through either electroencephalography magnetoencephalography. Secondary outcomes sensation reporting, effects. Risks bias study quality with Cochrane assessment tool.We obtained 1429 references, 20 met selection criteria. A statistically significant alpha-power increase observed nine studies using continuous two intermittent set at frequency within range. three more outside Heterogeneity among parameters recognized. Reported effects mild. implementation double blind identified as challenging tACS, part owing electrical artifacts generated by on recorded signal.Most reported that optimization noninvasive method is interest mostly its clinical applications neurological conditions associated perturbations activity. However, research efforts are needed standardize optimal achieve lasting modulation develop alternatives reduce experimental bias, improve

Язык: Английский

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The effect of transcranial alternating current stimulation on functional recovery in patients with stroke: a narrative review

Frontiers in Neurology, Год журнала: 2024, Номер 14

Опубликована: Янв. 10, 2024

Stroke is a common neurological disorder worldwide that can cause significant disabilities. Transcranial alternating current stimulation (tACS) an emerging non-invasive neuromodulation technique regulates brain oscillations and reshapes rhythms. This study aimed to investigate the effect of tACS on functional recovery in patients with stroke. The MEDLINE (PubMed), Cochrane Library, Embase, SCOPUS, Web Science databases were searched for English-language articles stroke, published up October 20, 2023. following key search phrases combined identify potentially relevant articles: 'tACS,' 'transcranial stimulation,' 'stroke,' 'cerebral infarct,' 'intracerebral hemorrhage.' inclusion criteria selection as follows: (1) studies involving stroke (2) used recovery. A total 34 identified. Five included this review after reading titles abstracts assessing their eligibility based full-text articles. Among studies, one investigated improvement overall status tACS, two motor function gait patterns. Moreover, reported efficacy aphasia recovery, evaluated hemispatial neglect. Our findings suggest improves application was associated improved sensorimotor impairment, aphasia, potential clinical should be supported by high-quality, evidence-based studies.

Язык: Английский

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Can non‐invasive brain stimulation modulate peak alpha frequency in the human brain? A systematic review and meta‐analysis

European Journal of Neuroscience, Год журнала: 2024, Номер 60(3), С. 4182 - 4200

Опубликована: Май 23, 2024

Peak alpha frequency (PAF), the dominant oscillatory within range (8-12 Hz), is associated with cognitive function and several neurological conditions, including chronic pain. Manipulating PAF could offer valuable insight into relationship between various functions potentially providing new treatment avenues. This systematic review aimed to comprehensively synthesise effects of non-invasive brain stimulation (NIBS) on speed. Relevant studies assessing pre- post-NIBS in healthy adults were identified through searches electronic databases (Embase, PubMed, PsychINFO, Scopus, The Cochrane Library) trial registers. risk-of-bias tool was employed for study quality. Quantitative analysis conducted pairwise meta-analysis when possible; otherwise, qualitative synthesis performed. protocol registered PROSPERO (CRD42020190512) Open Science Framework (https://osf.io/2yaxz/). Eleven NIBS included, all a low risk-of-bias, comprising seven transcranial alternating current (tACS), three repetitive magnetic (rTMS), one direct (tDCS) study. Meta-analysis active tACS conditions (eight from five studies) revealed no significant (mean difference [MD] = -0.12, 95% CI -0.32 0.08, p 0.24). Qualitative provided evidence that tDCS altered moderate transient increases 10 Hz rTMS. However, it crucial note small sample sizes used, there substantial variation protocols, most did not specifically target alteration. Further are needed determine NIBS's potential modulating PAF.

Язык: Английский

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Exploring the Prospects of Transcranial Electrical Stimulation (tES) as a Therapeutic Intervention for Post-Stroke Motor Recovery: A Narrative Review

Brain Sciences, Год журнала: 2024, Номер 14(4), С. 322 - 322

Опубликована: Март 27, 2024

Introduction: Stroke survivors often have motor impairments and related functional deficits. Transcranial Electrical Stimulation (tES) is a rapidly evolving field that offers wide range of capabilities for modulating brain function, it safe inexpensive. It has the potential widespread use post-stroke recovery. Direct Current (tDCS), Alternating (tACS), Random Noise (tRNS) are three recognized tES techniques gained substantial attention in recent years but different mechanisms action. tDCS been widely used stroke rehabilitation, while applications tACS tRNS very limited. The protocols could vary significantly, outcomes heterogeneous. Purpose: current review attempted to explore underlying commonly employed evaluate their prospective advantages challenges recovery after stroke. Conclusion: depolarize hyperpolarize potentials cortical neurons, target specific rhythms entrain neural networks. Despite extensive tDCS, complexity networks calls more sophisticated modifications like tRNS.

Язык: Английский

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Temporal Interference Stimulation Boosts Working Memory Performance in the Frontoparietal Network

Human Brain Mapping, Год журнала: 2025, Номер 46(3)

Опубликована: Фев. 12, 2025

ABSTRACT Temporal interference (TI) stimulation is a novel neuromodulation technique that overcomes the depth limitations of traditional transcranial electrical while avoiding invasiveness deep brain stimulation. Our previous behavioral research has demonstrated effects multi‐target TI in enhancing working memory (WM) performance, however, neural mechanisms this special form envelope modulation remain unclear. To address issue, here we designed randomized, double‐blind, crossover study, which consisted task‐based functional magnetic resonance imaging (fMRI) experiment, to explore how offline modulated activity and performance healthy adults. We conducted 2 × within‐subjects design with two factors: (TI vs. Sham) time (pre post). Participants received protocols random order: (beat frequency: 6 Hz, targeting middle frontal gyrus [MFG] inferior parietal lobule [IPL]) sham Neuroimaging data WM task different cognitive loads were acquisited immediately before after found significantly improved d ′ high‐demand task. Whole‐brain analysis showed significant time‐by‐stimulation interactions main clusters IPL precuneus lower activation The generalized psychophysiological interaction (gPPI) revealed task‐modulated connectivity between MFG IPL, improvement observed Notably, increasing induced by was positively correlated better performance. Overall, our findings show specific on frontoparietal network may contribute provide new perspectives for future applications.

Язык: Английский

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Repetitive temporal interference stimulation improves jump performance but not the postural stability in young healthy males: a randomized controlled trial

Journal of NeuroEngineering and Rehabilitation, Год журнала: 2024, Номер 21(1)

Опубликована: Март 20, 2024

Abstract Background Temporal interference (TI) stimulation, an innovative non-invasive brain stimulation technique, has the potential to activate neurons in deep regions. The objective of this study was evaluate effects repetitive TI targeting lower limb motor control area (i.e., M1 leg area) on function healthy individuals, which could provide evidence for further translational application stimulation. Methods In randomized, double-blinded, parallel-controlled trial, 46 male adults were randomly divided into or sham group. group received 2 mA (peak-to-peak) with a 20 Hz frequency difference (2 kHz and 2.02 kHz). Stimulation parameters consistent those but current input lasted only 1 min (30 s ramp-up ramp-down). Both groups twice daily five consecutive days. vertical jump test (countermovement [CMJ], squat [SJ], continuous [CJ]) Y-balance performed before after total intervention session. Two-way repeated measures ANOVA (group × time) function. Results Forty participants completed all scheduled visits. showed significant time interaction CMJ height ( F = 8.858, p 0.005) SJ 6.523, 0.015). effect average CJ first 15 marginally 3.550, 0.067). However, there no Y balance > 0.05). Further within-group comparisons post-intervention increase 0.004), 0.010) 0.004) Conclusion Repetitive effectively increased adult males had dynamic postural stability.

Язык: Английский

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Parvalbumin interneuron cell-to-network plasticity: mechanisms and therapeutic avenues

Trends in Pharmacological Sciences, Год журнала: 2024, Номер 45(7), С. 586 - 601

Опубликована: Май 18, 2024

Alzheimer's disease (AD) and schizophrenia (SCZ) represent two major neuropathological conditions with a high burden. Despite their distinct etiologies, patients suffering from AD or SCZ share common burden of disrupted memory functions unattended by current therapies. Recent preclinical analyses highlight cell-type-specific contributions parvalbumin interneurons (PVIs), particularly the plasticity cellular excitability, towards intact neuronal network function (cell-to-network plasticity) performance. Here we argue that deficits PVI cell-to-network may underlie in SCZ, explore therapeutic avenues: targeting PVI-specific neuromodulation, including neuropeptides, recruitment synchrony gamma frequency range (40 Hz) external stimulation. We finally propose these approaches be merged under consideration recent insights into human brain physiology.

Язык: Английский

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Effect of add-on transcranial alternating current stimulation (tACS) in major depressive disorder: A randomized controlled trial

Brain stimulation, Год журнала: 2024, Номер 17(4), С. 760 - 768

Опубликована: Июнь 15, 2024

Язык: Английский

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Transcranial alternating current stimulation (tACS) at gamma frequency: an up-and-coming tool to modify the progression of Alzheimer’s Disease

Translational Neurodegeneration, Год журнала: 2024, Номер 13(1)

Опубликована: Июнь 27, 2024

Abstract The last decades have witnessed huge efforts devoted to deciphering the pathological mechanisms underlying Alzheimer’s Disease (AD) and testing new drugs, with recent FDA approval of two anti-amyloid monoclonal antibodies for AD treatment. Beyond these drug-based experimentations, a number pre-clinical clinical trials are exploring benefits alternative treatments, such as non-invasive stimulation techniques on neuropathology symptoms. Among different brain approaches, transcranial alternating current (tACS) is gaining particular attention due its ability externally control gamma oscillations. Here, we outline knowledge concerning efficacy, safety, ease-of-use cost-effectiveness tACS early advanced AD, applied specifically at 40 Hz frequency, also summarise results validated models ongoing patient-centred trials.

Язык: Английский

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