Understanding mechanisms of antioxidant action in health and disease

Nature Reviews Molecular Cell Biology, Год журнала: 2023, Номер 25(1), С. 13 - 33

Опубликована: Сен. 15, 2023

Язык: Английский

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The role of gut microbiota in intestinal disease: from an oxidative stress perspective

Frontiers in Microbiology, Год журнала: 2024, Номер 15

Опубликована: Фев. 14, 2024

Recent studies have indicated that gut microbiota-mediated oxidative stress is significantly associated with intestinal diseases such as colorectal cancer, ulcerative colitis, and Crohn’s disease. The level of reactive oxygen species (ROS) has been reported to increase when the microbiota dysregulated, especially several bacterial metabolites are present. Although healthy plays a vital role in defending against excessive stress, disease influenced by ROS, this process controlled immunological responses, DNA damage, inflammation. In review, we discuss relationship between from an perspective. addition, also provide summary most recent therapeutic approaches for preventing or treating modifying microbiota.

Язык: Английский

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Recent advancements in deciphering the therapeutic properties of plant secondary metabolites: phenolics, terpenes, and alkaloids

Plant Physiology and Biochemistry, Год журнала: 2024, Номер 211, С. 108674 - 108674

Опубликована: Апрель 30, 2024

Язык: Английский

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Chinese herbal medicines: The modulator of nonalcoholic fatty liver disease targeting oxidative stress

Journal of Ethnopharmacology, Год журнала: 2023, Номер 318, С. 116927 - 116927

Опубликована: Июль 31, 2023

Язык: Английский

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Unravelling the Influence of Chlorogenic Acid on the Antioxidant Phytochemistry of Avocado (Persea americana Mill.) Fruit Peel

Antioxidants, Год журнала: 2024, Номер 13(4), С. 456 - 456

Опубликована: Апрель 12, 2024

Oxidative stress is pivotal in the pathology of many diseases. This study investigated antioxidant phytochemistry avocado (Persea americana Mill.) peel. Different solvent extracts (dichloromethane, ethyl acetate, methanol, and water) peel were subjected to total phenol flavonoid quantification, as well vitro radical scavenging ferric reducing evaluation. The methanol extract was gradient column chromatographic fractionation. Fraction 8 (eluted with hexane:chloroform:methanol volume ratio 3:6.5:0.5, respectively) LC-MS analysis. It assessed for cellular inhibition lipid peroxidation lipopolysaccharide (LPS)-induced ROS NO production. DPPH mechanism chlorogenic acid using Density Functional Theory (DFT). fraction had highest content activity. Chlorogenic (103.5 mg/mL) 1-O-caffeoylquinic (102.3 most abundant phenolics fraction. dose-dependently inhibited (IC50 = 5.73 6.17 µg/mL) 15.9 9.34 FeSO4-induced peroxidation, LPS-induced 39.6 28.2 63.5 107 production, while modulating enzyme not cytotoxic. DFT analysis suggest that an electron transfer, followed by proton transfer at carbons 3′OH 4′OH positions may be acid. Considering this bioassay-guided, it logical conclude strongly influences capacity fruit

Язык: Английский

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Post-operative Wound Healing Efficacy of Eucalyptus Camaldulensis Phenolic-rich Extracts Incorporated Hydrogel With Enhanced Antioxidant, Antibacterial, and Anti-inflammatory Activities

Journal of Polymers and the Environment, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 7, 2024

Язык: Английский

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Spotlight on iron overload and ferroptosis: Research progress in female infertility

Life Sciences, Год журнала: 2023, Номер 340, С. 122370 - 122370

Опубликована: Дек. 22, 2023

Язык: Английский

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Wine is more than just a beverage: Chemical diversity, health benefits, and immunomodulating potential of wine polyphenols

Food Safety and Health, Год журнала: 2024, Номер 2(2), С. 196 - 212

Опубликована: Фев. 15, 2024

Abstract Wine, the fermented juice of grape ( Vitis vinifera ), is a complex beverage composed primarily water and ethanol. On other hand, phenolic compounds are less abundant components that participate in taste color formation. In addition to their major role sensory profile wine, (also referred as polyphenols) function through various mechanisms, exerting positive influence on health. According recent research, consuming just one glass red wine positively contributes health protection, it connected maintenance redox endothelial balance, potential for reducing diabetes occurrence, preventing atherosclerosis, risk cardiovascular diseases. What more, lower incidence certain types cancers has also been observed. The promoting benefits explained by its wide spectrum structurally diverse whose content may depend numerous factors. most anthocyanins with up 400 mg/L, followed acids, flavanols, flavonols, hydrolyzable tannins, flavanones, stilbenes (up 200, 120, 60, 50, 25, 5 respectively). This review paper outlines structural variety, advantages, immunomodulatory capacity polyphenols, drawing upon latest pertinent scientific literature available this domain.

Язык: Английский

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A Comprehensive Analytical Review of Polyphenols: Evaluating Neuroprotection in Alzheimer’s Disease

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(11), С. 5906 - 5906

Опубликована: Май 28, 2024

Alzheimer's Disease (AD), a prevalent neurodegenerative disorder, is the primary cause of dementia. Despite significant advancements in neuroscience, definitive cure or treatment for this debilitating disease remains elusive. A notable characteristic AD oxidative stress, which has been identified as potential therapeutic target. Polyphenols, secondary metabolites plant origin, have attracted attention due to their potent antioxidant properties. Epidemiological studies suggest correlation between consumption polyphenol-rich foods and prevention chronic diseases, including disorders, underscores polyphenols strategy management. Hence, comprehensive review focuses on diverse roles AD, with particular emphasis neuroprotective potential. Scopus, ScienceDirect, Google Scholar were used leading databases study selection, from 2018 late March 2024. Analytical chemistry serves crucial tool characterizing polyphenols, nuanced exploration extraction methods various sources, often employing chemometric techniques holistic interpretation advances field. Moreover, examines current vitro vivo research, aiming enhance understanding polyphenols' role providing valuable insights forthcoming approaches context.

Язык: Английский

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Preserving wild edible plants using antibacterial and antibiofilm activities of Lactobacillus paracasei Z21 cell-free supernatant and thymol against Pseudomonas spp.

Food Bioscience, Год журнала: 2025, Номер unknown, С. 105835 - 105835

Опубликована: Янв. 1, 2025

Язык: Английский

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