Pancreatic
cancer
is
an
extremely
deadly
illness
for
which
there
are
few
reliable
treatments.
Recent
research
indicates
that
malignant
tumors
highly
variable
and
consist
of
a
tiny
subset
unique
cells,
known
as
stem
cells
(CSCs),
responsible
the
beginning
spread
tumors.
These
typically
identified
by
expression
specific
cell
surface
markers.
A
population
pancreatic
with
aberrantly
active
developmental
signaling
pathways
has
been
in
recent
studies
human
Among
these
Notch
pathway
key
regulator
CSCs
self-renewal,
making
it
attractive
target
therapeutic
intervention.
Chrysin-loaded
polylactic
acid
(PLA)
polymeric
nanoparticles
systems
have
growing
interest
using
platforms
improved
drug
delivery.
This
review
aims
to
explore
innovative
strategies
targeted
therapy
optimized
delivery
manipulating
leveraging
PLA-based
systems.
Furthermore,
we
will
assess
capability
PLA
enhance
bioavailability
effectiveness
gemcitabine
cells.
The
insights
gained
from
this
potential
contribute
development
novel
treatment
approaches
combine
advanced
utilizing
biodegradable
nanoparticles.
Military Medical Research,
Год журнала:
2022,
Номер
9(1)
Опубликована: Июль 4, 2022
Abstract
The
literature
is
full
of
claims
regarding
the
consumption
polyphenol
or
polyamine-rich
foods
that
offer
some
protection
from
developing
cardiovascular
disease
(CVD).
This
achieved
by
preventing
cardiac
hypertrophy
and
protecting
blood
vessels
through
improving
function
endothelium.
However,
do
these
interventions
work
in
aged
human
hearts?
Cardiac
aging
accompanied
an
increase
left
ventricular
hypertrophy,
along
with
diastolic
systolic
dysfunction.
It
also
confers
significant
risks
for
both
sexes.
incidence
prevalence
CVD
sharply
at
earlier
age
men
than
women.
Furthermore,
patterns
heart
failure
differ
between
sexes,
as
lifetime
risk
factors.
Do
caloric
restriction
(CR)-mimetics,
rich
polyamine,
delay
reverse
equally
women?
review
will
discuss
three
areas:
(1)
mechanisms
underlying
age-related
remodeling;
(2)
gender-related
differences
potential
diminished
response
older
women;
(3)
we
select
a
few
polyamine
compounds
CR-mimetics,
such
resveratrol,
quercetin,
curcumin,
epigallocatechin
gallate
spermidine,
due
to
their
capability
extend
health-span
induce
autophagy.
We
outline
abilities
issues
on
retarding
animal
hearts
humans.
confounding
factors
should
be
considered
therapeutic
strategies
against
Oxidative Medicine and Cellular Longevity,
Год журнала:
2022,
Номер
2022, С. 1 - 17
Опубликована: Ноя. 22, 2022
Energy
intake
and
metabolic
balance
are
the
pillars
of
health
preservation.
Overnutrition
causes
nonspecific,
persistently
low
inflammatory
state
known
as
inflammation.
This
condition
contributes
to
pathophysiology
various
disorders,
such
atherosclerosis,
obesity,
diabetes
mellitus,
syndrome.
The
mitochondria
maintain
energy
metabolism.
Excessive
stress
can
lead
mitochondrial
dysfunction,
which
promotes
environment
further
impairs
function.
Accordingly,
excellent
organism
design
keeps
body
metabolically
healthy
in
context
moderate
have
a
beneficial
effect.
review
summarises
research
progress
on
multifaceted
characterisation
dysfunction
its
role
The
World
Health
Organization
predicts
that
by
2050,
2.1
billion
people
worldwide
will
be
over
60
years
old,
a
drastic
increase
from
only
1
in
2019.
Considering
these
numbers,
strategies
to
ensure
an
extended
"healthspan"
or
healthy
longevity
are
urgently
needed.
present
study
approaches
the
promotion
of
healthspan
epigenetic
perspective.
Epigenetic
phenomena
modifiable
response
individual's
environmental
exposures,
and
therefore
link
environment
their
gene
expression
pattern.
studies
demonstrate
aging
is
associated
with
decondensation
chromatin,
leading
altered
heterochromatin
structure,
which
promotes
accumulation
errors.
In
this
review,
we
describe
how
impacts
epigenetics
nutrition
physical
exercise
can
positively
impact
process,
point
view.
Canonical
histones
replaced
histone
variants,
concomitant
post-translational
modifications.
A
slight
DNA
methylation
at
promoters
has
been
observed,
represses
transcription
previously
active
genes,
parallel
global
genome
hypomethylation.
Aging
also
deregulation
-
usually
provided
non-coding
RNAs
both
repression
transcribed
genes
repressed
genes.
Age-associated
events
less
common
individuals
lifestyle,
including
balanced
nutrition,
caloric
restriction
exercise.
Healthy
more
tightly
condensed
fewer
PTMs
greater
regulation
ncRNAs.
Pancreatic
cancer
is
an
extremely
deadly
illness
for
which
there
are
few
reliable
treatments.
Recent
research
indicates
that
malignant
tumors
highly
variable
and
consist
of
a
tiny
subset
unique
cells,
known
as
stem
cells
(CSCs),
responsible
the
beginning
spread
tumors.
These
typically
identified
by
expression
specific
cell
surface
markers.
A
population
pancreatic
with
aberrantly
active
developmental
signaling
pathways
has
been
in
recent
studies
human
Among
these
Notch
pathway
key
regulator
CSCs
self-renewal,
making
it
attractive
target
therapeutic
intervention.
Chrysin-loaded
polylactic
acid
(PLA)
polymeric
nanoparticles
systems
have
growing
interest
using
platforms
improved
drug
delivery.
This
review
aims
to
explore
innovative
strategies
targeted
therapy
optimized
delivery
manipulating
leveraging
PLA-based
systems.
Furthermore,
we
will
assess
capability
PLA
enhance
bioavailability
effectiveness
gemcitabine
cells.
The
insights
gained
from
this
potential
contribute
development
novel
treatment
approaches
combine
advanced
utilizing
biodegradable
nanoparticles.
