Caloric restriction-mimetics for the reduction of heart failure risk in aging heart: with consideration of gender-related differences

Military Medical Research, Journal Year: 2022, Volume and Issue: 9(1)

Published: July 4, 2022

Abstract The literature is full of claims regarding the consumption polyphenol or polyamine-rich foods that offer some protection from developing cardiovascular disease (CVD). This achieved by preventing cardiac hypertrophy and protecting blood vessels through improving function endothelium. However, do these interventions work in aged human hearts? Cardiac aging accompanied an increase left ventricular hypertrophy, along with diastolic systolic dysfunction. It also confers significant risks for both sexes. incidence prevalence CVD sharply at earlier age men than women. Furthermore, patterns heart failure differ between sexes, as lifetime risk factors. Do caloric restriction (CR)-mimetics, rich polyamine, delay reverse equally women? review will discuss three areas: (1) mechanisms underlying age-related remodeling; (2) gender-related differences potential diminished response older women; (3) we select a few polyamine compounds CR-mimetics, such resveratrol, quercetin, curcumin, epigallocatechin gallate spermidine, due to their capability extend health-span induce autophagy. We outline abilities issues on retarding animal hearts humans. confounding factors should be considered therapeutic strategies against

Language: Английский

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Mitochondrial Stress in Metabolic Inflammation: Modest Benefits and Full Losses

Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 17

Published: Nov. 22, 2022

Energy intake and metabolic balance are the pillars of health preservation. Overnutrition causes nonspecific, persistently low inflammatory state known as inflammation. This condition contributes to pathophysiology various disorders, such atherosclerosis, obesity, diabetes mellitus, syndrome. The mitochondria maintain energy metabolism. Excessive stress can lead mitochondrial dysfunction, which promotes environment further impairs function. Accordingly, excellent organism design keeps body metabolically healthy in context moderate have a beneficial effect. review summarises research progress on multifaceted characterisation dysfunction its role

Language: Английский

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How can we modulate aging through nutrition and physical exercise? An epigenetic approach

Aging, Journal Year: 2023, Volume and Issue: unknown

Published: April 20, 2023

The World Health Organization predicts that by 2050, 2.1 billion people worldwide will be over 60 years old, a drastic increase from only 1 in 2019. Considering these numbers, strategies to ensure an extended "healthspan" or healthy longevity are urgently needed. present study approaches the promotion of healthspan epigenetic perspective. Epigenetic phenomena modifiable response individual's environmental exposures, and therefore link environment their gene expression pattern. studies demonstrate aging is associated with decondensation chromatin, leading altered heterochromatin structure, which promotes accumulation errors. In this review, we describe how impacts epigenetics nutrition physical exercise can positively impact process, point view. Canonical histones replaced histone variants, concomitant post-translational modifications. A slight DNA methylation at promoters has been observed, represses transcription previously active genes, parallel global genome hypomethylation. Aging also deregulation - usually provided non-coding RNAs both repression transcribed genes repressed genes. Age-associated events less common individuals lifestyle, including balanced nutrition, caloric restriction exercise. Healthy more tightly condensed fewer PTMs greater regulation ncRNAs.

Language: Английский

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How calorie restriction slows aging: an epigenetic perspective

Journal of Molecular Medicine, Journal Year: 2024, Volume and Issue: 102(5), P. 629 - 640

Published: March 8, 2024

Language: Английский

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New insights into Notch signaling as a crucial pathway of pancreatic cancer stem cell behavior by chrysin-polylactic acid-based nanocomposite

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 1, 2025

Pancreatic cancer is an extremely deadly illness for which there are few reliable treatments. Recent research indicates that malignant tumors highly variable and consist of a tiny subset unique cells, known as stem cells (CSCs), responsible the beginning spread tumors. These typically identified by expression specific cell surface markers. A population pancreatic with aberrantly active developmental signaling pathways has been in recent studies human Among these Notch pathway key regulator CSCs self-renewal, making it attractive target therapeutic intervention. Chrysin-loaded polylactic acid (PLA) polymeric nanoparticles systems have growing interest using platforms improved drug delivery. This review aims to explore innovative strategies targeted therapy optimized delivery manipulating leveraging PLA-based systems. Furthermore, we will assess capability PLA enhance bioavailability effectiveness gemcitabine cells. The insights gained from this potential contribute development novel treatment approaches combine advanced utilizing biodegradable nanoparticles.

Language: Английский

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