Advances in chitosan-based drug delivery systems: A comprehensive review for therapeutic applications

European Polymer Journal, Journal Year: 2024, Volume and Issue: 210, P. 112983 - 112983

Published: March 26, 2024

Language: Английский

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Multifaceted bioactivity of thiosemicarbazide derivatives: Synthesis, characterization, and DFT investigations on inhibition of α-amylase, hydroxyl radical scavenging, and iron chelating activities with molecular docking insights

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1304, P. 137669 - 137669

Published: Jan. 29, 2024

Language: Английский

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Exploring the synthesis, molecular structure and biological activities of novel Bis-Schiff base derivatives: A combined theoretical and experimental approach

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1306, P. 137828 - 137828

Published: Feb. 17, 2024

Language: Английский

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Unveiling the potential effects of resveratrol in lung cancer treatment: Mechanisms and nanoparticle-based drug delivery strategies

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 172, P. 116207 - 116207

Published: Jan. 31, 2024

Lung cancer ranks among the most prevalent forms of and remains a significant factor in cancer-related mortality across world. It poses challenges to healthcare systems society as whole due its high incidence, rates, late-stage diagnosis. Resveratrol (RV), natural compound found various plants, has shown potential nanomedicine for lung treatment. RV varied effects on cells, including promoting apoptosis by increasing pro-apoptotic proteins (Bax Bak) decreasing anti-apoptotic (Bcl-2). also hinders cell proliferation influencing important signaling pathways (MAPK, mTOR, PI3K/Akt, Wnt/β-catenin) that govern progression. In addition, acts potent antioxidant, diminishing oxidative stress safeguarding cells against DNA damage. However, using alone treatment drawbacks, such low bioavailability, lack targeting ability, susceptibility degradation. contrast, nanoparticle-based delivery address these limitations hold promise improving outcomes cancer; nanoparticle formulations offer advantages improved drug delivery, increased stability, controlled release, targeted cells. This article will provide an overview cancer, explore therapeutic agent, discuss benefits highlight nanoparticles treatment, cancer. By optimizing clinical application, future studies aim enhance overall improve prognosis patients.

Language: Английский

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Solubility of digitoxin in supercritical CO2: Experimental study and modeling

European Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 195, P. 106731 - 106731

Published: Feb. 20, 2024

In this communication, the solubility of digitoxin drug in supercritical CO

Language: Английский

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Phlorizin, an Important Glucoside: Research Progress on Its Biological Activity and Mechanism

Molecules, Journal Year: 2024, Volume and Issue: 29(3), P. 741 - 741

Published: Feb. 5, 2024

Phlorizin, as a flavonoid from wide range of sources, is gradually becoming known for its biological activity. Phlorizin can exert antioxidant effects by regulating the IL-1β/IKB-α/NF-KB signaling pathway. At same time, it exerts antibacterial activity reducing intracellular DNA agglutination, protein and energy synthesis, destroying metabolism. In addition, phlorizin also has various pharmacological such antiviral, antidiabetic, antitumor, hepatoprotective effects. Based on domestic foreign research reports, this article reviews plant extraction, activities phlorizin, providing reference improving clinical application phlorizin.

Language: Английский

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Investigating lactic acid bacteria genus Lactococcus lactis properties: Antioxidant activity, antibiotic resistance, and antibacterial activity against multidrug-resistant bacteria Staphylococcus aureus

Heliyon, Journal Year: 2024, Volume and Issue: 10(11), P. e31957 - e31957

Published: May 28, 2024

BackgroundLactic acid bacteria (LAB) are utilized as a starter culture in the manufacturing of fermented dairy items, preservative for various food products, and probiotic. In our country, some research has been carried out, even if LAB plays principal role preservation improves texture taste foods, that is why we tried to evaluate their probiotic effect. The objective this was determine antibacterial activity Lactococcus lactis (L. lactis) against Staphylococcus aureus (S. aureus) ATCC 29213, investigate antioxidant activity, characterize sensitivity 18 antibiotics.MethodsA total 23 subsp. cremoris, L. Lactis diacetylactis, were isolated from cow's raw milk. performed using two techniques, competition nutrients technique utilizing components nature, disk diffusion method. studied different antibiotics tested on Man rogosa sharp (MRS) agar commercial antibiotic disks. All strains examined activity. by 2,2-diphenyl-1 picrylhydrazyl (DPPH).ResultsThe results showed MRS medium more adapted than Muller Hinton Agar (MHA) S. 29213. Also, exhibited notable degree displayed higher activities, followed ssp. biovar. lastly, cremoris Lc 26 among all high potential reaching 40±3 mm slightly moderate (10.56±1.28%-26.29±0.05%). resistance test indicate resistant cefotaxime, sulfamethoxazole-trimethoprim, streptomycin sensitive Ampicillin, Amoxicillin, Penicillin G, Teicoplanin, Vancomycin, Gentamicin 500, Tetracycline, Chloramphenicol. These strain falls within criteria not posing any harmful effects human health. important properties recorded derived production active metabolites, such protein, diacetyl, hydrogen peroxide, lactic acid, together with fight nutrients.ConclusionThis study suggests could be added an agent 29213 can provide nutritional property potential.

Language: Английский

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Investigation the biological activities and the metabolite profiles of endophytic fungi isolated from Gundelia tournefortii L.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 25, 2024

Abstract Endophytic fungi are microorganisms that considered as a potential source of natural compounds, and can be applied in various industries. The aims this research were molecular identification endophytic isolated from the Gundelia tournefortii stems, investigation their biological activities well phenolic fatty acid profile. Surface sterilized stems G. placed on potato dextrose agar (PDA) to isolate fungal endophytes. Genomic DNA was extracted by CTAB method, PCR amplification performed ITS 1 4 primers. enzyme production determined based formation clear zone appeared around colonies fungus. anti-oxidant activity evaluated measuring amount free radicals DPPH. Also, total phenol flavonoid contents measured obtained Folin-Ciocalteu aluminum chloride colorimetric methods, respectively. Moreover, separation acids done HPLC GC, Phylogenetic analysis Internal Transcribed Spacer (ITS) region, five isolates identified following: Aspergillus niger , Penicillium glabrum Alternaria alternata A. tenuissima Mucor circinelloides . Evaluation enzymatic properties showed P. gabrum (31 ± 1.9 mm), (23 1.7) had more ability for producing pectinase cellulase. extract (IC 50 = 471 29 µg/mL) highest properties, followed 512 19 µg/mL). greatest phenols flavonoids (8.2 0.4 mg GAL/g 2.3 0.3 QE/g, respectively). quantification rosmarinic acid, para-coumaric meta-coumaric (42.02 1.31, 7.53 0.19, 5.41 0.21 mg/g, respectively) main studied fungi. confirmed that, all fungi, stearic (27.9–35.2%), oleic (11.3–17.3%), palmitic (16.9–23.2%), linoleic (5.8–11.6%), caprylic (6.3–10.9%). Our finding bioactive which could used This is first report associated with provides knowledge future use biotechnological processes.

Language: Английский

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Boosting antitumor efficacy using docetaxel-loaded nanoplatforms: from cancer therapy to regenerative medicine approaches

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: May 30, 2024

Abstract The intersection of nanotechnology and pharmacology has revolutionized the delivery efficacy chemotherapeutic agents, notably docetaxel, a key drug in cancer treatment. Traditionally limited by poor solubility significant side effects, docetaxel’s therapeutic potential been significantly enhanced through its incorporation into nanoplatforms, such as nanofibers nanoparticles. This advancement offers targeted delivery, controlled release, improved bioavailability, dramatically reducing systemic toxicity enhancing patient outcomes. Nanofibers provide versatile scaffold for release utilizing techniques like electrospinning to tailor profiles. Nanoparticles, on other hand, enable precise tumor cells, minimizing damage healthy tissues sophisticated encapsulation methods nanoprecipitation emulsion. These nanotechnologies not only improve pharmacokinetic properties docetaxel but also open new avenues regenerative medicine facilitating therapy cellular regeneration. narrative review highlights transformative impact docetaxel-loaded nanoplatforms oncology beyond, showcasing overcome limitations traditional chemotherapy pave way future innovations therapies. Through these advancements, promises era precision medicine, treatments while adverse effects. Graphical

Language: Английский

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Determination of imatinib as anticancer drug in serum and urine samples by electrochemical technique using a chitosan/graphene oxide modified electrode

Alexandria Engineering Journal, Journal Year: 2024, Volume and Issue: 93, P. 80 - 89

Published: March 14, 2024

The purpose of this work was to construct an electrochemical sensor for the detection imatinib. It based on a modified glassy carbon electrode (chitosan/rGO/GCE) that reduced graphene oxide nanocomposite. By employing straightforward drop-casting technique, rGO/chitosan composite applied GCE surface. XRD, FT-IR, and FE-SEM structural studies verified successfully nanocomposite formed. synergistic effect rGO chitosan boosted electron transfer kinetics facilitated oxidation reaction imatinib surface, according experiments, which indicated chitosan/rGO/GCE's sensitive, selective, stable response findings showed sensitivity 0.16502 μA/μM, limit value 7.3 nM, wide linear range 1–300 µM. Differential pulse voltammetry measurements were performed prepared human serum urine samples evaluate applicability chitosan/rGO/GCE in real samples. For genuine samples, good recoveries ranging from 95.00% 99.20% with relative standard deviation 3.10–4.49%. These variety may be accurately analyzed using chitosan/rGO/GCE.

Language: Английский

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