Therapeutic Delivery,
Год журнала:
2024,
Номер
15(2), С. 135 - 155
Опубликована: Янв. 12, 2024
Bioactive
compounds
derived
from
plants
have
been
investigated
for
treating
various
pathological
conditions.
However,
the
utilization
of
these
has
challenges
such
as
instability,
low
solubility
and
bioavailability.
To
overcome
challenges,
encapsulation
bioactive
molecules
with
in
a
novel
nano
carrier
system
enabling
effective
delivery
clinical
translation
become
essential.
Lipid-based
nanocarriers
provide
versatile
platforms
encapsulating
delivering
challenges.
These
carriers
can
improve
solubility,
stability,
improved
drug
retention
therapeutic
efficacy
plant
compounds.
The
current
review
evaluates
bioactives
highlights
potential
lipid-based
designed
to
its
efficacy.
Plants,
Год журнала:
2025,
Номер
14(2), С. 206 - 206
Опубликована: Янв. 13, 2025
Medicinal
plants
are
sources
of
crude
traditional
herbal
medicines
that
utilized
to
reduce
the
risk
of,
treat,
or
manage
diseases
in
most
indigenous
communities.
This
is
due
their
potent
antioxidant
and
anti-inflammatory
effects.
It
estimated
about
80%
population
developing
countries
rely
on
for
healthcare.
signifies
need
medicines,
which
polyherbal
formulations
prepared
by
health
practitioners.
review
examines
preparatory
steps
extract
bioactive
phytoconstituents
post-extraction
processes
increase
potency
extracted
phytoconstituents.
Achieving
this
will
allow
reduced
use
plant
materials
promote
sustainable
limited
resource
medicinal
plants,
especially
our
South
African
context.
Electronic
ethnobotanical
books
online
databases
were
used
find
studies
focus
phytoconstituent
extraction
processing
enhance
Modification
synthesize
daughter
compounds
facilitates
an
enhancement
bioavailability.
Based
data
collected
through
review,
importance
understanding
properties
targeted
essential
selecting
required
method.
determines
quality
yield
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Март 13, 2025
The
latest
research
on
nanotechnology
through
the
new
tailored
scaffolds
encompassed
therapeutic
effects
of
natural
compounds,
and
unique
properties
metallic
nanoparticles
offer
possibilities
in
emerging
biomedical
fields.
Various
strategies
have
been
developed
to
address
limitations
existing
agents
concerning
specificity,
vectorization,
bioavailability,
drug
resistance,
adverse
effects.
In
this
study,
medicinal
plant
Portulaca
oleracea
L.
magnetite
were
used
develop
an
innovative
target
carrier
system,
designed
enhance
cytotoxic
effect
overcome
main
drawbacks
(permeability
localization)
phytoconstituents.
low-metabolite
profile
Romanian
wild-grown
exhibits
a
diverse
range
hundred
fifty-five
compounds
across
various
chemical
categories
(amino
acids,
peptides,
fatty
flavonoids,
alkaloids,
terpenoids,
phenolic
organic
esters,
sterols,
coumarins,
nucleosides,
lignans,
miscellaneous
compounds).
Morpho-structural
magnetic
phytocarrier
investigated
using
variety
methods,
including
XRD,
FTIR,
Raman,
SEM,
DLS),
determinations.
MTT
assay
was
conducted
evaluate
vitro
potential
cytotoxicity
normal
human
dermal
fibroblasts
(NHDF),
as
well
two
tumoral
cell
lines:
osteosarcoma
(HOS)
cervical
cancer
(HeLa).
Results
indicated
that
significant
inhibition
both
lines'
viability
exerted
by
compared
herbal
extract.
Furthermore,
results
obtained
for
total
content
antioxidant
screening
performed
FRAP
DPPH
assays
superior
system.
These
findings
suggest
applications
system
its
promising
implications
future
development
field.
European Journal of Medicinal Chemistry,
Год журнала:
2025,
Номер
290, С. 117535 - 117535
Опубликована: Март 20, 2025
Cancer
drug
delivery
remains
a
critical
challenge
with
systemic
toxicity,
poor
bioavailability,
and
lack
of
effective
targeting.
Overcoming
these
barriers
is
essential
for
improving
treatment
efficacy
patient
outcomes.
This
review
discusses
current
techniques
that
reshape
cancer
therapy
by
offering
precise,
controlled-release
tailored
to
tumor-specific
features.
Innovations
in
nanotechnology,
immunotherapy,
gene
enable
interventions
at
molecular
cellular
levels.
Radiomics
pathomics
integrate
high-dimensional
data
optimize
diagnostics
planning.
Combination
addresses
the
complexities
tumor
heterogeneity
synergizing
multiple
agents
within
single
therapeutic
framework,
while
peptide-drug
conjugates
enhance
specificity
potency.
Hydrogel-based
systems
microneedle
arrays
offer
localized,
sustained
release,
significantly
However,
clinical
translation
advancements
faces
significant
such
as
resistance,
off-target
effects,
scalability,
cost,
ethical
concerns.
Moreover,
regulatory
economic
feasibility
therapies
highlight
need
innovative
frameworks
make
them
accessible
globally.
Therefore,
there
innovation
cell
therapy,
next-generation
platforms,
personalized
medicine.
focuses
on
recent
over
past
decade,
evaluating
their
limitations
exploring
potential
future
directions
transforming
treatment.
The
phosphatidylinositol
3-kinase
(PI3K)/Akt
pathway
is
a
critical
intracellular
signaling
that
pivotal
in
various
cellular
functions.
It
senescence,
survival,
and
growth
under
normal
physiological
pathological
conditions,
including
neoplasms.
Additionally,
this
has
been
recognized
as
essential
for
the
regulation
of
cell
cycle.
Several
previous
studies
have
indicated
PI3K/Akt
can
be
influenced
by
natural
products,
with
resveratrol
(3,4',5-trihydroxy-trans-stilbene)
being
particularly
important
phytoalexin
polyphenol
context.
This
review
explores
impact
on
initiation
advancement
cancerous
conditions
potential
to
target
mechanism.
begins
summarizing
anti-tumor
capabilities
then
emphasizes
significant
role
progression
multiple
malignancies.
Finally,
we
discuss
therapeutic
effects
human
neoplasms,
from
brain
cancers
gastrointestinal
malignancies,
through
cascade.
Frontiers in Nutrition,
Год журнала:
2022,
Номер
9
Опубликована: Июль 15, 2022
Nowadays,
effective
cancer
therapy
is
a
global
concern,
and
recent
advances
in
nanomedicine
are
crucial.
Cancer
one
of
the
major
fatal
diseases
leading
cause
death
globally.
Nanotechnology
provides
rapidly
evolving
delivery
systems
science
for
treating
site-specific
manner
using
natural
bioactive
compounds,
which
gaining
widespread
attention.
combined
with
bioactives
very
appealing
relatively
new
area
treatment.
Natural
compounds
have
potential
to
be
employed
as
chemotherapeutic
agent
treatment
cancer,
addition
their
nutritional
benefits.
Alginate,
pullulan,
cellulose,
polylactic
acid,
chitosan,
other
biopolymers
been
effectively
used
therapeutics
specific
site.
Because
biodegradability,
biopolymeric
nanoparticles
(BNPs)
received
lot
attention
development
anticancer
drug
systems.
Biopolymer-based
nanoparticle
can
made
variety
ways.
These
developed
cost-effective
environmentally
friendly
solution
boost
efficacy.
Effective
improved
availability,
increased
selectivity,
lower
toxicity
needed.
Recent
research
findings
current
knowledge
on
use
BNPs
administration
chemicals
summarized
this
review.
Nanotheranostics,
Год журнала:
2023,
Номер
7(4), С. 368 - 379
Опубликована: Янв. 1, 2023
Cancer
diagnosis
and
management
have
been
a
slow-evolving
area
in
medical
science.Conventional
therapies
by
far
proved
to
various
limitations.Also,
the
concept
of
immunotherapy
which
was
thought
revolutionize
cancer
has
presented
its
range
drawbacks.To
overcome
these
limitations
nanoparticulate-derived
diagnostic
therapeutic
strategies
are
emerging.These
nanomaterials
be
explored
as
they
serve
prospect
for
theranostics.Nanoparticles
significant
yet
unclear
role
screening
well
therapy
cancer.However,
nanogels
Photodynamic
is
one
such
approach
developed
theranostics.Photoactive
theranostics
vivid
that
might
prove
help
manage
cancer.Also,
utilization
quantum
dots
tool
selectively
kill
cells,
especially
CNS
tumors.Additionally,
redox-sensitive
micelles
targeting
tumor
microenvironment
also
an
important
theranostic
tool.This
review
focuses
on
exploring
agents
currently
being
studied
or
can
further
theranostics.
