Lipid-Based Nanocarriers for Enhanced Delivery of Plant-Derived Bioactive Molecules: A Comprehensive Review DOI

K. Pavithra,

Manimaran Vasanthan

Therapeutic Delivery, Journal Year: 2024, Volume and Issue: 15(2), P. 135 - 155

Published: Jan. 12, 2024

Bioactive compounds derived from plants have been investigated for treating various pathological conditions. However, the utilization of these has challenges such as instability, low solubility and bioavailability. To overcome challenges, encapsulation bioactive molecules with in a novel nano carrier system enabling effective delivery clinical translation become essential. Lipid-based nanocarriers provide versatile platforms encapsulating delivering challenges. These carriers can improve solubility, stability, improved drug retention therapeutic efficacy plant compounds. The current review evaluates bioactives highlights potential lipid-based designed to its efficacy.

Language: Английский

Camptothecin and its derivatives: Advancements, mechanisms and clinical potential in cancer therapy DOI
Madhu Kamle, Shikha Pandhi, Sadhna Mishra

et al.

Medical Oncology, Journal Year: 2024, Volume and Issue: 41(11)

Published: Oct. 9, 2024

Language: Английский

Citations

10
Extraction and Processing of Bioactive Phytoconstituents from Widely Used South African Medicinal Plants for the Preparation of Effective Traditional Herbal Medicine Products: A Narrative Review DOI Creative Commons

Sphamandla Hlatshwayo,

Nokukhanya Thembane,

Suresh Babu Naidu Krishna

et al.

Plants, Journal Year: 2025, Volume and Issue: 14(2), P. 206 - 206

Published: Jan. 13, 2025

Medicinal plants are sources of crude traditional herbal medicines that utilized to reduce the risk of, treat, or manage diseases in most indigenous communities. This is due their potent antioxidant and anti-inflammatory effects. It estimated about 80% population developing countries rely on for healthcare. signifies need medicines, which polyherbal formulations prepared by health practitioners. review examines preparatory steps extract bioactive phytoconstituents post-extraction processes increase potency extracted phytoconstituents. Achieving this will allow reduced use plant materials promote sustainable limited resource medicinal plants, especially our South African context. Electronic ethnobotanical books online databases were used find studies focus phytoconstituent extraction processing enhance Modification synthesize daughter compounds facilitates an enhancement bioavailability. Based data collected through review, importance understanding properties targeted essential selecting required method. determines quality yield

Language: Английский

Citations

1
Development and Characterization of Genistein-Loaded Silver Nanoparticles for the Induction of Apoptosis on Human Hepatocellular Carcinoma Cell Lines DOI
Rohini Kharwade, Nilesh Mahajan, Mohamed Ali‐Seyed

et al.

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(2)

Published: Feb. 8, 2025

Language: Английский

Citations

1
Advanced particulate carrier-mediated technologies for nasal drug delivery DOI
Vivek P. Chavda,

Gargi Jogi,

Nirav Shah

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2022, Volume and Issue: 74, P. 103569 - 103569

Published: July 7, 2022

Language: Английский

Citations

30
Current status of Cancer Nanotheranostics: Emerging strategies for cancer management DOI Creative Commons
Vivek P. Chavda, Avinash Khadela,

Yasha Shah

et al.

Nanotheranostics, Journal Year: 2023, Volume and Issue: 7(4), P. 368 - 379

Published: Jan. 1, 2023

Cancer diagnosis and management have been a slow-evolving area in medical science.Conventional therapies by far proved to various limitations.Also, the concept of immunotherapy which was thought revolutionize cancer has presented its range drawbacks.To overcome these limitations nanoparticulate-derived diagnostic therapeutic strategies are emerging.These nanomaterials be explored as they serve prospect for theranostics.Nanoparticles significant yet unclear role screening well therapy cancer.However, nanogels Photodynamic is one such approach developed theranostics.Photoactive theranostics vivid that might prove help manage cancer.Also, utilization quantum dots tool selectively kill cells, especially CNS tumors.Additionally, redox-sensitive micelles targeting tumor microenvironment also an important theranostic tool.This review focuses on exploring agents currently being studied or can further theranostics.

Language: Английский

Citations

19
Antiproliferative activity of syringic acid-loaded nanostructured lipid carriers against MCF-7 human breast carcinoma cells DOI
Shikha Jha,

A Prabakaran,

Rakesh Kumar Sahoo

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 98, P. 105902 - 105902

Published: June 20, 2024

Language: Английский

Citations

7
Biopolymeric nanoparticles based effective delivery of bioactive compounds toward the sustainable development of anticancerous therapeutics DOI Creative Commons
Neelam Pathak, Pankaj Singh, Pradeep Kumar Singh

et al.

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: July 15, 2022

Nowadays, effective cancer therapy is a global concern, and recent advances in nanomedicine are crucial. Cancer one of the major fatal diseases leading cause death globally. Nanotechnology provides rapidly evolving delivery systems science for treating site-specific manner using natural bioactive compounds, which gaining widespread attention. combined with bioactives very appealing relatively new area treatment. Natural compounds have potential to be employed as chemotherapeutic agent treatment cancer, addition their nutritional benefits. Alginate, pullulan, cellulose, polylactic acid, chitosan, other biopolymers been effectively used therapeutics specific site. Because biodegradability, biopolymeric nanoparticles (BNPs) received lot attention development anticancer drug systems. Biopolymer-based nanoparticle can made variety ways. These developed cost-effective environmentally friendly solution boost efficacy. Effective improved availability, increased selectivity, lower toxicity needed. Recent research findings current knowledge on use BNPs administration chemicals summarized this review.

Language: Английский

Citations

27
Fabrication and characterization of bee pollen extract nanoparticles: Their potential in combination therapy against human A549 lung cancer cells DOI Creative Commons
Nemany A.N. Hanafy, Elsayed I. Salim,

Magdy E. Mahfouz

et al.

Food Hydrocolloids for Health, Journal Year: 2022, Volume and Issue: 3, P. 100110 - 100110

Published: Dec. 9, 2022

Bee pollen extract (BPE) based polymer nanoparticles (BPENP) were fabricated in the current study by using bovine serum albumin (BSA) and complex was then coated folic acid conjugated protamine to be targeted for cancer cells. Spectroscopic microscopic methods used characterize resultant nanoparticles. High flavonoid polyphenolic contents detected HPLC. At 336 nm, it found that BPENP provided highest absorption UV. The average particle size ranged between 25 40 nm. inhibitory effects IC50 values of acquired BPE, BPENP, Avastin, or their combination at 24 48 h against A549 lung therapy assay Avastin revealed a very significant synergism two drugs with low index (CI). These therapies particularly have significantly affected expression HRAS, MAPK, apoptotic genes such as Bax, Bcl-2, Caspase 3. It established obtained might employed support administration treatment cancer.

Language: Английский

Citations

25
CD44-Targeted Lipid Polymer Hybrid Nanoparticles Enhance Anti-Breast Cancer Effect of Cordyceps militaris Extracts DOI Creative Commons
Jiraphong Suksiriworapong, Nutthachai Pongprasert, Somnuk Bunsupa

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(6), P. 1771 - 1771

Published: June 20, 2023

This study aimed to improve the anticancer effect of Cordyceps militaris herbal extract (CME) on breast cancer cells with hyaluronic acid (HYA) surface-decorated lipid polymer hybrid nanoparticles (LPNPs) and evaluate applicability a synthesized poly(glycerol adipate) (PGA) for LPNP preparation. Firstly, cholesterol- vitamin E-grafted PGA polymers (PGA-CH PGA-VE, respectively) were fabricated, without maleimide-ended polyethylene glycol. Subsequently, CME, which contained an active cordycepin equaling 9.89% its weight, was encapsulated in LPNPs. The results revealed that could be used prepare CME-loaded formulations containing Mal-PEG decorated cysteine-grafted HYA via thiol-maleimide reactions. HYA-decorated PGA-based LPNPs substantially enhanced CME against MDA-MB-231 MCF-7 by enhancing cellular uptake through CD44 receptor-mediated endocytosis. demonstrated successful targeted delivery receptors tumor HYA-conjugated new application PGA-CH- PGA-VE-based developed showed promising potential extracts treatment clear translation vivo experiments.

Language: Английский

Citations

15
From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds DOI Creative Commons
Gabriela Isopencu,

Cristina-Ileana Covaliu-Mierlă,

Iuliana Mihaela Deleanu

et al.

Plants, Journal Year: 2023, Volume and Issue: 12(14), P. 2661 - 2661

Published: July 16, 2023

Transdermal delivery devices and wound dressing materials are constantly improved upgraded with the aim of enhancing their beneficial effects, biocompatibility, biodegradability, cost effectiveness. Therefore, researchers in field have shown an increasing interest using natural compounds as constituents for such systems. Plants, important source so-called “natural products” enormous variety structural diversity that still exceeds capacity present-day sciences to define or even discover them, been part medicine since ancient times. However, benefits just at beginning being fully exploited modern dermal transdermal Thus, plant-based primary compounds, without biological activity, contained gums mucilages, traditionally used gelling texturing agents food industry, now explored valuable cost-effective components biomedical field. Their non-toxicity compensate local availability compositional variations. Also, secondary metabolites, classified based on chemical structure, intensively investigated wide pharmacological toxicological effects. impact is highlighted detail through most recent reported studies. Innovative isolation purification techniques, new drug systems, advanced evaluation procedures presented.

Language: Английский

Citations

13