Advancements in clinical aspects of targeted therapy and immunotherapy in breast cancer

Molecular Cancer, Год журнала: 2023, Номер 22(1)

Опубликована: Июль 6, 2023

Abstract Breast cancer is the second leading cause of death for women worldwide. The heterogeneity this disease presents a big challenge in its therapeutic management. However, recent advances molecular biology and immunology enable to develop highly targeted therapies many forms breast cancer. primary objective therapy inhibit specific target/molecule that supports tumor progression. Ak strain transforming, cyclin-dependent kinases, poly (ADP-ribose) polymerase, different growth factors have emerged as potential targets subtypes. Many drugs are currently undergoing clinical trials, some already received FDA approval monotherapy or combination with other treatment yet achieve promise against triple-negative (TNBC). In aspect, immune has come up promising approach specifically TNBC patients. Different immunotherapeutic modalities including immune-checkpoint blockade, vaccination, adoptive cell transfer been extensively studied setting cancer, especially approved blockers chemotherapeutic treat several trials ongoing. This review provides an overview developments advancements immunotherapies treatment. successes, challenges, prospects were critically discussed portray their profound prospects.

Язык: Английский

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Global trends and forecasts of breast cancer incidence and deaths

Scientific Data, Год журнала: 2023, Номер 10(1)

Опубликована: Май 27, 2023

Breast cancer (BC) is one of the major public health challenges worldwide. Studies that address new evidence on trends BC are great importance for preventing and controlling occurrence development diseases improving health. The aim this study was to analyze outcomes global burden disease (GBD), incidence, deaths, risk factors from 1990 2019, predict GBD until 2050 inform control planning efforts. In study, results show regions with low levels socio-demographic index (SDI) will have largest in future. leading factor death attributable 2019 metabolic risks, followed by behavioral risks. This supports worldwide urgent need comprehensive prevention strategies reduce exposure, early screening, improve treatment effectively BC.

Язык: Английский

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Temporal trends of breast cancer burden in the Western Pacific Region from 1990 to 2044: Implications from the Global Burden of Disease Study 2019

Journal of Advanced Research, Год журнала: 2023, Номер unknown

Опубликована: Июль 1, 2023

Breast cancer (BC) is a malignant disease that occurs worldwide and poses serious health burden. To assess the prevalence of BC burden in Western Pacific region (WPR) from 1990 to 2019, predict trends 2020 2044. The driving factors are analyzed region-oriented improvement measures put forward. We used Global Burden Disease Study 2019 obtain information on cases, deaths, disability-adjusted life years (DALYs) age-standardized incidence rate (ASIR), death (ASDR), DALYs WPR 2019. Age-period-cohort (APC) models were analyze age, period, cohort effects breast cancer, Bayesian APC (BAPC) was over next 25 years. In conclusion, deaths have increased rapidly past 30 expected continue increase between High body mass index primary risk factor for mortality middle-income countries, whereas alcohol use Japan. Age key development BC, with 40 being critical point. Incidence coincide course economic development. remains an essential public issue will substantially future. More efforts should be made countries prompt behavior minimize because these nations accounts majority WPR.

Язык: Английский

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Trend of disease burden and risk factors of breast cancer in developing countries and territories, from 1990 to 2019: Results from the Global Burden of Disease Study 2019

Frontiers in Public Health, Год журнала: 2023, Номер 10

Опубликована: Янв. 16, 2023

The incidence, mortality, burden of disability-adjusted life years (DALYs), and attributable risk factors breast cancer vary significantly by country or region, particularly between developing developed countries. This study aimed to analyze development trends in countries based on the influence different sociodemographic indices (SDIs) World Bank (WB) income-level disease data from 1990 2019.

Язык: Английский

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The residual cancer burden index as a valid prognostic indicator in breast cancer after neoadjuvant chemotherapy

BMC Cancer, Год журнала: 2024, Номер 24(1)

Опубликована: Янв. 2, 2024

Abstract Purpose The residual cancer burden index (RCB) was proposed as a response evaluation criterion in breast patients treated with Neoadjuvant Chemotherapy (NAC). This study evaluated the relevance of RCB replase-free survival (RFS). Methods clinical data 254 who received NAC between 2016 and 2020 were retrospectively collected. relationship clinicopathologic factors RFS using Cox proportional hazards regression models. estimates determined by Kaplan–Meier(K-M) analysis compared log-rank test. Multivariate logistic used to evaluate risk associated RCB. Receiver operating characteristic (ROC) curves showed potential MP grading systems biomarkers for RFS. Results At median follow-up 52 months, 59 patients(23.23%) developed relapse. that older age ( P = 0.022), high Pathologic T stage after 0.023) score( 0.003) outcomes multivariate indicated 0 (pathologic complete [pCR]) HER2-positive 0.002) triple-negative (TNBC) 0.013). In addition, scoring served prognostic markers NAC, their area under (AUCs) 0.691 0.342, respectively. Conclusion These suggest can be equally applied predict Chinese NAC. application may help guide selection treatment strategies.

Язык: Английский

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Global evolution of breast cancer incidence in childbearing-age women aged 15–49 years: a 30-year analysis

Journal of Cancer Research and Clinical Oncology, Год журнала: 2025, Номер 151(2)

Опубликована: Фев. 11, 2025

Abstract Background Breast cancer (BC) poses an increasing threat to women’s health, yet its characteristics in women of childbearing age (WCBA) are infrequently reported. This study aims investigate the patterns and trends BC incidence among WCBA over past decades. Materials methods focuses on aged 15–49 years, consistent with WHO definition WCBA. Estimates 95% uncertainty intervals (UIs) for were obtained from Global Burden Diseases Study 2021. We utilized age-period-cohort (APC) model estimate overall annual percentage change (net drift, % per year) within each group (local year). also provided fitted longitudinal age-specific rates adjusted period deviations (age effects) period/cohort relative risks (period/cohort 1992 Results In 2021, global was 561.44 thousand (95% UI 519.76 606.99). Between estimated 0.47 CI 0.41–0.52) worldwide, ranging −0.43 −0.54–−0.31) High sociodemographic index (SDI) region 2.03 1.97–2.1) Low-middle SDI region. Local drift analysis showed that higher regions had age-standardized WCBA, effects demonstrating similar across different risk age. Notably, rising trend occurs at progressively younger ages. Globally, unfavorable cohort observed. All exhibited increased risks, except region, which saw a reduction influenced by effects, particularly those born after 1996. Conclusion The highlights urgent need effective intervention preventive policies alleviate this growing burden.

Язык: Английский

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Age period cohort analysis of cancer incidence from 1990 to 2019 in Türkiye

Cancer Epidemiology, Год журнала: 2025, Номер 96, С. 102803 - 102803

Опубликована: Март 22, 2025

Язык: Английский

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A Review of the Advancements in Targeted Therapies for Breast Cancer

Cureus, Год журнала: 2023, Номер unknown

Опубликована: Окт. 28, 2023

Breast cancer, the second-most common and lethal disease in women, poses a severe danger to global health. cancer rates continue climb despite advances medical technology. Predictions indicate that by 2040, there will be more than three million new cases yearly. Targeted medicines have experienced profound transformation treating breast allowing for individualized strategies lessen side effects improve patient outcomes. This thorough analysis gives rigorous investigation of current developments cancer-targeted treatments. It carefully examines several subtypes, including hormone receptor-positive (HR+), HER2-positive (HER2+), triple-negative (TNBC), recognizing illness' fundamental variety. offers specialized treatment plans catered each subtype's particular traits. The review also how precise genetic abnormalities like BRCA1/2 PIK3CA mutations molecular profiling facilitate therapy selection. Monoclonal antibodies small molecule inhibitors are some targeted examined study. explains these treatments works supports its findings with data from clinical trials. considers potential medications addresses persistent problems, such as resistance mechanisms, chances combining therapies, cutting-edge classification techniques. study seeks give healthcare professionals, researchers, patients overview recent advancements drawing on opinions top authorities area. coordinated effort aims create customized, efficient eventually bolstering battle against this powerful illness.

Язык: Английский

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Global burden and attributable risk factors of breast cancer in young women: historical trends from 1990 to 2019 and forecasts to 2030 by sociodemographic index regions and countries

Journal of Global Health, Год журнала: 2024, Номер 14

Опубликована: Июль 19, 2024

Abstract Background Breast cancer in young women (BCY) is much less common but has significant health sequelae and societal costs. We aimed to evaluate the global regional burden of breast aged 15–39 years from 1990 2019. Methods collected detailed data on Global Burden Disease Study 2019 (GBD 2019) Data Resources. The age-standardised incidence rate (ASIR), mortality (ASMR), disability-adjusted life (ASDR), estimated annual percentage change (EAPC) were used assess disease BCY. Bayesian Age-Period-Cohort model was forecast 2020 2030. Results From 2019, increases ASIR found for BCY (EAPC = 0.59, 95% confidence interval (CI) 0.5 0.68), whereas decreases ASMR −0.41, CI −0.53 −0.3) ASDR −0.35, −0.46 −0.24). Across countries with varying sociodemographic indexes (SDI), all regions showed an upward trend morbidity, except a high SDI. While DALYs rates have decreased high, high-middle, middle SDI, they increased low-middle low Countries lower SDIs are projected bear greatest over next decade, including both categories. Alcohol use main risk factor attributed deaths most countries, while exposure second hand smoke predominant SDI countries. Conclusions rise worldwide, there differences. or face even more challenges, as experienced increasing than higher SDIs.

Язык: Английский

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Differential patterns of reproductive and lifestyle risk factors for breast cancer according to birth cohorts among women in China, Japan and Korea

Breast Cancer Research, Год журнала: 2024, Номер 26(1)

Опубликована: Янв. 22, 2024

The birth cohort effect has been suggested to influence the rate of breast cancer incidence and trends associated reproductive lifestyle factors. We conducted a study determine whether differential pattern associations exists between certain factors risk based on cohorts.

Язык: Английский

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