Clinical & Translational Oncology, Journal Year: 2024, Volume and Issue: unknown
Published: July 16, 2024
Language: Английский
Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)
Published: July 6, 2023
Abstract Breast cancer is the second leading cause of death for women worldwide. The heterogeneity this disease presents a big challenge in its therapeutic management. However, recent advances molecular biology and immunology enable to develop highly targeted therapies many forms breast cancer. primary objective therapy inhibit specific target/molecule that supports tumor progression. Ak strain transforming, cyclin-dependent kinases, poly (ADP-ribose) polymerase, different growth factors have emerged as potential targets subtypes. Many drugs are currently undergoing clinical trials, some already received FDA approval monotherapy or combination with other treatment yet achieve promise against triple-negative (TNBC). In aspect, immune has come up promising approach specifically TNBC patients. Different immunotherapeutic modalities including immune-checkpoint blockade, vaccination, adoptive cell transfer been extensively studied setting cancer, especially approved blockers chemotherapeutic treat several trials ongoing. This review provides an overview developments advancements immunotherapies treatment. successes, challenges, prospects were critically discussed portray their profound prospects.
Language: Английский
Citations
270
Scientific Data, Journal Year: 2023, Volume and Issue: 10(1)
Published: May 27, 2023
Breast cancer (BC) is one of the major public health challenges worldwide. Studies that address new evidence on trends BC are great importance for preventing and controlling occurrence development diseases improving health. The aim this study was to analyze outcomes global burden disease (GBD), incidence, deaths, risk factors from 1990 2019, predict GBD until 2050 inform control planning efforts. In study, results show regions with low levels socio-demographic index (SDI) will have largest in future. leading factor death attributable 2019 metabolic risks, followed by behavioral risks. This supports worldwide urgent need comprehensive prevention strategies reduce exposure, early screening, improve treatment effectively BC.
Language: Английский
Citations
165
Journal of Advanced Research, Journal Year: 2023, Volume and Issue: unknown
Published: July 1, 2023
Breast cancer (BC) is a malignant disease that occurs worldwide and poses serious health burden. To assess the prevalence of BC burden in Western Pacific region (WPR) from 1990 to 2019, predict trends 2020 2044. The driving factors are analyzed region-oriented improvement measures put forward. We used Global Burden Disease Study 2019 obtain information on cases, deaths, disability-adjusted life years (DALYs) age-standardized incidence rate (ASIR), death (ASDR), DALYs WPR 2019. Age-period-cohort (APC) models were analyze age, period, cohort effects breast cancer, Bayesian APC (BAPC) was over next 25 years. In conclusion, deaths have increased rapidly past 30 expected continue increase between High body mass index primary risk factor for mortality middle-income countries, whereas alcohol use Japan. Age key development BC, with 40 being critical point. Incidence coincide course economic development. remains an essential public issue will substantially future. More efforts should be made countries prompt behavior minimize because these nations accounts majority WPR.
Language: Английский
Citations
39
Frontiers in Public Health, Journal Year: 2023, Volume and Issue: 10
Published: Jan. 16, 2023
The incidence, mortality, burden of disability-adjusted life years (DALYs), and attributable risk factors breast cancer vary significantly by country or region, particularly between developing developed countries. This study aimed to analyze development trends in countries based on the influence different sociodemographic indices (SDIs) World Bank (WB) income-level disease data from 1990 2019.
Language: Английский
Citations
36
BMC Cancer, Journal Year: 2024, Volume and Issue: 24(1)
Published: Jan. 2, 2024
Abstract Purpose The residual cancer burden index (RCB) was proposed as a response evaluation criterion in breast patients treated with Neoadjuvant Chemotherapy (NAC). This study evaluated the relevance of RCB replase-free survival (RFS). Methods clinical data 254 who received NAC between 2016 and 2020 were retrospectively collected. relationship clinicopathologic factors RFS using Cox proportional hazards regression models. estimates determined by Kaplan–Meier(K-M) analysis compared log-rank test. Multivariate logistic used to evaluate risk associated RCB. Receiver operating characteristic (ROC) curves showed potential MP grading systems biomarkers for RFS. Results At median follow-up 52 months, 59 patients(23.23%) developed relapse. that older age ( P = 0.022), high Pathologic T stage after 0.023) score( 0.003) outcomes multivariate indicated 0 (pathologic complete [pCR]) HER2-positive 0.002) triple-negative (TNBC) 0.013). In addition, scoring served prognostic markers NAC, their area under (AUCs) 0.691 0.342, respectively. Conclusion These suggest can be equally applied predict Chinese NAC. application may help guide selection treatment strategies.
Language: Английский
Citations
9
Journal of Global Health, Journal Year: 2024, Volume and Issue: 14
Published: July 19, 2024
Abstract Background Breast cancer in young women (BCY) is much less common but has significant health sequelae and societal costs. We aimed to evaluate the global regional burden of breast aged 15–39 years from 1990 2019. Methods collected detailed data on Global Burden Disease Study 2019 (GBD 2019) Data Resources. The age-standardised incidence rate (ASIR), mortality (ASMR), disability-adjusted life (ASDR), estimated annual percentage change (EAPC) were used assess disease BCY. Bayesian Age-Period-Cohort model was forecast 2020 2030. Results From 2019, increases ASIR found for BCY (EAPC = 0.59, 95% confidence interval (CI) 0.5 0.68), whereas decreases ASMR −0.41, CI −0.53 −0.3) ASDR −0.35, −0.46 −0.24). Across countries with varying sociodemographic indexes (SDI), all regions showed an upward trend morbidity, except a high SDI. While DALYs rates have decreased high, high-middle, middle SDI, they increased low-middle low Countries lower SDIs are projected bear greatest over next decade, including both categories. Alcohol use main risk factor attributed deaths most countries, while exposure second hand smoke predominant SDI countries. Conclusions rise worldwide, there differences. or face even more challenges, as experienced increasing than higher SDIs.
Language: Английский
Citations
6
Cureus, Journal Year: 2023, Volume and Issue: unknown
Published: Oct. 28, 2023
Breast cancer, the second-most common and lethal disease in women, poses a severe danger to global health. cancer rates continue climb despite advances medical technology. Predictions indicate that by 2040, there will be more than three million new cases yearly. Targeted medicines have experienced profound transformation treating breast allowing for individualized strategies lessen side effects improve patient outcomes. This thorough analysis gives rigorous investigation of current developments cancer-targeted treatments. It carefully examines several subtypes, including hormone receptor-positive (HR+), HER2-positive (HER2+), triple-negative (TNBC), recognizing illness' fundamental variety. offers specialized treatment plans catered each subtype's particular traits. The review also how precise genetic abnormalities like BRCA1/2 PIK3CA mutations molecular profiling facilitate therapy selection. Monoclonal antibodies small molecule inhibitors are some targeted examined study. explains these treatments works supports its findings with data from clinical trials. considers potential medications addresses persistent problems, such as resistance mechanisms, chances combining therapies, cutting-edge classification techniques. study seeks give healthcare professionals, researchers, patients overview recent advancements drawing on opinions top authorities area. coordinated effort aims create customized, efficient eventually bolstering battle against this powerful illness.
Language: Английский
Citations
15
Breast Cancer Research, Journal Year: 2024, Volume and Issue: 26(1)
Published: Jan. 22, 2024
The birth cohort effect has been suggested to influence the rate of breast cancer incidence and trends associated reproductive lifestyle factors. We conducted a study determine whether differential pattern associations exists between certain factors risk based on cohorts.
Language: Английский
Citations
4
Journal of Cancer Research and Clinical Oncology, Journal Year: 2025, Volume and Issue: 151(2)
Published: Feb. 11, 2025
Abstract Background Breast cancer (BC) poses an increasing threat to women’s health, yet its characteristics in women of childbearing age (WCBA) are infrequently reported. This study aims investigate the patterns and trends BC incidence among WCBA over past decades. Materials methods focuses on aged 15–49 years, consistent with WHO definition WCBA. Estimates 95% uncertainty intervals (UIs) for were obtained from Global Burden Diseases Study 2021. We utilized age-period-cohort (APC) model estimate overall annual percentage change (net drift, % per year) within each group (local year). also provided fitted longitudinal age-specific rates adjusted period deviations (age effects) period/cohort relative risks (period/cohort 1992 Results In 2021, global was 561.44 thousand (95% UI 519.76 606.99). Between estimated 0.47 CI 0.41–0.52) worldwide, ranging −0.43 −0.54–−0.31) High sociodemographic index (SDI) region 2.03 1.97–2.1) Low-middle SDI region. Local drift analysis showed that higher regions had age-standardized WCBA, effects demonstrating similar across different risk age. Notably, rising trend occurs at progressively younger ages. Globally, unfavorable cohort observed. All exhibited increased risks, except region, which saw a reduction influenced by effects, particularly those born after 1996. Conclusion The highlights urgent need effective intervention preventive policies alleviate this growing burden.
Language: Английский
Citations
0
Journal of Health Psychology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 26, 2025
This study aimed to evaluate the experiences of women with familial breast cancer history (FBCH) understand their emotions and reactions. A qualitative approach was used relying on constructivist grounded theory (CGT) methodology. Data were collected through in-depth semi-structured interviews 20 attending a Medical Imaging Center FBCH high risk (over 25%) according Tyrer-Cuzick assessment model. Theoretical concept derived from subset seven main research questions resulted in 30 subcategories 10 categories, which categorized into two core concepts, "adaptive responses" "maladaptive responses." Based findings, screening target women, physicians other healthcare professionals should consider referrals not only genetic medical imaging services but also psychological as supportive measures preserve quality life these individuals.
Language: Английский
Citations
0