The
initiation
of
the
"nanotechnology
era"
within
past
decade
has
been
prominently
marked
by
advancements
in
biomaterials.
This
intersection
opened
up
numerous
possibilities
for
enhancing
detection,
diagnosis,
and
treatment
various
illnesses
leveraging
synergy
between
biomaterials
nanotechnology.
term
"nano
biomaterials"
referring
to
featuring
constituent
or
surface
feature
sizes
below
100
nm,
presents
a
realm
extraordinary
materials
endowed
with
unique
structures
properties.
Beyond
addressing
common
biomedical
challenges,
these
nano
contribute
unprecedented
insights
principles
that
enrich
our
understanding
biology,
medicine,
science.
A
critical
evaluation
recent
technological
progress
employing
medicine
is
essential,
along
an
exploration
potential
future
trends.
Nanotechnology
breakthroughs
have
yielded
novel
surfaces,
materials,
configurations
notable
applications
domain.
integration
nanotechnology
already
begun
enhance
traditional
practices
across
diverse
fields
such
as
tissue
engineering,
intelligent
systems,
utilization
nanocomposites
implant
design,
controlled
release
biosensors,
more.
mini
review
encapsulates
into
biomaterials,
encompassing
their
types,
synthesis
methods,
roles
organic
inorganic
nanoparticles,
elucidating
mechanisms
action.
Furthermore,
focus
squarely
placed
on
versatile
applications,
particular
emphasis
anticancer
antimicrobial
interventions.
underscores
dynamic
landscape
nanotechnology,
envisioning
where
play
pivotal
role
advancing
medical
particularly
combating
cancer
microbial
infections.
Ovarian
cancer
is
one
the
deadliest
disease
wherein
survival
rate
very
low.
Despite
of
advances
in
medical
sciences,
researches
are
still
at
stage
infancy
where
patients
succumbing
to
this
malignancy.
Multidrug
resistance,
toxicity,
mode
treatment
related
issues
like
catheter
complication
poises
a
number
challenges
scientists
worldwide.
Novel
therapy
now
thus
being
focussed
sensitive
cells
more
towards
treatment.
Gold
nanoparticles
(Au
NPs),
known
for
their
high
biocompatibility,
and
strong
optical
magnetic
responses,
have
emerged
as
promising
agents
both
diagnosis
ovarian
cancer.
Owing
physical
characteristics,
AuNPs
may
be
used
adjuvants
bioimaging,
radiotherapy
fluorescence
imaging.
As
result,
these
characteristics
substantially
support
biological
domains.
In
addition
therapeutic
potential,
Au
NPs
exhibit
surface
plasmon
resonance
(SPR)
properties,
enhancing
imaging
techniques
early
detection
tumors.
Furthermore,
chemical
properties
such
Magnetic
Resonance
Imaging
Properties,
X-ray
property,
Two-photon
or
multiphoton
imaging,
Optical
coherence
tomography
(OCT)
enhance
use
diagnosis.
This
paper
highlights
targeting
potential
by
has
been
discussed.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
165, С. 115039 - 115039
Опубликована: Июнь 24, 2023
Maytansine
is
a
pharmacologically
active
19-membered
ansamacrolide
derived
from
various
medicinal
plants
and
microorganisms.
Among
the
most
studied
pharmacological
activities
of
maytansine
over
past
few
decades
are
anticancer
anti-bacterial
effects.
The
mechanism
action
primarily
mediated
through
interaction
with
tubulin
thereby
inhibiting
assembly
microtubules.
This
ultimately
leads
to
decreased
stability
microtubule
dynamics
cause
cell
cycle
arrest,
resulting
in
apoptosis.
Despite
its
potent
effects,
therapeutic
applications
clinical
medicine
quite
limited
due
non-selective
cytotoxicity.
To
overcome
these
limitations,
several
derivatives
have
been
designed
developed
mostly
by
modifying
parent
structural
skeleton
maytansine.
These
exhibit
improved
as
compared
present
review
provides
valuable
insight
into
synthetic
agents.
Nanomaterials,
Год журнала:
2023,
Номер
13(6), С. 1130 - 1130
Опубликована: Март 22, 2023
In
this
article,
we
provide
an
overview
of
the
progress
scientists
working
to
improve
quality
life
cancer
patients.
Among
known
methods,
treatment
methods
focusing
on
synergistic
action
nanoparticles
and
nanocomposites
have
been
proposed
described.
The
application
composite
systems
will
allow
precise
delivery
therapeutic
agents
cells
without
systemic
toxicity.
nanosystems
described
could
be
used
as
a
high-efficiency
photothermal
therapy
system
by
exploiting
properties
individual
nanoparticle
components,
including
their
magnetic,
photothermal,
complex,
bioactive
properties.
By
combining
advantages
it
is
possible
obtain
product
that
would
effective
in
treatment.
use
nanomaterials
produce
both
drug
carriers
those
active
substances
with
direct
anti-cancer
effect
has
extensively
discussed.
section,
attention
paid
metallic
nanoparticles,
metal
oxides,
magnetic
others.
complex
compounds
biomedicine
also
A
group
showing
significant
potential
therapies
are
natural
compounds,
which
Polymers,
Год журнала:
2023,
Номер
15(4), С. 1025 - 1025
Опубликована: Фев. 18, 2023
Alpha
mangostin
(AM)
has
potential
anticancer
properties
for
breast
cancer.
This
study
aims
to
assess
the
of
chitosan
nanoparticles
coated
with
hyaluronic
acid
targeted
delivery
AM
(AM-CS/HA)
against
MCF-7
cancer
cells.
AM-CS/HA
showed
a
spherical
shape
an
average
diameter
304
nm,
polydispersity
index
0.3,
and
negative
charge
24.43
mV.
High
encapsulation
efficiency
(90%)
drug
loading
(8.5%)
were
achieved.
released
from
at
acidic
pH
5.5
was
higher
than
physiological
7.4
sustained
release.
The
cytotoxic
effect
(IC50
4.37
µg/mL)
on
significantly
without
HA
coating
(AM-CS)
4.48
5.27
µg/mL).
These
findings
suggest
that
enhances
cytotoxicity
applications
therapy.
Cancers,
Год журнала:
2023,
Номер
15(9), С. 2661 - 2661
Опубликована: Май 8, 2023
Breast
cancer
is
a
heterogeneous
disease
which
accounts
globally
for
approximately
1
million
new
cases
annually,
wherein
more
than
200,000
of
these
turn
out
to
be
triple-negative
breast
(TNBC).
TNBC
an
aggressive
and
rare
subtype
that
10–15%
all
cases.
Chemotherapy
remains
the
only
therapy
regimen
against
TNBC.
However,
emergence
innate
or
acquired
chemoresistance
has
hindered
chemotherapy
used
treat
The
data
obtained
from
molecular
technologies
have
recognized
with
various
gene
profiling
mutation
settings
helped
establish
develop
targeted
therapies.
New
therapeutic
strategies
based
on
delivery
therapeutics
relied
application
biomarkers
derived
patients.
Several
been
found
are
targets
precision
in
TNBC,
such
as
EGFR,
VGFR,
TP53,
interleukins,
insulin-like
growth
factor
binding
proteins,
c-MET,
androgen
receptor,
BRCA1,
glucocorticoid,
PTEN,
ALDH1,
etc.
This
review
discusses
candidate
identified
treatment
along
evidence
supporting
their
use.
It
was
established
nanoparticles
had
considered
multifunctional
system
delivering
target
sites
increased
precision.
Here,
we
also
discuss
role
nanotechnology
translation
management.
Cancers,
Год журнала:
2024,
Номер
16(11), С. 2030 - 2030
Опубликована: Май 27, 2024
Immunotherapy
is
a
rapidly
advancing
field
of
research
in
the
treatment
conditions
such
as
cancer
and
autoimmunity.
Nanomaterials
can
be
designed
for
immune
system
manipulation,
with
precise
targeted
delivery
improved
immunomodulatory
efficacy.
Here,
we
elaborate
on
various
strategies
using
nanomaterials,
including
liposomes,
polymers,
inorganic
NPs,
discuss
their
detailed
design
intricacies,
mechanisms,
applications,
current
regulatory
issues.
This
type
nanomaterial
targeting
specific
cells
or
tissues
controlling
release
kinetics
could
push
technological
frontiers
provide
new
innovative
solutions
immune-related
disorders
diseases
without
off-target
effects.
These
materials
enable
interactions
cells,
thereby
enhancing
effectiveness
checkpoint
inhibitors,
vaccines,
adoptive
cell
therapies.
Moreover,
they
allow
fine-tuning
responses
while
minimizing
side
At
intersection
nanotechnology
immunology,
nanomaterial-based
platforms
have
immense
potential
to
revolutionize
patient-centered
immunotherapy
reshape
disease
management.
By
prioritizing
safety,
customization,
compliance
standards,
these
systems
make
significant
contributions
precision
medicine,
significantly
impacting
healthcare
landscape.
Abstract
Carica
papaya
(CP)
is
an
herbaceous
succulent
plant
extensively
used
in
Asian
folk
medicine.
CP
leaves
were
utilized
the
study
for
rapid
eco‐friendly
biosynthesis
of
silver
nanoparticles
(CP‐AgNP).
The
CP‐AgNP
obtained
was
spherical
(scanning
electron
microscope
images)
with
a
size
26.5
±
3.45
nm
as
evident
from
transmission
images
Zeta
Potential
−50
mV.
TNBC
cell
line
MDA‐MB
231
treated
various
doses
and
to
determine
IC
50
values
2.4
mg/mL
15.13
µg/mL,
respectively.
Cell
cycle
analysis
disclosed
G2/M
arrest
upon
administration
treatments.
tubulin
depolymerization
potential
treatments
affirmed
perturbation
polymerization
instigated
apoptosis
by
ROS
induction.
Further
testing
vivo
patient‐derived
ex
culture
platform
elicited
tumor
growth
reduction.
current
identified
few
probable
tubulin‐disrupting
candidates
our
crude
extract
through
molecular
docking.
Some
major
challenges
cancer
drug
delivery
addressed
nanoformulation
are
increased
stability,
higher
levels
biocompatibility,
reduced
toxicity.
Our
data
supports
that
modifications
coupled
targeted
can
act
novel
anticancer
therapeutic.
