pH/ROS Dual-Sensitive Natural Polysaccharide Nanoparticles Enhance “One Stone Four Birds” Effect of Rhein on Ulcerative Colitis

ACS Applied Materials & Interfaces, Год журнала: 2022, Номер 14(45), С. 50692 - 50709

Опубликована: Ноя. 3, 2022

Rhein (RH), a natural anthraquinone compound, is considered an effective treatment candidate for ulcerative colitis (UC), whose multiple biological activities contribute to UC, including anti-inflammation, antioxidation, intestinal barrier repair, and microflora regulation. However, the application of RH severely limited by its low water solubility, bioavailability, poor colonic targeting. Although some nanoparticles have been developed oral delivery RH, most them mainly highlighted only one effect drug strategies but above activities. Therefore, polysaccharide-based nanodelivery system, comprising chitosan (CS) fucoidan (FU), with pH/reactive oxygen species (ROS) sensitivity mucosal adhesion, was first used load as comprehensive UC. Briefly, RH-F/C-NPs were prepared using polyelectrolyte self-assembly method; average size 233.1 ± 5.7 nm, encapsulation rate 93.67 1.60%. And it could maintain gastric stability release in colon designed pH/ROS contributed structures. Cellular uptake experiments showed that both NCM 460 cells RAW 264.7 had good RH-F/C-NPs. Importantly, effects vivo experiments, results which significantly reduce DSS-induced inflammation inhibiting TLR4/NF-κB-mediated anti-inflammatory pathway, Nrf2/HO-1-mediated antioxidant In addition, pharmacokinetic studies shown F/C-NPs increase plasma concentration accumulation extent. short, this study develop nanosystem dual "one stone four birds" therapeutic on

Язык: Английский

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Folic acid-modified lactoferrin nanoparticles coated with a laminarin layer loaded curcumin with dual-targeting for ulcerative colitis treatment

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 232, С. 123229 - 123229

Опубликована: Янв. 13, 2023

Язык: Английский

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Anti-inflammatory natural products modulate interleukins and their related signaling markers in inflammatory bowel disease: A systematic review

Journal of Pharmaceutical Analysis, Год журнала: 2023, Номер 13(12), С. 1408 - 1428

Опубликована: Сен. 22, 2023

This review aims to identify in vivo studies investigating the potential of plant substances and their natural molecules managing inflammatory bowel disease (IBD). Specifically, objective is examine impact these on interleukins other key signaling markers. Relevant articles published up December 2022 were identified through a search PubMed, Scopus, Web Science, Embase databases. The used keywords including "inflammatory disease", "medicinal plants", "natural molecules", "anti-inflammatory", "ulcerative colitis", 1,878 potentially relevant articles, which 89 included this after completion selection process. study provides preclinical data products (NPs) that can treat IBD, ulcerative colitis. main actions NPs relate effects nuclear factor kappa B (NF-κB), Janus kinase (JAK)/signal transducer activator transcription (STAT) pathway, regulation T helper 17/regulatory cells balance, oxidative stress. ability inhibit intestinal inflammation appears be dependent lowering levels pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, IL-17, via Jun N-terminal (JNK)1, NF-κβ-p65, STAT3 pathways. In addition, shown reduce stress severity colitis, as well increase activity antioxidant enzymes. These suggest represent promising treatment for have greater efficacy safety than current treatments.

Язык: Английский

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Oral pectin/oligochitosan microspheres for colon-specific controlled release of quercetin to treat inflammatory bowel disease

Carbohydrate Polymers, Год журнала: 2023, Номер 316, С. 121025 - 121025

Опубликована: Май 23, 2023

Язык: Английский

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Potential interventions and interactions of bioactive polyphenols and functional polysaccharides to alleviate inflammatory bowel disease – A review

Food Chemistry, Год журнала: 2024, Номер 462, С. 140951 - 140951

Опубликована: Авг. 23, 2024

Язык: Английский

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Coumarin: A Natural Solution for Alleviating Inflammatory Disorders

Current Research in Pharmacology and Drug Discovery, Год журнала: 2024, Номер 7, С. 100202 - 100202

Опубликована: Янв. 1, 2024

Coumarin, a naturally occurring compound found in various plants, has rich history of use traditional medicine. Recent research highlighted its anti-inflammatory properties, positioning it as promising candidate for treating inflammatory disorders such rheumatoid arthritis, asthma, and bowel disease. This narrative review aims to comprehensively summarize the current knowledge regarding coumarin's pharmacological effects alleviating conditions by analyzing preclinical clinical studies. The focuses on elucidating mechanisms through which coumarin exerts effects, including antioxidant activity, inhibiting pro-inflammatory cytokine production, modulation immune cell functions. Additionally, paper addresses potential limitations using coumarin, concerns about toxicity at high doses or with prolonged use. Before widespread application, further investigation is needed fully understand benefits risks.

Язык: Английский

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Alkaloids Unveiled: A Comprehensive Analysis of Novel Therapeutic Properties, Mechanisms, and Plant-Based Innovations

Intelligent Pharmacy, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Язык: Английский

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Biological Activities Underlying the Therapeutic Effect of Quercetin on Inflammatory Bowel Disease

Mediators of Inflammation, Год журнала: 2022, Номер 2022, С. 1 - 8

Опубликована: Июль 23, 2022

Inflammatory bowel disease (IBD) is a chronic autoimmune disorder stemming from unrestrained immune activation and subsequent destruction of colon tissue. Genetic susceptibility, microbiota remodeling, environmental cues are involved in IBD pathogenesis. Up to now, there limited treatment options for IBD, so better therapies eagerly needed. The therapeutic effects naturally occurring compounds have been extensively investigated, among which quercetin becomes an attractive candidate owing its unique biochemical properties. To facilitate the clinical translation quercetin, we aimed get comprehensive understanding cellular molecular mechanisms underlying anti-IBD role quercetin. We summarized that exerts effect through consolidating intestinal mucosal barrier, enhancing diversity colonic microbiota, restoring local homeostasis, restraining oxidative stress response. also delineated on gut microbiome discussed potential side administration. Besides, could serve as prodrug, bioavailability improved chemical modifications or utilization effective drug delivery systems. Altogether, these lines evidence hint feasibility compound treatment.

Язык: Английский

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Inflammatory auto-immune diseases of the intestine and their management by natural bioactive compounds

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 151, С. 113158 - 113158

Опубликована: Май 26, 2022

Autoimmune diseases are caused by the overactivity of immune system towards self-constituents. Risk factors autoimmune multiple and include genetic, epigenetic, environmental, psychological. chronic inflammatory bowel diseases, including celiac (Crohn's disease ulcerative colitis), constitute a significant health problem worldwide. Besides complexity symptoms these their treatments have only been palliative. Numerous investigations showed that natural phytochemicals could be promising strategies to fight against diseases. In this respect, plant-derived compounds such as flavonoids, phenolic acids, terpenoids exhibited effects three affecting intestine, particularly This review focuses on role obtained from medicinal plants in modulating auto-immune intestine. It covers most recent literature related effect treatment prevention

Язык: Английский

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Surfactin Mitigates Dextran Sodium Sulfate-Induced Colitis and Behavioral Disorders in Mice by Mediating Gut–Brain-Axis Balance

Journal of Agricultural and Food Chemistry, Год журнала: 2023, Номер 71(3), С. 1577 - 1592

Опубликована: Янв. 12, 2023

Ulcerative colitis (UC) is associated with brain neurotransmitter disorders and intestinal dysbiosis. Bacillus amyloliquefaciens fmb50 produces the lipopeptide surfactin, which has a wide range of biological activities. However, effects surfactin on DSS-induced have not been reported. In present study, oral significantly ameliorated in mouse model reduced depression-like behavior, such as slowed walking speed, shortened movement distance open field test, weakened exploration ability light–dark shuttle test. Surfactin noticeably improved gut microbial dysbiosis, barrier dysfunction colon, blood–brain brain. Furthermore, colon levels occludin were upregulated by 68.51%, ZO-1 77.81% 36.42%, respectively. supplementation also inhibited inflammatory responses inactivating tumor necrosis factor-α (TNF-α), nuclear factor kappa-B (NF-κB), NLRP3 signaling pathways Thus, we believe that behavioral upregulating 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), norepinephrine (NE), brain-derived neurotrophic (BDNF), suppressing responses, improving dysfunction. abundances microbes are related to colitis, especially targeting facultative anaerobes phylum Proteobacteria, it increased abundance beneficial bacteria Lactobacillus unidentified Prevotella. Combined its nontoxic nature observed this long-term study mice, might be promising intervention strategy for preventing acting microbiota-gut–brain axis.

Язык: Английский

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