Vitamin E Analog Trolox Attenuates MPTP-Induced Parkinson’s Disease in Mice, Mitigating Oxidative Stress, Neuroinflammation, and Motor Impairment

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(12), С. 9942 - 9942

Опубликована: Июнь 9, 2023

Trolox is a potent antioxidant and water-soluble analog of vitamin E. It has been used in scientific studies to examine oxidative stress its impact on biological systems. shown have neuroprotective effect against ischemia IL-1β-mediated neurodegeneration. In this study, we investigated the potential protective mechanisms 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease mouse model. Western blotting, immunofluorescence staining, ROS/LPO assays were performed investigate role trolox neuroinflammation, mediated by MPTP (PD) model (wild-type mice (C57BL/6N), eight weeks old, average body weight 25-30 g). Our study showed that increased expression α-synuclein, decreased tyrosine hydroxylase (TH) dopamine transporter (DAT) levels striatum substantia nigra pars compacta (SNpc), impaired motor function. However, treatment significantly reversed these PD-like pathologies. Furthermore, reduced increasing nuclear factor erythroid-2-related 2 (Nrf2) heme oxygenase-1 (HO-1). Lastly, inhibited activated astrocytes (GFAP) microglia (Iba-1), also reducing phosphorylated factor-κB, (p-NF-κB) tumor necrosis factor-alpha (TNF-α) PD brain. Overall, our demonstrated may exert neuroprotection dopaminergic neurons MPTP-induced stress, dysfunction,

Язык: Английский

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Roflumilast escalates α-synuclein aggregate degradation in rotenone-induced Parkinson's disease in rats: Modulation of the ubiquitin-proteasome system and endoplasmic reticulum stress

Chemico-Biological Interactions, Год журнала: 2023, Номер 379, С. 110491 - 110491

Опубликована: Апрель 25, 2023

Язык: Английский

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Antioxidant therapy against TGF‐β/SMAD pathway involved in organ fibrosis

Journal of Cellular and Molecular Medicine, Год журнала: 2023, Номер 28(2)

Опубликована: Дек. 2, 2023

Abstract Fibrosis refers to excessive build‐up of scar tissue and extracellular matrix components in different organs. In recent years, it has been revealed that cytokines chemokines, especially Transforming growth factor beta (TGF‐β) is involved the pathogenesis fibrosis. It shown TGF‐β upregulated fibrotic tissues, contributes fibrosis by mediating pathways are related preservation fibroblasts differentiation. There no doubt antioxidants protect against inflammatory conditions reversing effects nitrogen, oxygen sulfur‐based reactive elements. Oxidative stress a direct impact on chronic inflammation, as results, prolonged inflammation ultimately results Different types antioxidants, forms vitamins, natural compounds or synthetic ones, have proven be beneficial protection both vitro vivo. this study, we reviewed role with antioxidant activity induction inhibition TGF‐β/SMAD signalling pathway, regard such gastro‐intestinal fibrosis, cardiac pulmonary skin renal also some rare cases animal models cell lines.

Язык: Английский

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Exploring the Comprehensive Neuroprotective and Anticancer Potential of Afzelin

Pharmaceuticals, Год журнала: 2024, Номер 17(6), С. 701 - 701

Опубликована: Май 28, 2024

Neurodegenerative diseases (Alzheimer’s disease, Parkinson’s Huntington’s and others) cancer, seemingly disparate in their etiology manifestation, exhibit intriguing associations certain cellular molecular processes. Both cancer neurodegenerative involve the deregulation of processes such as apoptosis, proliferation, DNA repair pose a significant global health challenge. Afzelin (kaempferol 3-O-rhamnoside) is flavonoid compound abundant various plant sources. exhibits diverse range biological activities, offering promising prospects for treatment hallmarked by oxidative stress cell death pathways. Its protective potential against also alleviating side effects chemotherapy. This review explores therapeutic implications afzelin, including its capacity to mitigate stress, modulate inflammation, promote regeneration diseases.

Язык: Английский

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Mechanism of Action and Therapeutic Implications of Nrf2/HO-1 in Inflammatory Bowel Disease

Antioxidants, Год журнала: 2024, Номер 13(8), С. 1012 - 1012

Опубликована: Авг. 20, 2024

Oxidative stress (OS) is a key factor in the generation of various pathophysiological conditions. Nuclear erythroid 2 (NF-E2)-related (Nrf2) major transcriptional regulator antioxidant reactions. Heme oxygenase-1 (HO-1), gene regulated by Nrf2, one most critical cytoprotective molecules. In recent years, Nrf2/HO-1 has received widespread attention as regulatory pathway for intracellular defense against oxidative stress. It considered potential target treatment inflammatory bowel disease (IBD). This review highlights mechanism action and therapeutic significance IBD complications (intestinal fibrosis colorectal cancer (CRC)), well phytochemicals targeting IBD. The results suggest that effects on mainly involve following aspects: (1) Controlling to reduce intestinal inflammation injury; (2) Regulation flora repair mucosal barrier; (3) Prevention ferroptosis epithelial cells. However, due complex role Nrf2/HO-1, more nuanced understanding exact mechanisms involved way forward future.

Язык: Английский

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Evidence for Oxidative Pathways in the Pathogenesis of PD: Are Antioxidants Candidate Drugs to Ameliorate Disease Progression?

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(13), С. 6923 - 6923

Опубликована: Июнь 22, 2022

Parkinson’s disease (PD) is a progressive neurodegenerative disorder that arises due to complex and variable interplay between elements including age, genetic, environmental risk factors manifest as the loss of dopaminergic neurons. Contemporary treatments for PD do not prevent or reverse extent neurodegeneration characteristic this accordingly, there strong need develop new approaches which address underlying process provide benefit patients with debilitating disorder. Mitochondrial dysfunction, oxidative damage, inflammation have been implicated pathophysiological mechanisms selective neurons seen in PD. However, results studies aiming inhibit these pathways shown success, outcomes from large-scale clinical trials are available report varying success interventions studied. Overall, data suggest further development testing novel therapies required identify potential combating Herein, review reports on most recent antioxidant anti-inflammatory positive cell animal models focus supplementation natural product selected synthetic drugs.

Язык: Английский

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Effect of esketamine pretreatment on acute sepsis-associated encephalopathy

Experimental Neurology, Год журнала: 2023, Номер 372, С. 114646 - 114646

Опубликована: Дек. 7, 2023

Язык: Английский

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Novel therapeutics to treat chronic pancreatitis: targeting pancreatic stellate cells and macrophages

Expert Review of Gastroenterology & Hepatology, Год журнала: 2024, Номер 18(4-5), С. 171 - 183

Опубликована: Май 3, 2024

Introduction Chronic pancreatitis (CP) is a persistent, recurrent, and progressive disorder that characterized by chronic inflammation irreversible fibrosis of the pancreas. It associated with severe morbidity, resulting in intense abdominal pain, diabetes, exocrine endocrine dysfunction, an increased risk pancreatic cancer. The etiological factors are diverse major include smoking, alcoholism, as well other environmental genetic factors. treatment management CP challenging, no definitive curative therapy currently available.

Язык: Английский

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Navigating the Complexities of Neuronal Signaling and Targets in Neurological Disorders: From Pathology to Therapeutics

European Journal of Pharmacology, Год журнала: 2025, Номер unknown, С. 177417 - 177417

Опубликована: Фев. 1, 2025

Язык: Английский

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Polyphenols from Thinned Young Apples: HPLC-HRMS Profile and Evaluation of Their Anti-Oxidant and Anti-Inflammatory Activities by Proteomic Studies

Antioxidants, Год журнала: 2022, Номер 11(8), С. 1577 - 1577

Опубликована: Авг. 15, 2022

The qualitative profile of thinned apple polyphenols (TAP) fraction (≈24% polyphenols) obtained by purification through absorbent resin was fully investigated LC-HRMS in positive and negative ion mode using ESI source. A total 68 were identified belonging to six different classes: flavanols, flavonols, dihydrochalchones, flavanones, flavones organic phenolic acids. antioxidant anti-inflammatory activities then cell models with gene reporter for NRF2 NF-κB quantitative proteomic (label-free SILAC) approaches. TAP dose-dependently activated the same concentration range (10-250 µg/mL) inhibited nuclear translocation induced TNF-α IL-1α as pro-inflammatory promoters. Proteomic studies elucidated molecular pathways evoked treatment: activation signaling pathway, which turn up-regulates protective oxidoreductases their nucleophilic substrates such GSH NADPH, latter resulting from up-regulation pentose phosphate pathway. increase enzymatic cellular activity together heme-oxygenase would explain effect TAP. results suggest that apples can be considered a valuable source used health care products prevent/treat oxidative inflammatory chronic conditions.

Язык: Английский

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