Ceramics International, Год журнала: 2025, Номер unknown
Опубликована: Май 1, 2025
Язык: Английский
Carbohydrate Research, Год журнала: 2024, Номер 542, С. 109199 - 109199
Опубликована: Июнь 27, 2024
Язык: Английский
Процитировано
45
Pharmaceutics, Год журнала: 2023, Номер 15(9), С. 2361 - 2361
Опубликована: Сен. 21, 2023
Nanoformulations have become increasingly useful as drug delivery technologies in recent decades. As therapeutics, oral administration is the most common method, although it not always effective route because of challenges with swallowing, gastrointestinal discomfort, low solubility, and poor absorption. One significant barriers that medications must overcome to exert a therapeutic effect impact first hepatic transit. Studies shown controlled-release systems using nanoparticles composed biodegradable natural polymers significantly improve administration, which why these materials attracted attention. Chitosan possesses wide variety properties functions pharmaceutical well healthcare industries. Drug encapsulation transport within body are two its important features. Moreover, chitosan can enhance efficacy by facilitating interaction target cells. Based on physicochemical properties, potentially be synthesized into nanoparticles, this review summarizes advances applications orally delivered nanoparticle interventions.
Язык: Английский
Процитировано
28
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Май 19, 2024
Our current study reports the successful synthesis of thiolated chitosan-based nanoparticles for targeted drug delivery 5-Fluorouracil. This process was achieved through ionic gelation technique, aiming to improve efficacy chemotherapeutic moiety by modifying surface (NPs) with a ligand. We coated these NPs hyaluronic acid (HA) actively target CD44 receptor, which is frequently overexpressed in various solid malignancies, including breast cancer. XRD, FTIR, SEM, and TEM were used physicochemical analysis NPs. These 5-Fluorouracil (5-FU) loaded evaluated on MDA-MB-231 (a triple-negative cell line) MCF-10A (normal epithelial cells) determine their vitro efficacy. The developed 5-FU-loaded exhibited particle size within favorable range (< 300 nm). positive zeta potential facilitated uptake negatively charged cancer cells. Moreover, they demonstrated robust stability high encapsulation efficiency. significant cytotoxicity compared crude (p < 0.05) displayed promising release pattern consistent basic diffusion model. traits pharmacokinetic profile, efficacy, ability precisely nanoparticles, offering potentially anticancer treatment However, additional vivo assessments formulations are obligatory confirm findings.
Язык: Английский
Процитировано
17
International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 8373 - 8400
Опубликована: Авг. 1, 2024
Despite all major advancements in drug discovery and development the pharmaceutical industry, cancer is still one of most arduous challenges for scientific community. The implications nanotechnology have certainly resolved issues related to conventional anticancer modalities; however, undesired recognition nanoparticles (NPs) by mononuclear phagocyte system (MPS), their poor stability biological fluids, premature release payload, low biocompatibility restricted clinical translation. In recent decades, chitosan (CS)-based nanodelivery systems (eg, polymeric NPs, micelles, liposomes, dendrimers, conjugates, solid lipid nanoparticles, etc.) attained promising from researchers improving pharmacokinetics pharmacodynamics chemotherapeutics. However, specialty this review mainly focus on critically discuss targeting potential various CS-based NPs treatment different types cancer. Based delivery mechanisms, we classified into stimuli-responsive, passive, or active nanosystems. Moreover, functionalization strategies grafting with polyethylene glycol (PEG), hydrophobic substitution, tethering stimuli-responsive linkers, conjugation ligands) adapted architecture CS-NPs target-specific chemotherapeutics also been considered. Nevertheless, based therapeutics hold great promise therapeutic outcomes while mitigating off-target effects chemotherapeutics, a long-term safety profile testing humans are warranted successful
Язык: Английский
Процитировано
10
International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 135893 - 135893
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
10
Journal of Controlled Release, Год журнала: 2024, Номер 370, С. 14 - 42
Опубликована: Апрель 17, 2024
Язык: Английский
Процитировано
9
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142486 - 142486
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
2
International Journal of Pharmaceutics X, Год журнала: 2025, Номер unknown, С. 100334 - 100334
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
2
International Journal of Pharmaceutics X, Год журнала: 2024, Номер 8, С. 100281 - 100281
Опубликована: Авг. 28, 2024
Cancer is the leading cause of death globally, and conventional treatments have limited efficacy with severe side effects. The use nanotechnology has potential to reduce effects drugs by creating efficient controlled anticancer drug delivery systems. Nanoparticles (NPs) used as carriers offer several advantages, including enhanced protection, biodistribution, selectivity and, pharmacokinetics. Therefore, this review devoted various organic (lipid, polymeric) well inorganic nanoparticles based on different building units providing a wide range potent Within these nanoparticulate systems, chitosan (CS)-based NPs are discussed particular emphasis due unique properties CS its derivatives non-toxicity, biodegradability, mucoadhesivity, tunable physico-chemical biological allowing their alteration specifically target cancer cells. In context streamlining systems (DDS), innovative nanoplatform-based therapy pathways involving passive active targeting stimuli-responsive DDS enhancing overall orthogonality developed NP-DDS towards included. most up-to-date information delivering anti-cancer using modern dosage forms specifically, CSNPs, summarised evaluated concerning benefits, limitations, advanced applications.
Язык: Английский
Процитировано
9
Current Issues in Molecular Biology, Год журнала: 2024, Номер 46(9), С. 10444 - 10461
Опубликована: Сен. 20, 2024
Hyaluronic acid (HA) is a naturally occurring, long, unbranched polysaccharide that plays critical role in maintaining skin structure and hydration. Its unique properties make it valuable component the field of nanopharmaceuticals. The combination HA into nanopharmaceuticals enhances its ability to interact with various therapeutic agents, improving delivery efficacy drugs. HA-based nanoparticles, including solid lipid polymeric nanogels, offer controlled release, enhanced stability, targeted agents. These innovations significantly improve outcomes reduce side effects, making an essential tool modern medicine. In general, HA-modified liposomes enhance drug encapsulation targeting, while nanoparticles (SLNs) provide core for encapsulation, offering release stability. This article provides overview potential applications recent advancements nanopharmaceuticals, emphasizing significant impact on evolving advanced strategies. By delving compatibility this review underscores promising revolutionizing
Язык: Английский
Процитировано
8