Cancer Nanotechnology,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: June 20, 2023
Abstract
The
in
vivo
anticancer
potential
of
vincristine
(VC)
loaded,
thiolated
chitosan-based
nanoformulation
(NFs)
with
an
outer
hyaluronic
acid
(VC-loaded
TCs-HA)
coating
was
studied
prostate
cancer
(PC)
xenograft
the
immunosuppressed
rat
model
induced
by
PC3
cell
lines.
Our
previous
study
has
already
reported
vitro
efficacy
said
NFs.
ADMET
Predictor
(TM)
Cloud
version
10.4.0.5,
64-bit,
used
to
simulate
VC's
physicochemical
and
pharmacokinetic
parameters.
percentage
encapsulation
efficiency
VC
direct
indirect
methods
81.5
90%,
respectively.
Plasma
samples
from
healthy
rats
showed
improved
bioavailability
profiles
NFs
compared
injection
via
HPLC.
haemolytic
analysis
two
times
lesser
toxicity
red
blood
cells.
Xenograft
maximum
tumour
volume
up
235
±
0.02
mm
3
increased
body
weight,
it
reduced
56
0.01
107.3
0.03
during
whole
treatment
pure
VC.
histopathology
group
less
malignancy
angiogenesis
significantly
metastasis
liver
kidney.
ELISA
high
expression
apoptotic
biomarkers,
including
Bax,
cleaved
Caspase
3,
PARP,
while
BCL2,
COX-II,
NFκB,
TNF-α
reduced.
Immunohistochemical
also
revealed
that
post-NF
administration,
cytoplasmic
expressions
COX-II
were
reduced,
as
nuclear
NFκB.
Thus,
prepared
chemotherapeutic
a
comparatively
potent
oncolytic
agent,
safe
off-target
toxicity,
had
profile.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(9), P. 2361 - 2361
Published: Sept. 21, 2023
Nanoformulations
have
become
increasingly
useful
as
drug
delivery
technologies
in
recent
decades.
As
therapeutics,
oral
administration
is
the
most
common
method,
although
it
not
always
effective
route
because
of
challenges
with
swallowing,
gastrointestinal
discomfort,
low
solubility,
and
poor
absorption.
One
significant
barriers
that
medications
must
overcome
to
exert
a
therapeutic
effect
impact
first
hepatic
transit.
Studies
shown
controlled-release
systems
using
nanoparticles
composed
biodegradable
natural
polymers
significantly
improve
administration,
which
why
these
materials
attracted
attention.
Chitosan
possesses
wide
variety
properties
functions
pharmaceutical
well
healthcare
industries.
Drug
encapsulation
transport
within
body
are
two
its
important
features.
Moreover,
chitosan
can
enhance
efficacy
by
facilitating
interaction
target
cells.
Based
on
physicochemical
properties,
potentially
be
synthesized
into
nanoparticles,
this
review
summarizes
advances
applications
orally
delivered
nanoparticle
interventions.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: May 19, 2024
Our
current
study
reports
the
successful
synthesis
of
thiolated
chitosan-based
nanoparticles
for
targeted
drug
delivery
5-Fluorouracil.
This
process
was
achieved
through
ionic
gelation
technique,
aiming
to
improve
efficacy
chemotherapeutic
moiety
by
modifying
surface
(NPs)
with
a
ligand.
We
coated
these
NPs
hyaluronic
acid
(HA)
actively
target
CD44
receptor,
which
is
frequently
overexpressed
in
various
solid
malignancies,
including
breast
cancer.
XRD,
FTIR,
SEM,
and
TEM
were
used
physicochemical
analysis
NPs.
These
5-Fluorouracil
(5-FU)
loaded
evaluated
on
MDA-MB-231
(a
triple-negative
cell
line)
MCF-10A
(normal
epithelial
cells)
determine
their
vitro
efficacy.
The
developed
5-FU-loaded
exhibited
particle
size
within
favorable
range
(<
300
nm).
positive
zeta
potential
facilitated
uptake
negatively
charged
cancer
cells.
Moreover,
they
demonstrated
robust
stability
high
encapsulation
efficiency.
significant
cytotoxicity
compared
crude
(p
<
0.05)
displayed
promising
release
pattern
consistent
basic
diffusion
model.
traits
pharmacokinetic
profile,
efficacy,
ability
precisely
nanoparticles,
offering
potentially
anticancer
treatment
However,
additional
vivo
assessments
formulations
are
obligatory
confirm
findings.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 8373 - 8400
Published: Aug. 1, 2024
Despite
all
major
advancements
in
drug
discovery
and
development
the
pharmaceutical
industry,
cancer
is
still
one
of
most
arduous
challenges
for
scientific
community.
The
implications
nanotechnology
have
certainly
resolved
issues
related
to
conventional
anticancer
modalities;
however,
undesired
recognition
nanoparticles
(NPs)
by
mononuclear
phagocyte
system
(MPS),
their
poor
stability
biological
fluids,
premature
release
payload,
low
biocompatibility
restricted
clinical
translation.
In
recent
decades,
chitosan
(CS)-based
nanodelivery
systems
(eg,
polymeric
NPs,
micelles,
liposomes,
dendrimers,
conjugates,
solid
lipid
nanoparticles,
etc.)
attained
promising
from
researchers
improving
pharmacokinetics
pharmacodynamics
chemotherapeutics.
However,
specialty
this
review
mainly
focus
on
critically
discuss
targeting
potential
various
CS-based
NPs
treatment
different
types
cancer.
Based
delivery
mechanisms,
we
classified
into
stimuli-responsive,
passive,
or
active
nanosystems.
Moreover,
functionalization
strategies
grafting
with
polyethylene
glycol
(PEG),
hydrophobic
substitution,
tethering
stimuli-responsive
linkers,
conjugation
ligands)
adapted
architecture
CS-NPs
target-specific
chemotherapeutics
also
been
considered.
Nevertheless,
based
therapeutics
hold
great
promise
therapeutic
outcomes
while
mitigating
off-target
effects
chemotherapeutics,
a
long-term
safety
profile
testing
humans
are
warranted
successful
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 7415 - 7471
Published: July 1, 2024
Abstract:
Cancer,
as
the
foremost
challenge
among
human
diseases,
has
plagued
medical
professionals
for
many
years.
While
there
have
been
numerous
treatment
approaches
in
clinical
practice,
they
often
cause
additional
harm
to
patients.
The
emergence
of
nanotechnology
brought
new
directions
cancer
treatment,
which
can
deliver
anticancer
drugs
specifically
tumor
areas.
This
article
first
introduces
application
scenarios
nanotherapies
and
strategies
nanomedicine.
Then,
noteworthy
characteristics
exhibited
by
biopolymer
materials
were
described,
make
biopolymers
stand
out
polymeric
nanomedicine
delivery.
Next,
we
focus
on
summarizing
state-of-art
studies
five
categories
proteins
(Albumin,
Gelatin,
Silk
fibroin,
Zein,
Ferritin),
nine
varieties
polysaccharides
(Chitosan,
Starch,
Hyaluronic
acid,
Dextran,
cellulose,
Fucoidan,
Carrageenan,
Lignin,
Pectin)
liposomes
field
drug
Finally,
also
provide
a
summary
advantages
limitations
these
biopolymers,
discuss
prevailing
impediments
their
application,
detail
prospective
research
directions.
review
not
only
helps
readers
understand
current
development
status
nano
delivery
systems
based
but
is
helpful
properties
various
find
suitable
solutions
this
through
comparative
reading.
Keywords:
delivery,
nanoformulations,
polymer,
proteins,
International Journal of Pharmaceutics X,
Journal Year:
2024,
Volume and Issue:
8, P. 100281 - 100281
Published: Aug. 28, 2024
Cancer
is
the
leading
cause
of
death
globally,
and
conventional
treatments
have
limited
efficacy
with
severe
side
effects.
The
use
nanotechnology
has
potential
to
reduce
effects
drugs
by
creating
efficient
controlled
anticancer
drug
delivery
systems.
Nanoparticles
(NPs)
used
as
carriers
offer
several
advantages,
including
enhanced
protection,
biodistribution,
selectivity
and,
pharmacokinetics.
Therefore,
this
review
devoted
various
organic
(lipid,
polymeric)
well
inorganic
nanoparticles
based
on
different
building
units
providing
a
wide
range
potent
Within
these
nanoparticulate
systems,
chitosan
(CS)-based
NPs
are
discussed
particular
emphasis
due
unique
properties
CS
its
derivatives
non-toxicity,
biodegradability,
mucoadhesivity,
tunable
physico-chemical
biological
allowing
their
alteration
specifically
target
cancer
cells.
In
context
streamlining
systems
(DDS),
innovative
nanoplatform-based
therapy
pathways
involving
passive
active
targeting
stimuli-responsive
DDS
enhancing
overall
orthogonality
developed
NP-DDS
towards
included.
most
up-to-date
information
delivering
anti-cancer
using
modern
dosage
forms
specifically,
CSNPs,
summarised
evaluated
concerning
benefits,
limitations,
advanced
applications.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: May 22, 2023
Introduction
Cervical
cancer
accounts
for
one
of
most
common
cancers
among
women
reproductive
age.
Oncolytic
virotherapy
has
emerged
as
a
promising
immunotherapy
modality
but
it
comes
with
several
drawbacks
that
include
rapid
clearance
virus
from
body
due
to
immune-neutralization
in
host.
To
overcome
this,
we
encapsulated
oncolytic
Newcastle
disease
(NDV)
polymeric
thiolated
chitosan
nanoparticles.
For
active
targeting
loaded
nanoformulation
against
CD44
(cluster
differentiation
44)
receptors
which
are
overly
expressed
on
cells,
these
nanoparticles
were
surface
functionalized
hyaluronic
acid
(HA).
Methods
Using
half
dose
NDV
(TCID
50
(50%
tissue
culture
infective
dose)
single
3
×
10
5
),
prepared
by
green
synthesis
approach
through
ionotropic
gelation
method.
Zeta
analysis
was
performed
analyse
size
and
charge
Nanoparticles
(NPs)
shape
analysed
SEM
(scanning
electron
microscope)
TEM
(transmission
while
functional
group
identification
done
FTIR
(fourier
transform
infrared)
XRD
(X-ray
diffraction).
Viral
quantification
TCID
Multiplicity
infection
(MOI)
determination
potential
NPs
MTT
(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl
tetrazolium
bromide)
assay
cell
morphology
analysis.
Results
showed
average
HA
(HA-ThCs-NDV)
290.4nm
zeta
22.3
mV
0.265
PDI
(polydispersity
index).
smooth
spherical
features
confirmed
the
presence
characteristic
groups
successful
encapsulation
virus.
In
vitro
release
continuous
sustained
up
48
hours.
HA-ThCs-NDV
2.63x
6
/mL
titter
exhibited
high
compared
naked
virus,
dependent
manner.
Discussion
These
findings
suggest
functionalization
is
not
only
helpful
achieving
masking
immune
system
but,
also
gives
tumor
microenvironment
longer
period
time
increases
bioavailability
