Current Pharmacology Reports, Год журнала: 2024, Номер 11(1)
Опубликована: Ноя. 29, 2024
Язык: Английский
Phytotherapy Research, Год журнала: 2024, Номер 38(7), С. 3271 - 3295
Опубликована: Апрель 10, 2024
Abstract St. John's Wort , commonly known as Hypericum perforatum L. is a flowering plant in the Clusiaceae family that traditionally been employed for treating anxiety depression wounds burns sunburn irritation and stomach ailments . This review provides synopsis of H. phytoconstituents their biological effects, highlighting its beneficial therapeutic properties dermatological indications, well antioxidant, antimicrobial, anti‐inflammatory, anti‐angiogenic activity various applications including wound healing skin conditions such eczema, sun burn minor also spastic paralysis, stiff neck mood disorders anti‐depressant nerve pains neuralgia. The data were collected from several databases Web Science PubMed, ScienceDirect, Scopus Google Scholar using terms: “ L.”, /phytochemistry,” extracts/wound healing” 1994 to 2023. findings suggest acts through mechanisms plays role each phase process, re‐epithelialization, angiogenesis, contraction, connective tissue regeneration. enhances collagen deposition, decreases inflammation, inhibits fibroblast migration, promotes epithelialization by increasing number fibroblasts with polygonal shape fibers within fibroblasts. Perforatum extracts modulate immune response reduce inflammation found accelerate process via inhibition inflammatory mediators' production like interleukin‐6, tumor necrosis factor‐α, cyclooxygenase‐2 gene expression, inducible nitric oxide synthase. Thus, represents potential remedy wide range problems, owing constituents properties. could be utilized development novel therapies.
Язык: Английский
Процитировано
14
Nutrients, Год журнала: 2024, Номер 16(12), С. 1813 - 1813
Опубликована: Июнь 8, 2024
Background: Ashwagandha has been reported to reduce stress and attenuate cognitive decline associated with inflammation neurodegeneration in clinical populations. However, the effects as a potential nootropic nutrient younger populations are unclear. This study examined of liposomal ashwagandha supplementation on function, mood, markers health safety healthy young men women. Methods: 59 women (22.7 ± 7 yrs., 74.9 16 kg, 26.2 5 BMI) fasted for 12 h, donated fasting blood sample, were administered COMPASS function test battery (Word Recall, Word recognition, Choice Reaction Time Task, Picture Recognition, Digit Vigilance Corsi Block test, Stroop test) profile mood states (POMS). In randomized double-blind manner, participants 225 mg placebo (Gum Arabic) or (Withania somnifera) root leaf extract coated covering. After 60-min, repeated assessments. Participants continued (225 mg/d) 30 days then returned lab repeat experiment. Data analyzed using general linear model (GLM) univariate analysis measures pairwise comparisons mean changes from baseline 95% confidence intervals (CI). Results: improved acute and/or 30-day Recall (correct recalled attempts), (targets identified), Recognition (“yes” correct responses, overall reaction time), Color-Word (congruent words identified, POMS (tension fatigue) more consistently several differences observed between groups. Conclusion: Results support contentions that mg) may improve some memory, attention, vigilance, executive while decreasing perceptions tension fatigue individuals. Retrospectively registered trial ISRCTN58680760.
Язык: Английский
Процитировано
12
Nutrients, Год журнала: 2025, Номер 17(3), С. 411 - 411
Опубликована: Янв. 23, 2025
The United Arab Emirates (UAE) is home to diverse indigenous medicinal plants traditionally used for centuries. This study systematically evaluates the pharmacological and nutritional potential of key plants, including Lawsonia inermis, Nigella sativa, Ziziphus spina-christi, Allium cepa, sativum, Cymbopogon schoenanthus, Matricaria aurea, Phoenix dactylifera, Portulaca oleracea, Reichardia tingitana, Salvadora persica, Solanum lycopersicum, Trigonella foenum-graecum, Withania somnifera, lotus. Comprehensive literature searches were conducted using PubMed, Scopus, Web Science identify studies relevant their uses. findings highlight therapeutic roles these in managing global health challenges such as gastrointestinal diseases, antimicrobial resistance through bioactive compounds like flavonoids, polyphenols, antioxidants. Additionally, contributions nutrition, essential vitamins minerals, are emphasized disease prevention promotion. While this research focuses on UAE, implications globally relevant, many also found traditional medicine across Asia, Africa, Europe. Integrating into healthcare systems offers solutions pressing public concerns, reduces reliance synthetic pharmaceuticals, promotes sustainable practices. work a valuable reference researchers, professionals, policymakers, bridging knowledge modern scientific applications globally.
Язык: Английский
Процитировано
1
Frontiers in Nutrition, Год журнала: 2024, Номер 11
Опубликована: Май 3, 2024
The health-beneficial effects of nutraceuticals in various diseases have received enhanced attention recent years. Aging is a continuous process wherein physiological activity an individual declines over time and characterized by indefinite hallmarks which contribute toward aging-related comorbidities include many neurodegenerative diseases, cardiac problems, diabetes, bone-degeneration, cancer. Cellular senescence homeostatic biological that has important function driving aging. Currently, growing body evidence substantiates the connection between epigenetic modifications aging process, along with diseases. These are now being recognized as promising targets for emerging therapeutic interventions. Considering almost all processes modulated RNAs, numerous RNA-binding proteins been found to be linked age-related complexities. studies shed light on ability nutraceutical Withania somnifera (Ashwagandha) influence RNA expression, stability, processing, offering insights into its mechanisms action. By targeting RNA-related pathways, may exhibit ameliorating age-associated molecular changes, gene expression signaling networks. This review summarizes potential role modulating RNA-level changes associated aging, encompassing both vitro vivo studies. Taken together, putative role(s) modulation key RNAs will provide understanding facilitate development preventive strategies employing healthy
Язык: Английский
Процитировано
9
Molecules, Год журнала: 2023, Номер 28(24), С. 8045 - 8045
Опубликована: Дек. 12, 2023
Humans are constantly at high risk of emerging pandemics caused by viral and bacterial infections. The emergence new is mainly evolved viruses bacteria that highly resistant to existing medications. rapid evolution infectious agents demands the urgent investigation therapeutic strategies prevent treat these infections an early stage. One includes use medicinal herbs for their antibacterial antiviral properties. herbal medicines as remedies very ancient has been employed centuries. Many studies have confirmed antimicrobial activities against various pathogens in vitro vivo. effect attributed natural bioactive molecules present plants such alkaloids, flavonoids, terpenoids. Different mechanisms proposed how enhance immune system combat pathogens. Such include disruption cell membranes, suppression protein synthesis, limitation pathogen replication through inhibition nucleic acid synthesis. Medicinal shown a number diseases modulating system's components. For instance, many alleviate inflammation reducing pro-inflammatory cytokines (e.g., tumor necrosis factor-alpha (TNF-α), interleukin-1, IL-6) while promoting production anti-inflammatory IL-10). also play role defense intracellular enhancing proliferation functions killer cells, T-helper-1 macrophages. In this review, we will explore most common preventing treating non-infectious diseases. Using current recently published studies, focus on immunomodulatory effects induced responses during
Язык: Английский
Процитировано
15
Ecological Genetics and Genomics, Год журнала: 2023, Номер 28, С. 100183 - 100183
Опубликована: Июнь 16, 2023
Язык: Английский
Процитировано
13
Trends in Immunotherapy, Год журнала: 2024, Номер 8(1), С. 2703 - 2703
Опубликована: Янв. 24, 2024
Withania somnifera is a famous medicinal plant. It popularly known as Aswagandha. This plant has been in use Ayurveda and Unani medicine for ages. The immense properties. rich potent phytocompounds. These phytocompounds are to have antioxidant, antiviral, antibacterial immunomodulatory efficacies. Our immune system the key player n fighting back any kind of pathogeni attack on us. extract certain isolated from boost our system. Studies show that mechanisms actions bioactive by affecting various cellular signaling pathways. primarily involve pathways associated with receptors present vital cells like dendritic cells, T-cells B-cells. Thus, some compounds suppress or activate components innate adaptive Unlike synthetic adjuvants, natural derived their derivatives, those sp. free such risk factors. A strong best possession fight invasions microbes bacteria viruses SARS-CoV-2. Detailed compact knowledge mechanism modulating impacting may make ways development new supportive therapies against almost all different types diseases including COVID 19.
Язык: Английский
Процитировано
4
Frontiers in Endocrinology, Год журнала: 2024, Номер 15
Опубликована: Янв. 17, 2024
The increasing life expectancy observed in recent years has resulted a higher prevalence of late-onset hypogonadism (LOH) older men. LOH is characterized by the decline testosterone levels and can have significant impacts on physical mental health. While underlying causes are not fully understood, there growing interest exploring role inflammaging its development. Inflammaging concept that describes chronic, low-grade, systemic inflammation occurs as result aging. This inflammatory state been implicated development various age-related diseases. Several cellular molecular mechanisms identified contributors to inflammaging, including immune senescence, autophagy defects, mitochondrial dysfunction. Despite extensive research relationship with yet thoroughly reviewed literature. To address this gap, we aim review latest findings related impact LOH. Additionally, will explore interventions target potential treatments for
Язык: Английский
Процитировано
3
Natural Product Communications, Год журнала: 2025, Номер 20(2)
Опубликована: Фев. 1, 2025
This systematic review delves into the potential of herbal remedies as anti-urticaria agents, examining recent advancements, current clinical status, and prospects. Despite advancements in conventional treatments, managing urticaria remains challenging. There is a growing interest drugs. A comprehensive literature search assessed studies on safety efficacy various herbs treatment. synthesizes key findings from trials, observational studies, experimental research, focusing evaluating used Indian Ayurveda Traditional Chinese Medicine. The discusses treatment mechanisms, synergies with therapies, challenges like chronic unpredictable nature, Identifying triggers, Variable response to treatment, side effects long-term quality life impact etc, standardization regulation. It emphasizes importance ongoing research therapies for urticaria, offering insights their role adjunctive or alternative treatments.
Язык: Английский
Процитировано
0
Journal of Ayurveda and Integrative Medicine, Год журнала: 2025, Номер 16(2), С. 101081 - 101081
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0