Phytotherapy Research,
Journal Year:
2024,
Volume and Issue:
38(7), P. 3271 - 3295
Published: April 10, 2024
Abstract
St.
John's
Wort
,
commonly
known
as
Hypericum
perforatum
L.
is
a
flowering
plant
in
the
Clusiaceae
family
that
traditionally
been
employed
for
treating
anxiety
depression
wounds
burns
sunburn
irritation
and
stomach
ailments
.
This
review
provides
synopsis
of
H.
phytoconstituents
their
biological
effects,
highlighting
its
beneficial
therapeutic
properties
dermatological
indications,
well
antioxidant,
antimicrobial,
anti‐inflammatory,
anti‐angiogenic
activity
various
applications
including
wound
healing
skin
conditions
such
eczema,
sun
burn
minor
also
spastic
paralysis,
stiff
neck
mood
disorders
anti‐depressant
nerve
pains
neuralgia.
The
data
were
collected
from
several
databases
Web
Science
PubMed,
ScienceDirect,
Scopus
Google
Scholar
using
terms:
“
L.”,
/phytochemistry,”
extracts/wound
healing”
1994
to
2023.
findings
suggest
acts
through
mechanisms
plays
role
each
phase
process,
re‐epithelialization,
angiogenesis,
contraction,
connective
tissue
regeneration.
enhances
collagen
deposition,
decreases
inflammation,
inhibits
fibroblast
migration,
promotes
epithelialization
by
increasing
number
fibroblasts
with
polygonal
shape
fibers
within
fibroblasts.
Perforatum
extracts
modulate
immune
response
reduce
inflammation
found
accelerate
process
via
inhibition
inflammatory
mediators'
production
like
interleukin‐6,
tumor
necrosis
factor‐α,
cyclooxygenase‐2
gene
expression,
inducible
nitric
oxide
synthase.
Thus,
represents
potential
remedy
wide
range
problems,
owing
constituents
properties.
could
be
utilized
development
novel
therapies.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(12), P. 1813 - 1813
Published: June 8, 2024
Background:
Ashwagandha
has
been
reported
to
reduce
stress
and
attenuate
cognitive
decline
associated
with
inflammation
neurodegeneration
in
clinical
populations.
However,
the
effects
as
a
potential
nootropic
nutrient
younger
populations
are
unclear.
This
study
examined
of
liposomal
ashwagandha
supplementation
on
function,
mood,
markers
health
safety
healthy
young
men
women.
Methods:
59
women
(22.7
±
7
yrs.,
74.9
16
kg,
26.2
5
BMI)
fasted
for
12
h,
donated
fasting
blood
sample,
were
administered
COMPASS
function
test
battery
(Word
Recall,
Word
recognition,
Choice
Reaction
Time
Task,
Picture
Recognition,
Digit
Vigilance
Corsi
Block
test,
Stroop
test)
profile
mood
states
(POMS).
In
randomized
double-blind
manner,
participants
225
mg
placebo
(Gum
Arabic)
or
(Withania
somnifera)
root
leaf
extract
coated
covering.
After
60-min,
repeated
assessments.
Participants
continued
(225
mg/d)
30
days
then
returned
lab
repeat
experiment.
Data
analyzed
using
general
linear
model
(GLM)
univariate
analysis
measures
pairwise
comparisons
mean
changes
from
baseline
95%
confidence
intervals
(CI).
Results:
improved
acute
and/or
30-day
Recall
(correct
recalled
attempts),
(targets
identified),
Recognition
(“yes”
correct
responses,
overall
reaction
time),
Color-Word
(congruent
words
identified,
POMS
(tension
fatigue)
more
consistently
several
differences
observed
between
groups.
Conclusion:
Results
support
contentions
that
mg)
may
improve
some
memory,
attention,
vigilance,
executive
while
decreasing
perceptions
tension
fatigue
individuals.
Retrospectively
registered
trial
ISRCTN58680760.
Frontiers in Nutrition,
Journal Year:
2024,
Volume and Issue:
11
Published: May 3, 2024
The
health-beneficial
effects
of
nutraceuticals
in
various
diseases
have
received
enhanced
attention
recent
years.
Aging
is
a
continuous
process
wherein
physiological
activity
an
individual
declines
over
time
and
characterized
by
indefinite
hallmarks
which
contribute
toward
aging-related
comorbidities
include
many
neurodegenerative
diseases,
cardiac
problems,
diabetes,
bone-degeneration,
cancer.
Cellular
senescence
homeostatic
biological
that
has
important
function
driving
aging.
Currently,
growing
body
evidence
substantiates
the
connection
between
epigenetic
modifications
aging
process,
along
with
diseases.
These
are
now
being
recognized
as
promising
targets
for
emerging
therapeutic
interventions.
Considering
almost
all
processes
modulated
RNAs,
numerous
RNA-binding
proteins
been
found
to
be
linked
age-related
complexities.
studies
shed
light
on
ability
nutraceutical
Withania
somnifera
(Ashwagandha)
influence
RNA
expression,
stability,
processing,
offering
insights
into
its
mechanisms
action.
By
targeting
RNA-related
pathways,
may
exhibit
ameliorating
age-associated
molecular
changes,
gene
expression
signaling
networks.
This
review
summarizes
potential
role
modulating
RNA-level
changes
associated
aging,
encompassing
both
vitro
vivo
studies.
Taken
together,
putative
role(s)
modulation
key
RNAs
will
provide
understanding
facilitate
development
preventive
strategies
employing
healthy
Molecules,
Journal Year:
2023,
Volume and Issue:
28(24), P. 8045 - 8045
Published: Dec. 12, 2023
Humans
are
constantly
at
high
risk
of
emerging
pandemics
caused
by
viral
and
bacterial
infections.
The
emergence
new
is
mainly
evolved
viruses
bacteria
that
highly
resistant
to
existing
medications.
rapid
evolution
infectious
agents
demands
the
urgent
investigation
therapeutic
strategies
prevent
treat
these
infections
an
early
stage.
One
includes
use
medicinal
herbs
for
their
antibacterial
antiviral
properties.
herbal
medicines
as
remedies
very
ancient
has
been
employed
centuries.
Many
studies
have
confirmed
antimicrobial
activities
against
various
pathogens
in
vitro
vivo.
effect
attributed
natural
bioactive
molecules
present
plants
such
alkaloids,
flavonoids,
terpenoids.
Different
mechanisms
proposed
how
enhance
immune
system
combat
pathogens.
Such
include
disruption
cell
membranes,
suppression
protein
synthesis,
limitation
pathogen
replication
through
inhibition
nucleic
acid
synthesis.
Medicinal
shown
a
number
diseases
modulating
system's
components.
For
instance,
many
alleviate
inflammation
reducing
pro-inflammatory
cytokines
(e.g.,
tumor
necrosis
factor-alpha
(TNF-α),
interleukin-1,
IL-6)
while
promoting
production
anti-inflammatory
IL-10).
also
play
role
defense
intracellular
enhancing
proliferation
functions
killer
cells,
T-helper-1
macrophages.
In
this
review,
we
will
explore
most
common
preventing
treating
non-infectious
diseases.
Using
current
recently
published
studies,
focus
on
immunomodulatory
effects
induced
responses
during
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(3), P. 411 - 411
Published: Jan. 23, 2025
The
United
Arab
Emirates
(UAE)
is
home
to
diverse
indigenous
medicinal
plants
traditionally
used
for
centuries.
This
study
systematically
evaluates
the
pharmacological
and
nutritional
potential
of
key
plants,
including
Lawsonia
inermis,
Nigella
sativa,
Ziziphus
spina-christi,
Allium
cepa,
sativum,
Cymbopogon
schoenanthus,
Matricaria
aurea,
Phoenix
dactylifera,
Portulaca
oleracea,
Reichardia
tingitana,
Salvadora
persica,
Solanum
lycopersicum,
Trigonella
foenum-graecum,
Withania
somnifera,
lotus.
Comprehensive
literature
searches
were
conducted
using
PubMed,
Scopus,
Web
Science
identify
studies
relevant
their
uses.
findings
highlight
therapeutic
roles
these
in
managing
global
health
challenges
such
as
gastrointestinal
diseases,
antimicrobial
resistance
through
bioactive
compounds
like
flavonoids,
polyphenols,
antioxidants.
Additionally,
contributions
nutrition,
essential
vitamins
minerals,
are
emphasized
disease
prevention
promotion.
While
this
research
focuses
on
UAE,
implications
globally
relevant,
many
also
found
traditional
medicine
across
Asia,
Africa,
Europe.
Integrating
into
healthcare
systems
offers
solutions
pressing
public
concerns,
reduces
reliance
synthetic
pharmaceuticals,
promotes
sustainable
practices.
work
a
valuable
reference
researchers,
professionals,
policymakers,
bridging
knowledge
modern
scientific
applications
globally.
Natural Product Communications,
Journal Year:
2025,
Volume and Issue:
20(2)
Published: Feb. 1, 2025
This
systematic
review
delves
into
the
potential
of
herbal
remedies
as
anti-urticaria
agents,
examining
recent
advancements,
current
clinical
status,
and
prospects.
Despite
advancements
in
conventional
treatments,
managing
urticaria
remains
challenging.
There
is
a
growing
interest
drugs.
A
comprehensive
literature
search
assessed
studies
on
safety
efficacy
various
herbs
treatment.
synthesizes
key
findings
from
trials,
observational
studies,
experimental
research,
focusing
evaluating
used
Indian
Ayurveda
Traditional
Chinese
Medicine.
The
discusses
treatment
mechanisms,
synergies
with
therapies,
challenges
like
chronic
unpredictable
nature,
Identifying
triggers,
Variable
response
to
treatment,
side
effects
long-term
quality
life
impact
etc,
standardization
regulation.
It
emphasizes
importance
ongoing
research
therapies
for
urticaria,
offering
insights
their
role
adjunctive
or
alternative
treatments.
International Journal of Food Science,
Journal Year:
2025,
Volume and Issue:
2025(1)
Published: Jan. 1, 2025
As
awareness
of
the
link
between
diet
and
health
grows,
people
are
increasingly
prioritizing
functional
foods
that
offer
additional
benefits
beyond
basic
nutrition.
Ashwagandha,
scientifically
known
as
Withania
somnifera
(WS)
,
is
a
perennial
plant
which
belongs
to
family
Solanaceae,
grows
abundantly
in
subtropical
regions
world.
Ashwagandha
renowned
Ayurvedic
herb
with
diverse
applications
global
dietary
supplements
traditional
medicines.
It
has
extensive
medicinal
potential
Indian
systems
such
(Ayurvedic,
Unani,
Siddha)
contemporary
medicine,
recognized
“Indian
ginseng.”
WS
additive
composed
various
phytochemicals
active
compounds
withanolides,
polyphenols,
flavonoids,
alkaloids,
exhibit
therapeutic
properties,
including
anti‐inflammatory,
anticancer,
antistress,
antioxidant,
antimicrobial,
antidiabetic,
cardioprotective,
hypoglycemic,
hepatoprotective,
immunomodulatory,
rejuvenating
effects.
been
proven
be
highly
effective
against
numerous
neurological
psychological
disorders.
The
incorporation
ashwagandha
into
food
enhances
biological
activity
well
making
it
valuable
benefits.
This
review
provides
an
updated
analysis
emphasizing
its
bioactive
compounds,
extraction
techniques,
applications.
Unlike
previous
studies
primarily
focused
on
this
highlights
integration
systems,
addressing
technological
challenges,
stability,
commercial
viability.
Additionally,
compiles
advancements
analytical
offering
insights
enhancing
bioavailability
sensory
optimization,
thereby
bridging
herbal
use
modern
science.
Trends in Immunotherapy,
Journal Year:
2024,
Volume and Issue:
8(1), P. 2703 - 2703
Published: Jan. 24, 2024
Withania
somnifera
is
a
famous
medicinal
plant.
It
popularly
known
as
Aswagandha.
This
plant
has
been
in
use
Ayurveda
and
Unani
medicine
for
ages.
The
immense
properties.
rich
potent
phytocompounds.
These
phytocompounds
are
to
have
antioxidant,
antiviral,
antibacterial
immunomodulatory
efficacies.
Our
immune
system
the
key
player
n
fighting
back
any
kind
of
pathogeni
attack
on
us.
extract
certain
isolated
from
boost
our
system.
Studies
show
that
mechanisms
actions
bioactive
by
affecting
various
cellular
signaling
pathways.
primarily
involve
pathways
associated
with
receptors
present
vital
cells
like
dendritic
cells,
T-cells
B-cells.
Thus,
some
compounds
suppress
or
activate
components
innate
adaptive
Unlike
synthetic
adjuvants,
natural
derived
their
derivatives,
those
sp.
free
such
risk
factors.
A
strong
best
possession
fight
invasions
microbes
bacteria
viruses
SARS-CoV-2.
Detailed
compact
knowledge
mechanism
modulating
impacting
may
make
ways
development
new
supportive
therapies
against
almost
all
different
types
diseases
including
COVID
19.
