Molecules, Journal Year: 2023, Volume and Issue: 28(16), P. 6141 - 6141
Published: Aug. 19, 2023
Fruits and vegetables are used not only for nutritional purposes but also as therapeutics to treat various diseases ailments. These food items prominent sources of phytochemicals that exhibit chemopreventive therapeutic effects against several diseases. Hirsutine (HSN) is a naturally occurring indole alkaloid found in Uncaria species has multitude benefits. It foodstuffs such fish, seafood, meat, poultry, dairy, some grain products among other things. In addition, it present fruits including corn, cauliflower, mushrooms, potatoes, bamboo shoots, bananas, cantaloupe, citrus fruits. The primary emphasis this study summarize the pharmacological activities underlying mechanisms HSN different diseases, well biopharmaceutical features. For this, data were collected (up date 1 July 2023) from reliable authentic literature by searching academic search engines, PubMed, Springer Link, Scopus, Wiley Online, Web Science, ScienceDirect, Google Scholar. Findings indicated exerts preclinical experimental systems. exhibits anti-inflammatory, antiviral, anti-diabetic, antioxidant with beneficial neurological cardiovascular Our findings indicate promising anticancer potentials via molecular mechanisms, apoptotic cell death, induction oxidative stress, cytotoxic effect, anti-proliferative genotoxic inhibition cancer migration invasion cancers lung, breast, antitumor human T-cell leukemia. Taken all together, show can be agent cancer.
Language: Английский
Citations
34
Chemistry & Biodiversity, Journal Year: 2023, Volume and Issue: 21(2)
Published: Dec. 27, 2023
Abstract Rotundic acid (RA) is a naturally occurring pentacyclic triterpene with multitude of pharmacological activities. The primary emphasis this study on summarizing the anticancer properties underlying mechanisms RA and its derivatives, as well pharmacokinetic features. Data was collected (up to date November 10, 2023) from various reliable authentic literatures by searching in different academic search engines, including PubMed, Springer Link, Scopus, Wiley Online, Web Science, ScienceDirect, Google Scholar. findings imply that synthetic derivatives possess promising anti‐cancer against breast, colorectal, liver, cervical cancers preclinical test systems. results also indicate demonstrated effects via number cellular mechanisms, apoptotic cell death, inhibition oxidative stress, anti‐inflammatory effect, cytotoxicity, cycle arrest, anti‐proliferative anti‐angiogenic cancer migration invasion. It has been proposed derived compounds have capability serve hopeful chemotherapeutic agent, so further extensive clinical research necessary.
Language: Английский
Citations
18
Archives of Toxicology, Journal Year: 2024, Volume and Issue: 98(6), P. 1659 - 1683
Published: April 25, 2024
Abstract Alternaria species are mycotoxin-producing fungi known to infect fresh produce and cause their spoilage. Humans get exposed fungal secondary metabolites as mycotoxin via the ingestion of contaminated food. Alternariol (AOH) (C 14 H 10 O 5 ) is an isocoumarins produced by different including alternata . AOH often found in grain, fruits fruits-based food products with high levels legumes, nuts, tomatoes. was first discovered 1953, it nowadays linked esophagus cancer endocrine disruption due its similarity estrogen. Although considered emerging no regulated food, occurs highly consumed dietary has been detected various masked forms, which adds occurrence. Therefore, this comprehensive review developed give overview on recent literature field AOH. The current study summarizes published data occurrence last ten years evaluates those comparison recommended regulating entities. Such surveillance facilitates work health risk assessors highlights commodities that most need regulation. In addition, effects cells animal models were summarized two tables; include two-year studies. addresses also main characteristics possible human exposure routes, populations at risk, effect anthropogenic activities widespread mycotoxin. commonly used detection control methods described latest discussed guide future researchers focus mitigating mycotoxins contamination industry. This aims mainly serve a guideline for regulation developers assessors.
Language: Английский
Citations
7
Molecules, Journal Year: 2024, Volume and Issue: 29(3), P. 579 - 579
Published: Jan. 24, 2024
Consumers in developed and Western European countries are becoming more aware of the impact food on their health, they demand clear, transparent, reliable information from industry about products consume. They recognise that safety risks often due to unexpected presence contaminants throughout supply chain. Among these, mycotoxins produced by food-infecting fungi, endogenous toxins certain plants organisms, pesticides, other drugs used excessively during farming production, which lead contamination accumulation foodstuffs, main causes concern. In this context, goals review provide a comprehensive overview toxic molecules reported foodstuffs since 2020 through Rapid Alert System for Food Feed (RASFF) portal use chromatography address challenge. Overall, natural toxins, environmental pollutants, food-processing most frequently molecules, liquid gas approaches control. However, faster, simpler, powerful analytical procedures necessary cope with growing pressures chain supply.
Language: Английский
Citations
4
Applied and Environmental Microbiology, Journal Year: 2024, Volume and Issue: 90(4)
Published: April 17, 2024
ABSTRACT Alternaria alternata FB1 is a marine fungus identified as candidate for plastic degradation in our previous study. This has been recently shown to produce secondary metabolites with significant antimicrobial activity against various pathogens, including methicillin-resistant Staphylococcus aureus (MRSA) and the notorious aquaculture pathogen Vibrio anguillarum . The antibacterial compounds were purified alternariol (AOH) its derivative, monomethyl ether (AME). We found that AOH AME primarily inhibited pathogenic bacteria (MRSA or V. ) by disordering cell division some other key physiological biochemical processes. further demonstrated could effectively inhibit unwinding of MRSA topoisomerases, which are closely related potential action target AOH. activities verified using zebrafish vivo model. Notably, did not significantly affect viability normal human liver cells at concentrations Finally, we developed genetic operation system A. blocked biosynthesis knocking out omtI (encoding an O-methyl transferase), facilitated only development this will accelerate discovery novel natural products bioactivity IMPORTANCE More more scientific reports indicate derivative (AME) exhibit activities. However, limited exploration their detailed mechanisms performed. In present study, produced disclosed vitro Given low toxicity on line under exhibiting different proposed be good candidates developing promising antibiotics also succeeded blocking AME, us easily obtain pure Moreover, based results, was enable polyethylene degradation.
Language: Английский
Citations
3
Food & medicine homology., Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0
International Journal of Food Science, Journal Year: 2025, Volume and Issue: 2025(1)
Published: Jan. 1, 2025
Due to the increasing rate of cancer and undesirable consequences manufactured drugs, there is a growing interest in development natural products as potential remedies. Ferulic acid (FA), phenolic substance, found naturally present Ferula foetida plant’s cell walls with therapeutic activities. The objective this study determine botanical sources, pharmacokinetics, anticancer activity FA its derivatives, focusing on molecular mechanism by using data obtained from literature database. study’s findings suggest that demonstrates promising effects preclinical pharmacological test methods. exhibit showed through underlying mechanisms, including induction oxidative stress, cytotoxic effect, cycle arrest, apoptotic suppression invasion migration, antiproliferative autophagy, genotoxic mutagenic effect regulating different pathways like PI3K/AKT, p38/MAPK/ERK, AKT/mTOR, NF‐ κ B signaling which are involved growth. Additionally, review indicated pharmacokinetic properties FA, indicating lower oral bioavailability affected liver’s fast conjugation process; limitation overcome applying nanoformulation FA. However, additional clinical investigations recommended appropriate effectiveness, safety, human dosage.
Language: Английский
Citations
0
Toxins, Journal Year: 2024, Volume and Issue: 16(5), P. 223 - 223
Published: May 11, 2024
Alternariol monomethyl-ether (AME), together with altenuene and alternariol, belongs to the
Language: Английский
Citations
2
Journal of Fungi, Journal Year: 2024, Volume and Issue: 10(5), P. 352 - 352
Published: May 15, 2024
Talaromyces sp. DC2 is an endophytic fungus that was isolated from the stem of Catharanthus roseus (L.) G. Don in Hanoi, Vietnam and capable producing vinca alkaloids. This study utilizes PacBio Sequel technology to completely sequence whole genome DC2The revealed contains a total 34.58 Mb spanned by 156 contigs, with GC content 46.5%. The identification prediction functional protein-coding genes, tRNA, rRNA were comprehensively predicted highly annotated using various BLAST databases, including non-redundant (Nr) protein sequence, Gene Ontology (GO), Kyoto Encyclopedia Genes Genomes (KEGG), Clusters Orthologous Groups (COG), Carbohydrate-Active Enzymes (CAZy) databases. has 149, 227, 65, 153, 53, 6 genes responsible for cellulose, hemicellulose, lignin, pectin, chitin, starch, inulin degradation, respectively. Antibiotics Secondary Metabolites Analysis Shell (AntiSMASH) analyses strain possesses 20 biosynthetic gene clusters secondary metabolites. also been found harbor DDC encoding aromatic L-amino acid decarboxylase enzyme. Conclusively, this provided comprehensive understanding processes involved metabolites ability degrade plant cell walls.
Language: Английский
Citations
2
LWT, Journal Year: 2024, Volume and Issue: 203, P. 116353 - 116353
Published: June 18, 2024
Alternariol (AOH) is a metabolic product of Alternaria, which has various toxic effects on humans and animals its pollution increasingly being discovered in fruits, vegetables, grains. At present, the detection AOH mainly achieved through high-performance liquid chromatography-mass spectrometry immunological methods. However, there currently lack fast methods for on-site use. Considering unique advantages testing methods, this study developed an immunolateral chromatographic quantitative method detecting using quantum dot fluorescent nanospheres (QDFNs) as signal amplification materials. The range 5.2–4798 μg/kg, 50 % inhibiting concentration (IC50) 156.4 limit (LOD) value 2.32 quantification (LOQ) 6.96 μg/kg. recovery rates tomato strawberry were 95.27%–111.63% 88.43%–96.22%, respectively. In brief, approach good accuracy repeatability can be used AOH.
Language: Английский
Citations
2