Neuroimmune response and oxidative stress in the prefrontal cortex mediate seizure susceptibility in experimental colitis in male mice
Journal of Biochemical and Molecular Toxicology,
Год журнала:
2024,
Номер
38(7)
Опубликована: Июнь 26, 2024
Inflammatory
bowel
disease
(IBD)
is
a
chronic
gastrointestinal
disorder.
Oxidative
stress
and
inflammatory
responses
have
vital
role
in
the
pathophysiology
of
IBD
as
well
seizure.
associated
with
extraintestinal
manifestations.
This
study
aimed
to
explore
relationship
between
colitis
susceptibility
seizures,
focus
on
roles
neuroinflammation
oxidative
acetic
acid-induced
mice.
Forty
male
Naval
Medical
Research
Institute
mice
were
divided
into
four
groups:
control,
colitis,
pentylenetetrazole
(PTZ),
+
PTZ.
Colitis
was
induced
by
intrarectal
administration
acid,
seizures
intravenous
injection
PTZ
7
days
postcolitis
induction.
Following
measurement
latency
seizure,
killed,
their
colons
prefrontal
cortex
(PFC)
dissected.
Gene
expression
markers
including
interleukin-1β,
tumor
necrosis
factor-alpha,
NOD-like
receptor
protein
3,
toll-like
4,
total
antioxidant
capacity
(TAC),
malondialdehyde
(MDA),
nitrite
levels
measured
colon
PFC.
Histopathological
evaluations
performed
samples.
Data
analyzed
t-test
or
one-way
variance
analysis.
decreased
increased
gene
markers,
altered
MDA,
nitrite,
TAC
both
Simultaneous
induction
seizure
exacerbated
neuroimmune
response
PFC
colon.
Results
concluded
that
at
least
partially
mediate
comorbid
decrease
colitis.
Язык: Английский
Modulation of Neuroinflammation and Oxidative Stress by Echinacea purpurea Extract: Therapeutic Potential in Maternal Separation-Induced Autism Spectrum Disorder
Journal of Psychiatric Research,
Год журнала:
2025,
Номер
184, С. 118 - 127
Опубликована: Фев. 24, 2025
Язык: Английский
Antioxidant-Effective Quercetin Through Modulation of Brain Interleukin-13 Mitigates Autistic-Like Behaviors in the Propionic Acid-Induced Autism Model in Rats
Journal of Neuroimmune Pharmacology,
Год журнала:
2025,
Номер
20(1)
Опубликована: Апрель 12, 2025
Язык: Английский
Nutritional interventions to counteract the detrimental consequences of early-life stress
Molecular Psychiatry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 27, 2025
Exposure
to
stress
during
sensitive
developmental
periods
comes
with
long
term
consequences
for
neurobehavioral
outcomes
and
increases
vulnerability
psychopathology
later
in
life.
While
we
have
advanced
our
understanding
of
the
mechanisms
underlying
programming
effects
early-life
(ES),
these
are
not
yet
fully
understood
often
hard
target,
making
development
effective
interventions
challenging.
In
recent
years,
others
suggested
that
nutrition
might
be
instrumental
modulating
possibly
combatting
ES-induced
increased
risk
psychopathologies
impairments.
Nutritional
strategies
very
promising
as
they
relatively
safe,
cheap
easy
implement.
Here,
set
out
comprehensively
review
existing
literature
on
nutritional
aimed
at
counteracting
ES
preclinical
clinical
settings.
We
identified
eighty
six
rodent
ten
human
studies
investigating
a
intervention
ameliorate
The
evidence
date,
is
too
few
heterogeneous
terms
interventions,
thus
allowing
conclusions,
however
studies,
despite
their
heterogeneity
designs,
used,
measured,
showed
Furthermore,
discuss
possible
involved
beneficial
brain
after
ES,
including
neuroinflammation,
oxidative
stress,
hypothalamus-pituitary-adrenal
axis
regulation
microbiome-gut-brain
axis.
Lastly,
highlight
critical
gaps
current
knowledge
make
recommendations
future
research
move
field
forward.
Язык: Английский
Joining up the scattered anticancer knowledge on auraptene and umbelliprenin: a meta-analysis
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Май 23, 2024
Abstract
Auraptene
(AUR)
and
umbelliprenin
(UMB)
are
naturally
occurring
prenylated
coumarins
that
have
demonstrated
promising
anticancer
effects
across
various
human
cancer
cell
lines.
This
meta-analysis
aimed
to
systematically
assess,
compare,
quantify
the
efficacy
of
AUR
UMB
by
synthesizing
evidence
from
in
vitro
studies.
A
comprehensive
literature
search
identified
27
eligible
studies
investigating
or
against
cells.
Mixed-effects
models
revealed
significant
negative
associations
between
coumarin
dose
viability
for
(est.
=
−
2.27)
3.990),
underscoring
their
dose-dependent
cytotoxicity.
Meta-regression
indicated
slightly
higher
potency
over
AUR,
potentially
due
increased
lipophilicity
imparted
additional
isoprenyl
units.
Machine
learning
approaches
type
as
most
influential
determinants
toxicity,
while
treatment
duration
specific
displayed
weaker
effects.
Moderate
substantial
between-study
heterogeneity
was
detected,
although
findings
proved
robust.
In
summary,
this
establishes
natural
candidates
with
clear
dose-toxicity
relationships
diverse
malignancies.
The
structural
insights
quantifications
can
inform
forthcoming
efforts
assessing
therapeutic
potential
pre-clinical
trials.
Язык: Английский
Roles of Epigenetics and Glial Cells in Drug-Induced Autism Spectrum Disorder
Biomolecules,
Год журнала:
2024,
Номер
14(4), С. 437 - 437
Опубликована: Апрель 3, 2024
Autism
spectrum
disorder
(ASD)
is
a
neurodevelopmental
characterized
by
severe
deficits
in
social
communication
and
interaction,
repetitive
movements,
abnormal
focusing
on
objects,
or
activity
that
can
significantly
affect
the
quality
of
life
afflicted.
Neuronal
glial
cells
have
been
implicated.
It
has
genetic
component
but
also
be
triggered
environmental
factors
drugs.
For
example,
prenatal
exposure
to
valproic
acid
acetaminophen,
ingestion
propionic
acid,
increase
risk
ASD.
Recently,
epigenetic
influences
ASD
come
forefront
investigations
etiology,
prevention,
treatment
this
disorder.
Epigenetics
refers
DNA
modifications
alter
gene
expression
without
making
any
changes
sequence.
Although
an
increasing
number
pharmaceuticals
chemicals
are
being
implicated
etiology
ASD,
here,
we
specifically
focus
molecular
abovementioned
alterations
neuronal
their
potential
connection
We
conclude
better
understanding
these
phenomena
lead
more
effective
interventions
Язык: Английский
Umbelliprenin attenuates comorbid behavioral disorders in acetic acid-induced colitis in mice: mechanistic insights into hippocampal oxidative stress and neuroinflammation
Naunyn-Schmiedeberg s Archives of Pharmacology,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 4, 2024
Язык: Английский
Therapeutic Potential of Ocimum basilicum L. Extract in Alleviating Autistic‐Like Behaviors Induced by Maternal Separation Stress in Mice: Role of Neuroinflammation and Oxidative Stress
Phytotherapy Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 4, 2024
A
confluence
of
genetic,
environmental,
and
epigenetic
factors
shapes
autism
spectrum
disorder
(ASD).
Early-life
stressors
like
MS
play
a
contributing
role
in
this
multifaceted
neurodevelopmental
disorder.
This
research
was
to
explore
the
efficacy
Ocimum
basilicum
L.
(O.B.)
extract
mitigating
behaviors
reminiscent
prompted
by
maternal
separation
(MS)
stress
male
mice,
focusing
on
its
impact
neuroinflammation
oxidative
stress.
mice
were
treated
with
O.B.
at
varying
dosages
(20,
40,
60
mg/kg)
from
postnatal
days
(PND)
51-53
PND
58-60.
Behavioral
experiments,
including
Morris
water
maze,
three-chamber
test,
shuttle
box,
resident-intruder
conducted
post-treatment.
The
method
involved
separating
pups
their
mothers
for
3
h
daily,
2
14.
Molecular
analysis
hippocampal
tissue
performed
assess
gene
expression
Toll-like
receptor
4
(TLR4),
tumor
necrosis
factor-α
(TNF-α),
interleukin-1β
(IL-1β).
Hippocampal
serum
malondialdehyde
(MDA)
levels
total
antioxidant
capacity
(TAC)
measured.
administration
resulted
amelioration
autistic-like
as
evidenced
improved
spatial
passive
avoidance
memories
social
interactions,
well
reduced
aggression
behavioral
tests.
attenuated
neuroinflammation,
indicated
decreased
MDA
increased
TAC
levels,
downregulation
TLR4,
TNF-α,
IL-1β
hippocampus.
may
offer
novel
therapeutic
avenue
ASD,
potentially
mediated
through
anti-inflammatory
properties.
Язык: Английский