Therapeutic Potential of Ocimum basilicum L. Extract in Alleviating Autistic‐Like Behaviors Induced by Maternal Separation Stress in Mice: Role of Neuroinflammation and Oxidative Stress DOI
Hossein Amini‐Khoei,

Nafiseh Taei,

Hossein Tahmasebi Dehkordi

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

A confluence of genetic, environmental, and epigenetic factors shapes autism spectrum disorder (ASD). Early-life stressors like MS play a contributing role in this multifaceted neurodevelopmental disorder. This research was to explore the efficacy Ocimum basilicum L. (O.B.) extract mitigating behaviors reminiscent prompted by maternal separation (MS) stress male mice, focusing on its impact neuroinflammation oxidative stress. mice were treated with O.B. at varying dosages (20, 40, 60 mg/kg) from postnatal days (PND) 51-53 PND 58-60. Behavioral experiments, including Morris water maze, three-chamber test, shuttle box, resident-intruder conducted post-treatment. The method involved separating pups their mothers for 3 h daily, 2 14. Molecular analysis hippocampal tissue performed assess gene expression Toll-like receptor 4 (TLR4), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β). Hippocampal serum malondialdehyde (MDA) levels total antioxidant capacity (TAC) measured. administration resulted amelioration autistic-like as evidenced improved spatial passive avoidance memories social interactions, well reduced aggression behavioral tests. attenuated neuroinflammation, indicated decreased MDA increased TAC levels, downregulation TLR4, TNF-α, IL-1β hippocampus. may offer novel therapeutic avenue ASD, potentially mediated through anti-inflammatory properties.

Language: Английский

Neuroimmune response and oxidative stress in the prefrontal cortex mediate seizure susceptibility in experimental colitis in male mice DOI

Fahimeh Moradipoor,

Nahid Jivad, Samira Asgharzade

et al.

Journal of Biochemical and Molecular Toxicology, Journal Year: 2024, Volume and Issue: 38(7)

Published: June 26, 2024

Inflammatory bowel disease (IBD) is a chronic gastrointestinal disorder. Oxidative stress and inflammatory responses have vital role in the pathophysiology of IBD as well seizure. associated with extraintestinal manifestations. This study aimed to explore relationship between colitis susceptibility seizures, focus on roles neuroinflammation oxidative acetic acid-induced mice. Forty male Naval Medical Research Institute mice were divided into four groups: control, colitis, pentylenetetrazole (PTZ), + PTZ. Colitis was induced by intrarectal administration acid, seizures intravenous injection PTZ 7 days postcolitis induction. Following measurement latency seizure, killed, their colons prefrontal cortex (PFC) dissected. Gene expression markers including interleukin-1β, tumor necrosis factor-alpha, NOD-like receptor protein 3, toll-like 4, total antioxidant capacity (TAC), malondialdehyde (MDA), nitrite levels measured colon PFC. Histopathological evaluations performed samples. Data analyzed t-test or one-way variance analysis. decreased increased gene markers, altered MDA, nitrite, TAC both Simultaneous induction seizure exacerbated neuroimmune response PFC colon. Results concluded that at least partially mediate comorbid decrease colitis.

Language: Английский

Citations

4
Modulation of Neuroinflammation and Oxidative Stress by Echinacea purpurea Extract: Therapeutic Potential in Maternal Separation-Induced Autism Spectrum Disorder DOI

Seyedeh Zahra Razavi,

Hossein Amini‐Khoei, Mohammad Rahimi‐Madiseh

et al.

Journal of Psychiatric Research, Journal Year: 2025, Volume and Issue: 184, P. 118 - 127

Published: Feb. 24, 2025

Language: Английский

Citations

0
Antioxidant-Effective Quercetin Through Modulation of Brain Interleukin-13 Mitigates Autistic-Like Behaviors in the Propionic Acid-Induced Autism Model in Rats DOI Creative Commons
Kubilay Doğan Kılıç, Gökçen Garipoğlu, Burak Çakar

et al.

Journal of Neuroimmune Pharmacology, Journal Year: 2025, Volume and Issue: 20(1)

Published: April 12, 2025

Language: Английский

Citations

0
Nutritional interventions to counteract the detrimental consequences of early-life stress DOI Creative Commons

J. Geertsema,

Hannah G. Juncker,

Lars Wilmes

et al.

Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: April 27, 2025

Exposure to stress during sensitive developmental periods comes with long term consequences for neurobehavioral outcomes and increases vulnerability psychopathology later in life. While we have advanced our understanding of the mechanisms underlying programming effects early-life (ES), these are not yet fully understood often hard target, making development effective interventions challenging. In recent years, others suggested that nutrition might be instrumental modulating possibly combatting ES-induced increased risk psychopathologies impairments. Nutritional strategies very promising as they relatively safe, cheap easy implement. Here, set out comprehensively review existing literature on nutritional aimed at counteracting ES preclinical clinical settings. We identified eighty six rodent ten human studies investigating a intervention ameliorate The evidence date, is too few heterogeneous terms interventions, thus allowing conclusions, however studies, despite their heterogeneity designs, used, measured, showed Furthermore, discuss possible involved beneficial brain after ES, including neuroinflammation, oxidative stress, hypothalamus-pituitary-adrenal axis regulation microbiome-gut-brain axis. Lastly, highlight critical gaps current knowledge make recommendations future research move field forward.

Language: Английский

Citations

0
Joining up the scattered anticancer knowledge on auraptene and umbelliprenin: a meta-analysis DOI Creative Commons
Mohammadhosein Shakiba, Fatemeh Behnam Rassouli

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: May 23, 2024

Abstract Auraptene (AUR) and umbelliprenin (UMB) are naturally occurring prenylated coumarins that have demonstrated promising anticancer effects across various human cancer cell lines. This meta-analysis aimed to systematically assess, compare, quantify the efficacy of AUR UMB by synthesizing evidence from in vitro studies. A comprehensive literature search identified 27 eligible studies investigating or against cells. Mixed-effects models revealed significant negative associations between coumarin dose viability for (est. = − 2.27) 3.990), underscoring their dose-dependent cytotoxicity. Meta-regression indicated slightly higher potency over AUR, potentially due increased lipophilicity imparted additional isoprenyl units. Machine learning approaches type as most influential determinants toxicity, while treatment duration specific displayed weaker effects. Moderate substantial between-study heterogeneity was detected, although findings proved robust. In summary, this establishes natural candidates with clear dose-toxicity relationships diverse malignancies. The structural insights quantifications can inform forthcoming efforts assessing therapeutic potential pre-clinical trials.

Language: Английский

Citations

2
Roles of Epigenetics and Glial Cells in Drug-Induced Autism Spectrum Disorder DOI Creative Commons
Antonei B. Csòka,

Nacer El Kouhen,

Samia Bennani

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(4), P. 437 - 437

Published: April 3, 2024

Autism spectrum disorder (ASD) is a neurodevelopmental characterized by severe deficits in social communication and interaction, repetitive movements, abnormal focusing on objects, or activity that can significantly affect the quality of life afflicted. Neuronal glial cells have been implicated. It has genetic component but also be triggered environmental factors drugs. For example, prenatal exposure to valproic acid acetaminophen, ingestion propionic acid, increase risk ASD. Recently, epigenetic influences ASD come forefront investigations etiology, prevention, treatment this disorder. Epigenetics refers DNA modifications alter gene expression without making any changes sequence. Although an increasing number pharmaceuticals chemicals are being implicated etiology ASD, here, we specifically focus molecular abovementioned alterations neuronal their potential connection We conclude better understanding these phenomena lead more effective interventions

Language: Английский

Citations

1
Umbelliprenin attenuates comorbid behavioral disorders in acetic acid-induced colitis in mice: mechanistic insights into hippocampal oxidative stress and neuroinflammation DOI

Negar Hajheidari,

Zahra Lorigooini,

Rohollah Mohseni

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 4, 2024

Language: Английский

Citations

1
Therapeutic Potential of Ocimum basilicum L. Extract in Alleviating Autistic‐Like Behaviors Induced by Maternal Separation Stress in Mice: Role of Neuroinflammation and Oxidative Stress DOI
Hossein Amini‐Khoei,

Nafiseh Taei,

Hossein Tahmasebi Dehkordi

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

A confluence of genetic, environmental, and epigenetic factors shapes autism spectrum disorder (ASD). Early-life stressors like MS play a contributing role in this multifaceted neurodevelopmental disorder. This research was to explore the efficacy Ocimum basilicum L. (O.B.) extract mitigating behaviors reminiscent prompted by maternal separation (MS) stress male mice, focusing on its impact neuroinflammation oxidative stress. mice were treated with O.B. at varying dosages (20, 40, 60 mg/kg) from postnatal days (PND) 51-53 PND 58-60. Behavioral experiments, including Morris water maze, three-chamber test, shuttle box, resident-intruder conducted post-treatment. The method involved separating pups their mothers for 3 h daily, 2 14. Molecular analysis hippocampal tissue performed assess gene expression Toll-like receptor 4 (TLR4), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β). Hippocampal serum malondialdehyde (MDA) levels total antioxidant capacity (TAC) measured. administration resulted amelioration autistic-like as evidenced improved spatial passive avoidance memories social interactions, well reduced aggression behavioral tests. attenuated neuroinflammation, indicated decreased MDA increased TAC levels, downregulation TLR4, TNF-α, IL-1β hippocampus. may offer novel therapeutic avenue ASD, potentially mediated through anti-inflammatory properties.

Language: Английский

Citations

1