Chemical Constituents, Bioactivities, and Pharmacological Mechanisms of Dendrobium officinale: A Review of the Past Decade

Journal of Agricultural and Food Chemistry, Год журнала: 2023, Номер 71(41), С. 14870 - 14889

Опубликована: Окт. 6, 2023

Dendrobium officinale, a plant in the Orchidaceae family, has been used traditional Chinese medicine for thousands of years. Sweet and slightly cold nature, it can invigorate stomach, promote fluid production, nourish Yin, dissipate heat. Over past decade, more than 60 compounds have derived from D. including flavonoids, bibenzyl, phenanthrene. Various studies explored underlying pharmacological mechanisms these compounds, which shown antitumor, hypoglycemic, hypertensive, gastrointestinal-regulatory, visceral organ protection, antiaging, neurorestorative effects. This paper presents systematic review structural classification, biological activity, different chemical components obtained officinale over decade. aims to provide reference future study establish foundation clinical applications. Furthermore, this identifies potential shortcomings current research as well directions methodologies research.

Язык: Английский

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Phytochemical analysis and investigation of antioxidant and anti-inflammatory activities of selected Ethiopian traditional medicinal plants

Journal of Herbal Medicine, Год журнала: 2025, Номер unknown, С. 100984 - 100984

Опубликована: Янв. 1, 2025

Язык: Английский

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Alkaloids extracted from Dendrobium officinale grown in diverse environments exhibited robust antioxidative and antiaging activity

Journal of Future Foods, Год журнала: 2025, Номер 5(6), С. 591 - 604

Опубликована: Янв. 29, 2025

Язык: Английский

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Polyamine-containing natural products: structure, bioactivity, and biosynthesis

Natural Product Reports, Год журнала: 2023, Номер 41(4), С. 525 - 564

Опубликована: Окт. 24, 2023

Polyamine-containing natural products have been isolated from a wide range of terrestrial and marine organisms. Most them exhibit remarkable diverse activities with potential applications in human health agriculture.

Язык: Английский

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Effects of Inonotus obliquus on ameliorating podocyte injury in ORG mice through TNF pathway and prediction of active compounds

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Авг. 21, 2024

Background Podocyte injury is a common pathologic mechanism in diabetic kidney disease (DKD) and obesity-related glomerulopathy (ORG). Our previous study confirmed that Inonotus obliquus (IO) improved podocyte on DKD rats. The current explored the pharmacological effects, related mechanisms possible active components of IO ORG mice. Methods Firstly, by combining ultra-high performance liquid chromatography tandem mass spectrometry analysis (UPLC-Q-TOF-MS) with network pharmacology to construct human protein-protein interaction enrich pathway, which led discover crucial against ORG. Then, mice were established high-fat diet biochemical assays, histopathology, Western blot used explore effects obesity injury. Finally, pharmacology-based findings immunohistochemistry. compositions absorbed plasma analyzed UPLC-Q-TOF-MS molecular docking was predict compounds. Results result suggested alleviated inflammatory response modulating TNF signal. 20-week vivo experiment glomerular hypertrophy, under electron microscopy, renal nephrin, synaptopodin, TNF-α IL-6 expressions blotting immunohistochemical staining. Other indicators such as body weight, serum total cholesterol, liver triglyceride also intervention. showed triterpenoids, including inoterpene F trametenolic acid, might be pharmacodynamic basis. Conclusion research based analysis, amelioration via its modulation Triterpenoids predicated acting components.

Язык: Английский

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The spatiotemporal profile of Dendrobium huoshanense and functional identification of bHLH genes under exogenous MeJA using comparative transcriptomics and genomics

Frontiers in Plant Science, Год журнала: 2023, Номер 14

Опубликована: Май 10, 2023

Alkaloids are one of the main medicinal components

Язык: Английский

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Metabolomics-Based Analysis of the Effects of Different Cultivation Strategies on Metabolites of Dendrobium officinale Kimura et Migo

Metabolites, Год журнала: 2023, Номер 13(3), С. 389 - 389

Опубликована: Март 6, 2023

Dendrobium officinale Kimura et Migo is a famous plant with high medicinal value which has been recorded in the Chinese Pharmacopoeia (2020 Edition). The properties of D. are based on its chemical composition. However, there no reports how different cultivation methods affect In order to reveal this issue, samples were collected study through tree epiphytic cultivation, stone and greenhouse cultivation. Polysaccharides determined by phenol sulfuric acid method secondary metabolites detected UPLC-MS technique. addition, regards metabolomics, we used multivariate analyses including principal component analysis (PCA) orthogonal partial least squares (OPLS-DA) screen for differential met conditions variable importance projection values >1, fold change >4, p < 0.05. taken further metabolic pathway enrichment analysis, was Kyoto Encyclopedia Genes Genomes (KEGG) database, validated antioxidant activity. Comparing three groups according standards ChP edition), results showed that polysaccharide content from stony significantly higher than live Metabolomic revealed 185 among 3 methods, 99 being highest strategies mainly effected four carbohydrate pathways, five metabolite synthesis six amino one nucleotide metabolism pathway, cofactor vitamin translation genetic information processing. Furthermore, had best activity implicated production. This effects composition also provided reference establishing quality control aid development utilization.

Язык: Английский

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Effect of storage temperature on the long term stability of Dendrobium catenatum Lindl. blended liquor

Journal of Food Measurement & Characterization, Год журнала: 2024, Номер 18(4), С. 2618 - 2630

Опубликована: Фев. 3, 2024

Язык: Английский

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Overview and limitations of database in global traditional medicines: A narrative review

Acta Pharmacologica Sinica, Год журнала: 2024, Номер unknown

Опубликована: Авг. 2, 2024

Язык: Английский

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Plant AT-rich protein and zinc-binding protein (PLATZ) family in Dendrobium huoshanense: identification, evolution and expression analysis

BMC Plant Biology, Год журнала: 2024, Номер 24(1)

Опубликована: Дек. 30, 2024

PLATZ (plant A/T-rich protein and zinc-binding protein) transcription factors are essential for plant growth, development, responses to abiotic stress. The regulatory role of genes in the environmental adaptation D. huoshanense is inadequately comprehended. genome-wide identification elucidates functions processes gene family. Our investigation encompassed examination structures chromosome distribution, construction phylogenetic tree with its relatives, analysis cis-acting elements expression profiles potentially implicated growth stress responses. Eleven DhPLATZs were classified into three clades (I, II, III) according their evolutionary homology. distribution these over six chromosomes indicated that both whole genome duplication (WGD) segmental events have contributed expansion this Ka/Ks revealed a pattern purifying selection after occurrences, suggesting little alterations functional divergence. collinearity microsynteny results DhPLATZ shared same conserved domains as paralogs from chrysotoxum. Expression profiling quantitative demonstrated had unique patterns response phytohormones cold Subcellular localization expressed nucleus, factors. These findings enhance our understanding genes' involvement species underscore significance important areas further research.

Язык: Английский

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