Autism Spectrum Disorder and Epilepsy: Pathogenetic Mechanisms and Therapeutic Implications

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(7), С. 2431 - 2431

Опубликована: Апрель 2, 2025

The co-occurrence of autism spectrum disorder (ASD) and epilepsy is a complex neurological condition that presents significant challenges for both patients clinicians. ASD group developmental disorders characterized by the following: (1) Social communication difficulties: in understanding responding to social cues, initiating maintaining conversations, developing relationships. (2) Repetitive behaviors: engaging repetitive actions, such as hand-flapping, rocking, or lining up objects. (3) Restricted interests: focusing intensely on specific topics activities, often exclusion other interests. (4) Sensory sensitivities: over- under-sensitivity sensory input, sounds, touch, tastes, smells, sights. These can significantly impact individuals' daily lives require specialized support interventions. Early diagnosis intervention improve quality life individuals with their families. Epilepsy chronic brain recurrent unprovoked (≥2) seizures occur >24 h apart. Single are not considered epileptic seizures. idiopathic, but various disorders, malformations, strokes, tumors, cause symptomatic epilepsy. While these two conditions were once distinct, growing evidence suggests substantial overlap underlying neurobiology. prevalence higher than general population. This review will explore epidemiology this comorbidity, delve into potential mechanisms linking epilepsy, discuss implications diagnosis, treatment, management.

Язык: Английский

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Working with Children with Autism Undergoing Health-Care Assessments in a Day Hospital Setting: A Perspective from the Health-Care Professionals

Children, Год журнала: 2023, Номер 10(3), С. 476 - 476

Опубликована: Фев. 27, 2023

Hospitals can be especially stressful for children with autism spectrum disorder (ASD) due to the communication and social skills deficits, lower capacity adapt disruption, sensory hypersensitivity that are typical of these patients.This study investigated how health-care professionals (HPs) experienced clinical care management ASD undergoing medical testing in a day hospital setting, assessed rate successful completion laboratory tests instrumental examinations.A cross-sectional questionnaire was administered 45 HPs, inquiring about their experience obtaining blood urine tests, ECG, audiometry, EEG from ASD. The sample included 153 consecutively referred (74.5% males, mean age 5.6 years) diagnostic work-up as part evaluation. success completing various assessments examined.HPs identified aggressive behavior deficits major challenges when providing parents were seen an important resource managing children. examinations high (between 88.5% 98.4% according specific type examination). lowest non-completion found (12.5%).Despite considerable being reported by HPs ASD, scheduled could completed large majority cases. Targeted approaches preventing behaviors obviating barriers exams warranted.

Язык: Английский

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Sleep disturbances and emotional dysregulation in young children with autism spectrum, intellectual disability, or global developmental delay

Sleep Medicine, Год журнала: 2023, Номер 105, С. 45 - 52

Опубликована: Март 8, 2023

Язык: Английский

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Emotion dysregulation in autism: A meta-analysis

Autism, Год журнала: 2024, Номер 28(12), С. 2986 - 3001

Опубликована: Июль 30, 2024

Autism is associated with significantly higher rates of internalizing and externalizing disorders compared to neurotypical (NT) individuals. Emotion dysregulation (ED) prevalent in autistic individuals has been proposed underlie both behavioral challenges autism. This study sought use a meta-analytic approach examine the magnitude ED severity samples NT other clinical (OC) samples. Following review literature, total 35 studies were included analyses. In general, when comparing non-autistic individuals, findings suggest medium difference between comparison groups overall. Subgroup analyses indicate that experience peers. However, OC peers, effect small, suggesting may be more similar groups. Moderators also explored, including traits, age, sex composition. These provide integral information about populations populations, assisting further clarifying presence mental health youth. Lay Abstract Autistic people often challenges, which makes it particularly important understand factors contribute development these conditions. dysregulation, or difficulties effectively regulating one’s own emotions response changing environment, one factor experienced frequently by commonly related wide range article represents quantitative synthesis current state literature on emotion specific focus how differs across lifespan. The elevated insights into experiences people. Overall, this underscores importance research inform areas can used better treatment targets.

Язык: Английский

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Beneficios de la Música en el Proceso de Enseñanza-Aprendizaje para Niños con Autismo

Ciencia Latina Revista Científica Multidisciplinar, Год журнала: 2025, Номер 8(6), С. 5699 - 5713

Опубликована: Янв. 5, 2025

El presente artículo bibliográfico aborda el uso de la música como herramienta pedagógica en enseñanza-aprendizaje niños con Trastorno del Espectro Autista (TEA). La introducción subraya complejidad diagnóstico TEA y falta evaluaciones psiquiátricas avanzadas Ecuador. Se destaca cómo puede mejorar las habilidades comunicativas, sociales emocionales los TEA, estudios que evidencian sus beneficios terapéuticos. metodología incluye una revisión sistemática artículos científicos recientes centrados educación inclusiva TEA. priorizaron empíricos examinan impacto desarrollo cognitivo, social, comunicativo emocional estos niños. Los resultados sugieren ofrece áreas atención, memoria, visual-espaciales, interacción social regulación emocional. Sin embargo, algunos señalan efectividad intervención musical depende factores gravedad trastorno duración tratamiento. También se importancia personalizar estrategias pedagógicas musicales según necesidades individuales estudiantes. Finalmente, concluye un recurso valioso para enseñanza inclusiva, aunque requieren más optimizar su aplicación.

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Understanding social behaviours across neurodiverse young people: roles of social cognition and self-regulation

BJPsych Open, Год журнала: 2025, Номер 11(1)

Опубликована: Янв. 1, 2025

Background Differences in social behaviours are common young people with neurodevelopmental conditions (NDCs). Recent research challenges the long-standing hypothesis that difficulties cognition explain behaviour differences. Aims We examined how regulating one's behaviour, emotions and thoughts to adapt environmental demands (i.e. dysregulation), alongside cognition, across neurodiverse people. Method analysed cross-sectional behavioural cognitive data of 646 6- 18-year-old typically developing those NDCs from Province Ontario Neurodevelopmental Network. Social dysregulation were measured by caregiver-reported Adaptive Behavior Assessment System domain Child Checklist Dysregulation Profile, respectively. was assessed Neuropsychological Affect-Recognition Theory-of-Mind, Reading Mind Eyes Test, Sandbox continuous false-belief task scores. split sample into training ( n = 324) test 322) sets. investigated explained through principal component regression hierarchical set. tested cognition-by-dysregulation interactions, whether mediated cognition–social association. model fits Results Two components adequately (13.88%). Lower further better β −0.163, 95% CI −0.191 −0.134). interaction non-significant −0.001, −0.023 0.021). partially association (total effect: 0.544, 0.370–0.695). Findings replicated Conclusions Self-regulation, beyond substantially explains

Язык: Английский

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Developmental Patterns in Autism and Other Neurodevelopmental Disorders in Preschool Children

Children, Год журнала: 2025, Номер 12(2), С. 125 - 125

Опубликована: Янв. 24, 2025

Background: Neurodevelopmental disorders (NDDs) encompass an inclusive group of conditions that appear during the developmental period but continue to persist in adulthood, ranging from particular difficulties a global impairment social, cognitive, and emotional functioning. The trajectories associated with these are highly heterogeneous. This study aimed analyze compare adaptive profiles preschool-aged children different NDDs better characterize their trajectories. Methods: We analyzed data initial evaluation 196 (aged 20 71 months), enrolled three subgroups: 108 autism spectrum disorder (ASD), 52 language (LD), 36 mixed specific (MSDD). A comprehensive neuropsychiatric was performed using standardized tools (Griffiths-III, ADOS-2, VABS-II, ADI-R), parents completed DP-3 CBCL 1½-5. Results: Our results showed all exhibited poor psychomotor skills, ASD being most impaired, although were comparable those MSDD communication motor areas. CBCL’s pervasive problem scale has been shown provide relevant information for distinguishing ASD. Furthermore, VABS-II measure differentiated each diagnostic group. Conclusions: highlighted importance including parents’/caregivers’ perspectives defining children’s functioning possibility as screening tool neurodevelopmental disorders.

Язык: Английский

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Investigating associations between emotion dysregulation and DSM-5 posttraumatic stress disorder (PTSD) using network analysis

Journal of Affective Disorders, Год журнала: 2025, Номер 377, С. 106 - 115

Опубликована: Фев. 19, 2025

Язык: Английский

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Linehan’s biosocial model applied to emotion dysregulation in autism: a narrative review of the literature and an illustrative case conceptualization

Frontiers in Psychiatry, Год журнала: 2023, Номер 14

Опубликована: Сен. 29, 2023

Emotion dysregulation (ED) is a transdiagnostic difficulty prevalent in autism spectrum condition (ASC). Importantly, recent research has suggested that ED involved self-harm and suicidality. Pre-existing models on the etiology of ASC focus mainly biological factors to features, such as sensory sensitivities, poor flexibility, sensitivity change. However, although psychosocial seem play role emergence well (e.g., childhood maltreatment camouflaging), there lack comprehensive model conceptualizing biosocial autistic people. Linehan’s (1993) one leading etiological borderline personality disorder (BPD). It conceptualizes emerging from transactions between pre-existing emotional vulnerability child an invalidating developmental environment. Beyond its clinical relevance, gathered empirical evidence supporting pertinence BPD other psychiatric disorders. Although are two distinct diagnoses, because they may share ED, might be useful for understanding development ASC. Hence, this article aims provide application extension conceptualize To do so, we conducted narrative review literature underlying perspective. investigate applied people, were interested data (i) behavioral correlates ASC, relation model, (ii) potential (iii) overlapping difficulties BPD. Finally, assess it case woman presenting with suicidal behaviors. Our suggest encompasses related both risk conceptualized framework, domains ASC-specific involved.

Язык: Английский

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Associations between executive functioning, challenging behavior, and quality of life in children and adolescents with and without neurodevelopmental conditions

Frontiers in Psychology, Год журнала: 2022, Номер 13

Опубликована: Окт. 20, 2022

The present study sought to clarify the impact of executive and social functioning on challenging behavior downstream influence quality life in a large transdiagnostic sample. Understanding these relationships is crucial for developing designing tailored intervention strategies. In cross-sectional study, parent informants 2,004 children completed measures functioning, behavior, child family life, reported functional impacts behavior. Using structural (path) modeling, analyses evaluated associations between including emotion regulation risk avoidance, with overall specific types Structural models also examined immediate extended environment, parent/child as well interactions medical/legal systems. Finally, mediational explored direct indirect effects via Results indicated that accounts substantial variance ( R 2 = 0.47) turn, 0.36) 0.31). Exploratory identified from These findings support development new strategies suggest need measure when assessing tailoring treatment clinical practice.

Язык: Английский

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