Organoid intelligence (OI): the new frontier in biocomputing and intelligence-in-a-dish

Frontiers in Science, Год журнала: 2023, Номер 1

Опубликована: Фев. 28, 2023

Recent advances in human stem cell-derived brain organoids promise to replicate critical molecular and cellular aspects of learning memory possibly cognition vitro . Coining the term “organoid intelligence” (OI) encompass these developments, we present a collaborative program implement vision multidisciplinary field OI. This aims establish OI as form genuine biological computing that harnesses using scientific bioengineering an ethically responsible manner. Standardized, 3D, myelinated can now be produced with high cell density enriched levels glial cells gene expression for learning. Integrated microfluidic perfusion systems support scalable durable culturing, spatiotemporal chemical signaling. Novel 3D microelectrode arrays permit high-resolution electrophysiological signaling recording explore capacity recapitulate mechanisms formation and, ultimately, their computational potential. Technologies could enable novel biocomputing models via stimulus-response training organoid-computer interfaces are development. We envisage complex, networked whereby connected real-world sensors output devices, ultimately each other sensory organ (e.g. retinal organoids), trained biofeedback, big-data warehousing, machine methods. In parallel, emphasize embedded ethics approach analyze ethical raised by research iterative, manner involving all relevant stakeholders. The many possible applications this urge strategic development discipline. anticipate OI-based allow faster decision-making, continuous during tasks, greater energy data efficiency. Furthermore, “intelligence-in-a-dish” help elucidate pathophysiology devastating developmental degenerative diseases (such dementia), potentially aiding identification therapeutic approaches address major global unmet needs.

Язык: Английский

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Patient-derived organoids in translational oncology and drug screening

Cancer Letters, Год журнала: 2023, Номер 562, С. 216180 - 216180

Опубликована: Апрель 13, 2023

Patient-derived organoids (PDO) are a new biomedical research model that can reconstruct phenotypic and genetic characteristics of the original tissue useful for on pathogenesis drug screening. To introduce progression in this field, we review key factors constructing derived from epithelial tissues cancers, covering culture medium matrix, morphological characteristics, profiles, high-throughput screening, application potential. We also discuss co-culture system cancer with tumor microenvironment (TME) associated cells. The is widely used evaluating crosstalk cells TME components, such as fibroblasts, endothelial cells, immune microorganisms. article provides prospective standardized cultivation mode, automatic evaluation, sensitivity screening using methods.

Язык: Английский

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The Promise and Potential of Brain Organoids

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(21)

Опубликована: Янв. 22, 2024

Brain organoids are 3D in vitro culture systems derived from human pluripotent stem cells that self-organize to model features of the (developing) brain. This review examines techniques behind organoid generation, their current and potential applications, future directions for field. possess complex architecture containing various neural cell types, synapses, myelination. They have been utilized toxicology testing, disease modeling, infection studies, personalized medicine, gene-environment interaction studies. An emerging concept termed Organoid Intelligence (OI) combines with artificial intelligence generate learning memory, goals modeling cognition enabling biological computing applications. allow neuroscience studies not previously achievable traditional techniques, transform drug development, understanding brain development disorders. The aspirational vision OI parallels origins intelligence, efforts underway map a roadmap toward its realization. In summary, constitute disruptive technology is rapidly advancing gaining traction across multiple disciplines.

Язык: Английский

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Revisiting the role of HR in the age of AI: bringing humans and machines closer together in the workplace

Frontiers in Artificial Intelligence, Год журнала: 2024, Номер 6

Опубликована: Янв. 15, 2024

The functions of human resource management (HRM) have changed radically in the past 20 years due to market and technological forces, becoming more cross-functional data-driven. In age AI, role HRM professionals organizations continues evolve. Artificial intelligence (AI) is transforming many practices throughout creating system process efficiencies, performing advanced data analysis, contributing value creation organization. A growing body evidence highlights benefits AI brings field HRM. Despite increased interest AI-HRM scholarship, focus on human-AI interaction at work AI-based technologies for limited fragmented. Moreover, lack considerations tech design deployment can hamper digital transformation efforts. This paper provides a contemporary forward-looking perspective strategic human-centric plays within as becomes integrated workplace. Spanning three distinct phases integration (technocratic, integrated, fully-embedded), it examines technical, human, ethical challenges each phase suggestions how overcome them using approach. Our importance evolving AI-driven organization roadmap bring humans machines closer together

Язык: Английский

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Humanized brain organoids-on-chip integrated with sensors for screening neuronal activity and neurotoxicity

Microchimica Acta, Год журнала: 2024, Номер 191(1)

Опубликована: Янв. 1, 2024

Язык: Английский

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From Organ-on-a-Chip to Human-on-a-Chip: A Review of Research Progress and Latest Applications

ACS Sensors, Год журнала: 2024, Номер 9(7), С. 3466 - 3488

Опубликована: Июль 11, 2024

Organ-on-a-Chip (OOC) technology, which emulates the physiological environment and functionality of human organs on a microfluidic chip, is undergoing significant technological advancements. Despite its rapid evolution, this technology also facing notable challenges, such as lack vascularization, development multiorgan-on-a-chip systems, replication body single chip. The progress has played crucial role in steering OOC toward mimicking microenvironment, including microenvironment replication, multiorgan microphysiological systems. Additionally, advancements detection, analysis, organoid imaging technologies have enhanced efficiency Organs-on-Chips (OOCs). In particular, integration artificial intelligence revolutionized imaging, significantly enhancing high-throughput drug screening. Consequently, review covers research Human-on-a-chip, sensors OOCs, latest applications biomedical field.

Язык: Английский

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Editorial: Intersection between the biological and digital: synthetic biological intelligence and organoid intelligence

Frontiers in Cellular Neuroscience, Год журнала: 2025, Номер 18

Опубликована: Янв. 8, 2025

At its core, synthetic biological intelligence seeks to enhance the functionality of systems by integrating artificial (AI) technologies. Organoid Intelligence (OI) (Smirnova et al., 2023), a subset SBI, demonstrates potential revolutionize biomedical research leveraging organoids-miniature, lab-grown versions human organs derived from stem cells-as computational models. These models o^er unparalleled insights into biology and disease mechanisms. This Research Topic is part attempts establishing community realize this promise (Morales Patoja 2023;Hartung 2023).The ability use organoids as personalized significant advancement.They provide platform test drug e^icacy toxicity in patient-specific contexts, moving us closer truly individualized medicine. Moreover, model rare diseases genetic disorders, which often lack e^ective animal or in-vitro analogs, underscores societal medical value research.While SBI OI immense, field faces several challenges. starts with common nomenclature, aka ontology (Kagan 2024). Reproducibility models, e^iciency AI algorithms interpreting complex data, integration these existing clinical pipelines remain hurdles. Additionally, interfacing controlling bioengineering perspective still largely uncharted.The presented that challenges are not insurmountable. Innovative experimental frameworks novel inspired in-silico solutions roadmap for overcoming barriers. Engineering advancements interfaces hardware will further accelerate progress domain.As we stand on brink creating living, thinking merge digital realms, ethical considerations paramount. The implications extend beyond medicine broader concerns, including privacy, consent, security data. topics require multidisciplinary dialogue establishment robust frameworks.This highlights transformative combining intelligence. It lays groundwork future exploration themes such unconventional computing, modeling, engineering. As evolve, they redefine our understanding push boundaries what possible technology medicine.As Editors, breadth work showcased collection passion researchers contributing burgeoning field. With continued collaboration, innovation, stewardship, organoid undoubtedly approach solving

Язык: Английский

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The technology, opportunities, and challenges of Synthetic Biological Intelligence

Biotechnology Advances, Год журнала: 2023, Номер 68, С. 108233 - 108233

Опубликована: Авг. 7, 2023

Integrating neural cultures developed through synthetic biology methods with digital computing has enabled the early development of Synthetic Biological Intelligence (SBI). Recently, key studies have emphasized advantages biological systems in some information processing tasks. However, neither technology behind this development, nor potential ethical opportunities or challenges, been explored detail yet. Here, we review aspects that facilitate SBI and explore applications. Considering these foreseeable use cases, various implications are proposed. Ultimately, work aims to provide a robust framework structure considerations ensure can be both researched applied responsibly.

Язык: Английский

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Organoid intelligence (OI) – The ultimate functionality of a brain microphysiological system

ALTEX, Год журнала: 2023, Номер unknown, С. 191 - 203

Опубликована: Янв. 1, 2023

Understanding brain function remains challenging as work with human and animal models is complicated by compensatory mechanisms, while in vitro have been too simple until now. With the advent of stem cells bioengineering microphysiological systems (MPS), understanding how both cognition long-term memory arise now coming into reach. We suggest combining cutting-edge AI MPS research to spearhead organoid intelligence (OI) synthetic biological intelligence. The vision realize cognitive functions scale them achieve relevant short- capabilities basic information processing ultimate functional experimental for neurodevelopment neurological cell-based assays drug chemical testing. By advancing frontiers computing, we aim (a) create intelligence-in-a-dish study basis functions, (b) provide advance search toxicants contributing diseases identify remedies maladies, (c) computational capacities complement traditional computing. Increased functionality, some respects still superior today's supercomputers, may allow imitate this neuromorphic computer architectures or might even open up computing silicon computers. At same time, raises ethical questions such where sentience consciousness start what relationship between a cell donor respective OI system is. Such discussions will be critical socially acceptable cognition.

Язык: Английский

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Revolutionizing developmental neurotoxicity testing – a journey from animal models to advanced in vitro systems

ALTEX, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Developmental neurotoxicity (DNT) testing has seen enormous progress over the last two decades. Preceding even publication of animal-based OECD test guideline for DNT in 2007, a series non-animal technology workshops and conferences (starting 2005) shaped community that delivered comprehensive battery vitro methods (IVB). Its data interpretation is covered by very recent guidance (No. 377). Here, we aim to overview field, focusing on evolution strategies, role emerging technologies, impact guidelines testing. In particular, this an example targeted development animal-free approach one most complex hazards chemicals human health. These developments started literally from blank slate, with no proposed alternative available. Over decades, cutting-edge science enabled design spares animals enables throughput challenging hazard. While it evident field needs regulation, massive economic decreased cognitive capacity caused chemical exposure should be prioritized more highly. Beyond this, claim fame scientific brought understanding brain, its development, how can perturbed. Plain language summaryDevelopmental predicts hazard brain development. Comprehensive advanced strategies using now replace approaches assess large numbers accurately efficiently than approach. Recent formalized DNT, marking pivotal achievement field. The shift towards reflects both commitment animal welfare growing recognition public health impacts associated impaired function exposures. innovations ultimately contribute safer management better protection health, especially during vulnerable stages

Язык: Английский

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