Frontiers in Microbiology,
Год журнала:
2023,
Номер
13
Опубликована: Янв. 12, 2023
Butyrate
is
thought
to
enhance
intestinal
mucosal
homeostasis,
but
the
detailed
mechanism
remains
unclear.
Therefore,
further
investigation
on
of
butyrate
regulation
homeostasis
was
performed.This
study
used
weaned
piglets
with
similar
metabolic
function
humans
as
a
research
model.
The
dietary
supplemented
0.2%
sodium
group
(0.2%
S)
and
negative
control
(CON)
were
established
detect
effects
growth
performance,
tissue
morphology,
barrier
function,
microbial
community
structure
in
piglets.There
an
increase
average
daily
gain
(ADG)
during
three
different
experimental
periods
reduction
feed
intake
(ADFI)
feed-to-gain
ratio
(F:G)
days
1-35
15-35
S
compared
CON
(P
>
0.05).
Furthermore,
villus
height
ileum
duodenum
increased,
crypt
depths
colon
jejunum
reduced
both
groups
<
Moreover,
depth
(V/C)
significantly
increased
0.05)
CON.
relative
mRNA
expression
PKC,
MUC1,
CLDN1,
ITGB1
upregulated
digesta
samples
S,
colon,
contained
greater
bacterial
abundance
diversity
probiotics,
including
Lactobacillus,
Streptococcus,
Megasphaera,
Blautia,
which
promoted
amino
acid
metabolism
energy
production
conversion
synthesis
carbon-containing
biomolecules
ileum.In
summary,
supplementation
shown
have
tendency
improve
performance
via
altering
gut
microbiota.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2024,
Номер
14
Опубликована: Фев. 16, 2024
Abnormal
behavior
of
α-synuclein
and
prion
proteins
is
the
hallmark
Parkinson’s
disease
(PD)
illnesses,
respectively,
being
complex
neurological
disorders.
A
primary
cause
protein
aggregation,
brain
injury,
cognitive
loss
in
illnesses
misfolding
normal
cellular
(PrP
C
)
into
an
infectious
form
Sc
).
Aggregation
causes
disruptions
processes
(PD),
leading
to
dopamine-producing
neurons
motor
symptoms.
Alteration
composition
or
activity
gut
microbes
may
weaken
intestinal
barrier
make
it
possible
for
prions
go
from
brain.
The
gut-brain
axis
linked
neuroinflammation;
metabolites
produced
by
microbiota
affect
aggregation
α-synuclein,
regulate
inflammation
immunological
responses,
influence
course
neurotoxicity
proteins,
even
if
their
targets
are
distinct
proteins.
This
thorough
analysis
explores
interactions
that
exist
between
neurodegenerative
particularly
involvement
microbiota,
a
collection
bacteria,
archaea,
fungi,
viruses
etc.,
various
becoming
increasingly
recognized.
microbiome
influences
neuroinflammation,
neurotransmitter
synthesis,
mitochondrial
function,
integrity
through
axis,
which
contributes
development
progression
disease.
review
delves
molecular
mechanisms
underlie
these
relationships,
emphasizing
effects
microbial
such
as
bacterial
lipopolysaccharides
(LPS),
short-chain
fatty
acids
(SCFAs)
regulating
functioning.
Additionally,
looks
at
how
environmental
dietary
decisions
whether
they
could
be
risk
factors
illnesses.
study
concludes
highlighting
critical
role
plays
It
also
provides
promising
direction
future
research
treatment
approaches.
People
afflicted
difficult
ailments
find
hope
new
preventive
therapeutic
approaches
diseases
better
understood.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2023,
Номер
64(20), С. 7004 - 7027
Опубликована: Фев. 15, 2023
Since
the
first
years
of
history,
microbial
fermentation
products
such
as
bread,
wine,
yogurt
and
vinegar
have
always
been
noteworthy
regarding
their
nutritional
health
effects.
Similarly,
mushrooms
a
valuable
food
product
in
point
both
nutrition
medicine
due
to
rich
chemical
components.
Alternatively,
filamentous
fungi,
which
can
be
easier
produce,
play
an
active
role
synthesis
some
bioactive
compounds,
are
also
important
for
health,
well
being
protein
content.
Therefore,
this
review
presents
compounds
(bioactive
peptides,
chitin/chitosan,
β-glucan,
gamma-aminobutyric
acid,
L-carnitine,
ergosterol
fructooligosaccharides)
synthesized
by
fungal
strains
benefits.
In
addition,
potential
probiotic-
prebiotic
fungi
were
researched
determine
effects
on
gut
microbiota.
The
current
uses
based
cancer
treatment
discussed.
use
industry,
especially
develop
innovative
production,
has
seen
promising
microorganisms
obtaining
healthy
nutritious
food.
Nutrients,
Год журнала:
2024,
Номер
16(20), С. 3494 - 3494
Опубликована: Окт. 15, 2024
Our
objective
was
to
review
published
studies
of
the
intestinal
barrier
and
permeability,
deleterious
effects
dietary
components
(particularly
fat),
impact
altered
permeability
in
disease
models
human
diseases,
role
microbiome
epigenomics
control
function,
opportunities
restore
normal
function
with
interventions
products
microbiota.
Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology,
Год журнала:
2024,
Номер
15(1)
Опубликована: Янв. 22, 2024
Abstract
Background
High
environmental
temperatures
induce
heat
stress
in
broiler
chickens,
affecting
their
health
and
production
performance.
Several
dietary,
managerial,
genetics
strategies
have
been
tested
with
some
success
mitigating
(HS)
broilers.
Developing
novel
HS
mitigation
for
sustaining
is
critically
needed.
This
study
investigated
the
effects
of
pre-hatch
thermal
manipulation
(TM)
post-hatch
baicalein
supplementation
on
growth
performance
parameters
heat-stressed
Results
Six
hundred
fertile
Cobb
500
eggs
were
incubated
21
d.
After
candling
embryonic
day
(ED)
10,
238
thermally
manipulated
at
38.5
°C
55%
relative
humidity
(RH)
from
ED
12
to
18,
then
transferred
hatcher
(ED
19
21,
standard
temperature)
236
a
controlled
temperature
(37.5
°C)
till
hatch.
hatch,
180-day-old
chicks
both
groups
raised
36
pens
(
n
=
10
birds/pen,
6
replicates
per
treatment).
The
treatments
were:
1)
Control,
2)
TM,
3)
control
(CHS),
4)
(TMHS),
5)
supplement
(CHSS),
6)
(TMHSS).
All
birds
under
environment
d,
followed
by
chronic
d
22
35
(32–33
8
h)
CHS,
TMHS,
CHSS,
TMHSS
groups.
A
thermoneutral
(22–24
was
maintained
Control
TM
RH
constant
(50%
±
5%)
throughout
trial.
data
analyzed
using
one-way
ANOVA
R
GraphPad
software
P
<
0.05
are
presented
as
mean
SEM.
Heat
significantly
decreased
0.05)
final
body
weight
ADG
CHS
TMHS
compared
other
Embryonic
increased
expression
shock
protein-related
genes
HSP70,
HSP90,
HSPH1
)
antioxidant-related
GPX1
TXN
).
showed
significant
increment
total
cecal
volatile
fatty
acid
(VFA)
concentration
birds.
microbial
analysis
enrichment
alpha
beta
diversity
Coprococcus
group.
Conclusions
Pre-hatch
mitigate
detrimental
chickens'
performance,
upregulate
favorable
gene
expression,
increase
VFA
production,
promote
gut
increasing
beneficial
communities.
International Journal of Food Science & Technology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 8, 2025
Summary
Grifola
frondosa
is
an
edible
and
medicinal
fungus
with
various
biological
activities.
Previously,
we
reported
Gaylussacia
polysaccharide
F2
can
improve
insulin
resistance
in
diabetic
rats.
In
the
present
study,
our
aim
was
to
identify
its
prebiotic
function.
The
structure
of
obtained
from
gel
permeation
chromatography
(GPC),
Infrared
(IR)
spectroscopy
saccharide
mapping.
Simulated
digestion
fecal
bacteria
fermentation
vitro
performed
investigate
characteristic.
Dynamic
changes
molecular
weight
composition
during
were
monitored
by
HPLC.
effects
on
intestinal
microbiota
studied
16S
rDNA
sequencing
bioinformatics
analysis.
results
simulated
showed
that
not
digested
saliva,
but
minor
degraded
stomach
intestine.
It
worth
noting
content
decreased
short-chain
fatty
acids
(SCFAs)
increased
process
fecal.
may
reshape
gut
microbiota,
enrich
microbial
communities
Bacteriodes
spp.,
Phascolarctobacterium
Enterococcus
spp.
Veillonella
Data
suggested
could
be
utilized
produce
hypoglycemic
components,
which
a
promising
prebiotic.
mechanism
associated
enhancement
SCFAs-producing
(Enterococcus
spp.)
BSH
(Bile
salt
hydrolase)-producing
(Bacteriodes
spp.),
acceleration
bile
metabolism
SCFAs
production.
Abstract
Background
Maintaining
gut
health
is
a
persistent
and
unresolved
challenge
in
the
poultry
industry.
Given
critical
role
of
chicken
performance
welfare,
there
pressing
need
to
identify
effective
intervention
(GHI)
strategies
ensure
optimal
outcomes
farming.
In
this
study,
across
three
broiler
production
cycles,
we
compared
metagenomes
broilers
provided
with
ionophores
(as
control
group)
against
birds
subjected
five
different
GHI
combinations
involving
vaccination,
probiotics,
prebiotics,
essential
oils,
reduction
ionophore
use.
Results
Using
binning
strategy,
84
(≥
75%
completeness,
≤
5%
contamination)
metagenome-assembled
genomes
(MAGs)
from
118
caecal
samples
were
recovered
annotated
for
their
metabolic
potential.
The
majority
these
(
n
=
52,
61%)
had
differential
response
all
cohorts
are
associated
parameter
—
European
efficiency
factor
(EPEF).
group
exhibited
highest
EPEF,
followed
closely
by
cohort
where
probiotics
used
conjunction
vaccination.
use
B,
commercial
Bacillus
strain-based
formulation,
was
determined
contribute
superior
birds.
supplementation
generally
affected
abundance
microbial
enzymes
relating
carbohydrate
protein
digestion
pathways
energy,
nucleotide
synthesis,
short-chain
fatty
acid
drug-transport
systems.
These
shifts
hypothesised
differentiate
among
groups
highlighting
beneficial
several
bacteria,
including
Rikenella
microfusus
UBA7160
species.
Conclusions
All
GHIs
shown
be
methods
modulation,
varying
influences
on
MAG
diversity,
composition,
functions.
metagenomic
insights
greatly
enhance
our
understanding
microbiota-related
pathways,
enabling
us
devise
enteric
pathogens
related
products
presenting
new
opportunities
improve
overall
health.
