Molecular cross-talk between long COVID-19 and Alzheimer’s disease DOI Creative Commons
Magdalena Pszczołowska,

Kamil Walczak,

Weronika Miśków

и другие.

GeroScience, Год журнала: 2024, Номер 46(3), С. 2885 - 2899

Опубликована: Фев. 23, 2024

Abstract The long COVID (coronavirus disease), a multisystemic condition following severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, is one of the widespread problems. Some its symptoms affect nervous system and resemble Alzheimer’s disease (AD)—a neurodegenerative caused by accumulation amyloid beta hyperphosphorylation tau proteins. Multiple studies have found dependence between these two conditions. Patients with greater risk SARS-CoV-2 infection due to increased levels angiotensin-converting enzyme 2 (ACE2), itself promotes generation which enhances AD. Also, molecular pathways are alike—misregulations in folate-mediated one-carbon metabolism, deficit Cq10, disease-associated microglia. Medical imaging both diseases shows decrease volume gray matter, global brain size reduction, hypometabolism parahippocampal gyrus, thalamus, cingulate cortex. In some studies, similar approach applied medication can be seen, including use amino adamantanes phenolic compounds rosemary. significance connections their possible application medical practice still needs further study but there possibility that they will help better understand COVID.

Язык: Английский

Biomedical features and therapeutic potential of rosmarinic acid DOI Open Access

Saba Noor,

Taj Mohammad,

Malik Abdul Rub

и другие.

Archives of Pharmacal Research, Год журнала: 2022, Номер 45(4), С. 205 - 228

Опубликована: Апрель 1, 2022

Язык: Английский

Процитировано

143
COVID-19 2022 update: transition of the pandemic to the endemic phase DOI Creative Commons
Michela Biancolella, Vito Luigi Colona, Ruty Mehrian‐Shai

и другие.

Human Genomics, Год журнала: 2022, Номер 16(1)

Опубликована: Июнь 1, 2022

Abstract COVID-19, which is caused by the SARS-CoV-2, has ravaged world for past 2 years. Here, we review current state of research into disease with focus on its history, human genetics and genomics transition from pandemic to endemic phase. We are particularly concerned lack solid information initial phases that highlighted necessity better preparation face similar future threats. On other hand, gratified progress genetic susceptibility investigations believe now time explore The latter will require worldwide vigilance cooperation, especially in emerging countries. In phase, vaccination rates have lagged developed countries should assist, as warranted, bolstering worldwide. also discuss status vaccines outlook COVID-19.

Язык: Английский

Процитировано

119
Small molecules in the treatment of COVID-19 DOI Creative Commons
Sibei Lei, Xiaohua Chen, Jieping Wu

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)

Опубликована: Дек. 5, 2022

Abstract The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to societies economies. Until now, effective therapeutics against are in high demand. Along with our improved understanding the structure, function, pathogenic process SARS-CoV-2, many small molecules potential anti-COVID-19 effects have been developed. So far, several antiviral strategies were explored. Besides directly inhibition viral proteins such as RdRp M pro , interference host enzymes including ACE2 proteases, blocking relevant immunoregulatory pathways represented by JAK/STAT, BTK, NF-κB, NLRP3 pathways, regarded feasible drug development. development treat achieved strategies, computer-aided lead compound design screening, natural product discovery, repurposing, combination therapy. Several representative remdesivir paxlovid proved or authorized emergency use countries. And candidates entered clinical-trial stage. Nevertheless, due epidemiological features variability issues it is necessary continue exploring novel COVID-19. This review discusses current findings for treatment. Moreover, their detailed mechanism action, chemical structures, preclinical clinical efficacies discussed.

Язык: Английский

Процитировано

80
The knowns and unknowns of long COVID-19: from mechanisms to therapeutical approaches DOI Creative Commons
Roxana Gheorghiţă, Iuliana Șoldănescu, Andrei Lobiuc

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Март 4, 2024

The coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has been defined as the greatest global health and socioeconomic crisis of modern times. While most people recover after being infected with virus, a significant proportion them continue to experience issues weeks, months even years acute infection SARS-CoV-2. This persistence clinical symptoms in individuals for at least three onset or emergence new lasting more than two months, without any other explanation alternative diagnosis have named long COVID, long-haul post-COVID-19 conditions, chronic post-acute sequelae (PASC). Long COVID characterized constellation disorders that vary widely their manifestations. Further, mechanisms underlying are not fully understood, which hamper efficient treatment options. review describes predictors common related COVID's effects on central peripheral nervous system organs tissues. Furthermore, transcriptional markers, molecular signaling pathways risk factors such sex, age, pre-existing condition, hospitalization during phase COVID-19, vaccination, lifestyle presented. Finally, recommendations patient rehabilitation management, well therapeutical approaches discussed. Understanding complexity this disease, its across multiple organ systems overlapping pathologies possible paramount developing diagnostic tools treatments.

Язык: Английский

Процитировано

21
Combination therapies and other therapeutic approaches targeting the NLRP3 inflammasome and neuroinflammatory pathways: a promising approach for traumatic brain injury DOI

Zana Montazeri-Khosh,

Ahmad Ebrahimpour, Mina Keshavarz

и другие.

Immunopharmacology and Immunotoxicology, Год журнала: 2025, Номер unknown, С. 1 - 17

Опубликована: Янв. 6, 2025

Objectives: Traumatic brain injury (TBI) precipitates a neuroinflammatory cascade, with the NLRP3 inflammasome emerging as critical mediator. This review scrutinizes complex activation pathways of by underscoring intricate interplay between calcium signaling, mitochondrial disturbances, redox imbalances, lysosomal integrity, and autophagy. It is hypothesized that combination therapy approach—integrating NF-κB pathway inhibitors antagonists—holds potential to synergistically dampen inflammatory storm associated TBI.

Язык: Английский

Процитировано

2
Role of SARS-CoV-2-induced cytokine storm in multi-organ failure: Molecular pathways and potential therapeutic options DOI
Yasaman Nazerian,

Mobina Ghasemi,

Younes Yassaghi

и другие.

International Immunopharmacology, Год журнала: 2022, Номер 113, С. 109428 - 109428

Опубликована: Ноя. 7, 2022

Язык: Английский

Процитировано

50
Therapeutic Potential of Polyphenols and Other Micronutrients of Marine Origin DOI Creative Commons
Leonel Pereira, João Cotas

Marine Drugs, Год журнала: 2023, Номер 21(6), С. 323 - 323

Опубликована: Май 26, 2023

Polyphenols are compounds found in various plants and foods, known for their antioxidant anti-inflammatory properties. Recently, researchers have been exploring the therapeutic potential of marine polyphenols other minor nutrients that algae, fish crustaceans. These unique chemical structures exhibit diverse biological properties, including anti-inflammatory, antioxidant, antimicrobial antitumor action. Due to these being investigated as possible agents treatment a wide variety conditions, such cardiovascular disease, diabetes, neurodegenerative diseases cancer. This review focuses on applications human health, also, phenolic classes, extraction methods, purification techniques future compounds.

Язык: Английский

Процитировано

39
Melatonin alleviates doxorubicin-induced cardiotoxicity via inhibiting oxidative stress, pyroptosis and apoptosis by activating Sirt1/Nrf2 pathway DOI Creative Commons
Wei Zhang, Xi Wang, Yanhong Tang

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 162, С. 114591 - 114591

Опубликована: Март 23, 2023

Melatonin confers cardioprotective effects on multiple cardiovascular diseases, including doxorubicin-induced cardiomyopathy. The effectiveness of melatonin in mitigating myocardial injuries caused by Doxorubicin through enhancement mitochondrial function is already established, however, the role regulating Sirtuin-1 (Sirt1)/Nuclear factor E2-associated 2 (Nrf2) pathway lessening onset Doxorubicin-induced cardiomyopathy yet to be elucidated. To address this, H9C2 cardiomyocytes and C57BL/6 mice were employed construct vitro vivo models Dox-induced impairments, respectively. Results showed that Dox markedly evoked oxidative stress, pyroptosis apoptosis both vivo, which significantly alleviated administration. Mechanistically, attenuated downregulation Sirt1 Nrf2, inhibition Nrf2 reversed melatonin. In conclusion, our studies suggest activation Sirt1/Nrf2 underlying mechanism behind melatonin's ability curtail pyroptosis, These promising results demonstrated potential application as a treatment for cardiac injury.

Язык: Английский

Процитировано

37
Neuroprotective Effects of Carnosic Acid: Insight into Its Mechanisms of Action DOI Creative Commons
Fatima Javed Mirza, Saadia Zahid, R. M. Damian Holsinger

и другие.

Molecules, Год журнала: 2023, Номер 28(5), С. 2306 - 2306

Опубликована: Март 2, 2023

Carnosic acid is a diterpenoid abundantly present in plants belonging to the genus Rosmarinus and Salvia of family Lamiaceae, accounting for their application traditional medicine. The diverse biological properties carnosic that include antioxidant, anti-inflammatory, anticarcinogenic activities have instigated studies on its mechanistic role, providing further insights into potential as therapeutic agent. Accumulating evidence has established relevance neuroprotective agent exhibiting efficacy combatting neuronal-injury-induced disorders. physiological importance mitigation neurodegenerative disorders just beginning be understood. This review summarizes current data mode action through which exerts role may serve strategize novel approaches these debilitating

Язык: Английский

Процитировано

31
Links between COVID-19 and Parkinson’s disease/Alzheimer’s disease: reciprocal impacts, medical care strategies and underlying mechanisms DOI Creative Commons
Pei Huang, Linyuan Zhang, Yuyan Tan

и другие.

Translational Neurodegeneration, Год журнала: 2023, Номер 12(1)

Опубликована: Янв. 30, 2023

Abstract The impact of coronavirus disease 2019 (COVID-19) pandemic on patients with neurodegenerative diseases and the specific neurological manifestations COVID-19 have aroused great interest. However, there are still many issues concern to be clarified. Therefore, we review current literature complex relationship between an emphasis Parkinson’s (PD) Alzheimer’s (AD). We summarize infection symptom severity, progression, mortality rate PD AD, discuss whether could trigger AD. In addition, susceptibility prognosis in AD also included. order achieve better management patients, modifications care strategies, drug therapies, vaccines during listed. At last, mechanisms underlying link reviewed.

Язык: Английский

Процитировано

29