Lutein Production and Extraction from Microalgae: Recent Insights and Bioactive Potential

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(5), С. 2892 - 2892

Опубликована: Март 1, 2024

Microalgae have been reported to be excellent producers of bioactive molecules. Lutein is a pigment various beneficial effects for humans, and especially eye well-being. In the current review, we summarize methods that developed optimize its extraction bioactivities human health. Several protective lutein, including antioxidant, anticancer, anti-inflammatory, cardioprotective activity. This review also reports attempts increase lutein production by microalgae changing culturing parameters or using pilot-scale systems. Genetic engineering discussed. Considering increasing aging worldwide population will create an increased need viable economic eco-sustainable method produce needed face this market demand.

Язык: Английский

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Effects and Mechanisms of Lutein on Aging and Age-Related Diseases

Antioxidants, Год журнала: 2024, Номер 13(9), С. 1114 - 1114

Опубликована: Сен. 14, 2024

Aging and age-related diseases are serious public health issues that receiving growing attention from researchers. Lutein has a critical function in the prevention management of these issues. Possible mechanisms mainly include suppressing inflammation oxidative stress, regulating cell activity, modulating levels toxic substances. In this narrative review paper, we sum up most current developments study effects lutein on aging five (age-related macular degeneration, cataracts, Alzheimer’s disease, Parkinson’s osteoporosis), fundamental reviewed. The bioavailability strategies to improve its discussed. This piece work can bring clearer comprehension protective against be also helpful for developing as functional food dietary supplements diseases.

Язык: Английский

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Tetrapleura tetraptera fruit extracts ameliorate pentylenetetrazol-induced seizures as well as ensuing cognitive deficit and oxidative stress

Metabolic Brain Disease, Год журнала: 2025, Номер 40(3)

Опубликована: Март 12, 2025

Язык: Английский

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Lutein, a versatile carotenoid: Insight on neuroprotective potential and recent advances

Phytomedicine, Год журнала: 2024, Номер 135, С. 156185 - 156185

Опубликована: Ноя. 1, 2024

Язык: Английский

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Cellular Membrane Protein GRINA is Highly Expressed and Associated with Survival Outcomes in Liver Cancer Patients

Current Medical Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 26, 2025

Язык: Английский

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Nutritional Factors: Benefits in Glaucoma and Ophthalmologic Pathologies

Life, Год журнала: 2023, Номер 13(5), С. 1120 - 1120

Опубликована: Апрель 30, 2023

Glaucoma is a chronic optic neuropathy that can lead to irreversible functional and morphological damage if left untreated. The gold standard therapeutic approaches in managing patients with glaucoma limiting progression include local drops, laser, and/or surgery, which are all geared at reducing intraocular pressure (IOP). Nutrients, antioxidants, vitamins, organic compounds, micronutrients have been gaining increasing interest the past decade as integrative IOP-independent strategies delay or halt glaucomatous retinal ganglion cell degeneration. In our minireview, we examine various nutrients compounds proposed current literature for management of ophthalmology diseases, especially glaucoma. With respect each substance considered, this minireview reports molecular biological characteristics, neuroprotective activities, antioxidant properties, beneficial mechanisms, clinical studies published field general medicine. This study highlights potential benefits these substances other ophthalmologic pathologies. Nutritional supplementation thus be useful Large multicenter trials based on morphologic data collected over long follow-up periods treatments pave way alternative coadjutant options ocular

Язык: Английский

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Effects of Long-Chain Polyunsaturated Fatty Acids in Combination with Lutein and Zeaxanthin on Episodic Memory in Healthy Older Adults

Nutrients, Год журнала: 2023, Номер 15(13), С. 2825 - 2825

Опубликована: Июнь 21, 2023

Arachidonic acid (ARA), docosahexaenoic (DHA), and eicosapentaenoic (EPA), which are long-chain polyunsaturated fatty acids (LCPUFAs), as well lutein (L) zeaxanthin (Z), can potentially improve brain function. However, the effect of a combination these components (LCPUFAs + LZ) on memory function in healthy older individuals remains unclear. This study aimed to determine if LCPUFAs LZ-supplemented food could Exploratory confirmatory trials (Trials 1 2, respectively) were conducted Japanese with complaints. We randomized, double-blind, placebo-controlled, parallel-group trials. Participants randomly allocated two groups: placebo or LZ. LZ participants provided supplements containing ARA, DHA, EPA, L, Z for 24 weeks Trial 12 2. Memory functions evaluated using Cognitrax before after each trial. Combined analyses performed subgroups cognitive decline Trials The results showed that supplementation did not significantly affect healthy, non-demented, complaints whereas it improved decline.

Язык: Английский

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Neuroprotective Effects of Albizia lebbeck (L.) Benth. Leaf Extract against Glutamate-Induced Endoplasmic Reticulum Stress and Apoptosis in Human Microglial Cells

Pharmaceuticals, Год журнала: 2023, Номер 16(7), С. 989 - 989

Опубликована: Июль 10, 2023

Endoplasmic reticulum (ER) stress caused by excessive glutamate in the central nervous system leads to neurodegeneration. Albizia lebbeck (L.) Benth. has been reported possess neuroprotective properties. We aimed investigate effect and mechanism of A. leaf extracts on glutamate-induced neurotoxicity apoptosis linked ER using human microglial HMC3 cells. leaves were extracted hexane (AHE), mixed solvents, ethanol. Each different extract was evaluated for cytotoxic effects cells, then non-cytotoxic concentrations pretreated with followed glutamate. Our results showed that AHE treatment exhibited highest protective thus selected finding mechanistic approach. inhibited specific proteins (calpain1 caspase-12). also suppressed apoptotic (Bax, cytochrome c, cleaved caspase-9, caspase-3); however, it increased antiapoptotic Bcl-2 protein. Remarkably, cellular antioxidant activities (SOD, CAT, GPx). To support activation defense inhibition our cell model, bioactive phytochemicals within identified HPLC analysis. found had high levels carotenoids (α-carotene, β-carotene, lutein) flavonoids (quercetin, luteolin, kaempferol). novel findings indicate can inhibit via signaling pathways activating enzymes suggesting a potential neuroprotection. As such, might potentially represent promising source alternative approach preventing neurodegenerative diseases.

Язык: Английский

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On the Role of Iron in Idiopathic Parkinson’s Disease

Biomedicines, Год журнала: 2023, Номер 11(11), С. 3094 - 3094

Опубликована: Ноя. 20, 2023

The transition metal characteristics of iron allow it to play a fundamental role in several essential aspects human life such as the transport oxygen through hemoglobin or electrons mitochondrial respiratory chain coupled synthesis ATP. However, an excess deficiency is related certain pathologies. maintenance homeostasis avoid pathologies deficiency. existence deposits postmortem tissues Parkinson’s patients has been interpreted evidence that plays degenerative process nigrostriatal system this disease. use chelators successful treatment diseases transfusion-dependent thalassemia and pantothenate kinase-associated neurodegeneration. clinical study with chelator deferiprone disease not shown positive effects but rather worsened symptoms. This suggests may

Язык: Английский

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Protective Effects of 3′-Epilutein and 3′-Oxolutein against Glutamate-Induced Neuronal Damage

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(15), С. 12008 - 12008

Опубликована: Июль 26, 2023

Dietary lutein can be naturally metabolized to 3'-epilutein and 3'-oxolutein in the human body. The epimerization of happen acidic pH, through cooking, product direct oxidation retina, which is also present serum. main lutein. Thus, allylic dietary result formation 3'-oxolutein, may undergo reduction either revert or epimerize form 3'-epilutein. We focused on effects itself glutamate-induced neurotoxicity SH-SY5Y neuroblastoma cells identify possible alterations oxidative stress, inflammation, antioxidant capacity, iron metabolism that affect neurological function. ROS measurements were performed differently treated cells. inflammatory state was followed by TNFα, IL-6, IL-8 cytokine ELISA measurements. status determined total capacity kit assay. genes related ferroptosis lipid peroxidation gene expression measurements; then, thiol performed. Lutein metabolites modulated effect glutamate ROS, ferroptosis-related metabolism, Our results revealed anti-inflammatory features as protective agents against stress cells, with greater efficacy case

Язык: Английский

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