Natural
polyphenolic
compound
rosmarinic
acid
(RA)
has
good
antitumor
activity.
However,
the
distinctive
tumor
microenvironment,
characterized
by
low
pH
and
elevated
levels
of
glutathione
(GSH),
enhances
tolerance
tumors
to
singular
anti-tumor
treatment
mode
using
RA,
resulting
in
unsatisfactory
therapeutic
efficacy.
Targeting
nonapoptotic
programmed
cell
death
processes
may
provide
another
impetus
inhibit
growth.
RA
possesses
capability
coordinate
with
metal
elements.
To
solve
effect
restriction
above
single
mode,
it
is
proposed
construct
a
self-assembled
nanocomposite,
Fe-RA.
Under
Fe-RA
nanocomposite
exerts
characteristics
POD-like
enzyme
activity
depletion
GSH,
producing
large
amount
hydroxyl
radical
(·OH)
while
disrupting
antioxidant
defense
system
cells.
Moreover,
due
enhanced
permeability
retention
(EPR),
can
transport
Fe
Applied Organometallic Chemistry,
Год журнала:
2025,
Номер
39(3)
Опубликована: Фев. 17, 2025
ABSTRACT
The
synthesis
of
4‐Bromo‐2‐({2‐[(5‐bromo‐2‐hydroxy‐benzylidene)‐amino]‐5‐nitro‐phenylimino}‐methyl)‐phenol
(BSNP
ligand),
a
straightforward,
highly
adjustable,
and
efficient
BSNP
ligand,
was
demonstrated.
Four
novel
ligand
coordinating
compounds
were
created.
structures
these
clarified
by
variety
spectroscopic
analytical
techniques,
such
as
elemental
analysis
(CHN),
spectroscopy
(IR,
NMR,
mass
spectrometry),
conductivity,
magnetic
susceptibility,
UV–Vis
spectrum
studies,
theoretical
investigations.
Additional
the
showed
that
they
surrounded
an
octahedral‐coordinating
environment.
With
conductance
values
ranging
from
0.9.60
to
11.87
Ω
−1
cm
2
mol
,
molar
Fe
(III),
Zn
(II),
Cu
Ru
(III)
complexes
are
non‐electrolytes
in
fresh
DMSO
solutions,
with
exception
BSNPRu
complex,
which
is
mono
electrolyte.
According
IR
spectra,
uses
(N
O)
donor
sites
(C=N
C‐O)
groups
moiety
coordinate
through
metal
ions
tetra‐dentate
form.
A
1:1
(metal:ligand)
ratio
proposed
Job's
approach
based
on
data
solution
complexation.
stability
constant
(
K
f
)
values,
complexes'
order
found
be
BSNPFe
>
BSNPCu
BSNPZn.
pH
profile
under
study
stable
throughout
broad
range,
usually
between
=
4
10.
geometric
coordination
capabilities
inferred
use
electronic
studies.
To
gain
deeper
insights
into
reactivity
potential
biological
activity
synthesized
complexes,
DFT
calculations
performed.
computational
carried
out
using
DFT/B3LYP/6‐311g
(d,p)/LANL2DZ
level
gas
phase
explore
active
quantum
chemical
compounds.
Building
encouraging
results
our
in‐vitro
analyses,
demonstrated
notable
antimicrobial,
antifungal,
anticancer
properties
molecular
docking
simulations
subsequently
performed
further
substantiate
promising
activities.
anti‐pathogenic
generated
materials
experimentally
verified
against
subset
gram
(+)
(−)
bacteria
well
some
fungi
agar
diffusion
method.
Additionally,
BSPN
ligand's
its
compounds'
cytotoxic
action
liver
cells,
breast,
colon
cancers
investigated.
Furthermore,
examined
ability
suppress
DPPH
radical
examined.
landing
ascertain
how
produced
attached
specific
protein
binding
sites.
Some
chelates
incorporating
their
elucidated
different
physico‐chemical,
computational.
Moreover,
all
new
investigated
tested
vitro
selected
microbial
strains
cancer
cell
lines
free
radicals.
biomedical
applications
confirmed
RSC Advances,
Год журнала:
2024,
Номер
14(45), С. 33094 - 33123
Опубликована: Янв. 1, 2024
This
review
highlights
the
antioxidant
potential
of
Schiff
base
ligands
via
DPPH
assay,
focusing
on
structure,
solvent
effects,
and
how
electron-donating
groups
enhance
radical
stabilization,
suggesting
their
role
as
eco-friendly
antioxidants.
Frontiers in Chemistry,
Год журнала:
2023,
Номер
11
Опубликована: Авг. 10, 2023
The
emergence
of
drug-resistant
bacterial
and
fungal
pathogens
has
highlighted
the
urgent
need
innovative
antimicrobial
therapeutics.
Transition
metal
complexes
with
biologically
active
ligands
(coumarins,
terpyridines,
triazoles,
uracils,
etc.)
have
long
been
investigated
for
activity.
1,2,3-Triazoles
their
molecular
derivatives
are
well
known
a
plethora
physiological
activities,
including
antibacterial
antifungal.
aim
present
mini-review
is
to
inform
reader
about
research
conducted
on
potential
1,2,3-triazole
transition
metals.
What
authors
find
surprising
how
little
such
experimentation
actually
performed
reported
in
scientific
literature.
goal
highlight
efforts
up
now
impress
upon
vast
perspectives
novel,
effective
medicinal
substances
hidden
this
yet
unexplored
field.
Pharmaceuticals,
Год журнала:
2023,
Номер
16(12), С. 1729 - 1729
Опубликована: Дек. 15, 2023
Poor
responses
to
medical
care
and
the
failure
of
pharmacological
treatment
for
many
high-frequency
diseases,
such
as
cancer
viral
infections,
have
been
widely
documented.
In
this
context,
numerous
metal-based
substances,
including
cisplatin,
auranofin,
various
gold
metallodrugs,
ruthenium
complexes,
are
under
study
possible
anticancer
antiviral
agents.
The
two
Ru(III)
Ru(II)
namely,
BOLD-100
RAPTA-C,
presently
being
studied
in
a
clinical
trial
preclinical
studies
evaluation,
respectively,
Interestingly,
has
also
recently
demonstrated
activity
against
SARS-CoV-2,
which
is
virus
responsible
COVID-19
pandemic.
Over
last
years,
much
effort
dedicated
discovering
new
dual
anticancer-antiviral
Ru-based
complexes
could
be
very
suitable
respect.
Thus,
review
focuses
on
most
recent
regarding
newly
synthesized
use
and/or
