PubMed,
Год журнала:
2024,
Номер
26(2), С. 201 - 206
Опубликована: Фев. 15, 2024
Attention
deficit
hyperactivity
disorder
(ADHD)
is
a
common
neurodevelopmental
in
children
and
adolescents,
its
etiology
pathogenesis
are
still
unclear.
Brain
the
organ
with
largest
oxygen
consumption
human
body
easily
affected
by
oxidative
imbalance.
Oxidative
stress
has
become
key
research
direction
for
of
ADHD,
but
there
lack
relevant
studies
China.
Based
on
latest
findings
China
overseas,
this
article
reviews
clinical
experimental
ADHD
explores
association
neurotransmitter
imbalance,
neuroinflammation,
cell
apoptosis
so
as
to
provide
new
ideas
exploring
ADHD.
Inflammopharmacology,
Год журнала:
2023,
Номер
32(2), С. 1421 - 1437
Опубликована: Авг. 4, 2023
Abstract
Parkinson’s
disease
(PD)
is
the
second
most
common
progressive
age-related
neurodegenerative
disorder.
Paramount
evidence
shed
light
on
role
of
PI3K/AKT
signaling
activation
in
treatment
disorders.
can
be
activated
via
cAMP-dependent
pathways
achieved
by
phosphodiesterase
4
(PDE4)
inhibition.
Roflumilast
a
well-known
PDE4
inhibitor
that
currently
used
chronic
obstructive
pulmonary
disease.
Furthermore,
roflumilast
has
been
proposed
as
favorable
candidate
for
neurological
The
current
study
aimed
to
unravel
neuroprotective
rotenone
model
PD
rats.
Ninety
male
rats
were
allocated
into
six
groups
follows:
control,
(1.5
mg/kg/48
h,
s.c.),
L-dopa
(22.5
mg/kg,
p.o),
and
(0.2,
0.4
or
0.8
p.o).
All
treatments
administrated
21
days
1
h
after
injection.
Rats
treated
with
showed
an
improvement
motor
activity
coordination
well
preservation
dopaminergic
neurons
striatum.
Moreover,
increased
cAMP
level
axis
stimulation
CREB/BDNF/TrkB
SIRT1/PTP1B/IGF1
cascades.
also
caused
upsurge
mTOR
Nrf2,
halted
GSK-3β
NF-ĸB,
suppressed
FoxO1
caspase-3.
Our
revealed
exerted
effects
rotenone-induced
neurotoxicity
These
mediated
crosstalk
between
which
activates
trajectory.
Therefore,
inhibition
likely
offer
reliable
persuasive
avenue
curing
activation.
Graphical
International Journal of Molecular Medicine,
Год журнала:
2024,
Номер
53(5)
Опубликована: Апрель 2, 2024
Chronic
neuroinflammation
serves
a
key
role
in
the
onset
and
progression
of
neurodegenerative
disorders.
Mitochondria
serve
as
central
regulators
neuroinflammation.
In
addition
to
providing
energy
cells,
mitochondria
also
participate
immunoinflammatory
response
disorders
including
Alzheimer's
disease,
Parkinson's
multiple
sclerosis
epilepsy,
by
regulating
processes
such
cell
death
inflammasome
activation.
Under
inflammatory
conditions,
mitochondrial
oxidative
stress,
epigenetics,
dynamics
calcium
homeostasis
imbalance
may
underlying
regulatory
mechanisms
for
these
diseases.
Therefore,
investigating
related
dysfunction
result
therapeutic
strategies
against
chronic
neurodegeneration.
The
present
review
summarizes
neuroinflammatory
diseases
current
treatment
approaches
that
target
Neurology International,
Год журнала:
2024,
Номер
16(3), С. 502 - 517
Опубликована: Апрель 29, 2024
Parkinson’s
disease
(PD)
is
a
progressive
neurodegenerative
condition
marked
by
the
gradual
deterioration
of
dopaminergic
neurons
in
substantia
nigra.
Oxidative
stress
has
been
identified
as
key
player
development
PD
recent
studies.
In
first
part,
we
discuss
sources
oxidative
PD,
including
mitochondrial
dysfunction,
dopamine
metabolism,
and
neuroinflammation.
This
paper
delves
into
possibility
mitigating
potential
treatment
approach
for
PD.
addition,
examine
hurdles
antioxidant
therapy,
challenge
delivering
antioxidants
to
brain
requirement
biomarkers
track
patients.
However,
even
if
therapy
holds
promise,
further
investigation
needed
determine
its
efficacy
safety
treatment.
Journal of Internal Medicine,
Год журнала:
2024,
Номер
295(5), С. 599 - 619
Опубликована: Март 6, 2024
Abstract
The
older
population
is
increasing
worldwide,
and
life
expectancy
continuously
rising,
predominantly
thanks
to
medical
technological
progress.
Healthspan
refers
the
number
of
years
an
individual
can
live
in
good
health.
From
a
gerontological
viewpoint,
mission
extend
spent
health,
promoting
well‐being
minimizing
impact
aging‐related
diseases
slow
aging
process.
Biologically,
malleable
process
characterized
by
intra‐
inter‐individual
heterogeneous
dynamic
balance
between
accumulating
damage
repair
mechanisms.
Cellular
senescence
key
component
this
process,
with
senescent
cells
different
tissues
organs,
leading
age‐related
disease
susceptibility
over
time.
Removing
from
body
or
slowing
down
burden
rate
has
been
proposed
as
efficient
way
reduce
age‐dependent
deterioration.
In
animal
models,
senotherapeutic
molecules
lifespan
either
senolytic
senomorphic
activity.
Much
research
shows
that
dietary
physical
activity‐driven
lifestyle
interventions
protect
against
senescence.
This
narrative
review
aims
summarize
current
knowledge
on
targeting
risk
models
their
translational
potential
for
humans.
We
focused
studies
have
examined
role
senotherapeutics
modifying
burdens.
concludes
general
discussion
mechanisms
underlying
unique
trajectory
its
implications
future
research.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Май 16, 2024
The
excessive
production
of
various
reactive
oxidant
species
over
endogenous
antioxidant
defense
mechanisms
leads
to
the
development
a
state
oxidative
stress,
with
serious
biological
consequences.
consequences
stress
depend
on
balance
between
generation
and
include
damage
biomolecules,
disruption
signal
transduction,
mutation,
cell
apoptosis.
Accumulating
evidence
suggests
that
is
involved
in
physiopathology
debilitating
illnesses
associated
chronic
inflammation,
including
cardiovascular
diseases,
diabetes,
cancer,
or
neurodegenerative
processes,
need
continuous
pharmacological
treatment.
Oxidative
inflammation
are
tightly
linked
pathophysiological
one
which
can
be
simply
promoted
by
another.
Although,
many
trials
have
been
unsuccessful
(some
showed
either
no
effect
even
harmful
effects)
human
patients
as
preventive
curative
measure,
targeting
remains
an
interesting
therapeutic
approach
for
new
agents
design
novel
anti-inflammatory
drugs
reliable
safety
profile.
In
this
regard,
several
natural
compounds
were
explored
potential
options
treatment
inflammatory
diseases.
Several
metalloenzymes,
such
superoxide
dismutase,
catalase,
glutathione
peroxidase,
among
essential
enzymes
maintain
low
nanomolar
physiological
concentrations
(O
2
•−)
hydrogen
peroxide
(H
O
),
major
redox
signaling
molecules,
thus
play
important
roles
alteration
homeostasis.
These
become
striking
source
motivation
catalytic
enhance
action
these
under
pathological
conditions
related
inflammation.
This
review
focused
representatives
synthetic
antioxidants
drug
candidates
Antioxidants,
Год журнала:
2024,
Номер
13(7), С. 762 - 762
Опубликована: Июнь 24, 2024
Neurodegenerative
diseases
are
a
significant
challenge
to
global
healthcare,
and
oxidative
stress
plays
crucial
role
in
their
development.
This
paper
presents
comprehensive
analysis
of
the
neuroprotective
potential
olive
oil,
with
primary
focus
on
its
antioxidant
properties.
The
chemical
composition
including
key
antioxidants,
such
as
oleuropein,
hydroxytyrosol,
oleocanthal,
is
systematically
examined.
mechanisms
by
which
these
compounds
provide
neuroprotection,
counteracting
damage
modulating
pathways,
explored.
efficacy
oil
evaluated
synthesizing
findings
from
various
sources,
vitro
studies,
animal
models,
clinical
trials.
integration
into
dietary
patterns,
particularly
Mediterranean
diet,
broader
implications
neurodegenerative
disease
prevention
also
discussed.
challenges
translating
preclinical
applications
acknowledged
future
research
directions
proposed
better
understand
mitigating
risk
conditions.
review
highlights
not
only
component,
but
promising
candidate
preventive
neurology,
advocating
for
further
investigation
context
diseases.
