Seven Editora eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: March 22, 2024
Parkinson's disease (PD) is characterized by the progressive degeneration of dopaminergic neurons substantia nigra, leading to motor changes that progress tremors, rigidity and bradykinesia with postural instability.
Language: Английский
Journal of Internal Medicine, Journal Year: 2024, Volume and Issue: 295(5), P. 599 - 619
Published: March 6, 2024
Abstract The older population is increasing worldwide, and life expectancy continuously rising, predominantly thanks to medical technological progress. Healthspan refers the number of years an individual can live in good health. From a gerontological viewpoint, mission extend spent health, promoting well‐being minimizing impact aging‐related diseases slow aging process. Biologically, malleable process characterized by intra‐ inter‐individual heterogeneous dynamic balance between accumulating damage repair mechanisms. Cellular senescence key component this process, with senescent cells different tissues organs, leading age‐related disease susceptibility over time. Removing from body or slowing down burden rate has been proposed as efficient way reduce age‐dependent deterioration. In animal models, senotherapeutic molecules lifespan either senolytic senomorphic activity. Much research shows that dietary physical activity‐driven lifestyle interventions protect against senescence. This narrative review aims summarize current knowledge on targeting risk models their translational potential for humans. We focused studies have examined role senotherapeutics modifying burdens. concludes general discussion mechanisms underlying unique trajectory its implications future research.
Language: Английский
Citations
18
International Journal of Molecular Medicine, Journal Year: 2024, Volume and Issue: 53(5)
Published: April 2, 2024
Chronic neuroinflammation serves a key role in the onset and progression of neurodegenerative disorders. Mitochondria serve as central regulators neuroinflammation. In addition to providing energy cells, mitochondria also participate immunoinflammatory response disorders including Alzheimer's disease, Parkinson's multiple sclerosis epilepsy, by regulating processes such cell death inflammasome activation. Under inflammatory conditions, mitochondrial oxidative stress, epigenetics, dynamics calcium homeostasis imbalance may underlying regulatory mechanisms for these diseases. Therefore, investigating related dysfunction result therapeutic strategies against chronic neurodegeneration. The present review summarizes neuroinflammatory diseases current treatment approaches that target
Language: Английский
Citations
18
Neuroscience Bulletin, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 4, 2025
Language: Английский
Citations
2
Inflammopharmacology, Journal Year: 2023, Volume and Issue: 32(2), P. 1421 - 1437
Published: Aug. 4, 2023
Abstract Parkinson’s disease (PD) is the second most common progressive age-related neurodegenerative disorder. Paramount evidence shed light on role of PI3K/AKT signaling activation in treatment disorders. can be activated via cAMP-dependent pathways achieved by phosphodiesterase 4 (PDE4) inhibition. Roflumilast a well-known PDE4 inhibitor that currently used chronic obstructive pulmonary disease. Furthermore, roflumilast has been proposed as favorable candidate for neurological The current study aimed to unravel neuroprotective rotenone model PD rats. Ninety male rats were allocated into six groups follows: control, (1.5 mg/kg/48 h, s.c.), L-dopa (22.5 mg/kg, p.o), and (0.2, 0.4 or 0.8 p.o). All treatments administrated 21 days 1 h after injection. Rats treated with showed an improvement motor activity coordination well preservation dopaminergic neurons striatum. Moreover, increased cAMP level axis stimulation CREB/BDNF/TrkB SIRT1/PTP1B/IGF1 cascades. also caused upsurge mTOR Nrf2, halted GSK-3β NF-ĸB, suppressed FoxO1 caspase-3. Our revealed exerted effects rotenone-induced neurotoxicity These mediated crosstalk between which activates trajectory. Therefore, inhibition likely offer reliable persuasive avenue curing activation. Graphical
Language: Английский
Citations
24
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: May 16, 2024
The excessive production of various reactive oxidant species over endogenous antioxidant defense mechanisms leads to the development a state oxidative stress, with serious biological consequences. consequences stress depend on balance between generation and include damage biomolecules, disruption signal transduction, mutation, cell apoptosis. Accumulating evidence suggests that is involved in physiopathology debilitating illnesses associated chronic inflammation, including cardiovascular diseases, diabetes, cancer, or neurodegenerative processes, need continuous pharmacological treatment. Oxidative inflammation are tightly linked pathophysiological one which can be simply promoted by another. Although, many trials have been unsuccessful (some showed either no effect even harmful effects) human patients as preventive curative measure, targeting remains an interesting therapeutic approach for new agents design novel anti-inflammatory drugs reliable safety profile. In this regard, several natural compounds were explored potential options treatment inflammatory diseases. Several metalloenzymes, such superoxide dismutase, catalase, glutathione peroxidase, among essential enzymes maintain low nanomolar physiological concentrations (O 2 •−) hydrogen peroxide (H O ), major redox signaling molecules, thus play important roles alteration homeostasis. These become striking source motivation catalytic enhance action these under pathological conditions related inflammation. This review focused representatives synthetic antioxidants drug candidates
Language: Английский
Citations
16
Neurology International, Journal Year: 2024, Volume and Issue: 16(3), P. 502 - 517
Published: April 29, 2024
Parkinson’s disease (PD) is a progressive neurodegenerative condition marked by the gradual deterioration of dopaminergic neurons in substantia nigra. Oxidative stress has been identified as key player development PD recent studies. In first part, we discuss sources oxidative PD, including mitochondrial dysfunction, dopamine metabolism, and neuroinflammation. This paper delves into possibility mitigating potential treatment approach for PD. addition, examine hurdles antioxidant therapy, challenge delivering antioxidants to brain requirement biomarkers track patients. However, even if therapy holds promise, further investigation needed determine its efficacy safety treatment.
Language: Английский
Citations
14
Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: 35(10), P. 109560 - 109560
Published: Feb. 1, 2024
Language: Английский
Citations
10
Antioxidants, Journal Year: 2024, Volume and Issue: 13(7), P. 762 - 762
Published: June 24, 2024
Neurodegenerative diseases are a significant challenge to global healthcare, and oxidative stress plays crucial role in their development. This paper presents comprehensive analysis of the neuroprotective potential olive oil, with primary focus on its antioxidant properties. The chemical composition including key antioxidants, such as oleuropein, hydroxytyrosol, oleocanthal, is systematically examined. mechanisms by which these compounds provide neuroprotection, counteracting damage modulating pathways, explored. efficacy oil evaluated synthesizing findings from various sources, vitro studies, animal models, clinical trials. integration into dietary patterns, particularly Mediterranean diet, broader implications neurodegenerative disease prevention also discussed. challenges translating preclinical applications acknowledged future research directions proposed better understand mitigating risk conditions. review highlights not only component, but promising candidate preventive neurology, advocating for further investigation context diseases.
Language: Английский
Citations
10
Neurochemistry International, Journal Year: 2024, Volume and Issue: 178, P. 105798 - 105798
Published: June 29, 2024
Language: Английский
Citations
10
Physics of Life Reviews, Journal Year: 2024, Volume and Issue: 49, P. 100 - 111
Published: March 24, 2024
Language: Английский
Citations
8