Fundamentals of redox regulation in biology
Nature Reviews Molecular Cell Biology,
Год журнала:
2024,
Номер
25(9), С. 701 - 719
Опубликована: Апрель 30, 2024
Язык: Английский
Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 24, 2025
Polyphenols,
naturally
occurring
phytonutrients
found
in
plant-based
foods,
have
attracted
significant
attention
for
their
potential
therapeutic
effects
neurological
diseases
and
neuroinflammation.
These
compounds
possess
diverse
neuroprotective
capabilities,
including
antioxidant,
anti-inflammatory,
anti-amyloid
properties,
which
contribute
to
mitigating
the
progression
of
neurodegenerative
conditions
such
as
Alzheimer's
Disease
(AD),
Parkinson's
(PD),
Dementia,
Multiple
Sclerosis
(MS),
Stroke,
Huntington's
(HD).
Polyphenols
been
extensively
studied
ability
regulate
inflammatory
responses
by
modulating
activity
pro-inflammatory
genes
influencing
signal
transduction
pathways,
thereby
reducing
neuroinflammation
neuronal
death.
Additionally,
polyphenols
shown
promise
various
cellular
signaling
pathways
associated
with
viability,
synaptic
plasticity,
cognitive
function.
Epidemiological
clinical
studies
highlight
polyphenol-rich
diets
decrease
risk
alleviate
symptoms
disorders
Furthermore,
demonstrated
through
regulation
key
Akt,
Nrf2,
STAT,
MAPK,
play
critical
roles
neuroprotection
body's
immune
response.
This
review
emphasizes
growing
body
evidence
supporting
combating
neurodegeneration
neuroinflammation,
well
enhancing
brain
health.
Despite
substantial
promising
hypotheses,
further
research
investigations
are
necessary
fully
understand
role
establish
them
advanced
targets
age-related
neuroinflammatory
conditions.
Язык: Английский
Protein Oxidative Modifications in Neurodegenerative Diseases: From Advances in Detection and Modelling to Their Use as Disease Biomarkers
Antioxidants,
Год журнала:
2024,
Номер
13(6), С. 681 - 681
Опубликована: Май 31, 2024
Oxidation–reduction
post-translational
modifications
(redox-PTMs)
are
chemical
alterations
to
amino
acids
of
proteins.
Redox-PTMs
participate
in
the
regulation
protein
conformation,
localization
and
function,
acting
as
signalling
effectors
that
impact
many
essential
biochemical
processes
cells.
Crucially,
dysregulation
redox-PTMs
proteins
has
been
implicated
pathophysiology
numerous
human
diseases,
including
neurodegenerative
diseases
such
Alzheimer’s
disease
Parkinson’s
disease.
This
review
aims
highlight
current
gaps
knowledge
field
biology
explore
new
methodological
advances
proteomics
computational
modelling
will
pave
way
for
a
better
understanding
role
therapeutic
potential
diseases.
Here,
we
summarize
main
types
while
providing
examples
their
occurrence
an
overview
state-of-the-art
methods
used
detection.
We
novel
approaches
tools
obtain
insights
into
precise
regulating
structure
function.
also
discuss
complex
crosstalk
between
various
PTMs
occur
living
Finally,
argue
could
be
future
diagnosis
prognosis
biomarkers
Язык: Английский
Oxidative Cysteine Post Translational Modifications Drive the Redox Code Underlying Neurodegeneration and Amyotrophic Lateral Sclerosis
Antioxidants,
Год журнала:
2024,
Номер
13(8), С. 883 - 883
Опубликована: Июль 23, 2024
Redox
dysregulation,
an
imbalance
between
oxidants
and
antioxidants,
is
crucial
in
the
pathogenesis
of
various
neurodegenerative
diseases.
Within
this
context,
"redoxome"
encompasses
network
redox
molecules
collaborating
to
maintain
cellular
balance
signaling.
Among
these,
cysteine-sensitive
proteins
are
fundamental
for
homeostasis.
Due
their
reactive
thiol
groups,
cysteine
(Cys)
residues
particularly
susceptible
oxidative
post-translational
modifications
(PTMs)
induced
by
free
radicals
(reactive
oxygen,
nitrogen,
sulfur
species)
which
profoundly
affect
protein
functions.
Cys-PTMs,
forming
what
referred
as
"cysteinet"
proteome,
essential
signaling
both
physiological
pathological
conditions,
including
neurodegeneration.
Such
significantly
influence
misfolding
aggregation,
key
hallmarks
diseases
such
Alzheimer's,
Parkinson's,
notably,
amyotrophic
lateral
sclerosis
(ALS).
This
review
aims
explore
complex
landscape
PTMs
environment,
elucidating
impact
on
neurodegeneration
at
level.
By
investigating
specific
regulatory
networks
involved,
particular
emphasis
placed
link
dysregulation
ALS,
highlighting
pathology
a
prime
example
disease
wherein
distinct
hallmark.
Язык: Английский
Biomarker potential of nuclear Nrf2 activation in the ABC subtype of diffuse large B‑cell lymphoma
Oncology Letters,
Год журнала:
2024,
Номер
29(1)
Опубликована: Окт. 25, 2024
Diffuse
large
B-cell
lymphoma
(DLBCL)
is
an
aggressive
characterized
by
distinct
subtypes
and
heterogeneous
treatment
outcomes.
Oxidative
stress
the
dysregulation
of
related
regulatory
genes
are
prevalent
in
DLBCL,
prompting
investigation
into
nuclear
factor
erythroid
2-related
2
(Nrf2)-kelch-like
ECH-associated
protein
1
(Keap1)
signaling
pathway
associated
genes.
The
present
study
assessed
pathological
specimens
clinical
data
from
43
newly
diagnosed
patients
with
comparing
associations
correlations
between
expression
Nrf2,
Keap1,
microtubule-associated
light
chain
3β
(LC3B)
nitrotyrosine
activated
(ABC)
germinal
center
(GCB)
DLBCL
using
immunohistochemistry
digital
image
analysis
software.
Nuclear
Nrf2
activation
was
observed
33.3%
ABC,
demonstrating
a
higher
prevalence
hepatitis
B
surface
antigen
positivity,
calcium
ions
significant
body
weight
loss
(P<0.05).
Total
GCB
subtype
inversely
correlated
Keap1
ABC
subtype.
Furthermore,
positive
correlation
demonstrated
LC3,
indicating
that
total
inhibited
regulates
LC3
expression.
also
lower
white
blood
cell
counts
more
frequent
chemotherapy
courses
than
These
findings
suggest
could
be
biomarker
for
diagnosis.
Язык: Английский
Donor Dependent Variations in Systemic Oxidative Stress and Their Association with One-Year Graft Outcomes In Kidney Transplantation
American Journal of Nephrology,
Год журнала:
2024,
Номер
unknown, С. 1 - 1
Опубликована: Июнь 10, 2024
Oxidative
stress
has
been
implicated
in
complications
after
kidney
transplantation
(KT),
including
delayed
graft
function
(DGF)
and
rejection.
However,
its
role
long-term
posttransplant
outcomes
remains
unclear.
Язык: Английский
Peptide-Bound Glycative, AGE and Oxidative Modifications as Biomarkers for the Diagnosis of Alzheimer’s Disease—A Feasibility Study
Biomedicines,
Год журнала:
2024,
Номер
12(9), С. 2127 - 2127
Опубликована: Сен. 19, 2024
Background:
The
diagnosis
of
Alzheimer’s
disease
(AD)
relies
on
core
cerebrospinal
fluid
(CSF)
biomarkers,
amyloid
beta
(Aβ)
and
tau.
As
the
brain
is
then
already
damaged,
researchers
still
strive
to
discover
earlier
biomarkers
onset
progression
AD.
Glycation,
advanced
glycation
end
products
(AGEs)
oxidative
modifications
proteins
in
CSF
mirror
underlying
biological
mechanisms
that
contribute
early
AD
pathology.
However,
analyzing
free
AGEs
body
fluids
patients
has
led
controversial
results.
Thus,
this
pilot
study
aimed
test
feasibility
detecting,
identifying
quantifying
differentially
glycated,
AGE
or
oxidatively
modified
peptides
(n
=
5)
compared
a
control
group
5).
Methods:
To
end,
we
utilized
data-dependent
(DDA)
nano
liquid
chromatography
(LC)
linear
ion
trap-Orbitrap
tandem
mass
spectrometry
(MS/MS)
)
approach
database
search
included
over
30
glycative
four
nodes
analyze
endogenous
individual
peptides.
Furthermore,
quantified
candidate
peptide
abundance
using
LC
Quan.
Results:
We
identified
299
sites
53
tryptophan.
From
those,
17
promising
candidates
as
putative
(receiver
operating
curve-area
under
curve
(ROC-AUC)
>
0.8),
albeit
without
statistical
significance.
Conclusions:
potential
with
higher
discrimination
power
showed
correlations
established
diagnostic
markers,
thus
hinting
toward
those
biomarkers.
Язык: Английский
Synergistic growth suppression of Fusarium oxysporum MLY127 through Dimethachlon Nanoencapsulation and co-application with Bacillus velezensis MLY71
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Дек. 2, 2024
Fusarium
oxysporum
is
a
destructive
plant
pathogen
with
robust
survival
mechanisms,
complicating
control
efforts.
This
study
aimed
to
develop
nanoformulated
fungicides,
screen
antagonistic
bacteria,
and
evaluate
their
combined
efficacy.
A
novel
self-emulsifying
nanoemulsion
(DZW)
was
formulated
using
zein
benzaldehyde-modified
wheat
gluten
(BgWG)
as
carriers
for
dimethachlon
(DTN).
The
preparation
process
optimized
material
ratios
emulsification
techniques.
Concurrently,
bacterial
strains
against
F.
were
screened
via
the
plate
standoff
method,
identifying
Bacillus
velezensis
MLY71
both
compatible
DTN.
DZW
achieved
particle
size
of
93.22
nm,
an
encapsulation
efficiency
(EE)
90.57%,
DTN
loading
capacity
(LC)
67.09%,
sustained
release
over
96
h.
combination
(0.04
mg·mL⁻¹)
B.
(1
×
10⁴
CFU·mL⁻¹)
76.66%
inhibition
rate
MLY127,
1.71
times
greater
than
alone,
indicating
significant
synergy.
At
concentration
0.20
mg·mL⁻¹,
showed
synergy
coefficient
1.33.
also
observed
in
soil
environments,
its
adaptability
controlling
soil-borne
pathogens.
As
sustainable
management
continues
gain
attention
agricultural
disease
control,
this
offers
promising
strategy
achieving
higher
efficacy
same
fungicide
dose
or
satisfactory
reduced
application.
excellent
drug-loading
performance
BgWG
expanded
applications
by-product
gluten.
Язык: Английский