Cellular and Molecular Neurobiology, Год журнала: 2023, Номер 43(8), С. 3847 - 3884
Опубликована: Сен. 19, 2023
Язык: Английский
Frontiers in Nutrition, Год журнала: 2023, Номер 10
Опубликована: Июнь 29, 2023
Dementia is a growing public health concern, with an estimated prevalence of 57 million adults worldwide. Alzheimer’s disease (AD) accounts for 60–80% the cases. Clinical trials testing potential drugs and neuroprotective agents have proven futile, currently approved only provide symptomatic benefits. Emerging epidemiological clinical studies suggest that lifestyle changes, including diet physical activity, offer alternative therapeutic route slowing preventing cognitive decline dementia. Age single most common risk factor dementia, it associated cellular bioenergetics metabolic processes. Therefore, nutrient-rich critical optimal brain health. Furthermore, type 2 diabetes (T2D) AD, diets reduce T2D may confer neuroprotection. Foods predominant in Mediterranean, MIND, DASH diets, fruits, leafy green vegetables, fish, nuts, olive oil, prevent or slow decline. The mechanisms by which these nutrients promote health, however, are not yet completely understood. Other dietary approaches eating regimes, ketogenic intermittent fasting, also emerging as beneficial This review summarizes pathophysiology, factors, pathways activated several regimes shown promising results promoting
Язык: Английский
Процитировано
35
Experimental and Therapeutic Medicine, Год журнала: 2023, Номер 25(5)
Опубликована: Апрель 3, 2023
Crocus sativus L. (saffron) is widely used as a traditional spice for flavoring, coloring and medicinal purposes. As Chinese herb, saffron promotes blood circulation, removes stasis, cools detoxifies the blood, relieves depression calms mind. According to modern pharmacological studies, active constituents of saffron, including crocetin, safranal crocus aldehyde, exhibit antioxidant, anti-inflammatory, mitochondrial function-improving antidepressant effects. Thus, has potential treat neurodegenerative diseases (NDs) associated with oxidative stress, inflammation impaired function, such Alzheimer's disease, Parkinson's multiple sclerosis cerebral ischemia. The present article provides review effects its in terms neuroprotective effects, antioxidant anti-inflammatory improvement dysfunction, well their clinical application treating NDs.
Язык: Английский
Процитировано
27
Carbon letters, Год журнала: 2023, Номер 33(4), С. 1057 - 1071
Опубликована: Апрель 6, 2023
Язык: Английский
Процитировано
27
Deleted Journal, Год журнала: 2024, Номер 6(5)
Опубликована: Апрель 16, 2024
Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder primarily associated with aging. This devastating condition characterized by significant memory loss, abnormal behavior, personality shifts, and decline in cognitive function. Despite extensive research, no cure for currently exists, available treatment options have shown limited effectiveness. Developing therapeutic interventions to slow down or prevent the onset progression of crucial address growing burden this condition. Ayurvedic medicinal herbs emerged as promising avenue drug numerous compounds derived from these undergoing clinical trials. Scientific studies explored potential application various plants their derivatives disease. Although precise mechanisms action remain largely unknown, phytochemical investigations identified wide range beneficial within plants. These include lignans, flavonoids, tannins, polyphenols, triterpenes, sterols, alkaloids, each exhibiting diverse pharmacological activities. activities encompass anti-inflammatory, anti-amyloidogenic, anticholinesterase, hypolipidemic, antioxidant effects. review highlights phytochemistry ethnomedicinal applications plants, along bioactive compounds. It underscores Ayurveda, one world’s oldest holistic healing systems, identifying effective disorders like The constituents suggest novel treatments findings offer hope addressing challenges posed debilitating Graphical
Язык: Английский
Процитировано
12
Pharmacological Research - Modern Chinese Medicine, Год журнала: 2024, Номер 10, С. 100403 - 100403
Опубликована: Фев. 23, 2024
: Centella asiatica (L.) Urb. is an authentic herbal medicine that frequently used in Southeast Asian regions and scientific investigations have demonstrated the benefits of its constituents various health issues. The active are pentacyclic triterpenoid (asiatic acid, adecassic madecassoside, asiaticoside) saponins. study includes a thorough review prior research findings assortment sources to gather data on therapeutic potential novel delivery approaches C. asiatica. This outlines evidence-based recent updates actions nanocarrier types employed deliver actives address issues poor stability, limited bioavailability, higher metabolism, providing new way utilize these bioactive as first-line treatment for disorders. revealed possesses broad array effects including anti-ulcer, anti-cancer, anti-diabetic, anti-osteoporotic, neuroprotective, antioxidant, cardioprotective, anti-inflammatory activities. Further, been examined overcome constraints with development carrier systems nanoparticles, polymeric nanocarriers, transferosomes, nanoemulsions, nanosuspensions, liposomes, hydrogels, microneedles, micelles. involves importance natural resource wide range traditional uses. Its medicinal properties, which include ability treat chronic illnesses like cancer well fight infections, emphasize this plant modern medicine. Future studies should prioritize vivo vitro clinical trials broaden understanding mechanism involved more advanced order improve utilization healthcare.
Язык: Английский
Процитировано
11
Опубликована: Апрель 12, 2024
Alzheimer's disease (AD) is a stealthy and progressive neurological disorder that leading cause of dementia in the global elderly population, imposing significant burden on both society. Currently, condition treated with medications alleviate symptoms. Nonetheless, these drugs may not consistently produce desired results can serious side effects. Hence, there vigorous pursuit alternative options to enhance quality life for patients. Ginkgo biloba (GB), an herb historical use traditional medicine, contains bioactive compounds such as terpenoids (Ginkgolides A, B, C), polyphenols, organic acids, flavonoids (quercetin, kaempferol, isorhamnetin). These are associated anti-inflammatory, antioxidant, neuroprotective properties, making them valuable cognitive health. A systematic search across three databases using specific keywords GB AD yielded 1702 documents, selection 15 clinical trials synthesis. In eleven studies, extract/EGb 761® was shown improve function, neuropsychiatric symptoms, functional abilities types. four however, were no differences between GB-treated placebo groups. Significant improvements observed scores obtained from Mini-Mental State Examination (MMSE), Short Cognitive Performance Test (SKT), Neuropsychiatric Inventory (NPI). While majority synthesized show has promising potential conditions, more research needed determine optimal dosages, effective delivery methods, appropriate pharmaceutical formulations. Furthermore, thorough assessment adverse effects, exploration long-term implications, investigation into drug interactions critical aspects must be carefully evaluated future studies.
Язык: Английский
Процитировано
11
Antioxidants, Год журнала: 2024, Номер 13(6), С. 651 - 651
Опубликована: Май 27, 2024
Alzheimer’s disease (AD) is a stealthy and progressive neurological disorder that leading cause of dementia in the global elderly population, imposing significant burden on both society. Currently, condition treated with medications alleviate symptoms. Nonetheless, these drugs may not consistently produce desired results can serious side effects. Hence, there vigorous pursuit alternative options to enhance quality life for patients. Ginkgo biloba (GB), an herb historical use traditional medicine, contains bioactive compounds such as terpenoids (Ginkgolides A, B, C), polyphenols, organic acids, flavonoids (quercetin, kaempferol, isorhamnetin). These are associated anti-inflammatory, antioxidant, neuroprotective properties, making them valuable cognitive health. A systematic search across three databases using specific keywords—GB AD dementia—yielded 1702 documents, selection 15 clinical trials synthesis. In eleven studies, GB extract/EGb 761® was shown improve function, neuropsychiatric symptoms, functional abilities types. four however, were no differences between GB-treated placebo groups. Significant improvements observed scores obtained from Mini-Mental State Examination (MMSE), Short Cognitive Performance Test (SKT), Neuropsychiatric Inventory (NPI). While majority synthesized show has promising potential treatment conditions, more research needed determine optimal dosages, effective delivery methods, appropriate pharmaceutical formulations. Furthermore, thorough assessment adverse effects, exploration long-term implications, investigation into drug interactions critical aspects must be carefully evaluated future studies.
Язык: Английский
Процитировано
10
Nutrients, Год журнала: 2024, Номер 16(12), С. 1813 - 1813
Опубликована: Июнь 8, 2024
Background: Ashwagandha has been reported to reduce stress and attenuate cognitive decline associated with inflammation neurodegeneration in clinical populations. However, the effects as a potential nootropic nutrient younger populations are unclear. This study examined of liposomal ashwagandha supplementation on function, mood, markers health safety healthy young men women. Methods: 59 women (22.7 ± 7 yrs., 74.9 16 kg, 26.2 5 BMI) fasted for 12 h, donated fasting blood sample, were administered COMPASS function test battery (Word Recall, Word recognition, Choice Reaction Time Task, Picture Recognition, Digit Vigilance Corsi Block test, Stroop test) profile mood states (POMS). In randomized double-blind manner, participants 225 mg placebo (Gum Arabic) or (Withania somnifera) root leaf extract coated covering. After 60-min, repeated assessments. Participants continued (225 mg/d) 30 days then returned lab repeat experiment. Data analyzed using general linear model (GLM) univariate analysis measures pairwise comparisons mean changes from baseline 95% confidence intervals (CI). Results: improved acute and/or 30-day Recall (correct recalled attempts), (targets identified), Recognition (“yes” correct responses, overall reaction time), Color-Word (congruent words identified, POMS (tension fatigue) more consistently several differences observed between groups. Conclusion: Results support contentions that mg) may improve some memory, attention, vigilance, executive while decreasing perceptions tension fatigue individuals. Retrospectively registered trial ISRCTN58680760.
Язык: Английский
Процитировано
10
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(14), С. 7530 - 7530
Опубликована: Июль 9, 2024
Aging is a multifaceted process influenced by hereditary factors, lifestyle, and environmental elements. As time progresses, the human body experiences degenerative changes in major functions. The external internal signs of aging manifest various ways, including skin dryness, wrinkles, musculoskeletal disorders, cardiovascular diseases, diabetes, neurodegenerative cancer. Additionally, cancer, like aging, complex disease that arises from accumulation genetic epigenetic alterations. Circadian clock dysregulation has recently been identified as an important risk factor for cancer development. Natural compounds herbal medicines have gained significant attention their potential preventing age-related diseases inhibiting progression. These demonstrate antioxidant, anti-inflammatory, anti-proliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects well circadian regulation. This review explores cancers, specific natural targeting key features these conditions.
Язык: Английский
Процитировано
8
Pharmacological Research - Modern Chinese Medicine, Год журнала: 2021, Номер 2, С. 100030 - 100030
Опубликована: Дек. 12, 2021
Alzheimer's disease (AD) is a progressive neurological and the most common form of dementia, affecting more than 10 million people all over world. Clinically, AD characterized by deficits in memory, cognitive impairment, altered behavior. Although researches have largely continued, there still no appropriate treatment option for disease-modifying AD. However, symptomatic options exist. Medicinal plants been used different systems medicine from ancient times diseases. Numerous herbs shown to improve brain function may role play treatment. In this review, we provide systematic review on medicinal useful disease, effect these hormones, herb-drug interactions as well stability-related testing herbal pharmaceutical medicines.
Язык: Английский
Процитировано
45