Journal of Colloid and Interface Science,
Год журнала:
2024,
Номер
664, С. 338 - 348
Опубликована: Март 5, 2024
Combination
therapies
demand
co-delivery
platforms
with
efficient
entrapment
of
distinct
payloads
and
specific
delivery
to
cells
possibly
organelles.
Herein,
we
introduce
the
combination
two
therapeutic
modalities,
gene
photodynamic
therapy,
in
a
purely
peptidic
platform.
The
simultaneous
formation
cargo
loading
multi-micellar
platform
is
governed
by
self-assembly
at
nanoscale.
architecture
nanocarrier
positive
charge
its
constituent
micelles
offer
controlled
dual
capacity
locations
for
hydrophobic
photosensitizer
(PS)
negatively
charged
antisense
oligonucleotides
(ASOs).
Moreover,
nuclear
localization
signal
(NLS)
sequence
built-in
peptide
targets
PS
+
ASO-loaded
nanocarriers
nucleus.
Breast
cancer
treated
demonstrated
photo-triggered
enhancement
radical
oxygen
species
(ROS)
associated
increased
cell
death.
Besides,
ASO
resulted
up
90
%
knockdown
Bcl-2,
an
inhibitor
apoptosis
that
overexpressed
more
than
half
all
human
cancers.
Simultaneous
elicited
synergistic
extent
could
not
be
reached
singly
loaded
or
free
form
drugs.
Both,
location
compounds
prevents
them
from
interfering
each
other,
highly
cellular
support
great
potential
this
versatile
therapy.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 541 - 569
Опубликована: Янв. 1, 2024
Natural
products
have
proven
to
significant
curative
effects
and
are
increasingly
considered
as
potential
candidates
for
clinical
prevention,
diagnosis,
treatment.
Compared
with
synthetic
drugs,
natural
not
only
diverse
structures
but
also
exhibit
a
range
of
biological
activities
against
different
disease
states
molecular
targets,
making
them
attractive
development
in
the
field
medicine.
Despite
advancements
use
purposes,
there
remain
obstacles
that
hinder
their
full
potential.
These
challenges
include
issues
such
limited
solubility
stability
when
administered
orally,
well
short
durations
effectiveness.
To
address
these
concerns,
nano-drug
delivery
systems
emerged
promising
solution
overcome
barriers
faced
application
products.
offer
notable
advantages,
large
specific
surface
area,
enhanced
targeting
capabilities,
ability
achieve
sustained
controlled
release.
Extensive
vitro
vivo
studies
provided
further
evidence
supporting
efficacy
safety
nanoparticle-based
delivering
preclinical
models.
This
review
describes
limitations
product
applications
current
status
combined
nanotechnology.
The
latest
advances
from
three
aspects:
connecting
warheads,
self-assembly,
co-delivery.
Finally,
translation
nano-drugs
discussed.
Materials Today Bio,
Год журнала:
2023,
Номер
22, С. 100767 - 100767
Опубликована: Авг. 7, 2023
Atherosclerosis
is
the
build-up
of
fatty
deposits
in
arteries.
main
underlying
cause
cardiovascular
diseases
and
leading
global
morbidity
mortality.
Current
pharmaceutical
treatment
options
are
unable
to
effectively
treat
plaque
later
stages
disease.
Instead,
they
aimed
at
resolving
risk
factors.
Nanomaterials
nanoparticle-mediated
therapies
have
become
increasingly
popular
for
atherosclerosis
due
their
targeted
controlled
release
therapeutics.
In
this
review,
we
discuss
different
types
therapeutics
used
disease
focus
on
nanomaterial
strategies
employed
delivery
these
drugs,
enabling
effective
efficient
resolution
atherosclerotic
plaque.
The
ideal
strategy
each
drug
type
(e.g.
statins,
nucleic
acids,
small
molecule
peptides)
will
be
comprehensively
discussed.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(6), С. 5121 - 5121
Опубликована: Март 7, 2023
Drug
and
gene
delivery
systems
mediated
by
nanoparticles
have
been
widely
studied
for
life
science
in
the
past
decade.
The
application
of
nano-delivery
can
dramatically
improve
stability
efficiency
carried
ingredients,
overcoming
defects
administration
routes
cancer
therapy,
possibly
maintaining
sustainability
agricultural
systems.
However,
a
drug
or
alone
sometimes
cannot
achieve
satisfactory
effect.
nanoparticle-mediated
co-delivery
system
load
multiple
drugs
genes
simultaneously,
effectiveness
each
component,
thus
amplifying
efficacy
exhibiting
synergistic
effects
therapy
pest
management.
has
reported
medical
field,
studies
on
its
field
recently
begun
to
emerge.
In
this
progress
report,
we
summarize
recent
preparation
discuss
remaining
challenges
future
perspectives
design
fabrication.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Май 7, 2024
Improving
the
efficacy
of
chemotherapy
remains
a
key
challenge
in
cancer
treatment,
considering
low
bioavailability,
high
cytotoxicity,
and
undesirable
side
effects
some
clinical
drugs.
Targeted
delivery
sustained
release
therapeutic
drugs
to
cells
can
reduce
whole-body
cytotoxicity
agent
deliver
safe
localized
treatment
patient.
There
is
growing
interest
herbal
drugs,
such
as
curcumin,
which
highly
noted
promising
anti-tumor
drug,
its
wide
range
bioactivities
properties
against
various
tumors.
Conversely,
curcumin
limited
because
poor
oral
water
solubility,
instability
gastrointestinal
fluids,
unsuitable
pH
stability.
Drug-delivery
colloid
vehicles
like
liposomes
nanoparticles
combined
with
microbubbles
ultrasound-mediated
are
currently
being
explored
effective
modes
cases.
This
study
aimed
synthesize
(CLs)
optimize
high-frequency
ultrasound
uptake
by
human
breast
cell
line
(HCC
1954)
through
vitro
studies
culture
viability
cytotoxicity.
CLs
were
effectively
prepared
particles
sized
at
81
±
2
nm,
demonstrating
stability
controlled
under
exposure.
In
using
HCC1954
cells,
combination
CLs,
ultrasound,
Definity
significantly
improved
curcumin's
effects,
particularly
specific
conditions:
15
s
continuous
0.12
W/cm
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июль 22, 2024
Abstract
Rheumatoid
arthritis
(RA)
is
an
autoimmune
disease
with
multifactorial
etiology
and
intricate
pathogenesis.
In
RA,
repeated
monotherapy
frequently
associated
inadequate
efficacy,
drug
resistance,
severe
side
effects.
Therefore,
a
shift
has
occurred
in
clinical
practice
toward
combination
therapy.
However,
conventional
therapy
encounters
several
hindrances,
including
low
selectivity
to
arthritic
joints,
short
half-lives,
varying
pharmacokinetics
among
coupled
drugs.
Emerging
nanotechnology
offers
incomparable
opportunity
for
developing
advanced
against
RA.
First,
it
allows
co-delivering
multiple
drugs
augmented
physicochemical
properties,
targeted
delivery
capabilities,
controlled
release
profiles.
Second,
enables
therapeutic
nanomaterials
development,
thereby
expanding
regimens
include
multifunctional
nanomedicines.
Lastly,
facilitates
the
construction
of
all-in-one
nanoplatforms
assembled
modalities,
such
as
phototherapy,
sonodynamic
therapy,
imaging.
Thus,
promising
solution
current
bottleneck
both
RA
treatment
diagnosis.
This
review
summarizes
rationale,
advantages,
recent
advances
nano-empowered
It
also
discusses
safety
considerations,
drug–drug
interactions,
potential
translation.
Additionally,
provides
design
tips
outlook
on
future
developments
The
objective
this
achieve
comprehensive
understanding
mechanisms
underlying
unlock
maximum
nanotechnology,
facilitating
smooth
transition
research
findings
from
laboratory
practice.
Nanomaterials,
Год журнала:
2022,
Номер
12(18), С. 3201 - 3201
Опубликована: Сен. 15, 2022
Cancer
nanotherapeutics
is
an
important
field
of
research
which
utilizes
nanomaterials
as
approach
to
cancer
therapy.
Nano-mediated
therapeutic
delivery
systems
overcome
the
adverse
side
effects
traditional
treatment
methods.
Nanoparticles
(NPs)
are
considered
excellent
tumor-targeting
vehicles
due
their
compact
and
variable
size,
large
surface
area,
ability
load
several
genes
drugs,
mediation
increased
payload
uptake.
Despite
rapid
development
nanotechnology,
there
growing
concern
regarding
possible
long-term
NPs
on
environment
human
health.
Green
chemistry
using
plant
materials,
such
curcumin,
a
sustainable
alternative
conventional
reduction
methods
confers
dual
reducing
capping
properties.
Curcumin
bioactive
compound
isolated
from
rhizome
Curcuma
longa
plant,
exhibits
various
medicinal
Curcumin-capped
exhibit
solubility,
bioavailability,
indices,
antitumor
This
review
highlights
potential
properties
economical,
simple,
eco-friendly
curcumin-synthesized
capped
for
localized
drugs
tumor
microenvironment
with
fewer
effects.
Acta Pharmaceutica Sinica B,
Год журнала:
2023,
Номер
14(5), С. 2263 - 2280
Опубликована: Дек. 16, 2023
Chemotherapeutics
can
induce
immunogenic
cell
death
(ICD)
in
tumor
cells,
offering
new
possibilities
for
cancer
therapy.
However,
the
efficiency
of
immune
response
generated
is
insufficient
due
to
inhibitory
nature
microenvironment
(TME).
Here,
we
developed
a
pH/reactive
oxygen
species
(ROS)
dual-response
system
enhance
chemoimmunotherapy
melanoma.
The
productively
accumulated
tumors
by
specific
binding
phenylboronic
acid
(PBA)
sialic
acids
(SA).
nanoparticles
(NPs)
rapidly
swelled
and
released
quercetin
(QUE)
doxorubicin
(DOX)
upon
stimulation
