Advances in medical diagnosis, treatment, and care (AMDTC) book series,
Год журнала:
2024,
Номер
unknown, С. 409 - 428
Опубликована: Дек. 17, 2024
The
advent
of
precision
oncology
has
brought
about
a
paradigm
shift
in
the
management
cancer,
with
increased
emphasis
on
personalized
treatment
approaches.
key
aspects
this
approach
are
to
identify
spatially
variable
genes,
which
exhibit
significant
expression
differences
across
distinct
regions
tumor.
These
genes
have
emerged
as
potential
therapeutic
targets
and
biomarkers
they
reflect
inherent
heterogeneity
within
disease.
By
capturing
spatial
variability
gene
tumor,
researchers
clinicians
learn
important
things
underlying
biology
develop
more
targeted
effective
strategies
for
individual
patients.
recent
advances
associated
methods
main
topics
chapter.
understanding
how
varies
tumors,
we
can
potentially
improve
diagnostic
accuracy,
efficacy,
patient
outcomes
oncology.
Journal of Medical Case Reports,
Год журнала:
2023,
Номер
17(1)
Опубликована: Окт. 18, 2023
Abstract
Background
Medullary
carcinoma
of
the
colon
is
a
rare
subtype
colorectal
cancer
that
has
unique,
and
sometimes
varied,
clinical
histologic
profile.
It
usually
presents
in
adult
patients
older
than
50
years.
Here,
we
report
unique
case
young
male
patient
who
initially
presented
with
abdominal
pain
followed
by
large
bowel
obstruction.
Case
presentation
A
40-year-old
SriLankan
right-sided
on
examination,
there
was
palpable
right
iliac
fossa
mass.
Colonoscopy
computed
tomography
scan
revealed
cecal
Later,
while
waiting
for
elective
resection,
developed
symptoms
signs
He
underwent
laparoscopic
hemicolectomy
an
uneventful
postoperative
course.
The
histopathologic
evaluation
resected
specimens
showed
invasive
syncytial
growth
pattern,
foci
lymphoid
host
response,
dirty
necrosis,
keeping
medullary
pT4a
pN2b.
Unlike
most
reported
cases,
this
caudal-related
homeobox
transcription
factor
2
positive.
Conclusion
We
have
another
characteristics.
Reporting
such
cases
helps
refine
understanding
genetic,
as
well
clinical,
phenotypes
colon.
Journal of Translational Medicine,
Год журнала:
2023,
Номер
21(1)
Опубликована: Ноя. 25, 2023
Abstract
Background
The
tumor
microenvironment
and
intercellular
communication
between
solid
tumors
the
surrounding
stroma
play
crucial
roles
in
cancer
initiation,
progression,
prognosis.
Radiomics
provides
clinically
relevant
information
from
radiological
images;
however,
its
biological
implications
uncovering
pathophysiology
driven
by
cellular
heterogeneity
are
largely
unknown.
We
aimed
to
identify
radiogenomic
signatures
of
tumor-stroma
(TSH)
improve
breast
management
prognosis
analysis.
Methods
This
retrospective
multicohort
study
included
five
datasets.
Cell
subpopulations
were
estimated
using
bulk
gene
expression
data,
relative
difference
cell
was
used
as
a
biomarker
categorize
patients
into
good-
poor-survival
groups.
A
signature-based
model
utilizing
dynamic
contrast-enhanced
magnetic
resonance
imaging
(DCE-MRI)
developed
target
TSH,
clinical
significance
relation
survival
outcomes
independently
validated.
Results
final
cohorts
1330
women
for
TSH
identification
(n
=
112,
mean
age,
57.3
years
±
14.6)
validation
886,
58.9
13.1),
signature
91,
55.5
11.4),
prognostic
241)
assessments.
cytotoxic
lymphocyte
differentiated
groups
(
p
<
0.0001)
validated
0.014).
good
group
exhibited
denser
interconnections.
identified
showed
positive
association
with
overall
0.038)
recurrence-free
3
×
10
–4
).
Conclusion
Radiogenomic
provide
insights
factors
that
reflect
imbalanced
environment,
thereby
presenting
cancer-specific
significance.
Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Март 16, 2024
Abstract
Background
Protein
cysteine
oxidation
is
substantially
involved
in
various
biological
and
pathogenic
processes,
but
its
implications
pancreatic
cancer
development
remains
poorly
understood.
Methods
results
In
this
study,
we
performed
a
global
characterization
of
protein
targets
PDAC
cells
through
iodoTMT-based
quantitative
proteomics,
which
identified
over
4300
oxidized
sites
more
than
2100
proteins
HPDE6c7
PANC-1
cells.
Among
them,
1715
residues
were
shown
to
be
differentially
between
Also,
charged
amino
acids
including
aspartate,
glutamate
lysine
significantly
overrepresented
flanking
sequences
cysteines.
Differentially
enriched
multiple
cancer-related
processes
signaling
pathways.
Specifically,
the
HIF-1
exhibited
significant
alterations
cells,
reduced
PHD2
human
tissues
was
correlated
with
lower
survival
time
patients.
Conclusion
These
investigations
provided
new
insights
into
oxidation-regulated
during
pathogenesis,
might
further
explored
for
diagnosis
treatment.
Sensors,
Год журнала:
2024,
Номер
24(14), С. 4712 - 4712
Опубликована: Июль 20, 2024
Conventional
screening
options
for
colorectal
cancer
(CRC)
detection
are
mainly
direct
visualization
and
invasive
methods
including
colonoscopy
flexible
sigmoidoscopy,
which
must
be
performed
in
a
clinical
setting
may
linked
to
adverse
effects
some
patients.
Non-invasive
CRC
diagnostic
tests
such
as
computed
tomography
colonography
stool
either
too
costly
or
less
reliable
than
ones.
On
the
other
hand,
volatile
organic
compounds
(VOCs)
potentially
ideal
non-invasive
biomarkers
monitoring.
The
present
review
is
comprehensive
presentation
of
current
state-of-the-art
VOC-based
diagnostics,
with
specific
focus
on
recent
advancements
biosensor
design
application.
Among
them,
breath-based
chromatography
pattern
analysis
sampling
techniques
overviewed,
along
nanoparticle-based
optical
electrochemical
approaches.
Limitations
currently
available
technologies
also
discussed
an
outlook
improvement
combination
big
data
analytics
advanced
instrumentation,
well
expanding
scope
specificity
CRC-related
biomarkers.
Genomic psychiatry :,
Год журнала:
2024,
Номер
unknown, С. 1 - 13
Опубликована: Июль 18, 2024
Unipolar
and
bipolar
depression
[major
depressive
disorder
(MDD)
(BD)]
are
complex
psychiatric
disorders
characterized
by
disturbances
in
mood,
affect,
cognition.
Increasing
evidence
has
confirmed
epigenetic
malfunctioning
at
the
core
of
these
two
mental
conditions;
however,
exact
molecular
nature
that
maladaptivity
is
less
known.
Lately,
long
noncoding
RNAs
(lncRNAs)
have
emerged
as
essential
regulators
gene
expression
cellular
processes,
offering
new
avenues
for
exploring
pathophysiology
mood
disorders.
In
this
report,
we
present
a
comprehensive
review
recent
clinical
studies
investigating
involvement
lncRNA
MDD
BD,
emphasizing
their
disease-specific
contribution
potential
biomarkers.
We
explore
dysregulation
specific
lncRNAs
detected
peripheral
blood
samples
individuals
with
disorders,
while
underscoring
significance
diagnosis,
prognosis,
predicting
treatment
response.
Additionally,
provide
future
directions
research
context
