The role of gut and genital microbiota and the estrobolome in endometriosis, infertility and chronic pelvic pain

Human Reproduction Update, Год журнала: 2021, Номер 28(1), С. 92 - 131

Опубликована: Сен. 30, 2021

Endometriosis is a chronic, burdensome condition that historically understudied. Consequently, there lack of understanding the etiology disease and its associated symptoms, including infertility chronic pelvic pain (CPP). development influenced by estrogen metabolism inflammation, which are modulated several factors microbiome estrobolome (the collection genes encoding estrogen-metabolizing enzymes in gut microbiome). Therefore, increasing interest role microbiota endometriosis etiology.To date, no cure for treatment options often ineffective. This manuscript will review potential relationship between endometriosis, CPP highlight available data on relation to related symptoms. The overarching goal this inform future research lead deeper possible diagnostic modalities treatments. impact regulation estrobolome, as well inflammation other endometriosis-promoting mechanisms within genital tract, be reviewed. methodological limitations microbiome-related studies critically assessed provide improved guidelines clinical studies.PubMed databases were searched using following keywords: AND microbiome, IVF (in-vitro fertilization) infertility. Clinical preclinical animal trials eligible review, or included. All manuscripts published 2002-2021.In total, 28 6 included review. In both human studies, bacteria enriched groups, although was clear consensus specific compositions with endometriosis. However, bacterial vaginosis-associated Lactobacillus depletion cervicovaginal majority (23/28) studies. Interpretation endometrial limited owing variety factors, discussed addition, metadata outlining antibiotic usage, age, race/ethnicity, menopausal status timing sample diagnosis not consistently reported. Animal (6/6) support bidirectional onset progression.There evidence dysbiotic multiple gynecologic conditions, mounting supporting an association These microbiomes likely play gut-brain axis, further supports putative spectrum symptoms CPP. Collectively, highlights demand more rigorous transparent methodology controls, consistency across field, inclusion key demographic characteristics comparison participants. Rigorous study designs allow better disorders female reproductive tract.

Язык: Английский

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Gut microbial beta-glucuronidase: a vital regulator in female estrogen metabolism

Gut Microbes, Год журнала: 2023, Номер 15(1)

Опубликована: Авг. 9, 2023

A growing amount of evidence has supported that gut microbiota plays a vital role in the reproductive endocrine system throughout woman's whole life, and microbial β-glucuronidase (gmGUS) is key factor regulating host estrogen metabolism. Moreover, levels also influence composition as well diversity microbiota. In normal condition, gmGUS-estrogen crosstalk maintains body homeostasis physiological level. Once this broken, metabolism will be disturbed, resulting estrogen-related diseases, such gynecological cancers, menopausal syndrome, etc. together with dysbiosis, which may accelerate these pathological processes. review, we highlight regulatory gmGUS on physical summarize present interaction between metabolism, unwrap potential mechanisms behind them. Finally, become biomarker for early diagnosis estrogen-induced diseases. Regulating activity or transplanting gmGUS-producing microbes shows promise treating

Язык: Английский

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Gut Microbiota and Breast Cancer: The Dual Role of Microbes

Cancers, Год журнала: 2023, Номер 15(2), С. 443 - 443

Опубликована: Янв. 10, 2023

Breast cancer is the most frequently diagnosed and also one of leading causes mortality among women. The genetic environmental factors known to date do not fully explain risk developing this disease. In recent years, numerous studies have highlighted dual role gut microbiota in preservation host health development different pathologies, them. Our capable producing metabolites that protect homeostasis but can produce molecules with deleterious effects, which, turn, may trigger inflammation carcinogenesis, even affect immunotherapy. purpose review describe mechanisms by which cause general, breast particular, compile clinical trials address alterations or changes women cancer.

Язык: Английский

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Microbial Therapy and Breast Cancer Management: Exploring Mechanisms, Clinical Efficacy, and Integration within the One Health Approach

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(2), С. 1110 - 1110

Опубликована: Янв. 16, 2024

This comprehensive review elucidates the profound relationship between human microbiome and breast cancer management. Recent findings highlight significance of microbial alterations in tissue, such as gut breast, their role influencing risk, development, progression, treatment outcomes. We delve into how can modulate systemic inflammatory responses estrogen levels, thereby impacting initiation therapeutic drug efficacy. Furthermore, we explore unique diversity within indicating potential imbalances brought about by highlighting specific microbes promising targets. Emphasizing a holistic One Health approach, this underscores importance integrating insights from human, animal, environmental health to gain deeper understanding complex microbe-cancer interplay. As field advances, strategic manipulation its metabolites presents innovative prospects for enhancement diagnostics therapeutics. However, rigorous clinical trials remain essential confirm microbiota-based interventions

Язык: Английский

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Molecular crosstalk between polyphenols and gut microbiota in cancer prevention

Nutrition Research, Год журнала: 2024, Номер 124, С. 21 - 42

Опубликована: Янв. 27, 2024

Язык: Английский

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The Microbiota of the Human Mammary Ecosystem

Frontiers in Cellular and Infection Microbiology, Год журнала: 2020, Номер 10

Опубликована: Ноя. 20, 2020

Human milk contains a dynamic and complex site-specific microbiome, which is not assembled in an aleatory way, formed by organized microbial consortia networks. Presence of some genera, such as Staphylococcus, Streptococcus, Corynebacterium, Cutibacterium (formerly known Propionibacterium ), Lactobacillus , Lactococcus Bifidobacterium has been detected both culture-dependent culture-independent approaches. DNA from gut-associated strict anaerobes also repeatedly found studies have revealed the presence cells and/or nucleic acids viruses, archaea, fungi protozoa human milk. Colostrum microbes are transmitted to infant and, therefore, they among first colonizers gut. Still, significance gut colonization remains open question. Clinical trying elucidate question confounded profound impact non-microbial components intestinal microecology. Modifications microbiota may biological consequences for colonization, metabolism, immune neuroendocrine development, mammary health. However, factors driving differences composition microbiome remain poorly known. In addition colostrum milk, breast tissue lactating non-lactating women contain microbiota, with implications pathogenesis cancer adverse outcomes associated implants. This other issues, origin current limitations future prospects addressed this review.

Язык: Английский

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Impact of the Gut Microbiota Balance on the Health–Disease Relationship: The Importance of Consuming Probiotics and Prebiotics

Foods, Год журнала: 2021, Номер 10(6), С. 1261 - 1261

Опубликована: Июнь 2, 2021

Gut microbiota is a group of microorganisms that are deposited throughout the entire gastrointestinal tract. Currently, thanks to genomic tools, studies gut have pointed towards understanding metabolism important bacteria not cultivable and their relationship with human homeostasis. Alterations in composition could explain, at least part, some epidemics, such as diabetes obesity. Likewise, dysbiosis has been associated disorders, neurodegenerative diseases, even cancer. That why several recently focused on direct these types conditions specific microbiota, case microbiota–intestine–brain axis. In same way, control related diet. Therefore, this review highlights importance from its health–disease condition, well emphasizes effect probiotic prebiotic consumption balance composition.

Язык: Английский

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The Gut Microbiome and Female Health

Biology, Год журнала: 2022, Номер 11(11), С. 1683 - 1683

Опубликована: Ноя. 21, 2022

The possession of two X chromosomes may come with the risk various illnesses, females are more likely to be affected by osteoarthritis, heart disease, and anxiety. Given reported correlations between gut microbiome dysbiosis female is worthy exploration. Herein, we discuss composition microbiota its in pathologies affecting population. Using PubMed, performed a literature search, using key terms, namely: “gut microbiome”, “estrogen”, “menopause”, “polycystic ovarian syndrome”, “pregnancy”, “menstruation”. In polycystic syndrome (PCOS), abundance Bacteroides vulgatus, Firmicutes, Streptococcus, ratio Escherichia/Shigella was found increased while that Tenericutes ML615J-28, 124-7, Akkermansia, Ruminococcaceae, Bacteroidetes S24-7 reduced. breast cancer, Clostridiales enhanced, cervical Prevotella, Porphyromonas, Dialister were enhanced but Bacteroides, Alistipes, members Lachnospiracea, decreased. Prevotella increased. Interestingly, administration Lactobacillus acidophilus, Bifidobacterium bifidum, reuteri, fermentum ameliorated PCOS symptoms mix lactis W51, bifidum W23, brevis W63, W52, salivarius W24, acidophilus W37, Lactococcus W19, casei W56, W58 alleviated vascular malfunction arterial stiffness obese postmenopausal women, finally, further research needed, maybe protective against bone mass loss. As several studies report therapeutic potential probiotics since certain pathological states has been relatively characterized, speculate bacterial species as warranted, novel independent or adjunct therapies for pathologies.

Язык: Английский

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Microbiome composition indicate dysbiosis and lower richness in tumor breast tissues compared to healthy adjacent paired tissue, within the same women

BMC Cancer, Год журнала: 2022, Номер 22(1)

Опубликована: Янв. 3, 2022

Breast cancer (BC) is the most common malignancy in women, whom it reaches 20% of total neoplasia incidence. Most BCs are considered sporadic and a number factors, including familiarity, age, hormonal cycles diet, have been reported to be BC risk factors. Also gut microbiota plays role breast development. In fact, its imbalance has associated various human diseases although consequential cause-effect phenomenon never proven.The aim this work was characterize tissue microbiome 34 women affected by using an NGS-based method, analyzing tumoral adjacent non-tumoral each patient.The healthy tumor tissues differed bacterial composition richness: Amplicon Sequence Variants (ASVs) higher than (p = 0.001). Moreover, our analyses, able investigate from phylum down species taxa for sample, revealed major differences two richest phyla, namely, Proteobacteria Actinobacteria. Notably, levels Actinobacteria were, respectively, lower with respect tissues.Our study provides information about microbial composition, as compared very closely (paired samples within same woman); found such possible diagnostic therapeutic implications; further studies necessary clarify if simply association or concausative pathogenetic effect BC. A comparison different results on similar seems not assess universal signature, but single ones depending environmental cohorts' locations.

Язык: Английский

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Analysis of Gut Microbiota in Patients with Breast Cancer and Benign Breast Lesions

Polish Journal of Microbiology, Год журнала: 2022, Номер 71(2), С. 217 - 226

Опубликована: Май 31, 2022

Breast cancer (BC) and benign breast lesions (BBLs) are common diseases in women worldwide. The gut microbiota plays a vital role regulating diseases' formation, progression, therapy response. Hence, we explored the structure function of microflora patients with BC BBLs. A cohort 66 subjects was enrolled study. Twenty-six had BC, 20 BBLs, matched healthy controls. High throughput 16S ribosomal RNA (16S rRNA) gene sequencing technology used to determine microbial community structure. Compared individuals, significantly lower alpha diversity indices (Sobs index, p = 0.019; Chao1 0.033). Sobs were also BBLs than without statistical significance (p 0.279, 0.314, respectively). Both unweighted weighted UniFrac analysis showed that beta differed among three groups 3.376e-14, < 0.001, levels Porphyromonas Peptoniphilus higher 0.004, 0.007, respectively), whereas Escherichia Lactobacillus more enriched lesion group 0.011, Our study indicates may undergo significant changes intestinal microbiota. These findings can help elucidate flora patients.

Язык: Английский

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