Postharvest Biology and Technology, Год журнала: 2023, Номер 204, С. 112441 - 112441
Опубликована: Июль 3, 2023
Язык: Английский
Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Июнь 15, 2024
Abstract Exposure to ambient air pollution has significant adverse health effects; however, whether is associated with urological cancer largely unknown. We conduct a systematic review and meta-analysis epidemiological studies, showing that 5 μg/m 3 increase in PM 2.5 exposure 6%, 7%, 9%, increased risk of overall urological, bladder, kidney cancer, respectively; 10 NO 2 linked 3%, 4%, 4% higher prostate respectively. Were these associations reflect causal relationships, lowering levels 5.8 could reduce the age-standardized rate by 1.5 ~ 27/100,000 across 15 countries highest level from top 30 burden. Implementing global policies can improve quality potentially urologic alleviate its
Язык: Английский
Процитировано
11
Communications Biology, Год журнала: 2023, Номер 6(1)
Опубликована: Июль 3, 2023
Abstract Hepatitis B virus (HBV) may integrate into the genome of infected cells and contribute to hepatocarcinogenesis. However, role HBV integration in hepatocellular carcinoma (HCC) development remains unclear. In this study, we apply a high-throughput sequencing approach that allows sensitive identification sites enumeration clones. We identify 3339 paired tumour non-tumour tissue samples from 7 patients with HCC. detect 2107 clonally expanded integrations (1817 290 tissues), significant enrichment clonal mitochondrial DNA (mtDNA) preferentially occurring oxidative phosphorylation genes (OXPHOS) D-loop region. also find RNA sequences are imported mitochondria hepatoma involvement polynucleotide phosphorylase (PNPASE), might have process mtDNA. Our results suggest potential mechanism by which HCC development.
Язык: Английский
Процитировано
18
Cellular Signalling, Год журнала: 2024, Номер 122, С. 111329 - 111329
Опубликована: Авг. 5, 2024
Язык: Английский
Процитировано
7
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Март 6, 2024
This comprehensive review delves into the complex interplay between mitochondrial gene defects and pancreatic cancer pathogenesis through a multiomics approach. By amalgamating data from genomic, transcriptomic, proteomic, metabolomic studies, we dissected mechanisms by which genetic variations dictate progression. Emphasis has been placed on roles of these genes in altering cellular metabolic processes, signal transduction pathways, immune system interactions. We further explored how findings could refine therapeutic interventions, with particular focus precision medicine applications. analysis not only fills pivotal knowledge gaps about anomalies but also paves way for future investigations personalized therapy options. finding underscores crucial nexus genetics oncological immunology, opening new avenues targeted treatment strategies.
Язык: Английский
Процитировано
6
Open Medicine, Год журнала: 2023, Номер 18(1)
Опубликована: Янв. 1, 2023
Uterine cervical intraepithelial abnormalities and cancer development may also depend upon biological problems that arise as a result of complex molecular disturbances within the vaginal space, in addition to widely known causative effect human papillomavirus (HPV) infection. Chronic oxidative stress is consequence oxygen reduction space. Reactive species (ROS) free radicals are yet unrecognizable agents probably very important factors for neoplasia (CIN) development. The intermediate compounds on these metabolic pathways superoxide anion (O2˙-), hydrogen peroxide (H2O2), hydroxide ions (OH-), hydroxyl radical (HO˙). Considering points, aim this work was summarize how can damage all molecules, including DNA, vulnerable metaplastic epithelium. Finally, some women with poor immune defense system, ROS alone or accompanied by high-risk HPV type promote levels CIN
Язык: Английский
Процитировано
15
Cytokine & Growth Factor Reviews, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Cell and Developmental Biology, Год журнала: 2021, Номер 9
Опубликована: Ноя. 3, 2021
Mitosis ensures genome integrity by mediating precise segregation of the duplicated genetic material. Segregation subcellular organelles during mitosis also needs to be tightly coordinated in order warrant their proper inheritance and cellular homeostasis. The mitochondria, a powerhouse cell, is regulated meet high energy demand fuel mitotic machinery. Mitochondria are highly dynamic organelles, which undergo events fission, fusion transport different cell cycle stages. Importantly, several kinases phosphorylate key mitochondrial factors drive fragmentation mitochondria allow for efficient distribution two daughter cells. Recent evidence suggests that fission can actively contribute regulation progression. This review aims at summarizing established emerging concepts about complex regulatory networks couple crucial dynamics could implicated human disease.
Язык: Английский
Процитировано
31
Journal of Translational Medicine, Год журнала: 2023, Номер 21(1)
Опубликована: Июль 17, 2023
Abstract Background Interleukin-1 receptor antagonist (IL-1RA), a member of the IL-1 family, has diverse roles in cancer development. However, role IL-1RA oral squamous cell carcinoma (OSCC), particular underlying mechanisms, remains to be elucidated. Methods Tumor tissues from OSCC patients were assessed for protein expression by immunohistochemistry. Patient survival was evaluated Kaplan–Meier curve analysis. Impact differential on cultured lines vitro clonogenic survival, tumorsphere formation, soft agar colony and transwell migration invasion assays. Oxygen consumption rate measured Seahorse analyzer or multi-mode plate reader. PCR array applied screen human stem cell-related genes, proteome phosphorylation status kinases, Western blot cells. In vivo tumor growth investigated orthotopic xenograft mice, tumors Results Clinical analysis revealed that elevated associated with increased size stage, reduced patient group receiving adjuvant radiotherapy compared without radiotherapy. data supported these observations, showing overexpression growth, migration/invasion abilities, resistance ionizing radiation, whereas knockdown had largely opposite effects. Additionally, we identified EGFR/JNK activation SOX2 modulated downstream mitochondrial metabolism, application complex inhibitors suppressing pathways. Furthermore, treatment cisplatin metformin—a inhibitor conventional therapy type 2 diabetes—reduced IL-1RA-associated as well expression. This inhibitory effect further augmented combination metformin. Conclusions The current study suggests promoted malignancy through metabolism-mediated Inhibition this metabolic pathway may present potential therapeutic strategy OSCC.
Язык: Английский
Процитировано
11
Medicinal Research Reviews, Год журнала: 2023, Номер 44(3), С. 1121 - 1146
Опубликована: Дек. 26, 2023
Cancer heterogeneity remains a significant challenge for effective cancer treatments. Altered energetics is one of the hallmarks and influences tumor growth drug resistance. Studies have shown that exists within metabolic profile tumors, personalized-combination therapy with relevant interventions could improve patient response. Metabolomic studies are identifying novel biomarkers therapeutic targets improved treatment The spatial location elements in microenvironment becoming increasingly important understanding disease progression. evolution metabolomics analysis now allows scientists to deeply understand how metabolite distribution contributes biology. Recently, these techniques spatially resolved subcellular level. It has been proposed mapping outcomes by improving precision medicine, enabling earlier diagnosis intraoperatively margins. This review will discuss altered pathways contribute progression resistance explore current capabilities technologies be integrated into clinical practice outcomes.
Язык: Английский
Процитировано
11
Antioxidants, Год журнала: 2025, Номер 14(1), С. 115 - 115
Опубликована: Янв. 20, 2025
The role of mitochondria as the electric engine cells is well established. Over past two decades, accumulating evidence has pointed out that, despite presence a highly active glycolytic pathway (Warburg effect), functional and even upregulated mitochondrial respiration occurs in cancer to meet need high energy biosynthetic demand sustain their anabolic growth. Mitochondria are also primary source intracellular ROS. Cancer maintain moderate levels ROS promote tumorigenesis, metastasis, drug resistance; indeed, once cytotoxicity threshold exceeded, trigger oxidative damage, ultimately leading cell death. Based on this, metabolic functions generation considered attractive targets synthetic natural anticancer compounds. Tocotrienols (TTs), specifically δ- γ-TT isoforms, vitamin E-derived biomolecules widely shown possess striking properties since they regulate several molecular pathways. Herein, we provide for first time an overview reprogramming redox homeostasis perturbation occurring cells, highlighting involvement TTs. This sheds light use these compounds promising preventive or therapeutic approach novel strategies.
Язык: Английский
Процитировано
0