lncRNA involvement in cancer stem cell function and epithelial-mesenchymal transitions

Seminars in Cancer Biology, Год журнала: 2020, Номер 75, С. 38 - 48

Опубликована: Дек. 18, 2020

Язык: Английский

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Extracellular vesicles and anti-cancer drug resistance

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2018, Номер 1870(2), С. 123 - 136

Опубликована: Июль 10, 2018

Extracellular vesicles (EVs) including exosomes, microvesicles, oncosomes, and microparticles have been associated with communicating anti-cancer drug-resistance. The in vitro, pre-clinical vivo patients' data linking EVs to drug-resistance (and the specific drugs involved) breast cancer, prostate lung ovarian haematological malignancies, colorectal gastric pancreatic glioblastoma, neuroblastoma, melanoma, kidney cancer osteosarcoma. Details of mechanisms by which resistance seems be occurring (e.g. transferring drug-efflux pumps from drug-resistant cells, binding monoclonal antibodies peripheral circulation so reducing their bioavailability, tumour microenvironment etc.) are outlined, as efforts try block such resistance. Research date strongly supports playing a key role Further studies tailored clinical now warranted determine how best prevent this occurring, interest patients also for economic benefit. Furthermore, exploit safe (non-cancer origin) drug delivery vehicles that may achieve efficacy more limited side-effects than free drug, deserve further investigation.

Язык: Английский

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Molecular Landscape of LncRNAs in Prostate Cancer: A focus on pathways and therapeutic targets for intervention

Journal of Experimental & Clinical Cancer Research, Год журнала: 2022, Номер 41(1)

Опубликована: Июль 1, 2022

Abstract Background One of the most malignant tumors in men is prostate cancer that still incurable due to its heterogenous and progressive natures. Genetic epigenetic changes play significant roles development. The RNA molecules with more than 200 nucleotides length are known as lncRNAs these factors do not encode protein. They regulate gene expression at transcriptional, post-transcriptional levels. LncRNAs vital biological functions cells pathological events, hence their undergoes dysregulation. Aim review role alterations development emphasized here. Therefore, were chosen for this purpose level interaction other signaling networks progression examined. Key scientific concepts aberrant has been well-documented rate tumor regulated via affecting STAT3, NF-κB, Wnt, PI3K/Akt PTEN, among molecular pathways. Furthermore, radio-resistance chemo-resistance features cells. Overexpression tumor-promoting such HOXD-AS1 CCAT1 can result drug resistance. Besides, induce immune evasion upregulating PD-1. Pharmacological compounds quercetin curcumin have applied targeting lncRNAs. siRNA tool reduce thereby suppressing progression. Prognosis diagnosis clinical course be evaluated by exosomal lncRNA-p21 investigated serum patients a reliable biomarker.

Язык: Английский

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The Epithelial–Mesenchymal Transition at the Crossroads between Metabolism and Tumor Progression

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(2), С. 800 - 800

Опубликована: Янв. 12, 2022

The transition between epithelial and mesenchymal phenotype is emerging as a key determinant of tumor cell invasion metastasis. It plastic process in which cells first acquire the ability to invade extracellular matrix migrate into bloodstream via transdifferentiation cells, phenomenon known epithelial–mesenchymal (EMT), then reacquire phenotype, reverse called mesenchymal–epithelial (MET), colonize new organ. During all metastatic stages, metabolic changes, give cancer adapt increased energy demand withstand hostile environment, are also important determinants successful progression. In this review, we describe complex interaction EMT metabolism during First, outline main connections two processes, with particular emphasis on role stem LncRNAs. Then, focus some specific cancers, such breast, lung, thyroid cancer.

Язык: Английский

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Knockdown of SOX2OT inhibits the malignant biological behaviors of glioblastoma stem cells via up-regulating the expression of miR-194-5p and miR-122

Molecular Cancer, Год журнала: 2017, Номер 16(1)

Опубликована: Ноя. 13, 2017

Abstract Background Accumulating evidence has highlighted the potential role of long non-coding RNAs (lncRNAs) in biological behaviors glioblastoma stem cells (GSCs). Here, we elucidated function and possible molecular mechanisms effect lncRNA-SOX2OT on GSCs. Results Real-time PCR demonstrated that SOX2OT expression was up-regulated glioma tissues Knockdown inhibited proliferation, migration invasion GSCs, promoted GSCs apoptosis. MiR-194-5p miR-122 were down-regulated human miR-194-5p respectively exerted tumor-suppressive functions by inhibiting while promoting significantly increased Dual-luciferase reporter assay revealed bound to both miR-122. SOX3 TDGF-1 apoptosis, decreased mRNA protein through direct binding promoter. Over-expression targeting its 3’UTR. JAK/STAT signaling pathway. Furthermore, knockdown also promoter formed a positive feedback loop. Conclusion This study is first demonstrate SOX2OT-miR-194-5p/miR-122-SOX3-TDGF-1 pathway forms loop regulates these findings might provide novel strategy for treatment.

Язык: Английский

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Long noncoding RNAs as regulators of cancer immunity

Molecular Oncology, Год журнала: 2018, Номер 13(1), С. 61 - 73

Опубликована: Ноя. 30, 2018

Long noncoding RNAs (lncRNAs) are increasingly known to be important in cancer as they directly interact with the cell cycle, proliferation pathways and microbiome balance. Moreover, lncRNAs regulate immune system: do not encode proteins of innate or adaptive immunity, but differentiation function, such dendritic activity, T ratio metabolism. The result this complex interaction is that processes through a multimodal system involving metabolism infection. possible functions their roles regulation immunity will reported discussed present review. Recent studies showed function regulators tumour microenvironment (TME), epithelial-mesenchymal transition, microbiota, differentiation. However, there much knowledge regarding regulation. Thus, main aim review describe have specifically been associated cycle TME.

Язык: Английский

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The emerging role of lncRNAs in inflammatory bowel disease

Experimental & Molecular Medicine, Год журнала: 2018, Номер 50(12), С. 1 - 14

Опубликована: Дек. 1, 2018

Abstract Dysregulation of long noncoding RNA (lncRNA) expression is linked to the development various diseases. Recently, an emerging body evidence has indicated that lncRNAs play important roles in pathogenesis inflammatory bowel diseases (IBDs), including Crohn’s disease (CD) and ulcerative Colitis (UC). In IBD, have been shown be involved diverse processes, regulation intestinal epithelial cell apoptosis, association with lipid metabolism, cell–cell interactions, thereby enhancing inflammation functional regulatory T cells. this review, we aim summarize current knowledge regarding role IBD highlight potential avenues for future investigation. We also collate potentially immune-relevant, IBD-associated identified through a built-by analysis respect their neighboring protein-coding genes within IBD-susceptible loci. further underscore importance by highlighting enrichment aspects immune system regulation, antigen processing/presentation, proliferation differentiation, chronic responses. Finally, as diagnostic biomarkers IBD.

Язык: Английский

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LncRNAs as potential diagnostic and prognostic biomarkers in gastric cancer: A novel approach to personalized medicine

Journal of Cellular Physiology, Год журнала: 2019, Номер 235(4), С. 3189 - 3206

Опубликована: Окт. 8, 2019

Abstract Gastric cancer is the third leading cause of death with 5‐year survival rate about 30–35%. Since early detection associated decreased mortality, identification novel biomarkers for diagnosis and proper management patients best response to therapy urgently needed. Long noncoding RNAs (lncRNAs) due their high specificity, easy accessibility in a noninvasive manner, as well aberrant expression under different pathological physiological conditions, have received great attention potential diagnostic, prognostic, or predictive biomarkers. They may also serve targets treating gastric cancer. In this review, we highlighted role lncRNAs tumor suppressors oncogenes that make them prognosis Relatively, such H19 , HOTAIR UCA1 PVT1 tissue differentiation‐inducing nonprotein coding, LINC00152 could be diagnostic prognostic markers Also, impact ecCEBPA MLK7‐AS1 TUG1 HOXA11‐AS GAPLINC LEIGC multidrug resistance‐related upregulated lncRNA, on epigenetic drug resistance therapeutic personalized medicine was discussed.

Язык: Английский

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Thyroid cancer stem-like cell exosomes: regulation of EMT via transfer of lncRNAs

Laboratory Investigation, Год журнала: 2018, Номер 98(9), С. 1133 - 1142

Опубликована: Июль 2, 2018

Язык: Английский

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Roles of E-cadherin and Noncoding RNAs in the Epithelial–mesenchymal Transition and Progression in Gastric Cancer

International Journal of Molecular Sciences, Год журнала: 2019, Номер 20(12), С. 2870 - 2870

Опубликована: Июнь 12, 2019

The epithelial–mesenchymal transition (EMT) is thought to be at the root of invasive and metastatic cancer cell spreading. E-cadherin an important player in this process, which forms structures that establish maintain cell–cell interactions. A partial or complete loss expression EMT presumably mediated by mechanisms block regulators involve E-cadherin-associated transcription factors. protein involved several oncogenic signaling pathways, such as Wnt/β-catenin, Rho GTPase, EGF/EGFR, whereby it plays a role many tumors, including gastric cancer. Such noncoding transcripts microRNAs long RNAs—critical components epigenetic control gene carcinogenesis—contribute regulation function acting directly through numerous factors controlling its gene, thus affecting not only proliferation metastasis, but also EMT. This review focuses on non-coding RNAs-mediated expressional during stomach carcinogenesis.

Язык: Английский

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