Exploration of neuroscience,
Journal Year:
2025,
Volume and Issue:
4
Published: March 24, 2025
The
SAR-CoV-2
virus
has
evolved
to
co-exist
with
human
hosts,
albeit
at
a
substantial
energetic
cost
resulting
in
post-infection
neurological
manifestations
[Neuro-post-acute
sequelae
of
SARS-CoV-2
infection
(PASC)]
that
significantly
impact
public
health
and
economic
productivity
on
global
scale.
One
the
main
molecular
mechanisms
responsible
for
development
Neuro-PASC,
individuals
all
ages,
is
formation
inadequate
proteolysis/clearance
phase-separated
amyloid
crystalline
aggregates—a
hallmark
feature
aging-related
neurodegenerative
disorders.
Amyloidogenesis
during
viral
persistence
natural,
inevitable,
protective
defense
response
exacerbated
by
SARS-CoV-2.
Acting
as
chemical
catalyst,
accelerates
hydrophobic
collapse
heterogeneous
nucleation
amorphous
amyloids
into
stable
β-sheet
aggregates.
clearance
aggregates
most
effective
slow
wave
sleep,
when
high
levels
adenosine
triphosphate
(ATP)—a
biphasic
modulator
biomolecular
condensates—and
melatonin
are
available
solubilize
removal.
dysregulation
mitochondrial
dynamics
SARS-CoV-2,
particular
fusion
fission
homeostasis,
impairs
proper
distinct
subpopulations
can
remedy
challenges
created
diversion
substrates
away
from
oxidative
phosphorylation
towards
glycolysis
support
replication
maintenance.
subsequent
reduction
ATP
inhibition
synthesis
sleep
results
incomplete
brain
aggregates,
leading
commonly
associated
age-related
Exogenous
not
only
prevents
dysfunction
but
also
elevates
production,
effectively
augmenting
solubilizing
effect
moiety
ensure
timely,
optimal
disaggregation
pathogenic
prevention
attenuation
Neuro-PASC.
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(4), P. 514 - 514
Published: April 1, 2025
Aging
is
the
result
of
various
compounding
stresses
that
gradually
overcome
homeostatic
regulation
cell,
resulting
in
irreversible
damage.
This
manifests
as
many
acute
and
chronic
conditions,
most
common
which
are
neurodegeneration
dementia.
Epidemiological
studies
have
shown
significant,
strong
correlations
between
viral
infection
neurodegenerative
diseases.
review
overlays
characteristics
pathogenesis
with
hallmarks
aging
to
discuss
how
active
latent
viruses
contribute
aging.
Through
our
contextualization
myriad
basic
science
papers,
we
offer
explanations
for
premature
via
induction
stress
response
pathways.
Viruses
induce
stresses:
dysregulated
homeostasis
by
exogenous
proteins
overwhelmed
protein
quality
control
mechanisms,
DNA
damage
through
direct
integration
epigenetic
manipulation,
immune-mediated
oxidative
immune
exhaustion,
general
energy
theft
amplified
an
system.
Overall,
this
highlights
long-term
importance
vaccines
antivirals
addition
their
benefits.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: July 25, 2024
The
average
lifespan
of
humans
has
been
increasing,
resulting
in
a
rapidly
rising
percentage
older
individuals
and
high
morbidity
aging-associated
diseases,
especially
cardiovascular
diseases
(CVDs).
Diverse
intracellular
extracellular
factors
that
interrupt
homeostatic
functions
the
endoplasmic
reticulum
(ER)
induce
ER
stress.
Cells
employ
dynamic
signaling
pathway
unfolded
protein
response
(UPR)
to
buffer
Recent
studies
have
demonstrated
stress
triggers
various
cellular
processes
associated
with
aging
many
including
CVDs.
Autophagy
is
conserved
process
involving
lysosomal
degradation
recycling
cytoplasmic
components,
proteins,
organelles,
pathogens
invade
cytoplasm.
vital
for
combating
adverse
influence
on
heart.
present
report
summarizes
recent
mechanism
autophagy
their
overlap
CVD
pathogenesis
context
aging.
It
also
discusses
possible
therapeutic
interventions
targeting
might
delay
prevent
or
treat
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 24, 2025
Abstract
Lumpy
skin
disease
(LSD),
caused
by
lumpy
virus
(LSDV),
is
an
emerging
infectious
in
China
that
primarily
affects
cattle.
LSDV
and
goatpox
(GTPV)
belong
to
the
Capripoxvirus
genus
exhibit
high
genomic
homology,
enabling
cross-immunogenicity.
Comparative
genome
analysis
revealed
contains
a
unique
gene,
Orf132,
whose
function
remains
uncharacterized.
In
this
study,
we
first
confirmed
recombinant
ORF132
protein
exhibits
immunoreactivity
against
sera
from
LSDV-infected
cattle
GTPV-vaccinated
cattle,
cross-reactivity
excluded
possibility
of
using
distinguish
between
GTPV.
To
investigate
biological
role
generated
Orf132
deletion
strain
(LSDV-ΔOrf132).
Compared
with
wild-type
LSDV,
replication
capacity
LSDV-ΔOrf132
was
reduced
approximately
tenfold,
indicating
critical
for
viral
replication.
Transcriptomic
infected
MDBK
cells
significant
alterations
Endoplasmic
reticulum(ER)
processing
unfolded
response(UPR)
pathways
following
deletion.
RT-qPCR
validation
showed
marked
upregulation
ER
stress
markers
including
Grp78,
Chop,
Gadd34.
Subsequent
apoptosis
assays
established
triggers
CHOP-Caspase12-mediated
apoptotic
pathways.
This
dysregulated
response
cascade
culminates
premature
scenarios,
possibly
resulting
weakening
Our
findings
collectively
gene
replication,
plays
essential
virus's
life
cycle,
its
significantly
impairs
while
inducing
stress-related
apoptosis.
Acute
HSV-1
infection
is
associated
with
mild
symptom,
such
as
fever
and
lesions
of
the
mouth,
face
skin.
This
phase
followed
by
a
latency
period
before
reactivation
which
symptoms
ranging
from
ulcers
to
encephalitis.
Despite
available
anti-HSV-1
drugs,
development
new
antiviral
agents
sought
due
presence
resistant
viruses.
Melatonin,
molecule
secreted
pineal
gland,
has
been
shown
be
an
antioxidant,
inducer
antioxidant
enzymes,
regulator
various
biological
processes.
Clinical
trials
have
explored
its
therapeutic
utility
in
conditions
including
infections.
study
focuses
on
melatonin's
role
replication
underlying
mechanisms.
Melatonin
was
found
decrease
synthesis
proteins
infected
Vero
cells
measured
inmunofluorescence
indicating
inhibition
replication.
Additionally,
it
regulates
activities
enzymes
affects
proteasome
activity.
activates
unfolded
protein
response
(UPR)
autophagy
suppresses
apoptosis
HSV-1-infected
cells.
In
summary,
melatonin
demonstrates
inhibitory
modulating
cellular
responses,
suggesting
potential
treatment
viral
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(7), P. 4037 - 4037
Published: April 4, 2024
Acute
HSV-1
infection
is
associated
with
mild
symptoms,
such
as
fever
and
lesions
of
the
mouth,
face
skin.
This
phase
followed
by
a
latency
period
before
reactivation,
which
symptoms
ranging
from
ulcers
to
encephalitis.
Despite
available
anti-HSV-1
drugs,
development
new
antiviral
agents
sought
due
presence
resistant
viruses.
Melatonin,
molecule
secreted
pineal
gland,
has
been
shown
be
an
antioxidant,
inducer
antioxidant
enzymes,
regulator
various
biological
processes.
Clinical
trials
have
explored
its
therapeutic
utility
in
conditions
including
infections.
study
focuses
on
melatonin’s
role
replication
underlying
mechanisms.
Melatonin
was
found
decrease
synthesis
proteins
infected
Vero
cells
measured
immunofluorescence,
indicating
inhibition
replication.
Additionally,
it
regulates
activities
enzymes
affects
proteasome
activity.
activates
unfolded
protein
response
(UPR)
autophagy
suppresses
apoptosis
HSV-1-infected
cells.
In
summary,
melatonin
demonstrates
inhibitory
modulating
cellular
responses,
suggesting
potential
treatment
viral
npj Viruses,
Journal Year:
2024,
Volume and Issue:
2(1)
Published: Dec. 17, 2024
Positive-sense
single-stranded
RNA
(+ssRNA)
viruses
exert
a
profound
influence
on
cellular
organelles
and
metabolic
pathway
by
usurping
host
processes
to
promote
their
replication.
In
this
review,
we
present
portrait
of
selected
pathways
perturbed
in
SARS-CoV-2
infection:
the
effect
viral
translation,
replication
assembly
morphology
function
ER,
remodelling
degradative
with
focus
autophagic
processes,
alterations
affecting
membranes
lipid
metabolism.
For
each
these
highlight
specific
factors
involved
interplay
microscopic
tug-of-war
between
pro-viral
anti-viral
effects
that
ultimately
tip
scale
toward
propagation
or
resolution
infection.
