Frontiers in Pharmacology,
Год журнала:
2022,
Номер
13
Опубликована: Май 26, 2022
Immune
abnormality
involves
in
various
diseases,
such
as
infection,
allergic
autoimmune
well
transplantation.
Several
signal
pathways
have
been
demonstrated
to
play
a
central
role
the
immune
response,
including
JAK/STAT,
NF-κB,
PI3K/AKT-mTOR,
MAPK,
and
Keap1/Nrf2/ARE
pathway,
which
multiple
targets
used
develop
immunosuppressive
agents.
In
recent
years,
varieties
of
agents
approved
for
clinical
use,
JAK
inhibitor
tofacitinib
mTOR
everolimus,
shown
good
therapeutic
effects.
Additionally,
many
are
still
trials
or
preclinical
studies.
this
review,
we
classified
according
immunopharmacological
mechanisms,
summarized
phase
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(10), С. 5556 - 5556
Опубликована: Май 20, 2024
The
most
common
malignancy
in
women
is
breast
cancer.
During
the
development
of
cancer,
oncogenic
transcription
factors
facilitate
overproduction
inflammatory
cytokines
and
cell
adhesion
molecules.
Antiapoptotic
proteins
are
markedly
upregulated
cancer
cells,
which
promotes
tumor
development,
metastasis,
survival.
Promising
findings
have
been
found
studies
on
cycle-mediated
apoptosis
pathway
for
medication
treatment.
Dietary
phytoconstituents
studied
great
detail
their
potential
to
prevent
by
triggering
body’s
defense
mechanisms.
underlying
mechanisms
action
may
be
clarified
considering
role
polyphenols
important
signaling
pathways.
Phenolic
acids,
flavonoids,
tannins,
coumarins,
lignans,
lignins,
naphthoquinones,
anthraquinones,
xanthones,
stilbenes
examples
natural
chemicals
that
being
anticancer
drugs.
These
substances
also
vital
This
review
focuses
innovations
study
polyphenol
genistein’s
effects
cells
presents
integrated
chemical
biology
methods
harness
therapeutic
advances.
Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Сен. 9, 2022
Dietary
polyphenol
treatment
of
non-alcoholic
fatty
liver
disease
(NAFLD)
is
a
novel
direction,
and
the
existing
clinical
studies
have
little
effective
evidence
for
its
therapeutic
effect,
some
inconsistent
results.
The
effectiveness
dietary
polyphenols
in
NAFLD
still
controversial.
aim
this
study
was
to
evaluate
efficacy
oral
patients
with
NAFLD.The
literature
(both
Chinese
English)
published
before
30
April
2022
PubMed,
Cochrane,
Medline,
CNKI,
other
databases
on
searched.
Manual
screening,
quality
assessment,
data
extraction
search
results
were
conducted
strictly
according
inclusion
exclusion
criteria.
RevMan
5.3
software
used
perform
meta-analysis.The
RCTs
included
involved
supplementation
eight
(curcumin,
resveratrol,
naringenin,
anthocyanin,
hesperidin,
catechin,
silymarin,
genistein)
2,173
participants.
This
systematic
review
meta-analysis
found
that
1)
curcumin
may
decrease
body
mass
index
(BMI),
Aspartate
aminotransferase
(AST),
Alanine
(ALT),
Triglycerides
(TG)
total
cholesterol
(TC),
Homeostasis
Model
Assessment-Insulin
Resistance
(HOMA-IR)
compared
placebo;
does
not
increase
occurrence
adverse
events.
2)
Although
all
randomized
controlled
trials
(RCTs)
did
reveal
significant
positive
changes,
individual
showed
meaningful
3)
Naringenin
significantly
decreased
percentage
grade,
TG,
TC,
low-density
lipoprotein
(LDL-C)
increased
high-density
(HDL-C)
but
had
no
effect
AST
ALT,
it
safe
supplementation.
4)
Only
one
team
presents
protocol
about
anthocyanin
(from
Cornus
mas
L.
fruit
extract)
NAFLD.
5)
Hesperidin
BMI,
AST,
HOMA-IR,
so
on.
6)
Catechin
TG
level,
well
tolerated
by
patients.
7)
Silymarin
improving
ALT
reducing
hepatic
fat
accumulation
stiffness
patients.Based
current
evidence,
can
reduce
enzymes,
insulin
resistance;
catechin
resistance,
effectively;
silymarin
enzymes.
For
more
are
needed
further
their
safety.
Frontiers in Cell and Developmental Biology,
Год журнала:
2022,
Номер
10
Опубликована: Сен. 29, 2022
In
today’s
scenario,
when
cancer
cases
are
increasing
rapidly,
anticancer
herbal
compounds
become
imperative.
Studies
on
the
molecular
mechanisms
of
action
polyphenols
published
in
specialized
databases
such
as
Web
Science,
Pubmed/Medline,
Google
Scholar,
and
Science
Direct
were
used
sources
information
for
this
review.
Natural
provide
established
efficacy
against
chemically
induced
tumor
growth
with
fewer
side
effects.
They
can
sensitize
cells
to
various
therapies
increase
effectiveness
biotherapy.
Further
pharmacological
translational
research
clinical
trials
needed
evaluate
theirs
vivo
efficacy,
possible
effects
toxicity.
Polyphenols
be
design
a
potential
treatment
conjunction
existing
drug
regimens
chemotherapy
radiotherapy.
Chemistry & Biodiversity,
Год журнала:
2023,
Номер
20(9)
Опубликована: Авг. 7, 2023
With
the
increasing
prevalence
of
cancer
and
toxic
side
effects
synthetic
drugs,
natural
products
are
being
developed
as
promising
therapeutic
approaches.
Gracillin
is
a
naturally
occurring
triterpenoid
steroidal
saponin
with
several
activities.
It
obtained
major
compound
from
different
Dioscorea
species.
This
review
was
designated
to
summarize
research
progress
on
anti-cancer
activities
gracillin
focusing
underlying
cellular
molecular
mechanisms,
well
its
pharmacokinetic
features.
The
data
were
collected
(up
date
May
1,
2023)
various
reliable
authentic
literatures
comprising
PubMed,
Springer
Link,
Scopus,
Wiley
Online,
Web
Science,
ScienceDirect,
Google
Scholar.
findings
demonstrated
that
displays
anticancer
through
including
anti-inflammatory
effects,
apoptotic
cell
death,
induction
oxidative
stress,
cytotoxicity,
genotoxicity,
cycle
arrest,
anti-proliferative
effect,
autophagy,
inhibition
glycolysis,
blocking
migration.
Additionally,
this
highlighted
features
gracillin,
indicating
lower
oral
bioavailability.
As
conclusion,
it
can
be
proposed
could
serve
hopeful
chemotherapeutic
agent.
However,
further
extensive
clinical
recommended
establish
safety,
efficacy,
potential
in
treatment.
The Journal of Nutritional Biochemistry,
Год журнала:
2023,
Номер
118, С. 109368 - 109368
Опубликована: Апрель 25, 2023
The
human
gut
is
a
host
for
trillions
of
microorganisms,
divided
into
more
than
3,000
heterogeneous
species
that
called
the
microbiota.
microbiota
composition
can
be
altered
by
many
different
endogenous
and
exogenous
factors,
especially
diet
nutrition.
A
rich
in
phytoestrogens,
variable
group
chemical
compounds
similar
to
17-β-estradiol
(E2),
essential
female
steroid
sex
hormone
potent
change
However,
metabolism
phytoestrogens
also
highly
depends
on
action
enzymes
produced
Novel
studies
have
shown
could
play
an
important
role
treatment
types
cancers,
such
as
breast
cancer
women,
due
their
potential
decrease
estrogen
levels.
This
review
aims
summarize
recent
findings
about
lively
dialogue
between
address
possible
future
application,
treating
patients
with
diagnosed
cancer.
therapeutic
approach
prevention
improving
outcomes
based
targeted
probiotic
supplementation
use
soy
phytoestrogens.
positive
effect
probiotics
outcome
survival
has
been
established.
vivo
scientific
are
needed
pave
way
clinical
practice
treatment.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Июль 22, 2024
Cancer
refers
to
the
proliferation
and
multiplication
of
aberrant
cells
inside
human
body,
characterized
by
their
capacity
proliferate
infiltrate
various
anatomical
regions.
Numerous
biochemical
pathways
signaling
molecules
have
an
impact
on
cancer
auto
biogenesis
process.
The
regulation
crucial
cellular
processes
necessary
for
cell
survival
proliferation,
which
are
triggered
phytochemicals,
is
significantly
influenced
pathways.
These
or
components
regulated
phytochemicals.
Medicinal
plants
a
significant
reservoir
diverse
anticancer
medications
employed
in
chemotherapy.
effects
phytochemicals
mediated
several
methods,
including
induction
apoptosis,
cessation
cycle,
inhibition
kinases,
prevention
carcinogenic
substances.
This
paper
analyzes
phytochemistry
seven
prominent
plant
constituents,
namely,
alkaloids,
tannins,
flavonoids,
phenols,
steroids,
terpenoids,
saponins,
focusing
involvement
MAPK/ERK
pathway,
TNF
signaling,
death
receptors,
p53,
p38,
actin
dynamics.
Hence,
this
review
has
examined
range
encompassing
structural
characteristics
potential
mechanisms.
It
underscored
significance
plant-derived
bioactive
compounds
cancer,
utilizing
molecular
In
addition,
endeavor
also
seeks
incentivize
scientists
carry
out
clinical
trials
derived
from
plants.
