Treatment of Posttraumatic Stress Disorder: A State-of-the-art Review

Current Neuropharmacology, Год журнала: 2023, Номер 22(4), С. 557 - 635

Опубликована: Май 3, 2023

Abstract: This narrative state-of-the-art review paper describes the progress in understanding and treatment of Posttraumatic Stress Disorder (PTSD). Over last four decades, scientific landscape has matured, with many interdisciplinary contributions to its diagnosis, etiology, epidemiology. Advances genetics, neurobiology, stress pathophysiology, brain imaging have made it apparent that chronic PTSD is a systemic disorder high allostatic load. The current state includes wide variety pharmacological psychotherapeutic approaches, which are evidence-based. However, myriad challenges inherent disorder, such as individual barriers good outcome, comorbidity, emotional dysregulation, suicidality, dissociation, substance use, trauma-related guilt shame, often render response suboptimal. These discussed drivers for emerging novel including early interventions Golden Hours, interventions, medication augmentation use psychedelics, well targeting nervous system. All this aims improve symptom relief clinical outcomes. Finally, phase orientation recognized tool strategize position step progression pathophysiology. Revisions guidelines systems care will be needed incorporate innovative treatments evidence emerges they become mainstream. generation well-positioned address devastating disabling impact traumatic events through holistic, cutting-edge efforts research.

Язык: Английский

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The Burden of Carbohydrates in Health and Disease

Nutrients, Год журнала: 2022, Номер 14(18), С. 3809 - 3809

Опубликована: Сен. 15, 2022

Foods high in carbohydrates are an important part of a healthy diet, since they provide the body with glucose to support bodily functions and physical activity. However, abusive consumption refined, simple, low-quality has direct implication on mental pathophysiology. Then, carbohydrate is postulated as crucial factor development main Western diseases 21st century. We conducted this narrative critical review using MedLine (Pubmed), Cochrane (Wiley), Embase, CinAhl databases MeSH-compliant keywords: evolution, development, phylogenetic, GUT, microbiota, stress, metabolic health, behaviors, disease, cardiovascular anxiety, depression, cancer, chronic kidney failure, allergies, asthma order analyze impact health. Evidence suggests that carbohydrates, especially fiber, beneficial for well-being growth gut microorganisms consequently host symbiotic relationship, producing microbial alterations negative effect health different organic systems. In addition, evidence simple refined mood categories, including alertness tiredness, reinforcing vicious circle. Regarding sugar intake can affect prognosis uncontrolled puts individuals at risk developing syndrome subsequently disease.

Язык: Английский

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New Insights and Potential Therapeutic Interventions in Metabolic Diseases

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(13), С. 10672 - 10672

Опубликована: Июнь 26, 2023

Endocrine homeostasis and metabolic diseases have been the subject of extensive research in recent years. The development new techniques insights has led to a deeper understanding mechanisms underlying these conditions opened up avenues for diagnosis treatment. In this review, we discussed rise diseases, especially Western countries, genetical, psychological, behavioral basis role nutrition physical activity single-cell transcriptomics, gut microbiota, epigenetics, advanced imaging techniques, cell-based therapies diseases. Finally, practical applications derived from information are made.

Язык: Английский

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Physical activity and COVID-19. The basis for an efficient intervention in times of COVID-19 pandemic

Physiology & Behavior, Год журнала: 2021, Номер 244, С. 113667 - 113667

Опубликована: Дек. 1, 2021

Язык: Английский

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Sustainable Development Goals in the COVID-19 Pandemic: A Narrative Review

Sustainability, Год журнала: 2022, Номер 14(13), С. 7726 - 7726

Опубликована: Июнь 24, 2022

The present narrative review aimed to analyze the impact of COVID-19 pandemic on sustainable development goals (SDGS). This information would allow a better comprehension actual state SDGS and more efficient programming in future interventions. To achieve objective study, consensual critical was carried out using both primary sources, such as scientific articles, secondary bibliographic indexes, web pages databases. Sustainable Development Goals are global call action end poverty, close gender gap, protect planet, improve lives people around world. In 2015, United Nations General Assembly adopted 17 part 2030 Agenda for Development, which sets plan 15 years. However, crisis has been turning point achievement these goals, due all its consequences at political, economic, socio-cultural levels. can be used guide research reviews order understand status each SDGs what actions have taken proposed aftermath recent

Язык: Английский

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Mis–Dis Information in COVID-19 Health Crisis: A Narrative Review

International Journal of Environmental Research and Public Health, Год журнала: 2022, Номер 19(9), С. 5321 - 5321

Опубликована: Апрель 27, 2022

In this narrative review, we address the COVID-19 pandemic mis-dis information crisis in which healthcare systems have been pushed to their limits, with collapses occurring worldwide. The context of uncertainty has resulted skepticism, confusion, and general malaise among population. Informing public one major challenges during pandemic. Misinformation is defined as false shared by people who no intention misleading others. Disinformation deliberately created disseminated malicious intentions. To reach a consensus critical review about crisis. A database search was conducted PsychINFO, MedLine (Pubmed), Cochrane (Wiley), Embase CinAhl. Databases used MeSH-compliant keywords COVID-19, 2019-nCoV, Coronavirus 2019, SARS-CoV-2, misinformation, disinformation, information, vaccines, vaccination, origin, target, spread, communication. Both misinformation disinformation can affect population's confidence vaccines (development, safety, efficacy well denial severity SARS-CoV infection). Institutions should take into account that great part success intervention combat relationship power stop processes. response be well-structured addressed from different key points: central level community level, official centralized communication channels. approach multifactorial enhanced collaboration social media companies trustworthy both working or not health care boost message. clearly message based on scientific evidence.

Язык: Английский

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Assessment of Anxiety, Stress, and Depression Among COVID-19 Survivors After 40 Months in the Kurdistan Region of Iraq: An Online Cross-Sectional Study

Cureus, Год журнала: 2024, Номер unknown

Опубликована: Июль 3, 2024

Background and aims: COVID-19 survivors often experience significant pervasive psychological distress. This study aimed to investigate the prevalence demographic factors affecting anxiety, stress, depression levels among in Kurdistan region of Iraq. Method: online cross-sectional was conducted from August 1, 2023 December 17, 2023, Iraq, including Erbil, Sulaymaniyah, Duhok. Purposive sampling used collect data using an survey. The survey included information Depression, Anxiety, Stress Scale - 21 Items (DASS-21). Statistical analysis performed Stata version 12 (StataCorp LLC, College Station, TX), with frequency percentage for categorical variables mean standard deviation quantitative variables. Ordinal regression analyses were assess associations between mental health outcomes. A p-value less than 0.05 considered statistically significant. Results: total 783 participants enrolled study. score anxiety 11.62 ± 4.71, indicating moderate levels. For depression, 11.54 5.21, mild levels, 14.0 5.78, normal Younger individuals (15-27) showed higher stress (Estimate: 18.96, P=0.001) 2.79, compared older age groups. Males reported significantly lower -1.01, P=0.001), -1.29, -0.72, females. Participants a diploma had 0.65, P=0.004) 0.77, P=0.002) those only elementary education. Conclusions: found survivors, To address these issues, it is recommended that policymakers develop targeted interventions. Healthcare providers should focus on early identification treatment, providing personalized counseling support enhance coping mechanisms overall well-being. By implementing measures, outcomes Iraq can be improved.

Язык: Английский

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Perceptions of Stress and Mood Associated With Listening to Music in Daily Life During the COVID-19 Lockdown

JAMA Network Open, Год журнала: 2023, Номер 6(1), С. e2250382 - e2250382

Опубликована: Янв. 10, 2023

Music listening is a universal human experience. People of all ages and cultures often use music to reduce stress improve mood, particularly in times crisis. However, ecologically valid research examining the real-time association with mood during COVID-19 pandemic scarce.

Язык: Английский

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Mental health, risk perception, and coping strategies among healthcare workers in Egypt during the COVID-19 pandemic

PLoS ONE, Год журнала: 2023, Номер 18(2), С. e0282264 - e0282264

Опубликована: Фев. 27, 2023

Coronavirus disease-19 emerged in December 2019. Healthcare workers were exposed to this highly infectious virus during the pandemic and suffered several social psychological consequences, such as anxiety, distress, burnout.To assess depression, coping strategies, risk perception, attitude toward interprofessional teamwork among Egyptian healthcare COVID-19 pandemic.We conducted a cross-sectional online survey which consisted of five sections. The primary outcomes anxiety (GAD-7), depression (PHQ-9), perception towards COVID-19, attitude, strategies pandemic. web-based questionnaire was distributed from 20th April 2020 May 2020. A snowball sampling method used. Regression analysis test relationship between socioeconomic characteristics previously mentioned outcomes.A total 403 participants responded questionnaire. majority females (70.5%) within age group 26-40 years (77.7%), with 2-5 work experience (43.2%). Most pharmacists (33%) physicians (22.1%). Eighty-two (21%) reported moderate severe 79 (19.4%) depressive symptoms. In univariate model, marital status associated (OR 0.47, 95% CI 0.28-0.78), 0.52, 0.32-0.85), an (β = -1.96 -2.72 -1.2). Providing direct care patients lower symptoms (AOR 0.256, 0.094-0.697). More difficulties everyday life professional environment 4.246 3.3, P 0.003 0.01, respectively). Availability mental health facilities at workplace -0.79, -1.24 -0.34) more positive 2.77 1.38-4.15).According our results, mild Egypt, especially physicians. We recommend research targeting Egypt. If proven cost-effective needed, wide-scale screening public campaigns can facilitate effective prevention treatment strategies. addition, availability could alleviate some emergencies improve teamwork.

Язык: Английский

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Review of the unprecedented impact of the COVID-19 pandemic on the occurrence of eating disorders

Current Opinion in Psychiatry, Год журнала: 2022, Номер 35(6), С. 353 - 361

Опубликована: Июль 29, 2022

Purpose of review To the recent literature on impact coronavirus disease-2019 (COVID-19) pandemic incidence and severity symptoms eating disorders (EDs). Recent findings A worrying increase EDs in- outpatients has been reported since COVID-19 began in 2019/2020. Restrictions implemented during to protect populations against increased risk for onset worsening by disrupting exercise routines, social isolation, lack support, limited access healthcare. Substantial increases start have overall (15%), hospital admissions (48%) emergency department visits (11%) EDs, with even higher among women children or adolescents an ED. During pandemic, ED patients ED-specific anxiety, depression suicidal ideations -attempts. Treatments shifted largely toward online methods continuity care, despite concerns about quality care provided difficulties self-monitoring. Our provides preliminary evidence a similar effectiveness treatment prepandemic face-to-face treatment. In-person assessment remains essential detecting those requiring medical admission. Summary Although ongoing COVID-2019 affected mental health globally, research shows that it particularly individuals diagnosis at ED, especially women, adolescents, anorexia nervosa.

Язык: Английский

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