Cardiovascular autonomic dysfunction in “Long COVID”: pathophysiology, heart rate variability, and inflammatory markers

Frontiers in Cardiovascular Medicine, Год журнала: 2023, Номер 10

Опубликована: Сен. 1, 2023

Long COVID is characterized by persistent signs and symptoms that continue or develop for more than 4 weeks after acute COVID-19 infection. Patients with experience a cardiovascular autonomic imbalance known as dysautonomia. However, the underlying pathophysiological mechanisms behind this remain unclear. Current hypotheses include neurotropism, cytokine storms, inflammatory persistence. Certain immunological factors indicate autoimmune dysfunction, which can be used to identify patients at higher risk of COVID. Heart rate variability imbalances in individuals suffering from COVID, measurement non-invasive low-cost method assessing modulation. Additionally, biochemical markers are diagnosing monitoring These improve understanding driving response its effects on sympathetic parasympathetic pathways nervous system. Autonomic may result lower heart variability, impaired vagal activity, substantial sympathovagal imbalance. New research subject must encouraged enhance long-term risks cause

Язык: Английский

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Autoimmunity in Long Covid and POTS

Oxford Open Immunology, Год журнала: 2023, Номер 4(1)

Опубликована: Янв. 1, 2023

Abstract Orthostatic intolerance and other autonomic dysfunction syndromes are emerging as distinct symptom clusters in Long Covid. Often accompanying these common, multi-system constitutional features such fatigue, malaise skin rashes which can signify generalized immune dysregulation. At the same time, multiple autoantibodies identified both Covid-related disorders non-Covid disorders, implying a possible underlying autoimmune pathology. The lack of specificity findings precludes direct interpretations cause association, but their prevalence with its supporting evidence is compelling.

Язык: Английский

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Long-Term Impact of COVID-19 on Heart Rate Variability: A Systematic Review of Observational Studies

Healthcare, Год журнала: 2023, Номер 11(8), С. 1095 - 1095

Опубликована: Апрель 11, 2023

Coronavirus disease 2019 (COVID-19) sequelae (or long COVID) has become a clinically significant concern. Several studies have reported the relationship between heart rate variability (HRV) parameters and COVID-19. This review investigates long-term association COVID-19 HRV parameters. Four electronic databases were searched up to 29 July 2022. We included observational comparing (measurement durations: 1 min or more) in participants with without history of used assessment tools developed by National Heart, Lung, Blood Institute group evaluate methodological quality studies. Eleven cross-sectional compared individuals who recovered from acute infection controls (n = 2197). Most standard deviation normal-to-normal intervals (SDNN) root mean square successive differences. The was not optimal. generally found decreased SDNN parasympathetic activity post-COVID-19 individuals. Compared controls, decreases observed had COVID. emphasized inhibition conditions. Due limitations measuring parameters, findings should be further validated robust prospective longitudinal

Язык: Английский

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The chronification of post-COVID condition associated with neurocognitive symptoms, functional impairment and increased healthcare utilization

Scientific Reports, Год журнала: 2022, Номер 12(1)

Опубликована: Авг. 25, 2022

Post-COVID condition is prevalent in 10-35% of cases outpatient settings, however a stratification the duration and severity symptoms still lacking, adding to complexity heterogeneity definition post-COVID its oucomes. In addition, potential impacts longer disease are not yet clear, along with which risk factors associated chronification beyond initial 12 weeks. this study, follow-up was conducted at 7 15 months after testing SARS-CoV-2 center Geneva University Hospitals. The defined as continuous presence each evaluation timepoint (7 months). Adjusted estimates healthcare utilization, treatment, functional impairment quality life were calculated. Logistic regression models used evaluate associations between predictors. Overall 1383 participants included, mean age 44.3 years, standard deviation (SD) 13.4 61.4% women 54.5% did have any comorbidities. Out positive (n = 767), 37.0% had their test 47.9% resolution second (15 infection), 52.1% persistent considered condition. Individuals an increased utilization resources, more recourse impairment, poorer life. Having several difficulty concentrating symptoms. COVID-19 patients develop varying degrees duration. experience long-term impact on health status, capacity life, requiring special attention, involved care early identification considering

Язык: Английский

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The impact of long COVID on heart rate variability: a cross-sectional study

BMC Infectious Diseases, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 24, 2025

Long-term COVID-19 (LC), which may affect the autonomic nervous system (ANS), is term for symptoms that some patients had an additional month after contracting virus. Therefore, during LC phase, ANS status was evaluated in with mild-to-moderate using heart rate variability (HRV), a measurement of function. A cross-sectional research 173 participants - both positive and negative – conducted. Based on self-reports, were classified as to whether they or not. 5-minute ECG recorder data detection response report used measure ANS. There notable age differences across groups (p = 0.034). Patients under 25 years lower HRV categorized very-low-frequency (VLF) domain 0.012). Compared group without LC, higher number people aberrant neuroactivity 0.048). Mild-to-moderate young middle develop dysfunction one infection.

Язык: Английский

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Body composition and cardiorespiratory fitness in overweight or obese people post COVID-19: A comparative study

Frontiers in Physiology, Год журнала: 2022, Номер 13

Опубликована: Сен. 21, 2022

The present study aimed to evaluate the body composition and cardiorespiratory fitness of overweight or obese people after COVID-19. 171 volunteers both sexes (men, n = 93 women, 78) between 19 65 years old were allocated into three groups according severity their symptoms COVID-19: non-hospitalized people/mild (n 61), hospitalized 58), in an intensive care unit-ICU 52). Two laboratory visits carried out 24 h apart. First, a medical consultation was out, with subsequent measurement weight height (calculation mass index) assessment via electrical bioimpedance. After h, test performed using Bruce protocol, direct gas exchange analysis. Hospitalized individuals had significantly higher values for fat percentage than (p < 0.05). Significantly found heart rate (HR) peak oxygen consumption (VO2peak) who not when compared those ICU distance, ventilation, relationship respiratory quotient test, peripheral saturation (SpO2) observed all Diastolic blood pressure at tenth fifteenth minute post-Bruce participants Based on these results, proposals cardiopulmonary rehabilitation are indispensable considering responses pressure. Monitoring HR, SpO2, necessary during avoid possible physical complications. Volume intensity exercise prescription should respect physiologic adaptation. Given lower conditioning among groups, recovering from health conditions urgent COVID-19 survivors.

Язык: Английский

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Reduced autonomic function in patients with long-COVID-19 syndrome is mediated by cardiorespiratory fitness

Current Problems in Cardiology, Год журнала: 2024, Номер 49(9), С. 102732 - 102732

Опубликована: Июль 1, 2024

Long-COVID-19 syndrome (LCS) exhibits neurological problems such as peripheral neuropathy and autonomic nervous system (ANS) dysfunction. Exercise intolerance and, consequently, low cardiorespiratory fitness (CRF) are some of the most common symptoms LCS. We describe a series individuals exhibiting LCS compared to control group posit that this condition may be related exercise capacity-mediated disruption ANS resulting particularly in intolerance.

Язык: Английский

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Impact of COVID-19 on cardiac autonomic function in healthy young adults: potential role of symptomatology and time since diagnosis

AJP Heart and Circulatory Physiology, Год журнала: 2022, Номер 323(6), С. H1206 - H1211

Опубликована: Ноя. 4, 2022

The potential role of persistent COVID-19 symptoms on cardiac autonomic function in young adults was investigated. We observed no differences heart rate variability or baroreflex sensitivity between controls who never had and those COVID-19, regardless symptomology. However, there were significant relationships measures time since diagnosis, suggesting that COVID-19-related changes are transient young, otherwise healthy adults.

Язык: Английский

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COVID-19 and athletes: Endurance sport and activity resilience study—CAESAR study

Frontiers in Physiology, Год журнала: 2022, Номер 13

Опубликована: Дек. 16, 2022

Background: The COVID-19 pandemic and imposed restrictions influenced athletic societies, although current knowledge about mild consequences on cardiopulmonary physiologic parameters remains inconclusive. This study aimed to assess the impact of inflection exercise test (CPET) performance among endurance athletes (EA) with varied fitness level. Materials Methods: 49 EA (n male = 43, n female 6, mean age 39.94 ± 7.80 yr, height 178.45 cm, weight 76.62 kg; BMI 24.03 kgm −2 ) underwent double treadmill or cycle ergometer CPET body analysis (BA) pre- post-mild infection. Mild infection was defined as: (1) without hospitalization (2) prolonged health complications lasting for &gt;14 days. Speed, power, heart rate (HR), oxygen uptake (VO 2 ), pulmonary ventilation, blood lactate concentration (at anaerobic threshold (AT)), respiratory compensation point (RCP), maximum exertion were measured before after Pearson’s Spearman’s r correlation coefficients Student t-test applied relationship between variables time. Results: anthropometric measurements did not differ significantly COVID-19. There a significant reduction in VO at AT RCP (both p &lt; 0.001). Pre-COVID-19 34.97 6.43 ml kg·min −1 , 43.88 7.31 47.81 7.81 respectively AT, maximal post-COVID-19 32.35 5.93 40.49 6.63 44.97 7.00 maximal. Differences HR ( 0.001) observed. 145.08 10.82 bpm 168.78 9.01 141.12 9.99 165.14 9.74 RCP. Time-adjusted measures showed significance fat (r 0.46, 0.001), mass 0.33, 0.020), cycling power −0.29, 0.045), −0.30, 0.036). Conclusion: A resulted decrease EA’s performance. most changes observed HR. Medical Professionals Training Specialists should be aware order recommend optimal therapeutic methods properly adjust intensity training.

Язык: Английский

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Heart Rate Variability during Virtual Reality Activity in Individuals after Hospitalization for COVID-19: A Cross-Sectional Control Study

Electronics, Год журнала: 2023, Номер 12(8), С. 1925 - 1925

Опубликована: Апрель 19, 2023

(1) Background: COVID-19 can lead to many complications, including cardiorespiratory complications and dysautonomia. This be assessed by heart rate variability (HRV), which reflects the autonomic nervous system. There are different possibilities for physical rehabilitation after COVID, one of that has been growing fast is use Virtual reality (VR) rehabilitation. VR may represent an innovative effective tool minimize deficits could permanent disabilities in patients outpatient services. The aim this protocol establish whether practicing a task using game with body movements influences physiological variables, such as rate, HRV, oxygen saturation, blood pressure, perceptual variables during exercise individuals post-hospitalization COVID. (2) Methods: cross-sectional study evaluated divided into two groups, group healthy control group. Subjects underwent session task, were measured rest, activity, recovery. In addition, considering influence age HRV impact COVID-19, we participants age. (3) Results: all indices both increase sympathetic decrease parasympathetic activity found VR. Additionally, older post-COVID-19 performed worse non-linear indices, peripheral rating perceived exertion (RPE). (4) Conclusions: positively affects therefore utilized secure hospitalization COVID-19. system patients’ post-hospitalization, partly due higher BMI reduced capacity population, affecting their ability perform activities. Other important observations RPE exercise, reflect altered responses. Taken together high reporting fatigue finding, usually lower compared non-VR strengthens potential patients.

Язык: Английский

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