Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)
Опубликована: Июнь 7, 2023
Abstract The coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection has become a global pandemic due to the high viral transmissibility and pathogenesis, bringing enormous burden our society. Most patients infected are asymptomatic or have mild symptoms. Although only small proportion of progressed severe COVID-19 with symptoms including acute respiratory distress syndrome (ARDS), disseminated coagulopathy, cardiovascular disorders, is accompanied mortality rates near 7 million deaths. Nowadays, effective therapeutic patterns for still lacking. It been extensively reported that host metabolism plays essential roles in various physiological processes during virus infection. Many viruses manipulate avoid immunity, facilitate their own replication, initiate pathological response. Targeting interaction between holds promise developing strategies. In this review, we summarize discuss recent studies dedicated uncovering role life cycle aspects entry, assembly, pathogenesis an emphasis on glucose lipid metabolism. Microbiota long also discussed. Ultimately, recapitulate metabolism-modulating drugs repurposed statins, ASM inhibitors, NSAIDs, Montelukast, omega-3 fatty acids, 2-DG, metformin.
Язык: Английский
Процитировано
36Long COVID-19 Pathophysiology: What Do We Know So Far?
Microorganisms, Год журнала: 2023, Номер 11(10), С. 2458 - 2458
Опубликована: Сен. 30, 2023
Long COVID-19 is a recognized entity that affects millions of people worldwide. Its broad clinical symptoms include thrombotic events, brain fog, myocarditis, shortness breath, fatigue, muscle pains, and others. Due to the binding virus with ACE-2 receptors, expressed in many organs, it can potentially affect any system; however, most often cardiovascular, central nervous, respiratory, immune systems. Age, high body mass index, female sex, previous hospitalization, smoking are some its risk factors. Despite great efforts define pathophysiology, gaps remain be explained. The main mechanisms described literature involve viral persistence, hypercoagulopathy, dysregulation, autoimmunity, hyperinflammation, or combination these. exact may differ from system system, but share same pathways. This review aims describe prevalent pathophysiological pathways explaining this syndrome.
Язык: Английский
Процитировано
35Precision nutrition to reset virus-induced human metabolic reprogramming and dysregulation (HMRD) in long-COVID
npj Science of Food, Год журнала: 2024, Номер 8(1)
Опубликована: Март 30, 2024
Язык: Английский
Процитировано
11Robust cross-cohort gut microbiome associations with COVID-19 severity
Gut Microbes, Год журнала: 2023, Номер 15(1)
Опубликована: Авг. 7, 2023
Although many recent studies have examined associations between the gut microbiome and COVID-19 disease severity in individual patient cohorts, questions remain on robustness across international cohorts of biomarkers they reported. Here, we performed a meta-analysis eight shotgun metagenomic patients (comprising 1,023 stool samples) 23 > 16S rRNA gene amplicon sequencing (16S) (2,415 total samples). We found that (as defined by WHO clinical progression scale) was associated with taxonomic functional differences. This alteration configuration peaks at days 7–30 post diagnosis, after which returns to becomes more similar healthy controls over time. Furthermore, identified core set species were consistently whose abundance can accurately predict category SARS-CoV-2 infected subjects, Actinomyces oris predicting population-level mortality rate COVID-19. Additionally, used relational diet-microbiome databases constructed from cohort microbiota-targeted diet patterns would modulate microbiota composition toward controls. Finally, demonstrated association intestinal archaeal, fungal, viral, parasitic communities. Collectively, this study has robust biomarkers, established accurate predictive models as basis for prognostic tests severity, proposed biomarker-targeted diets managing infection.
Язык: Английский
Процитировано
22Baseline Gut Microbiome Signatures Correlate with Immunogenicity of SARS-CoV-2 mRNA Vaccines
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(14), С. 11703 - 11703
Опубликована: Июль 20, 2023
The powerful immune responses elicited by the mRNA vaccines targeting SARS-CoV-2 Spike protein contribute to their high efficacy. Yet, efficacy can vary greatly between individuals. For not based on mRNA, cumulative evidence suggests that differences in composition of gut microbiome, which impact vaccine immunogenicity, are some factors variations However, it is unclear if microbiome impacts novel mode immunogenicity vaccines. We conducted a prospective longitudinal cohort study individuals receiving where we measured levels anti-Spike IgG and characterized composition, at pre-vaccination (baseline), one week following first second immunizations. While found microbial diversity all timepoints correlated with final levels, only baseline did predicted function correlate immunogenicity. Specifically, phylum Desulfobacterota genus Bilophila, producers immunostimulatory LPS, positively IgG, while Bacteroides was negatively correlated. KEGG pathways relating SCFA metabolism sulfur metabolism, as well structural components such flagellin capsular polysaccharides, also levels. Consistent these findings, depleting antibiotics reduced BNT162b2 mice. These findings suggest
Язык: Английский
Процитировано
15Gut Microbiome and Cytokine Profiles in Post-COVID Syndrome
Viruses, Год журнала: 2024, Номер 16(5), С. 722 - 722
Опубликована: Май 2, 2024
Recent studies highlight the crucial role of gut microbiome in post-infectious complications, especially patients recovering from severe COVID-19. Our research aimed to explore connection between changes and cytokine profile with post-COVID syndrome. Using 16S rRNA amplicon sequencing, we analyzed composition 60 COVID-19 over course one year. We also measured levels serum cytokines chemokines using Milliplex system. results showed that SARS-CoV-2 infection cases, those complicated by pneumonia, induce a pro-inflammatory microbial milieu heightened presence Bacteroides, Faecalibacterium, Prevotella_9. Furthermore, found syndrome is characterized cross-correlation various MDC, IL-1b, Fractalkine, TNFa, FGF-2, EGF, IL-1RA, IFN-a2, IL-10, sCD40L, IL-8, Eotaxin, IL-12p40, MIP-1b as well shift towards profile. At functional level, our analysis revealed associations post-COVID-19 homolactic fermentation, pentose phosphate, NAD salvage, flavin biosynthesis. These findings intricate interplay microbiota, their metabolites, systemic shaping symptoms. Unraveling microbiome’s complications opens avenues for new treatments prolonged
Язык: Английский
Процитировано
6The contribution of gut-brain axis to development of neurological symptoms in COVID-19 recovered patients: A hypothesis and review of literature
Frontiers in Cellular and Infection Microbiology, Год журнала: 2022, Номер 12
Опубликована: Дек. 22, 2022
The gut microbiota undergoes significant alterations in response to viral infections, particularly the novel SARS-CoV-2. As impaired can trigger numerous neurological disorders, we suggest that long-term symptoms of COVID-19 may be related intestinal disorders these patients. Thus, have gathered available information on how virus affect gastrointestinal systems, both acute and recovery phase disease, described several mechanisms through which this dysbiosis lead such as Guillain-Barre syndrome, chronic fatigue, psychiatric depression anxiety, even neurodegenerative diseases Alzheimer’s Parkinson’s disease. These mediated by inflammatory cytokines, well certain chemicals hormones (e.g., CCK), neurotransmitters 5-HT), etc. short-chain fatty acids), autonomic nervous system. In addition direct influences virus, repurposed medications used for patients also play a role dysbiosis. conclusion, although there are many dark spots our current knowledge mechanism COVID-19-related gut-brain axis disturbance, based evidence, hypothesize two phenomena more than just coincidence highly recommend large-scale epidemiologic studies future.
Язык: Английский
Процитировано
21Pentosan Polysulfate Affords Pleotropic Protection to Multiple Cells and Tissues
Pharmaceuticals, Год журнала: 2023, Номер 16(3), С. 437 - 437
Опубликована: Март 13, 2023
Pentosan polysulfate (PPS), a small semi-synthetic highly sulfated heparan sulfate (HS)-like molecule, shares many of the interactive properties HS. The aim this review was to outline potential PPS as an interventional therapeutic protective agent in physiological processes affecting pathological tissues. is multifunctional molecule with diverse actions against disease processes. has been used for decades treatment interstitial cystitis and painful bowel disease, it tissue-protective protease inhibitor cartilage, tendon IVD, cell-directive component bioscaffolds tissue engineering applications. regulates complement activation, coagulation, fibrinolysis thrombocytopenia, promotes synthesis hyaluronan. Nerve growth factor production osteocytes inhibited by PPS, reducing bone pain osteoarthritis rheumatoid arthritis (OA/RA). also removes fatty compounds from lipid-engorged subchondral blood vessels OA/RA joint pain. cytokine inflammatory mediator anti-tumor that proliferation differentiation mesenchymal stem cells development progenitor cell lineages have proven be useful strategies designed effect repair degenerate intervertebral disc (IVD) OA cartilage. stimulates proteoglycan chondrocytes presence or absence interleukin (IL)-1, hyaluronan synoviocytes. thus application range
Язык: Английский
Процитировано
9Correlation between Hepatocyte Growth Factor (HGF) with D-Dimer and Interleukin-6 as Prognostic Markers of Coagulation and Inflammation in Long COVID-19 Survivors
Current Issues in Molecular Biology, Год журнала: 2023, Номер 45(7), С. 5725 - 5740
Опубликована: Июль 8, 2023
In general, an individual who experiences the symptoms of Severe Acute Respiratory Syndrome Coronavirus 2 or SARS-CoV-2 infection is declared as recovered after weeks. However, approximately 10–20% these survivors have been reported to encounter long-term health problems, defined ‘long COVID-19’, e.g., blood coagulation which leads stroke with estimated incidence 3%, and pulmonary embolism 5% incidence. At time infection, immune response produces pro-inflammatory cytokines that stimulate stromal cells produce pro-hepatocyte growth factor (pro-HGF) eventually activated into hepatocyte (HGF), helps process in endothelial epithelial cells. HGF a marker appears inflammatory coagulation. Currently, there no information on effect serum concentrations prognosis long COVID-19 survivors. This review discusses pathophysiology between HGF, IL-6, D-dimer.
Язык: Английский
Процитировано
9Profiles of gut microbiota associated with clinical outcomes in patients with different stages of SARS-CoV-2 infection
Life Sciences, Год журнала: 2023, Номер 332, С. 122136 - 122136
Опубликована: Окт. 1, 2023
Язык: Английский
Процитировано
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