The effects of resveratrol on metabolic status in patients with type 2 diabetes mellitus and coronary heart disease

Food & Function, Год журнала: 2019, Номер 10(9), С. 6042 - 6051

Опубликована: Янв. 1, 2019

This study was performed to investigate the effects of resveratrol on metabolic status in patients with type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD). randomized, double-blind, placebo-controlled trial 56 having T2DM CHD. The were randomly divided into two groups receive either 500 mg per day (n = 28) or placebo for 4 weeks. Resveratrol reduced fasting glucose (β-10.04 dL-1; 95% CI, -18.23, -1.86; P 0.01), insulin (β-1.09 μIU mL-1; -1.93, -0.24; 0.01) resistance (β-0.48; -0.76, -0.21; 0.001) significantly increased sensitivity (β 0.006; 0.001, 0.01; 0.02) when compared placebo. also HDL-cholesterol levels 3.38 1.72, 5.05; < decreased total-/HDL-cholesterol ratio (β-0.36; -0.59, -0.13; 0.002) Additionally, caused a significant increase total antioxidant capacity (TAC) 58.88 mmol L-1; 17.33, 100.44; 0.006) reduction malondialdehyde (MDA) (β-0.21 μmol -0.41, -0.005; 0.04) upregulated PPAR-γ (P sirtuin 1 (SIRT1) peripheral blood mononuclear cells (PBMCs) supplementation did not have any effect inflammatory markers. Four-week CHD had beneficial glycemic control, levels, ratio, TAC MDA levels. SIRT1 PBMCs

Язык: Английский

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Resveratrol and endothelial function: A literature review

Pharmacological Research, Год журнала: 2021, Номер 170, С. 105725 - 105725

Опубликована: Июнь 10, 2021

Язык: Английский

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Vascular ageing: moving from bench towards bedside

European Journal of Preventive Cardiology, Год журнала: 2023, Номер 30(11), С. 1101 - 1117

Опубликована: Фев. 4, 2023

Abstract Prevention of cardiovascular disease (CVD) remains one the largest public health challenges our time. Identifying individuals at increased risk an asymptomatic, sub-clinical stage is paramount importance for minimizing progression as well substantial and economic burden associated with overt CVD. Vascular ageing (VA) involves deterioration in vascular structure function over time ultimately leads to damage heart, brain, kidney, other organs. encompasses cumulative effect all factors on arterial wall life course thus may help identify those elevated risk, early development. Although concept VA gaining interest clinically, it seldom measured routine clinical practice due lack consensus how characterize physiological vs. pathological various practical issues. In this state-of-the-art review a network scientists, clinicians, engineers, industry partners expertise VA, we address six questions related attempt increase knowledge among broader medical community move measurement little closer from bench towards bedside.

Язык: Английский

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Targeting oxidative stress as a preventive and therapeutic approach for cardiovascular disease

Journal of Translational Medicine, Год журнала: 2023, Номер 21(1)

Опубликована: Авг. 2, 2023

Abstract Cardiovascular diseases (CVDs) continue to exert a significant impact on global mortality rates, encompassing conditions like pulmonary arterial hypertension (PAH), atherosclerosis (AS), and myocardial infarction (MI). Oxidative stress (OS) plays crucial role in the pathogenesis advancement of CVDs, highlighting its significance as contributing factor. Maintaining an equilibrium between reactive oxygen species (ROS) antioxidant systems not only aids mitigating oxidative but also confers protective benefits cardiac health. Herbal monomers can inhibit OS CVDs by activating multiple signaling pathways, such increasing activity endogenous decreasing level ROS expression. Given actions herbal significantly protect normal function heart reduce damage caused organism. Hence, it is imperative recognize prospective therapeutic interventions for CVDs. This paper aims comprehensively review origins mechanisms underlying OS, elucidate intricate association explore potential treatment utilizing monomers. Furthermore, particular emphasis will be placed examining cardioprotective effects evaluating their pathways subsequent treatment. Graphical

Язык: Английский

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Arterial Stiffness: From Basic Primers to Integrative Physiology

Annual Review of Physiology, Год журнала: 2024, Номер 86(1), С. 99 - 121

Опубликована: Фев. 12, 2024

The elastic properties of conductance arteries are one the most important hemodynamic functions in body, and data continue to emerge regarding importance their dysfunction vascular aging a range cardiovascular diseases. Here, we provide new insight into integrative physiology arterial stiffening its clinical consequence. We also comprehensively review progress made on pathways/molecules that appear today as basic determinants stiffness, particularly those mediating smooth muscle cell (VSMC) contractility, plasticity stiffness. focus membrane nuclear mechanotransduction, clearance function wall, phenotypic switching VSMCs, immunoinflammatory stimuli epigenetic mechanisms. Finally, discuss advances latest studies revisit classical therapeutic concepts stiffness lead patient-by-patient strategy according risk exposure underlying disease.

Язык: Английский

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Oxidative Stress and Erectile Dysfunction: Pathophysiology, Impacts, and Potential Treatments

Current Issues in Molecular Biology, Год журнала: 2024, Номер 46(8), С. 8807 - 8834

Опубликована: Авг. 14, 2024

Erectile dysfunction (ED) is a prevalent condition affecting men’s sexual health, with oxidative stress (OS) having recently been identified as significant contributing causative factor. This narrative review aims to elucidate the role of OS in pathophysiology ED, focusing on impact, mechanisms, and potential therapeutic interventions. Key findings indicate that disrupts endothelial function nitric oxide (NO) signaling, crucial for erectile function. Various sources reactive oxygen species (ROS) their detrimental effects penile tissue are discussed, including aging, diabetes mellitus, hypertension, hyperlipidemia, smoking, obesity, alcohol consumption, psychological stress, hyperhomocysteinemia, chronic kidney disease, sickle cell disease. Major ROS, such NADPH oxidase, xanthine uncoupled NO synthase (eNOS), mitochondrial electron transport, identified. scavenged by these leading characterized reduced availability, impaired vasodilation, increased vascular tone, inflammation. ultimately results ED due decreased blood flow inability achieve or maintain an erection. Furthermore, ROS impact transmission nitrergic neurotransmitters causing death neurons reducing signaling neuronal (nNOS), exacerbating ED. Therapeutic approaches targeting OS, antioxidants lifestyle modifications, show promise ameliorating symptoms. The underscores need further research develop effective treatments, emphasizing interplay between health Integrating pharmacological non-pharmacological strategies could enhance clinical outcomes patients, advocating management treatment protocols improve patient quality life.

Язык: Английский

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Impact of Lifestyles (Diet and Exercise) on Vascular Health: Oxidative Stress and Endothelial Function

Oxidative Medicine and Cellular Longevity, Год журнала: 2020, Номер 2020, С. 1 - 22

Опубликована: Сен. 26, 2020

Healthy lifestyle and diet are associated with significant reduction in risk of obesity, type 2 diabetes, cardiovascular diseases. Oxidative stress the imbalance between prooxidants antioxidants linked to metabolic Changes antioxidant capacity body may lead oxidative vascular dysfunction. Diet is an important source antioxidants, while exercise offers many health benefits as well. Recent findings have evidenced that physical factors correlated stress. debatable roles modulating effects on endothelium. Since endothelium play critical diseases, dietary could implications prevention This review aimed at summarizing current knowledge impact manipulation stress, focusing We discuss friend-and-foe role modification (including different styles, calorie restriction, nutrient supplementation) well potential concerns activity A fine balance for normal functions cells interfering this unfavorable effects. Further studies needed identify best composition intensity.

Язык: Английский

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Aging-Associated miR-217 Aggravates Atherosclerosis and Promotes Cardiovascular Dysfunction

Arteriosclerosis Thrombosis and Vascular Biology, Год журнала: 2020, Номер 40(10), С. 2408 - 2424

Опубликована: Авг. 27, 2020

microRNAs are master regulators of gene expression with essential roles in virtually all biological processes. miR-217 has been associated aging and cellular senescence, but its role vascular disease is not understood. Approach Results: We have used an inducible endothelium-specific knock-in mouse model to address the function atherosclerosis. reduced NO production promoted endothelial dysfunction, increased blood pressure, exacerbated atherosclerosis proatherogenic apoE-/- mice. Moreover, led development coronary artery altered left ventricular heart function, inducing diastolic systolic dysfunction. Conversely, inhibition endogenous mice improved contractility diminished Transcriptome analysis revealed that regulates signaling hub downregulates a network eNOS (endothelial synthase) activators, including VEGF (vascular growth factor) apelin receptor pathways, resulting expression. Further human plasma biomarker cardiovascular risk.Our results highlight therapeutic potential inhibitors aging-related disease.

Язык: Английский

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The glycolytic process in endothelial cells and its implications

Acta Pharmacologica Sinica, Год журнала: 2021, Номер 43(2), С. 251 - 259

Опубликована: Апрель 13, 2021

Abstract Endothelial cells play an obligatory role in regulating local vascular tone and maintaining homeostasis biology. Cell metabolism, converting food to energy organisms, is the primary self-sustaining mechanism for cell proliferation reproduction, structure maintenance, fight-or-flight responses stimuli. Four major metabolic processes take place energy-producing process, including glycolysis, oxidative phosphorylation, glutamine fatty acid oxidation. Among them, glycolysis endothelial cells. The present review focused on under both physiological pathological conditions. Since switches among precede functional changes disease developments, some prophylactic and/or therapeutic strategies concerning of cardiovascular are discussed.

Язык: Английский

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Resveratrol in Cancer Patients: From Bench to Bedside

International Journal of Molecular Sciences, Год журнала: 2020, Номер 21(8), С. 2945 - 2945

Опубликована: Апрель 22, 2020

Resveratrol (3,5,4′-trihydroxystilbene) is a natural phytoalexin that accumulates in several vegetables and fruits like nuts, grapes, apples, red fruits, black olives, capers, rice as well wines. Being both an extremely reactive molecule capable to interact with cytoplasmic nuclear proteins human cells, resveratrol has been studied over the years complementary alternative medicine (CAM) for therapy of cancer, metabolic cardiovascular diseases myocardial ischemia, myocarditis, cardiac hypertrophy heart failure. This review will describe main biological targets, outcomes, physico-chemical pharmacokinetic properties preclinical clinical models implementing its potential use cancer patients.

Язык: Английский

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