Food & Function,
Journal Year:
2019,
Volume and Issue:
10(9), P. 6042 - 6051
Published: Jan. 1, 2019
This
study
was
performed
to
investigate
the
effects
of
resveratrol
on
metabolic
status
in
patients
with
type
2
diabetes
mellitus
(T2DM)
and
coronary
heart
disease
(CHD).
randomized,
double-blind,
placebo-controlled
trial
56
having
T2DM
CHD.
The
were
randomly
divided
into
two
groups
receive
either
500
mg
per
day
(n
=
28)
or
placebo
for
4
weeks.
Resveratrol
reduced
fasting
glucose
(β-10.04
dL-1;
95%
CI,
-18.23,
-1.86;
P
0.01),
insulin
(β-1.09
μIU
mL-1;
-1.93,
-0.24;
0.01)
resistance
(β-0.48;
-0.76,
-0.21;
0.001)
significantly
increased
sensitivity
(β
0.006;
0.001,
0.01;
0.02)
when
compared
placebo.
also
HDL-cholesterol
levels
3.38
1.72,
5.05;
<
decreased
total-/HDL-cholesterol
ratio
(β-0.36;
-0.59,
-0.13;
0.002)
Additionally,
caused
a
significant
increase
total
antioxidant
capacity
(TAC)
58.88
mmol
L-1;
17.33,
100.44;
0.006)
reduction
malondialdehyde
(MDA)
(β-0.21
μmol
-0.41,
-0.005;
0.04)
upregulated
PPAR-γ
(P
sirtuin
1
(SIRT1)
peripheral
blood
mononuclear
cells
(PBMCs)
supplementation
did
not
have
any
effect
inflammatory
markers.
Four-week
CHD
had
beneficial
glycemic
control,
levels,
ratio,
TAC
MDA
levels.
SIRT1
PBMCs
Journal of Translational Medicine,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: Aug. 2, 2023
Abstract
Cardiovascular
diseases
(CVDs)
continue
to
exert
a
significant
impact
on
global
mortality
rates,
encompassing
conditions
like
pulmonary
arterial
hypertension
(PAH),
atherosclerosis
(AS),
and
myocardial
infarction
(MI).
Oxidative
stress
(OS)
plays
crucial
role
in
the
pathogenesis
advancement
of
CVDs,
highlighting
its
significance
as
contributing
factor.
Maintaining
an
equilibrium
between
reactive
oxygen
species
(ROS)
antioxidant
systems
not
only
aids
mitigating
oxidative
but
also
confers
protective
benefits
cardiac
health.
Herbal
monomers
can
inhibit
OS
CVDs
by
activating
multiple
signaling
pathways,
such
increasing
activity
endogenous
decreasing
level
ROS
expression.
Given
actions
herbal
significantly
protect
normal
function
heart
reduce
damage
caused
organism.
Hence,
it
is
imperative
recognize
prospective
therapeutic
interventions
for
CVDs.
This
paper
aims
comprehensively
review
origins
mechanisms
underlying
OS,
elucidate
intricate
association
explore
potential
treatment
utilizing
monomers.
Furthermore,
particular
emphasis
will
be
placed
examining
cardioprotective
effects
evaluating
their
pathways
subsequent
treatment.
Graphical
European Journal of Preventive Cardiology,
Journal Year:
2023,
Volume and Issue:
30(11), P. 1101 - 1117
Published: Feb. 4, 2023
Abstract
Prevention
of
cardiovascular
disease
(CVD)
remains
one
the
largest
public
health
challenges
our
time.
Identifying
individuals
at
increased
risk
an
asymptomatic,
sub-clinical
stage
is
paramount
importance
for
minimizing
progression
as
well
substantial
and
economic
burden
associated
with
overt
CVD.
Vascular
ageing
(VA)
involves
deterioration
in
vascular
structure
function
over
time
ultimately
leads
to
damage
heart,
brain,
kidney,
other
organs.
encompasses
cumulative
effect
all
factors
on
arterial
wall
life
course
thus
may
help
identify
those
elevated
risk,
early
development.
Although
concept
VA
gaining
interest
clinically,
it
seldom
measured
routine
clinical
practice
due
lack
consensus
how
characterize
physiological
vs.
pathological
various
practical
issues.
In
this
state-of-the-art
review
a
network
scientists,
clinicians,
engineers,
industry
partners
expertise
VA,
we
address
six
questions
related
attempt
increase
knowledge
among
broader
medical
community
move
measurement
little
closer
from
bench
towards
bedside.
Annual Review of Physiology,
Journal Year:
2024,
Volume and Issue:
86(1), P. 99 - 121
Published: Feb. 12, 2024
The
elastic
properties
of
conductance
arteries
are
one
the
most
important
hemodynamic
functions
in
body,
and
data
continue
to
emerge
regarding
importance
their
dysfunction
vascular
aging
a
range
cardiovascular
diseases.
Here,
we
provide
new
insight
into
integrative
physiology
arterial
stiffening
its
clinical
consequence.
We
also
comprehensively
review
progress
made
on
pathways/molecules
that
appear
today
as
basic
determinants
stiffness,
particularly
those
mediating
smooth
muscle
cell
(VSMC)
contractility,
plasticity
stiffness.
focus
membrane
nuclear
mechanotransduction,
clearance
function
wall,
phenotypic
switching
VSMCs,
immunoinflammatory
stimuli
epigenetic
mechanisms.
Finally,
discuss
advances
latest
studies
revisit
classical
therapeutic
concepts
stiffness
lead
patient-by-patient
strategy
according
risk
exposure
underlying
disease.
Current Issues in Molecular Biology,
Journal Year:
2024,
Volume and Issue:
46(8), P. 8807 - 8834
Published: Aug. 14, 2024
Erectile
dysfunction
(ED)
is
a
prevalent
condition
affecting
men’s
sexual
health,
with
oxidative
stress
(OS)
having
recently
been
identified
as
significant
contributing
causative
factor.
This
narrative
review
aims
to
elucidate
the
role
of
OS
in
pathophysiology
ED,
focusing
on
impact,
mechanisms,
and
potential
therapeutic
interventions.
Key
findings
indicate
that
disrupts
endothelial
function
nitric
oxide
(NO)
signaling,
crucial
for
erectile
function.
Various
sources
reactive
oxygen
species
(ROS)
their
detrimental
effects
penile
tissue
are
discussed,
including
aging,
diabetes
mellitus,
hypertension,
hyperlipidemia,
smoking,
obesity,
alcohol
consumption,
psychological
stress,
hyperhomocysteinemia,
chronic
kidney
disease,
sickle
cell
disease.
Major
ROS,
such
NADPH
oxidase,
xanthine
uncoupled
NO
synthase
(eNOS),
mitochondrial
electron
transport,
identified.
scavenged
by
these
leading
characterized
reduced
availability,
impaired
vasodilation,
increased
vascular
tone,
inflammation.
ultimately
results
ED
due
decreased
blood
flow
inability
achieve
or
maintain
an
erection.
Furthermore,
ROS
impact
transmission
nitrergic
neurotransmitters
causing
death
neurons
reducing
signaling
neuronal
(nNOS),
exacerbating
ED.
Therapeutic
approaches
targeting
OS,
antioxidants
lifestyle
modifications,
show
promise
ameliorating
symptoms.
The
underscores
need
further
research
develop
effective
treatments,
emphasizing
interplay
between
health
Integrating
pharmacological
non-pharmacological
strategies
could
enhance
clinical
outcomes
patients,
advocating
management
treatment
protocols
improve
patient
quality
life.
Food Chemistry X,
Journal Year:
2025,
Volume and Issue:
25, P. 102182 - 102182
Published: Jan. 1, 2025
In
this
study,
multifunctional
Resveratrol-derived
carbon
dots
(Res-CDs)
were
prepared
using
a
hydrothermal
method.
Res-CDs
exhibited
good
free-radical
scavenging
activities,
attributed
to
abundant
surface
hydroxyl
groups,
and
effectively
inhibited
Staphylococcus
aureus
Escherichia
coli
growth
at
concentration
of
2
mg/mL.
Composite
films
by
combining
with
gelatin/chitosan.
As
well
as
excellent
mechanical
properties,
the
smooth
surfaces,
thermal
stability,
antioxidant,
ultraviolet-shielding,
antibacterial,
pH-responsive
properties.
Furthermore,
cell
viability
measurements
showed
that
safe.
When
applied
keeping
pork
fresh,
gelatin/chitosan/Res-CDs
film
significantly
reduced
total
viable
bacterial
count
on
prevented
discoloration.
Additionally,
pH,
volatile
basic
nitrogen,
weight
loss
confirmed
preservative
effects
pork.
This
work
provides
new
approach
for
synthesizing
bionanocomposite
applicability
in
food
industry.
Oxidative Medicine and Cellular Longevity,
Journal Year:
2020,
Volume and Issue:
2020, P. 1 - 22
Published: Sept. 26, 2020
Healthy
lifestyle
and
diet
are
associated
with
significant
reduction
in
risk
of
obesity,
type
2
diabetes,
cardiovascular
diseases.
Oxidative
stress
the
imbalance
between
prooxidants
antioxidants
linked
to
metabolic
Changes
antioxidant
capacity
body
may
lead
oxidative
vascular
dysfunction.
Diet
is
an
important
source
antioxidants,
while
exercise
offers
many
health
benefits
as
well.
Recent
findings
have
evidenced
that
physical
factors
correlated
stress.
debatable
roles
modulating
effects
on
endothelium.
Since
endothelium
play
critical
diseases,
dietary
could
implications
prevention
This
review
aimed
at
summarizing
current
knowledge
impact
manipulation
stress,
focusing
We
discuss
friend-and-foe
role
modification
(including
different
styles,
calorie
restriction,
nutrient
supplementation)
well
potential
concerns
activity
A
fine
balance
for
normal
functions
cells
interfering
this
unfavorable
effects.
Further
studies
needed
identify
best
composition
intensity.
Arteriosclerosis Thrombosis and Vascular Biology,
Journal Year:
2020,
Volume and Issue:
40(10), P. 2408 - 2424
Published: Aug. 27, 2020
microRNAs
are
master
regulators
of
gene
expression
with
essential
roles
in
virtually
all
biological
processes.
miR-217
has
been
associated
aging
and
cellular
senescence,
but
its
role
vascular
disease
is
not
understood.
Approach
Results:
We
have
used
an
inducible
endothelium-specific
knock-in
mouse
model
to
address
the
function
atherosclerosis.
reduced
NO
production
promoted
endothelial
dysfunction,
increased
blood
pressure,
exacerbated
atherosclerosis
proatherogenic
apoE-/-
mice.
Moreover,
led
development
coronary
artery
altered
left
ventricular
heart
function,
inducing
diastolic
systolic
dysfunction.
Conversely,
inhibition
endogenous
mice
improved
contractility
diminished
Transcriptome
analysis
revealed
that
regulates
signaling
hub
downregulates
a
network
eNOS
(endothelial
synthase)
activators,
including
VEGF
(vascular
growth
factor)
apelin
receptor
pathways,
resulting
expression.
Further
human
plasma
biomarker
cardiovascular
risk.Our
results
highlight
therapeutic
potential
inhibitors
aging-related
disease.
Acta Pharmacologica Sinica,
Journal Year:
2021,
Volume and Issue:
43(2), P. 251 - 259
Published: April 13, 2021
Abstract
Endothelial
cells
play
an
obligatory
role
in
regulating
local
vascular
tone
and
maintaining
homeostasis
biology.
Cell
metabolism,
converting
food
to
energy
organisms,
is
the
primary
self-sustaining
mechanism
for
cell
proliferation
reproduction,
structure
maintenance,
fight-or-flight
responses
stimuli.
Four
major
metabolic
processes
take
place
energy-producing
process,
including
glycolysis,
oxidative
phosphorylation,
glutamine
fatty
acid
oxidation.
Among
them,
glycolysis
endothelial
cells.
The
present
review
focused
on
under
both
physiological
pathological
conditions.
Since
switches
among
precede
functional
changes
disease
developments,
some
prophylactic
and/or
therapeutic
strategies
concerning
of
cardiovascular
are
discussed.
