Effects of Resveratrol, Curcumin and Quercetin Supplementation on Bone Metabolism—A Systematic Review

Nutrients, Год журнала: 2022, Номер 14(17), С. 3519 - 3519

Опубликована: Авг. 26, 2022

Phenolic compounds are natural phytochemicals that have recently reported numerous health benefits. Resveratrol, curcumin, and quercetin received the most attention among these molecules due to their documented antioxidant effects. The review aims investigate effects of on bone metabolism role in several diseases such as osteopenia osteoporosis, tumours, periodontitis. PubMed/Medline, Web Science, Google Scholar, Scopus, Cochrane Library, Embase electronic databases were searched for papers line with study topic. According an English language restriction, screening period was from January 2012 3 July 2022, following Boolean keywords: (“resveratrol” AND “bone”); (“curcumin” (“quercetin” “bone”). A total 36 identified relevant purpose our investigation. studies positive investigated phenolic potential application adjuvant treatments Furthermore, use titanium surfaces orthopaedic prostheses could represent a possible improve osteogenic processes osseointegration. findings, resveratrol, wide variety beneficial supplement therapies. seem positively mediate osteoclast-related pathologies.

Язык: Английский

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Piezo-enhanced near infrared photocatalytic nanoheterojunction integrated injectable biopolymer hydrogel for anti-osteosarcoma and osteogenesis combination therapy

Bioactive Materials, Год журнала: 2024, Номер 34, С. 381 - 400

Опубликована: Янв. 6, 2024

Preventing local tumor recurrence while promoting bone tissue regeneration is an urgent need for osteosarcoma treatment. However, the therapeutic efficacy of traditional photosensitizers limited, and they lack ability to regenerate bone. Here, a piezo-photo nanoheterostructure developed based on ultrasmall bismuth/strontium titanate nanocubes (denoted as Bi/SrTiO3), which achieve piezoelectric field-driven fast charge separation coupling with surface plasmon resonance efficiently generate reactive oxygen species. These hybrid nanotherapeutics are integrated into injectable biopolymer hydrogels, exhibit outstanding anticancer effects under combined irradiation NIR ultrasound. In vivo studies using patient-derived xenograft models tibial demonstrate that hydrogels suppression rates 98.6 % 67.6 in respective models. Furthermore, hydrogel had good filling retention capabilities defect region, exerted repair by polarizing conveying electrical stimuli cells mild ultrasound radiation. This study provides comprehensive clinically feasible strategy overall treatment osteosarcoma.

Язык: Английский

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Recent Advances in the Treatment of Bone Metastases and Primary Bone Tumors: An Up-to-Date Review

Cancers, Год журнала: 2021, Номер 13(16), С. 4229 - 4229

Опубликована: Авг. 23, 2021

In the last decades, treatment of primary and secondary bone tumors has faced a slow-down in its development, being mainly based on chemotherapy, radiotherapy, surgical interventions. However, these conventional therapeutic strategies present series disadvantages (e.g., multidrug resistance, tumor recurrence, severe side effects, formation large defects), which limit their application efficacy. recent years, procedures were combined with several adjuvant therapies, different degrees success. To overcome drawbacks current therapies improve outcomes, other started investigated, like carrier-mediated drug delivery, substitutes for repairing defects, multifunctional scaffolds tissue regeneration antitumor properties. Thus, this paper aims to types approaches, further focusing advances new alternatives.

Язык: Английский

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M6A demethylase FTO-mediated downregulation of DACT1 mRNA stability promotes Wnt signaling to facilitate osteosarcoma progression

Oncogene, Год журнала: 2022, Номер 41(12), С. 1727 - 1741

Опубликована: Фев. 4, 2022

Язык: Английский

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Novel Immunotherapies for Osteosarcoma

Frontiers in Oncology, Год журнала: 2022, Номер 12

Опубликована: Апрель 1, 2022

Osteosarcoma (OS) is the most common primary malignant bone sarcoma mainly affecting adolescents and young adults, which often progresses to pulmonary metastasis leads death of OS patients. characterized as a highly heterogeneous cancer type underlying pathologic mechanisms triggering tumor progress are incompletely recognized. Surgery combined with neoadjuvant postoperative chemotherapy has elevated 5-year survival over 70% for patients localized tumors, opposed only 20% recurrence and/or metastasis. Therefore, novel therapeutic strategies needed overcome drawbacks conventional treatments. Immunotherapy gaining momentum treatment an increasing number FDA-approved therapies malignancies resistant therapies. Here, we review microenvironment appraise promising immunotherapies available in management OS.

Язык: Английский

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A facile strategy toward hierarchically porous composite scaffold for osteosarcoma ablation and massive bone defect repair

Composites Part B Engineering, Год журнала: 2022, Номер 234, С. 109660 - 109660

Опубликована: Янв. 20, 2022

Язык: Английский

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Canine and murine models of osteosarcoma

Veterinary Pathology, Год журнала: 2022, Номер 59(3), С. 399 - 414

Опубликована: Март 26, 2022

Osteosarcoma (OS) is the most common malignant bone tumor in children. Despite efforts to develop and implement new therapies, patient outcomes have not measurably improved since 1980s. Metastasis continues be main source of mortality, with 30% cases developing metastatic disease within 5 years diagnosis. Research models are critical advancement cancer research include a variety species. For example, xenograft patient-derived (PDX) mouse provide opportunities study human cells vivo while transgenic offered significant insight into molecular mechanisms underlying OS development. A growing recognition naturally occurring cancers companion species has led insights how veterinary patients can contribute studies biology drug The canine cases, including use diagnostic tissue archives clinical trials, offers potential mechanism further research. Advancement field requires continued development appropriate animal models. In this review, described focus on tumor-bearing pet dog as parallel complementary OS.

Язык: Английский

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An overview of resistance to chemotherapy in osteosarcoma and future perspectives

Cancer Drug Resistance, Год журнала: 2022, Номер 5(2), С. 762 - 93

Опубликована: Янв. 1, 2022

Osteosarcoma (OS) is the most common type of bone sarcoma. Despite availability multimodal treatment with surgery and chemotherapy, clinical results remain unsatisfactory. The main reason for poor outcomes in patients OS development resistance to methotrexate, cisplatin, doxorubicin, ifosfamide. Molecular cellular mechanisms associated chemotherapy include DNA repair cell-cycle alterations, enhanced drug efflux, increased detoxification, apoptosis, autophagy, tumor extracellular matrix, angiogenesis. This versatility cells generate chemoresistance has motivated use anti-angiogenic therapy based on tyrosine kinase inhibitors. approach shown that other therapies, along standard can improve responses OS. Moreover, microRNAs may act as predictors review provides insight into molecular involved during discusses promising novel therapies (e.g., afatinib palbociclib) overcoming

Язык: Английский

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CRISPR‐Cas9 screening identified lethal genes enriched in necroptosis pathway and of prognosis significance in osteosarcoma

The Journal of Gene Medicine, Год журнала: 2023, Номер 25(12)

Опубликована: Июль 8, 2023

The present study aimed to identify indispensable genes associated with tumor cell viability according the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) datasets, which may support new therapeutic targets for patients osteosarcoma.The transcriptome patterns between and normal tissues, were obtained from Therapeutically Applicable Research Generate Effective Treatments dataset, overlapped genomics screened by CRISPR-Cas9 technology. Kyoto Encyclopedia of Genes Genomes Gene Ontology analyses employed determine enrichment pathways related lethal genes. Least absolute shrinkage selection operator (LASSO) regression was construct a risk model predicting clinical outcomes osteosarcoma. Univariate multivariate Cox regressions conducted assess prognostic value this feature. Weighted gene co-expression network analysis performed modules high-risk score.In total, 34 identified in investigation. These enriched necroptosis pathway. based on LASSO algorithm distinguishes score low-risk score. Compared patients, showed shorter overall survival rate both training validation sets. time-dependent receiver operating characteristic curves 1, 3 5 years displayed that has great prediction performance. pathway represents main difference biological behavior group group. Meanwhile, CDK6 SMARCB1 serve as important detecting osteosarcoma progression.The developed predictive outperformed classical clinicopathological parameters specific genes, including SMARCB1, well findings potential future treatments.

Язык: Английский

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Nanoparticles and bone microenvironment: a comprehensive review for malignant bone tumor diagnosis and treatment

Molecular Cancer, Год журнала: 2024, Номер 23(1)

Опубликована: Ноя. 1, 2024

Malignant bone tumors, which are difficult to treat with current clinical strategies, originate from tissues and can be classified into primary secondary types. Due the specificity of microenvironment, results traditional means treating tumors often unsatisfactory, so there is an urgent need develop new treatments for malignant tumors. Recently, nanoparticle-based approaches have shown great potential in diagnosis treatment. Nanoparticles (NPs) gained significant attention due their versatility, making them highly suitable applications tissue engineering, advanced imaging techniques, targeted drug delivery. For diagnosis, NPs enhance contrast sensitivity by integrating targeting ligands, significantly improve specific recognition localization tumor cells early detection. treatment, enable delivery, increasing accumulation at sites while reducing systemic toxicity. In conclusion, understanding microenvironment using unique properties holds promise improving disease management, enhancing treatment outcomes, ultimately quality life patients Further research development will undoubtedly contribute advancement personalized medicine field oncology.

Язык: Английский

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