Chronic inflammation and the hallmarks of aging

Molecular Metabolism, Год журнала: 2023, Номер 74, С. 101755 - 101755

Опубликована: Июнь 16, 2023

Recently, the hallmarks of aging were updated to include dysbiosis, disabled macroautophagy, and chronic inflammation. In particular, low-grade inflammation during aging, without overt infection, is defined as "inflammaging," which associated with increased morbidity mortality in population. Emerging evidence suggests a bidirectional cyclical relationship between development age-related conditions, such cardiovascular diseases, neurodegeneration, cancer, frailty. How crosstalk other underlies biological mechanisms disease thus particular interest current geroscience research.

Язык: Английский

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Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Март 14, 2023

Abstract The ageing process is a systemic decline from cellular dysfunction to organ degeneration, with more predisposition deteriorated disorders. Rejuvenation refers giving aged cells or organisms youthful characteristics through various techniques, such as reprogramming and epigenetic regulation. great leaps in rejuvenation prove that not one-way street, many rejuvenative interventions have emerged delay even reverse the process. Defining mechanism by which roadblocks signaling inputs influence complex programs essential for understanding developing strategies. Here, we discuss intrinsic extrinsic factors counteract cell rejuvenation, targeted core mechanisms involved this Then, critically summarize latest advances state-of-art strategies of rejuvenation. Various methods also provide insights treating specific ageing-related diseases, including reprogramming, removal senescence (SCs) suppression senescence-associated secretory phenotype (SASP), metabolic manipulation, stem cells-associated therapy, dietary restriction, immune heterochronic transplantation, etc. potential applications therapy extend cancer treatment. Finally, analyze detail therapeutic opportunities challenges technology. Deciphering will further into anti-ageing disease treatment clinical settings.

Язык: Английский

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Aging Hallmarks and Progression and Age-Related Diseases: A Landscape View of Research Advancement

ACS Chemical Neuroscience, Год журнала: 2023, Номер 15(1), С. 1 - 30

Опубликована: Дек. 14, 2023

Aging is a dynamic, time-dependent process that characterized by gradual accumulation of cell damage. Continual functional decline in the intrinsic ability living organisms to accurately regulate homeostasis leads increased susceptibility and vulnerability diseases. Many efforts have been put forth understand prevent effects aging. Thus, major cellular molecular hallmarks aging identified, their relationships age-related diseases malfunctions explored. Here, we use data from CAS Content Collection analyze publication landscape recent aging-related research. We review advances knowledge delineate trends research advancements on factors attributes across time geography. also current concepts related molecular, cellular, organismic level, age-associated diseases, with attention brain health, as well biochemical processes associated Major outlined, correlations features are hope this will be helpful for apprehending field mechanisms progression, an effort further solve remaining challenges fulfill its potential.

Язык: Английский

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Radiation-induced senescence: therapeutic opportunities

Radiation Oncology, Год журнала: 2023, Номер 18(1)

Опубликована: Янв. 13, 2023

Abstract The limitation of cancer radiotherapy does not derive from an inability to ablate tumor, but rather do so without excessively damaging critical tissues and organs adversely affecting patient’s quality life. Although cellular senescence is a normal consequence aging, there increasing evidence showing that the radiation-induced in both tumor adjacent contributes recurrence, metastasis, resistance therapy, while chronic senescent cells tissue organ are source many late effects. In this review, we discuss how identify using various bio-markers role so-called senescence-associated secretory phenotype characteristics on pathogenesis We also therapeutic options eliminate either senolytics and/or senostatics. Finally, discussion reprogramming presented, another promising avenue improve gain radiotherapy.

Язык: Английский

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iPSC Preparation and Epigenetic Memory: Does the Tissue Origin Matter?

Cells, Год журнала: 2021, Номер 10(6), С. 1470 - 1470

Опубликована: Июнь 11, 2021

The production of induced pluripotent stem cells (iPSCs) represent a breakthrough in regenerative medicine, providing new opportunities for understanding basic molecular mechanisms human development and aspects degenerative diseases. In contrast to embryonic (ESCs), iPSCs do not raise any ethical concerns regarding the onset personhood. Still, they present some technical issues related immune rejection after transplantation potential tumorigenicity, indicating that more steps forward must be completed use as viable tool vivo tissue regeneration. On other hand, cell source origin may pivotal iPSC generation since residual epigenetic memory could influence phenotype outcome. this paper, we first review impact reprogramming methods choice on or their differentiated cells. Next, describe importance induction determine efficiency avoid integration host genome alter gene expression. Finally, compare significance inter-individual genetic variation modification has been lightly evaluated so far, but which significantly impacts reprogramming.

Язык: Английский

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Current Trends in Anti-Aging Strategies

Annual Review of Biomedical Engineering, Год журнала: 2023, Номер 25(1), С. 363 - 385

Опубликована: Июнь 8, 2023

The process of aging manifests from a highly interconnected network biological cascades resulting in the degradation and breakdown every living organism over time. This natural development increases risk for numerous diseases can be debilitating. Academic industrial investigators have long sought to impede, or potentially reverse, hopes alleviating clinical burden, restoring functionality, promoting longevity. Despite widespread investigation, identifying impactful therapeutics has been hindered by narrow experimental validation lack rigorous study design. In this review, we explore current understanding mechanisms how both informs limits interpreting data models based on these mechanisms. We also discuss select therapeutic strategies that yielded promising model systems with potential translation. Lastly, propose unifying approach needed rigorously vet future guide evaluation toward efficacious therapies.

Язык: Английский

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Antiaging Strategies and Remedies: A Landscape of Research Progress and Promise

ACS Chemical Neuroscience, Год журнала: 2024, Номер 15(3), С. 408 - 446

Опубликована: Янв. 12, 2024

Aging is typified by a gradual loss of physiological fitness and accumulation cellular damage, leading to deteriorated functions enhanced vulnerability diseases. Antiaging research has long history throughout civilization, with many efforts put forth understand prevent the effects aging. Multiple strategies aiming promote healthy aging extend lifespan have been developed including lifestyle adjustments, medical treatments, social programs. A multitude antiaging medicines remedies also explored. Here, we use data from CAS Content Collection analyze publication landscape recent related treatments. We review advances delineate trends in headway knowledge practice across time, geography, development pipelines. further assess state-of-the-art approaches explore their correlations age-related The drugs outlined Well-recognized novel, currently evaluated agents summarized. Finally, clinical applications products objective this summarize current on preventive treatment field aging, outline challenges evaluate growth opportunities, order solve problems that remain.

Язык: Английский

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Highly efficient construction of monkey blastoid capsules from aged somatic cells

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 28, 2025

Abstract Blastoids—blastocyst-like structures created in vitro—emerge as a valuable model for early embryonic development research. Non-human primates stem cell-derived blastoids are an ethically viable alternative to human counterparts, yet the low formation efficiency of monkey blastoid cavities, typically below 30%, has limited their utility. Prior research predominantly utilized cells. In this work, we demonstrate efficient generation from induced pluripotent cells and somatic cell nuclear transfer derived aged monkeys, achieving 80% efficiency. We also introduce hydrogel-based microfluidics platform scalable reproducible production size-adjustable, biodegradable capsules, providing stable 3D structure mechanical protection. This advancement high-efficiency, capsules reprogrammed significantly enhances study holds promise regenerative medicine.

Язык: Английский

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Oxysterols are potential physiological regulators of ageing

Ageing Research Reviews, Год журнала: 2022, Номер 77, С. 101615 - 101615

Опубликована: Март 27, 2022

Язык: Английский

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Ageing in the brain: mechanisms and rejuvenating strategies

Cellular and Molecular Life Sciences, Год журнала: 2023, Номер 80(7)

Опубликована: Июнь 24, 2023

Abstract Ageing is characterized by the progressive loss of cellular homeostasis, leading to an overall decline organism’s fitness. In brain, ageing highly associated with cognitive and neurodegenerative diseases. With rise in life expectancy, characterizing brain process becomes fundamental for developing therapeutic interventions against increased incidence age-related diseases aim increase human span and, more importantly, health span. this review, we start introducing molecular/cellular hallmarks their impact on cell populations. Subsequently, assess emerging evidence how systemic translates into ageing. Finally, revisit mainstream novel rejuvenating strategies, discussing most successful ones delaying related

Язык: Английский

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