Antioxidant Activity, Metabolism, and Bioavailability of Polyphenols in the Diet of Animals

Antioxidants, Год журнала: 2023, Номер 12(6), С. 1141 - 1141

Опубликована: Май 23, 2023

As the world’s population grows, so does need for more and animal feed. In 2006, EU banned use of antibiotics other chemicals in order to reduce chemical residues food consumed by humans. It is well known that oxidative stress inflammatory processes must be combated achieve higher productivity. The adverse effects pharmaceuticals synthetic compounds on health product quality safety have increased interest phytocompounds. With plant polyphenols nutrition, they are gaining attention as a supplement Livestock feeding based sustainable, environmentally friendly approach (clean, safe, green agriculture) would also win–win farmers society. There an increasing producing healthier products origin with ratio polyunsaturated fatty acids (PUFAs) saturated modulating nutrition. Secondary metabolites (polyphenols) essential physiology involved various functions such growth, pigmentation, resistance pathogenic organisms. Polyphenols exogenous antioxidants act one first lines cell defense. Therefore, discoveries intracellular antioxidant activity contributed significantly improvement activity, prevent damage eliminate excessively produced free radicals. To welfare, medicines, increase origin, addition research breeding can practised part free-choice

Язык: Английский

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Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway

Cell, Год журнала: 2023, Номер 186(11), С. 2361 - 2379.e25

Опубликована: Май 1, 2023

Язык: Английский

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Strategic Design of Conquering Hypoxia in Tumor for Advanced Photodynamic Therapy

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(24)

Опубликована: Апрель 26, 2023

Photodynamic therapy (PDT), with its advantages of high targeting, minimally invasive, and low toxicity side effects, has been widely used in the clinical various tumors, especially superficial tumors. However, tumor microenvironment (TME) presents hypoxia due to oxygen (O2 ) supply caused by abnormal vascularization neoplastic tissues O2 consumption induced rapid proliferation cells. The efficacy oxygen-consumping PDT can be hampered a hypoxic TME. To address this problem, researchers have developing advanced nanoplatforms strategies enhance therapeutic effect treatment. This review summarizes recent against TME, thus enhancing efficacy, including increasing content TME through delivering tumors situ generations ; decreasing during design type I photosensitizers. Moreover, synergistically combined other methods such as chemotherapy, photothermal therapy, immunotherapy, gas is accounted for addressing challenging problems mono environments, resistance, proliferation, metastasis. Finally, perspectives opportunities challenges future research translations are provided.

Язык: Английский

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Current Overview of Metal Nanoparticles’ Synthesis, Characterization, and Biomedical Applications, with a Focus on Silver and Gold Nanoparticles

Pharmaceuticals, Год журнала: 2023, Номер 16(10), С. 1410 - 1410

Опубликована: Окт. 4, 2023

Metal nanoparticles (NPs) have garnered considerable attention, due to their unique physicochemical properties, that render them promising candidates for various applications in medicine and industry. This article offers a comprehensive overview of the most recent advancements manufacturing, characterization, biomedical utilization metal NPs, with primary focus on silver gold NPs. Their potential as effective anticancer, anti-inflammatory, antimicrobial agents, drug delivery systems, imaging agents diagnosis treatment variety disorders is reviewed. Moreover, translation therapeutic settings, issue inclusion clinical trials, are assessed light over 30 investigations concentrate administering either or NPs conditions ranging from nosocomial infections different types cancers. paper aims not only examine biocompatibility nanomaterials but also emphasize challenges may limit safe integration into healthcare practices. More than 100 nanomedicines currently market, which justifies ongoing study use medicine. Overall, present review highlight innovative therapeutics field biomedicine, citing some relevant current applications.

Язык: Английский

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Gasdermin D pore-forming activity is redox-sensitive

Cell Reports, Год журнала: 2023, Номер 42(1), С. 112008 - 112008

Опубликована: Янв. 1, 2023

Reactive oxygen species (ROS) regulate the activities of inflammasomes, which are innate immune signaling organelles that induce pyroptosis. The mechanisms by ROS control inflammasome unclear and may be multifaceted. Herein, we report protein gasdermin D (GSDMD), forms membrane pores upon cleavage inflammasome-associated caspases, is a direct target ROS. Exogenous endogenous sources ROS, ROS-inducing stimuli prime cells for pyroptosis induction, promote oligomerization cleaved GSDMD, leading to rupture cell death. We find enhance GSDMD through oxidative modification cysteine 192 (C192). Within macrophages, mutants lacking C192 show impaired ability form Reciprocal mutagenesis studies reveal only within mediates responsiveness. Cellular redox state therefore key determinant activities.

Язык: Английский

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Current Advances in Photodynamic Therapy (PDT) and the Future Potential of PDT-Combinatorial Cancer Therapies

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(2), С. 1023 - 1023

Опубликована: Янв. 13, 2024

Photodynamic therapy (PDT) is a two-stage treatment that implies the use of light energy, oxygen, and light-activated compounds (photosensitizers) to elicit cancerous precancerous cell death after activation (phototoxicity). The biophysical, bioengineering aspects its combinations with other strategies are highlighted in this review, both conceptually as they currently applied clinically. We further explore recent advancements PDT nanotechnology, including quantum dots innovative photosensitizers or energy donors well combination radiotherapy immunotherapy future promising cancer treatments. Finally, we emphasize potential significance organoids physiologically relevant models for PDT.

Язык: Английский

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Nanoplastics are bioaccumulated in fish liver and muscle and cause DNA damage after a chronic exposure

Environmental Research, Год журнала: 2022, Номер 212, С. 113433 - 113433

Опубликована: Май 14, 2022

The extent of the widespread, planetary contamination by plastic waste is difficult to fully capture. Nanoplastics (NPs) are currently in center research concerning litter, both for analytical challenges they pose and their potential provoke hazardous effects organisms. However, there still many unanswered questions this multidisciplinary field, with a crucial missing piece being quantification NPs fish tissues after vivo exposures. Another relevant question that greatly unexplored how chronic exposure will affect health. This study aims provide answers these knowledge gaps. To end, goldfish (Carassius auratus) were exposed 44 nm polystyrene (PS)-NPs via water 30 days. Following exposure, gastrointestinal tract, liver muscle sampled PS-NPs analysis means size exclusion chromatography coupled high resolution mass spectrometry. detected all samples fish, higher concentrations than muscle, whereas no tract. Nevertheless, did not induce changes hematology parameters nor cortisol glucose levels plasma. On other hand, even relatively low concentration was able cause DNA damage, measured an increase erythrocyte nuclear abnormalities, suggesting can reach cell nucleus genotoxicity. These results show first time find way where bioaccumulate, but do alter survival hematological or physiological stress indicators. accumulation represent threat human health as possible route small-sized plastics. present model species open windows future studies edible species.

Язык: Английский

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Hypochlorous Acid Chemistry in Mammalian Cells—Influence on Infection and Role in Various Pathologies

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(18), С. 10735 - 10735

Опубликована: Сен. 14, 2022

This review discusses the formation of hypochlorous acid HOCl and role reactive chlorinated species (RCS), which are catalysed by enzyme myeloperoxidase MPO, mainly located in leukocytes turn contribute to cellular oxidative stress. The reactions RCS with various organic molecules such as amines, amino acids, proteins, lipids, carbohydrates, nucleic DNA described, an attempt is made explain chemical mechanisms derivatives data available so far on effects halogenative Their presence numerous pathologies atherosclerosis, arthritis, neurological renal diseases, diabetes, obesity reviewed were found be a feature debilitating diseases.

Язык: Английский

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Environmental persistence, bioaccumulation, and ecotoxicology of heavy metals

Chemistry and Ecology, Год журнала: 2024, Номер 40(3), С. 322 - 349

Опубликована: Янв. 22, 2024

Heavy metals, pervasive in the environment due to natural processes and human activities, pose substantial threats ecosystems health. This study aims delve into sources, contamination pathways waters, subsequent bioaccumulation of heavy metals across various organisms. The overview encompasses an exploration environmental persistence, dynamics, ecotoxicological impacts these metals. Methodologically, this research undertakes a comprehensive review synthesizing existing literature studies on metal contamination, mechanisms, ecotoxicity. Key findings highlight protracted persistence perpetuating significant ecological balance well-being. Notably, transfer through food chains culminates their diverse organisms, raising concerns about potential toxicity, including exposure. discussion underscores imperative nature assessing pollution its ramifications Emphasizing essential role bioindicators biomarkers, article elucidates significance evaluating metal-induced stressors impact both biota populations. contributes nuanced understanding advocating for proactive measures monitoring mitigating deleterious effects

Язык: Английский

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Oxidative Stress, Antioxidants and Hypertension

Antioxidants, Год журнала: 2023, Номер 12(2), С. 281 - 281

Опубликована: Янв. 27, 2023

As a major cause of morbidity and mortality globally, hypertension remains serious threat to global public health. Despite the availability many antihypertensive medications, several hypertensive individuals are resistant standard treatments, unable control their blood pressure. Regulation renin-angiotensin-aldosterone system (RAAS) controlling pressure, activation immune triggering inflammation production reactive oxygen species, leading oxidative stress redox-sensitive signaling, have been implicated in pathogenesis hypertension. Thus, besides which lower arterial antioxidant medications were tested improve treatment. We review discuss role pathophysiology potential use antioxidants management its associated organ damage.

Язык: Английский

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