ACS Biomaterials Science & Engineering,
Год журнала:
2023,
Номер
9(5), С. 2235 - 2250
Опубликована: Апрель 4, 2023
Serum
albumin
(SA),
one
of
the
most
abundant
proteins
in
blood
plasma,
plays
essential
roles
all
living
processes
and
has
been
used
various
biomedical
applications.
Biomaterials
fabricated
from
SAs
(human
SA,
bovine
ovalbumin)
exhibit
proper
microstructure
hydrophilicity
as
well
remarkable
biocompatibility;
this
makes
them
ideal
for
use
bone
regeneration.
This
review
provides
a
comprehensive
overview
structure,
physicochemical
properties,
biological
features
SAs.
can
be
to
generate
wide
array
biomaterials
repair
because
their
flexible
structure
diverse
functions,
which
enables
us
control
morphology
modulate
responses
with
host
tissue.
summarizes
material
categories,
forms,
fabrication
methods
SA
repair.
Finally,
concerns
future
studies
fields
SA-derived
are
discussed.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(2), С. 786 - 786
Опубликована: Янв. 8, 2024
Studies
on
bionanocomposite
drug
carriers
are
a
key
area
in
the
field
of
active
substance
delivery,
introducing
innovative
approaches
to
improve
therapy.
Such
play
crucial
role
enhancing
bioavailability
substances,
affecting
therapy
efficiency
and
precision.
The
targeted
delivery
drugs
sites
action
minimization
toxicity
body
is
becoming
possible
through
use
these
advanced
carriers.
Recent
research
has
focused
structures
based
biopolymers,
including
lipids,
polysaccharides,
proteins.
This
review
paper
description
lipid-containing
nanocomposite
(including
liposomes,
lipid
emulsions,
nanoparticles,
solid
nanostructured
carriers),
polysaccharide-containing
alginate
cellulose),
protein-containing
(e.g.,
gelatin
albumin).
It
was
demonstrated
many
investigations
that
such
show
ability
load
therapeutic
substances
efficiently
precisely
control
release.
They
also
desirable
biocompatibility,
which
promising
sign
for
their
potential
application
development
indicates
novel
approach
improving
processes,
contribute
significant
advances
pharmacology,
efficacy
while
minimizing
side
effects.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 6945 - 6980
Опубликована: Июль 1, 2024
Nanoparticle-based
systems
are
extensively
investigated
for
drug
delivery.
Among
others,
with
superior
biocompatibility
and
enhanced
targeting
capacity,
albumin
appears
to
be
a
promising
carrier
Albumin
nanoparticles
highly
favored
in
many
disease
therapies,
as
they
have
the
proper
chemical
groups
modification,
cell-binding
sites
cell
adhesion,
affinity
protein
drugs
nanocomplex
generation.
Herein,
this
review
summarizes
recent
fabrication
techniques,
modification
strategies,
application
of
nanoparticles.
We
first
discuss
various
nanoparticle
methods,
from
both
pros
cons.
Then,
we
provide
comprehensive
introduction
section,
including
organic
nanoparticles,
metal
inorganic
nanoparticle-based
hybrids.
finally
bring
further
perspectives
on
used
critical
diseases.
Viruses,
Год журнала:
2024,
Номер
16(4), С. 491 - 491
Опубликована: Март 22, 2024
Tenofovir
(TFV)
is
the
active
form
of
prodrugs
tenofovir
disoproxil
fumarate
(TDF)
and
alafenamide
(TAF),
both
clinically
prescribed
as
HIV
reverse
transcriptase
inhibitors.
The
biophysical
interactions
between
these
compounds
human
serum
albumin
(HSA),
primary
carrier
exogenous
in
bloodstream,
have
not
yet
been
thoroughly
characterized.
Thus,
present
study
reports
interaction
profile
HSA
TFV,
TDF,
TAF
via
UV–Vis,
steady-state,
time-resolved
fluorescence
techniques
combined
with
isothermal
titration
calorimetry
(ITC)
silico
calculations.
A
spontaneous
ground
state,
which
does
perturb
microenvironment
close
to
Trp-214
residue,
classified
weak.
In
case
HSA/TFV
HSA/TDF,
binding
enthalpically
entropically
driven,
while
for
HSA/TAF,
only
dominated.
constant
(Ka)
thermodynamic
parameters
obtained
ITC
assays
agree
those
using
steady-state
quenching
measurements,
reinforcing
reliability
data.
small
internal
cavity
known
site
I
probably
main
pocket
TFV
due
low
steric
volume
drug.
contrast,
most
external
sites
(II
III)
can
better
accommodate
high
this
prodrug.
cross-docking
approach
corroborated
experimental
drug-displacement
assays,
indicating
that
affinity
might
be
impacted
by
presence
different
bound
albumin.
Overall,
weak
capacity
one
factors
residence
time
antiretrovirals
bloodstream;
however,
positive
cooperativity
TDF
was
detected
some
drugs,
improve
their
(pharmacokinetic
profile).
Polymers,
Год журнала:
2022,
Номер
14(5), С. 1032 - 1032
Опубликована: Март 4, 2022
The
field
of
tissue
engineering
is
constantly
evolving
as
it
aims
to
develop
bioengineered
and
functional
tissues
organs
for
repair
or
replacement.
Due
their
large
surface
area
ability
interact
with
proteins
peptides,
graphene
oxides
offer
valuable
physiochemical
biological
features
biomedical
applications
have
been
successfully
employed
optimizing
scaffold
architectures
a
wide
range
organs,
from
the
skin
cardiac
tissue.
This
review
critically
focuses
on
opportunities
employ
protein-graphene
oxide
structures
either
nanocomposites
biocomplexes
highlights
effects
carbonaceous
nanostructures
protein
conformation
structural
stability
in
regenerative
medicine.
Herein,
recent
activity
nanocomposite
bioconjugates
are
analyzed
respect
cell
viability
proliferation,
along
these
constructs
sustain
formation
new
Novel
strategies
approaches
based
stem
therapy,
well
involvement
extracellular
matrix
design
smart
nanoplatforms,
discussed.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(18), С. 10557 - 10557
Опубликована: Сен. 12, 2022
Albumin
is
a
constitutional
plasma
protein,
with
well-known
biological
functions,
e.g.,
nutrient
for
stem
cells
in
culture.
However,
albumin
underutilized
as
biomaterial
regenerative
medicine.
This
review
summarizes
the
advanced
therapeutic
uses
of
albumin,
focusing
on
novel
compositions
that
take
advantage
excellent
potential
this
protein.
coating
can
be
used
enhancing
biocompatibility
various
types
implants,
such
bone
grafts
or
sutures.
mainly
known
an
anti-attachment
protein;
however,
using
it
implantable
surfaces
just
opposite:
enhances
cell
adhesion
and
proliferation.
The
anticoagulant,
antimicrobial
anti-inflammatory
properties
allow
fine-tuning
reaction
to
tissue-engineering
constructs.
Another
use
combining
natural
synthetic
materials
results
composites
suitable
cardiac,
neural,
hard
soft
tissue
engineering.
Recent
advances
have
made
possible
electrospin
globular
opening
up
new
possibilities
albumin-based
scaffolds
therapy.
Several
described
technologies
already
entered
clinical
phase,
making
good
biological,
but
also
regulatory,
manufacturing
features
serum
albumin.
Coordination Chemistry Reviews,
Год журнала:
2023,
Номер
480, С. 215026 - 215026
Опубликована: Янв. 17, 2023
Human
serum
albumin
(HSA)
plays
a
major
role
in
the
transport
of
metallodrugs,
affecting
pharmacokinetics
and
pharmacodynamics
these
molecules.
This
work
highlights
recent
achievements
metalation
by
anticancer
with
special
emphasis
on
structure
metallodrug/protein
adducts.
The
effect
protein
HSA
is
discussed
together
possibility
to
use
metallodrug/HSA
adducts
as
agents.
HSA,
that
can
be
influenced
pH
changes
fatty
acid
binding,
not
significantly
affected
metal
compound
binding.
Coordinative
bonds
non-covalent
interactions
used
compounds
interact
protein.
Several
metallodrug
binding
sites
are
available
structure:
side
chains
Cys34,
His105
(subdomain
IA),
His67
His247
(i.e.
Site
A,
Zn2+
site),
His128,
His146
IB),
Lys199
His242
IIA),
His288
Met298,
Met329,
His338
IIB),
Lys436
His440
IIIA),
Met548,
His535
IIIB).
Non-covalent
has
been
observed
(mainly
hydrophobic)
pockets
lined
residues
belonging
subdomain
IB.
Pt(II)-based
drugs
prefer
His
Met,
Ru(II)/(III)
(or
Lys)
residues,
Au(III)/Au(I)-based
chain
Au(III)
also
bind
His146.
study
assist
design
new
metallodrugs
extended
plasma
half-life
improved
delivery
into
tumors.
