Insight on Serum Albumin: From Structure and Biological Properties to Functional Biomaterials for Bone Repair DOI

Mengmeng Jin,

Songsong Zhu,

Yi Hou

и другие.

ACS Biomaterials Science & Engineering, Год журнала: 2023, Номер 9(5), С. 2235 - 2250

Опубликована: Апрель 4, 2023

Serum albumin (SA), one of the most abundant proteins in blood plasma, plays essential roles all living processes and has been used various biomedical applications. Biomaterials fabricated from SAs (human SA, bovine ovalbumin) exhibit proper microstructure hydrophilicity as well remarkable biocompatibility; this makes them ideal for use bone regeneration. This review provides a comprehensive overview structure, physicochemical properties, biological features SAs. can be to generate wide array biomaterials repair because their flexible structure diverse functions, which enables us control morphology modulate responses with host tissue. summarizes material categories, forms, fabrication methods SA repair. Finally, concerns future studies fields SA-derived are discussed.

Язык: Английский

Applications of human and bovine serum albumins in biomedical engineering: A review DOI
Xinhao Xu, Jinyu Hu,

Huaqian Xue

и другие.

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 253, С. 126914 - 126914

Опубликована: Сен. 15, 2023

Язык: Английский

Процитировано

68

A Beefy-R culture medium: Replacing albumin with rapeseed protein isolates DOI Creative Commons
Andrew J. Stout,

Miriam L. Rittenberg,

Michelle Shub

и другие.

Biomaterials, Год журнала: 2023, Номер 296, С. 122092 - 122092

Опубликована: Март 20, 2023

Язык: Английский

Процитировано

49

Interaction of food colorant indigo carmine with human and bovine serum albumins: A multispectroscopic, calorimetric, and theoretical investigation DOI

Gouranga Jana,

Shukdeb Sing,

Arindam Das

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 259, С. 129143 - 129143

Опубликована: Янв. 3, 2024

Язык: Английский

Процитировано

24

Advanced Drug Carriers: A Review of Selected Protein, Polysaccharide, and Lipid Drug Delivery Platforms DOI Open Access

Mateusz Jamroży,

Sonia Kudłacik–Kramarczyk, Anna Drabczyk

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(2), С. 786 - 786

Опубликована: Янв. 8, 2024

Studies on bionanocomposite drug carriers are a key area in the field of active substance delivery, introducing innovative approaches to improve therapy. Such play crucial role enhancing bioavailability substances, affecting therapy efficiency and precision. The targeted delivery drugs sites action minimization toxicity body is becoming possible through use these advanced carriers. Recent research has focused structures based biopolymers, including lipids, polysaccharides, proteins. This review paper description lipid-containing nanocomposite (including liposomes, lipid emulsions, nanoparticles, solid nanostructured carriers), polysaccharide-containing alginate cellulose), protein-containing (e.g., gelatin albumin). It was demonstrated many investigations that such show ability load therapeutic substances efficiently precisely control release. They also desirable biocompatibility, which promising sign for their potential application development indicates novel approach improving processes, contribute significant advances pharmacology, efficacy while minimizing side effects.

Язык: Английский

Процитировано

24

Albumin Nanoparticle-Based Drug Delivery Systems DOI Creative Commons
Na Qu, Ke Song, Yating Ji

и другие.

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 6945 - 6980

Опубликована: Июль 1, 2024

Nanoparticle-based systems are extensively investigated for drug delivery. Among others, with superior biocompatibility and enhanced targeting capacity, albumin appears to be a promising carrier Albumin nanoparticles highly favored in many disease therapies, as they have the proper chemical groups modification, cell-binding sites cell adhesion, affinity protein drugs nanocomplex generation. Herein, this review summarizes recent fabrication techniques, modification strategies, application of nanoparticles. We first discuss various nanoparticle methods, from both pros cons. Then, we provide comprehensive introduction section, including organic nanoparticles, metal inorganic nanoparticle-based hybrids. finally bring further perspectives on used critical diseases.

Язык: Английский

Процитировано

24

Profiling the Interaction between Human Serum Albumin and Clinically Relevant HIV Reverse Transcriptase Inhibitors DOI Creative Commons

Andreia Costa-Tuna,

Otávio Augusto Chaves, Zaida L. Almeida

и другие.

Viruses, Год журнала: 2024, Номер 16(4), С. 491 - 491

Опубликована: Март 22, 2024

Tenofovir (TFV) is the active form of prodrugs tenofovir disoproxil fumarate (TDF) and alafenamide (TAF), both clinically prescribed as HIV reverse transcriptase inhibitors. The biophysical interactions between these compounds human serum albumin (HSA), primary carrier exogenous in bloodstream, have not yet been thoroughly characterized. Thus, present study reports interaction profile HSA TFV, TDF, TAF via UV–Vis, steady-state, time-resolved fluorescence techniques combined with isothermal titration calorimetry (ITC) silico calculations. A spontaneous ground state, which does perturb microenvironment close to Trp-214 residue, classified weak. In case HSA/TFV HSA/TDF, binding enthalpically entropically driven, while for HSA/TAF, only dominated. constant (Ka) thermodynamic parameters obtained ITC assays agree those using steady-state quenching measurements, reinforcing reliability data. small internal cavity known site I probably main pocket TFV due low steric volume drug. contrast, most external sites (II III) can better accommodate high this prodrug. cross-docking approach corroborated experimental drug-displacement assays, indicating that affinity might be impacted by presence different bound albumin. Overall, weak capacity one factors residence time antiretrovirals bloodstream; however, positive cooperativity TDF was detected some drugs, improve their (pharmacokinetic profile).

Язык: Английский

Процитировано

23

Biopolymers: An inclusive review DOI Creative Commons
Great Iruoghene Edo, Winifred Ndudi,

Ali B. M. Ali

и другие.

Hybrid Advances, Год журнала: 2025, Номер unknown, С. 100418 - 100418

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

4

Graphene Oxide–Protein-Based Scaffolds for Tissue Engineering: Recent Advances and Applications DOI Open Access
Elena Iuliana Bîru, Mădălina Ioana Necolau, Adriana Zainea

и другие.

Polymers, Год журнала: 2022, Номер 14(5), С. 1032 - 1032

Опубликована: Март 4, 2022

The field of tissue engineering is constantly evolving as it aims to develop bioengineered and functional tissues organs for repair or replacement. Due their large surface area ability interact with proteins peptides, graphene oxides offer valuable physiochemical biological features biomedical applications have been successfully employed optimizing scaffold architectures a wide range organs, from the skin cardiac tissue. This review critically focuses on opportunities employ protein-graphene oxide structures either nanocomposites biocomplexes highlights effects carbonaceous nanostructures protein conformation structural stability in regenerative medicine. Herein, recent activity nanocomposite bioconjugates are analyzed respect cell viability proliferation, along these constructs sustain formation new Novel strategies approaches based stem therapy, well involvement extracellular matrix design smart nanoplatforms, discussed.

Язык: Английский

Процитировано

54

Albumin as a Biomaterial and Therapeutic Agent in Regenerative Medicine DOI Open Access
Olga Kuten-Pella, István Hornyák, Dénes B. Horváthy

и другие.

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(18), С. 10557 - 10557

Опубликована: Сен. 12, 2022

Albumin is a constitutional plasma protein, with well-known biological functions, e.g., nutrient for stem cells in culture. However, albumin underutilized as biomaterial regenerative medicine. This review summarizes the advanced therapeutic uses of albumin, focusing on novel compositions that take advantage excellent potential this protein. coating can be used enhancing biocompatibility various types implants, such bone grafts or sutures. mainly known an anti-attachment protein; however, using it implantable surfaces just opposite: enhances cell adhesion and proliferation. The anticoagulant, antimicrobial anti-inflammatory properties allow fine-tuning reaction to tissue-engineering constructs. Another use combining natural synthetic materials results composites suitable cardiac, neural, hard soft tissue engineering. Recent advances have made possible electrospin globular opening up new possibilities albumin-based scaffolds therapy. Several described technologies already entered clinical phase, making good biological, but also regulatory, manufacturing features serum albumin.

Язык: Английский

Процитировано

53

Metallodrug binding to serum albumin: Lessons from biophysical and structural studies DOI Creative Commons
Antonello Merlino

Coordination Chemistry Reviews, Год журнала: 2023, Номер 480, С. 215026 - 215026

Опубликована: Янв. 17, 2023

Human serum albumin (HSA) plays a major role in the transport of metallodrugs, affecting pharmacokinetics and pharmacodynamics these molecules. This work highlights recent achievements metalation by anticancer with special emphasis on structure metallodrug/protein adducts. The effect protein HSA is discussed together possibility to use metallodrug/HSA adducts as agents. HSA, that can be influenced pH changes fatty acid binding, not significantly affected metal compound binding. Coordinative bonds non-covalent interactions used compounds interact protein. Several metallodrug binding sites are available structure: side chains Cys34, His105 (subdomain IA), His67 His247 (i.e. Site A, Zn2+ site), His128, His146 IB), Lys199 His242 IIA), His288 Met298, Met329, His338 IIB), Lys436 His440 IIIA), Met548, His535 IIIB). Non-covalent has been observed (mainly hydrophobic) pockets lined residues belonging subdomain IB. Pt(II)-based drugs prefer His Met, Ru(II)/(III) (or Lys) residues, Au(III)/Au(I)-based chain Au(III) also bind His146. study assist design new metallodrugs extended plasma half-life improved delivery into tumors.

Язык: Английский

Процитировано

36