Trends in biotechnology, Год журнала: 2023, Номер 41(11), С. 1343 - 1359
Опубликована: Июнь 9, 2023
Язык: Английский
Journal of Controlled Release, Год журнала: 2022, Номер 353, С. 1127 - 1149
Опубликована: Дек. 26, 2022
Язык: Английский
Процитировано
162
Inflammopharmacology, Год журнала: 2023, Номер 31(1), С. 145 - 169
Опубликована: Янв. 7, 2023
Язык: Английский
Процитировано
161
ACS Biomaterials Science & Engineering, Год журнала: 2023, Номер 9(2), С. 577 - 594
Опубликована: Янв. 9, 2023
Exosomes are the phospholipid-membrane-bound subpopulation of extracellular vesicles derived from plasma membrane. The main activity exosomes is cellular communication. In cancer, play an important rolefrom two distinct perspectives, one related to carcinogenesis and other as theragnostic drug delivery tools. outer phospholipid membrane Exosome improves targeting efficiency. . Some vital features such biocompatibility, low toxicity, immunogenicity make it a more exciting system. Exosome-based new innovative approach cancer treatment. Exosome-associated biomarker analysis heralded era diagnostics in specific way. This Review focuses on exosome biogenesis, sources, isolation, interrelationship with exosome-related biomarkers, loading methods, exosome-based biomolecule delivery, advances limitations clinical settings studies. understanding will change diagnostic therapeutic future.
Язык: Английский
Процитировано
130
Experimental & Molecular Medicine, Год журнала: 2022, Номер unknown
Опубликована: Сен. 22, 2022
Abstract Exosomes are vesicles encompassed by a lipid bilayer that released various living cells. Exosomal proteins encapsulated within the membrane or embedded on surface. As an important type of exosome cargo, exosomal can reflect physiological status parent cell and play essential role in cell–cell communication. regulate tumor development, including tumor-related immune regulation, microenvironment reconstruction, angiogenesis, epithelial–mesenchymal transition, metastasis, etc. The features provide insight into generation, targeting, biological function potential sources markers for cancer diagnosis, prognosis, treatment. Here, we summarize effects biology, latest progress application diagnosis contribution therapeutics vaccines.
Язык: Английский
Процитировано
121
Nano Today, Год журнала: 2023, Номер 49, С. 101771 - 101771
Опубликована: Фев. 7, 2023
Exosomes are small nanosized biovesicles that form when multivesicular bodies and the plasma membrane fuse released into surrounding body fluids. They best known for their multifunction in mediating intercellular communication by transferring various biomolecules, including DNA, RNAs, proteins, lipids, a short- long-distance manner have been identified as health disease messengers. Importantly, exosomes necessary physiological processes disease. The generation of depends on status disease, which usually exhibits opposite roles inducing enhanced cellular stress damage. Recently, exosome-based nanotechnologies provided unprecedented opportunities to boost developments exosome-related biology, chemistry, pathology, therapeutics different diseases based unique structural/compositional/morphological characteristics next-generation nanomedicines. Herein, we provide comprehensive overview recent advances exosome nanotechnology research, classification, isolation preparation, constitution, biological function, nanobiomedical applications treatment diagnosis. Furthermore, future prospects were also concluded. This review will more inspiration promoting development advanced theranostic nanoplatforms nanotechnology.
Язык: Английский
Процитировано
82
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(4), С. 3188 - 3188
Опубликована: Фев. 6, 2023
Biopolymeric nanoparticles are gaining importance as nanocarriers for various biomedical applications, enabling long-term and controlled release at the target site. Since they promising delivery systems therapeutic agents offer advantageous properties such biodegradability, biocompatibility, non-toxicity, stability compared to toxic metal nanoparticles, we decided provide an overview on this topic. Therefore, review focuses use of biopolymeric animal, plant, algal, fungal, bacterial origin a sustainable material potential drug systems. A particular focus is encapsulation many different categorized bioactive compounds, drugs, antibiotics, other antimicrobial agents, extracts, essential oils into protein- polysaccharide-based nanocarriers. These show benefits human health, especially successful anticancer activity. The article, divided protein-based further according biopolymer, enables reader select appropriate more easily incorporation desired component. latest research results from last five years in field production loaded with healthcare applications included review.
Язык: Английский
Процитировано
66
Extracellular Vesicle, Год журнала: 2023, Номер 3, С. 100032 - 100032
Опубликована: Дек. 9, 2023
Exosomes are nanovesicles released from cells due to pathophysiological events. These nanoparticles resistant metabolic destruction and can transcend the blood-brain barrier. Exosome therapy could be employed as precision medicine by targeting underlying etiology. This article briefly elucidates basic physiology of exosomes, their types, characteristics, cargo that for drug administration. It then delves into therapeutic applications, such oncology, neurological disorders, regenerative medicine. Exosome-based delivery using small molecules, nucleic acids, proteins is also demonstrated. Finally, global organizations successfully creating testing medicinal biomaterials highlighted.
Язык: Английский
Процитировано
49
Journal of Controlled Release, Год журнала: 2023, Номер 356, С. 463 - 480
Опубликована: Март 15, 2023
Complexity and difficulties in wound management are pressing concerns that affect patients' quality of life may result tissue infection, necrosis, loss local systemic functions. Hence, novel approaches to accelerate healing being actively explored over the last decade. Exosomes as important mediators intercellular communications promising natural nanocarriers due their biocompatibility, low immunogenicity, drug loading targeting capacities, innate stability. More importantly, exosomes developed a versatile pharmaceutical engineering platform for repair. This review provides an overview biological physiological functions derived from variety origins during phases, strategies exosomal engineering, therapeutic applications skin regeneration.
Язык: Английский
Процитировано
46
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(11), С. 5842 - 5842
Опубликована: Май 27, 2024
This study provides a brief discussion of the major nanopharmaceuticals formulations as well impact nanotechnology on future pharmaceuticals. Effective and eco-friendly strategies biofabrication are also highlighted. Modern approaches to designing pharmaceutical nanoformulations (e.g., 3D printing, Phyto-Nanotechnology, Biomimetics/Bioinspiration, etc.) outlined. paper discusses need use natural resources for “green” design new with therapeutic efficiency. Nanopharmaceuticals research is still in its early stages, preparation nanomaterials must be carefully considered. Therefore, safety long-term effects not overlooked. The testing represents an essential point their further applications. Vegetal scaffolds obtained by decellularizing plant leaves represent valuable, bioinspired model nanopharmaceutical that avoids using animals. Nanoformulations critical various fields, especially pharmacy, medicine, agriculture, material science, due unique properties advantages over conventional allows improved solubility, bioavailability, targeted drug delivery, controlled release, reduced toxicity. have transitioned from experimental stages being vital component clinical practice, significantly improving outcomes medical fields cancer treatment, infectious diseases, neurological disorders, personalized advanced diagnostics. Here key points highlighting importance. significant challenges, opportunities, directions mentioned final section.
Язык: Английский
Процитировано
22
Nanomedicine Nanotechnology Biology and Medicine, Год журнала: 2022, Номер 47, С. 102613 - 102613
Опубликована: Окт. 14, 2022
Язык: Английский
Процитировано
54